Adipose Manipulation Transplantation (AMT) Transforming Fat into an Active Ally Against Cancer - Master of Translational Medicine - UC Berkeley & UCSF
Adipose Manipulation Transplantation (AMT) Transforming Fat into an Active Ally Against Cancer
Overview
Adipose Manipulation Transplantation (AMT) is a novel approach to fight cancer. It uses engineered adipose tissues to deprive tumors of the resources they need to survive and proliferate, transforming ordinary fat into an active ally against cancer.
The Issue
Cancer cells are highly metabolically active, changing their surroundings to steal nutrients and energy for uncontrolled growth. While existing therapies primarily focus on directly killing cancer cells, many face significant limitations, including systemic toxicity, drug resistance, and incomplete tumor eradication, leaving an urgent need for safer and more effective strategies.
Approach
To address this challenge, AMT engineers white adipose tissue to outcompete cancer cells, starving them of vital nutrients that keep them alive, ultimately reducing tumor size. In addition, this therapy can be customized for different cancer-associated metabolic programs, and to secrete cancer fighting molecules, enabling more precise tumor targeting and maximizing therapeutic efficacy.
MTM Student Engagement
The MTM student team brings experiences from engineering, clinical medicine, wet lab experience and clinical and regulatory strategy. The team is working closely with the project sponsor to identify the target market through business development activities, clinical strategy and regulatory planning, to help bring this therapy to clinicians and patients.
Project Brief
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