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Mevalonate Biosynthesis is a Metabolic Vulnerability of Gemcitabine-resistant Pancreatic Cancer. bioRxiv. 2025 Sep 20. Beutel AK, Calderon S, Nghiem E, Gulay K, Santana LPS, Zimmer E, Singh R, Anaraki C, Yousefian N, Allgöwer C, Tong G, Geller C, Chao A, Juarez D, Seufferlein T, Muir A, Jang C, Edinger AL, Seldin M, Martinez TF, Kleger A, Chang DK, Tiriac H, Valerin JB, Fruman DA, Halbrook CJ. PMID: 41000736; PMCID: PMC12458164.
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Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A. EMBO J. 2025 Aug; 44(16):4473-4498. Jayashankar V, Kubiniok P, McCracken AN, Gentry RG, Eckenstein KH, Sernissi L, Vece V, Garsi JB, Valles SY, Jung S, Hoffman NC, Perrochon AS, Selwan EM, Finicle BT, Pitman M, Lin D, Bonneil É, Xu R, Mao C, Kaiser P, Fruman DA, Mobley D, Jang C, Hanessian S, Thibault P, Edinger AL. PMID: 40588551; PMCID: PMC12361511.
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Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke. bioRxiv. 2025 May 20. Cottarelli A, Jamoul D, Tuohy MC, Shahriar S, Glendinning M, Prochilo G, Edinger AL, Arac A, Agalliu D. PMID: 37693406; PMCID: PMC10491261.
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Stem design affects templating adherence in total hip arthroplasty - a retrospective cohort study comparing two types of cementless short stems. J Orthop Surg Res. 2025 Apr 17; 20(1):383. Stadler C, Edinger A, Schauer B, Haslhofer DJ, Gotterbarm T, Luger M. PMID: 40247404; PMCID: PMC12004617.
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CARMIL1-AA selectively inhibits macropinocytosis while sparing autophagy. Mol Biol Cell. 2025 Jan 01; 36(1):ar4. Lim RM, Lu A, Chuang BM, Anaraki C, Chu B, Halbrook CJ, Edinger AL. PMID: 39602282; PMCID: PMC11742120.
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Circulating biomarkers of kidney angiomyolipoma and cysts in tuberous sclerosis complex patients. iScience. 2024 Jul 19; 27(7):110265. Rubtsova VI, Chun Y, Kim J, Ramirez CB, Jung S, Choi W, Kelly ME, Lopez ML, Cassidy E, Rushing G, Aguiar DJ, Lau WL, Ahdoot RS, Smith M, Edinger AL, Lee SG, Jang C, Lee G. PMID: 39027368; PMCID: PMC11255849.
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A high dose KRP203 induces cytoplasmic vacuoles associated with altered phosphoinositide segregation and endosome expansion. Biochem Biophys Res Commun. 2024 07 23; 718:149981. Kofuji S, Wolfe K, Sumita K, Kageyama S, Yoshino H, Hirota Y, Ogawa-Iio A, Kanoh H, Sasaki M, Kofuji K, Davis MI, Pragani R, Shen M, Boxer MB, Nakatsu F, Nigorikawa K, Sasaki T, Takeuchi K, Senda T, Kim SM, Edinger AL, Simeonov A, Sasaki AT. PMID: 38735134; PMCID: PMC11416131.
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Diversifying faculty recruitment in biomedical sciences. FASEB J. 2023 11; 37(11):e23224. Yassa MA, Edinger AL. PMID: 37779389.
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Disruption of the Rab7-Dependent Final Common Pathway of Endosomal and Autophagic Processing Results in a Severe Podocytopathy. J Am Soc Nephrol. 2023 07 01; 34(7):1191-1206. Vöing K, Michgehl U, Mertens ND, Picciotto C, Maywald ML, Goretzko J, Waimann S, Gilhaus K, Rogg M, Schell C, Klingauf J, Tsytsyura Y, Hansen U, van Marck V, Edinger AL, Vollenbröker B, Rescher U, Braun DA, George B, Weide T, Pavenstädt H. PMID: 37022133; PMCID: PMC10356157.
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Simultaneous inhibition of endocytic recycling and lysosomal fusion sensitizes cells and tissues to oligonucleotide therapeutics. Nucleic Acids Res. 2023 02 28; 51(4):1583-1599. Finicle BT, Eckenstein KH, Revenko AS, Anderson BA, Wan WB, McCracken AN, Gil D, Fruman DA, Hanessian S, Seth PP, Edinger AL. PMID: 36727438; PMCID: PMC9976930.
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Drug-like sphingolipid SH-BC-893 opposes ceramide-induced mitochondrial fission and corrects diet-induced obesity. EMBO Mol Med. 2021 08 09; 13(8):e13086. Jayashankar V, Selwan E, Hancock SE, Verlande A, Goodson MO, Eckenstein KH, Milinkeviciute G, Hoover BM, Chen B, Fleischman AG, Cramer KS, Hanessian S, Masri S, Turner N, Edinger AL. PMID: 34231322; PMCID: PMC8350895.
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Macropinocytosis confers resistance to therapies targeting cancer anabolism. Nat Commun. 2020 02 28; 11(1):1121. Jayashankar V, Edinger AL. PMID: 32111826; PMCID: PMC7048872.
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Synthetic Sphingolipids with 1,2-Pyridazine Appendages Improve Antiproliferative Activity in Human Cancer Cell Lines. ACS Med Chem Lett. 2020 May 14; 11(5):686-690. Bachollet SPJT, Vece V, McCracken AN, Finicle BT, Selwan E, Ben Romdhane N, Dahal A, Ramirez C, Edinger AL, Hanessian S. PMID: 32435371; PMCID: PMC7236038.
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Biocompatible Chemotherapy for Leukemia by Acid-Cleavable, PEGylated FTY720. Bioconjug Chem. 2020 03 18; 31(3):673-684. Kemp JA, Keebaugh A, Edson JA, Chow D, Kleinman MT, Chew YC, McCracken AN, Edinger AL, Kwon YJ. PMID: 31986014.
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Leveraging insights into cancer metabolism-a symposium report. Ann N Y Acad Sci. 2020 02; 1462(1):5-13. Cable J, Finley L, Tu BP, Patti GJ, Oliver TG, Vardhana S, Mana M, Ericksen R, Khare S, DeBerardinis R, Stockwell BR, Edinger A, Haigis M, Kaelin W. PMID: 31792987; PMCID: PMC7255687.
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Design, synthesis and anticancer activity of constrained sphingolipid-phenoxazine/phenothiazine hybrid constructs targeting protein phosphatase 2A. Bioorg Med Chem Lett. 2019 09 15; 29(18):2681-2685. Garsi JB, Vece V, Sernissi L, Auger-Morin C, Hanessian S, McCracken AN, Selwan E, Ramirez C, Dahal A, Romdhane NB, Finicle BT, Edinger AL. PMID: 31383588; PMCID: PMC7784717.
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Dynamic Phosphoproteomics Uncovers Signaling Pathways Modulated by Anti-oncogenic Sphingolipid Analogs. Mol Cell Proteomics. 2019 03; 18(3):408-422. Kubiniok P, Finicle BT, Piffaretti F, McCracken AN, Perryman M, Hanessian S, Edinger AL, Thibault P. PMID: 30482847; PMCID: PMC6398214.
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Nutrient scavenging in cancer. Nat Rev Cancer. 2018 10; 18(10):619-633. Finicle BT, Jayashankar V, Edinger AL. PMID: 30097614.
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In search of constrained FTY720 and phytosphingosine analogs as dual acting anticancer agents targeting metabolic and epigenetic pathways. Eur J Med Chem. 2018 Nov 05; 159:217-242. Garsi JB, Sernissi L, Vece V, Hanessian S, McCracken AN, Simitian G, Edinger AL. PMID: 30292898; PMCID: PMC6217821.
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Starving PTEN-deficient prostate cancer cells thrive under nutrient stress by scavenging corpses for their supper. Mol Cell Oncol. 2018; 5(4):e1472060. Jayashankar V, Finicle BT, Edinger AL. PMID: 30250923; PMCID: PMC6149707.
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Sphingolipids inhibit endosomal recycling of nutrient transporters by inactivating ARF6. J Cell Sci. 2018 06 25; 131(12). Finicle BT, Ramirez MU, Liu G, Selwan EM, McCracken AN, Yu J, Joo Y, Nguyen J, Ou K, Roy SG, Mendoza VD, Corrales DV, Edinger AL. PMID: 29848659; PMCID: PMC6031383.
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PTEN Deficiency and AMPK Activation Promote Nutrient Scavenging and Anabolism in Prostate Cancer Cells. Cancer Discov. 2018 07; 8(7):866-883. Kim SM, Nguyen TT, Ravi A, Kubiniok P, Finicle BT, Jayashankar V, Malacrida L, Hou J, Robertson J, Gao D, Chernoff J, Digman MA, Potma EO, Tromberg BJ, Thibault P, Edinger AL. PMID: 29572236; PMCID: PMC6030497.
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Rab7-a novel redox target that modulates inflammatory pain processing. Pain. 2017 07; 158(7):1354-1365. Kallenborn-Gerhardt W, Möser CV, Lorenz JE, Steger M, Heidler J, Scheving R, Petersen J, Kennel L, Flauaus C, Lu R, Edinger AL, Tegeder I, Geisslinger G, Heide H, Wittig I, Schmidtko A. PMID: 28394828.
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Branched chain amino acid metabolism and cancer: the importance of keeping things in context. Transl Cancer Res. 2017 May; 6(Suppl 3):S578-S584. Selwan EM, Edinger AL. PMID: 30613481; PMCID: PMC6319930.
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Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase-activating protein Armus. J Cell Sci. 2016 12 01; 129(23):4424-4435. Jaber N, Mohd-Naim N, Wang Z, DeLeon JL, Kim S, Zhong H, Sheshadri N, Dou Z, Edinger AL, Du G, Braga VM, Zong WX. PMID: 27793976; PMCID: PMC5201010.
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Targeting cancer metabolism by simultaneously disrupting parallel nutrient access pathways. J Clin Invest. 2016 11 01; 126(11):4088-4102. Kim SM, Roy SG, Chen B, Nguyen TM, McMonigle RJ, McCracken AN, Zhang Y, Kofuji S, Hou J, Selwan E, Finicle BT, Nguyen TT, Ravi A, Ramirez MU, Wiher T, Guenther GG, Kono M, Sasaki AT, Weisman LS, Potma EO, Tromberg BJ, Edwards RA, Hanessian S, Edinger AL. PMID: 27669461; PMCID: PMC5096903.
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Phosphorylation of a constrained azacyclic FTY720 analog enhances anti-leukemic activity without inducing S1P receptor activation. Leukemia. 2017 03; 31(3):669-677. McCracken AN, McMonigle RJ, Tessier J, Fransson R, Perryman MS, Chen B, Keebaugh A, Selwan E, Barr SA, Kim SM, Roy SG, Liu G, Fallegger D, Sernissi L, Brandt C, Moitessier N, Snider AJ, Clare S, Müschen M, Huwiler A, Kleinman MT, Hanessian S, Edinger AL. PMID: 27573555; PMCID: PMC5332311.
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Oligodendroglial deletion of ESCRT-I component TSG101 causes spongiform encephalopathy. Biol Cell. 2016 Nov; 108(11):324-337. Walker WP, Oehler A, Edinger AL, Wagner KU, Gunn TM. PMID: 27406702.
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Effects of stereochemistry, saturation, and hydrocarbon chain length on the ability of synthetic constrained azacyclic sphingolipids to trigger nutrient transporter down-regulation, vacuolation, and cell death. Bioorg Med Chem. 2016 09 15; 24(18):4390-4397. Perryman MS, Tessier J, Wiher T, O'Donoghue H, McCracken AN, Kim SM, Nguyen DG, Simitian GS, Viana M, Rafelski S, Edinger AL, Hanessian S. PMID: 27475534.
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Age-related myelin degradation burdens the clearance function of microglia during aging. Nat Neurosci. 2016 08; 19(8):995-8. Safaiyan S, Kannaiyan N, Snaidero N, Brioschi S, Biber K, Yona S, Edinger AL, Jung S, Rossner MJ, Simons M. PMID: 27294511; PMCID: PMC7116794.
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Attacking the supply wagons to starve cancer cells to death. FEBS Lett. 2016 Apr; 590(7):885-907. Selwan EM, Finicle BT, Kim SM, Edinger AL. PMID: 26938658; PMCID: PMC4833639.
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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, et al. PMID: 26799652; PMCID: PMC4835977.
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Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo. ACS Chem Biol. 2016 Feb 19; 11(2):409-14. Chen B, Roy SG, McMonigle RJ, Keebaugh A, McCracken AN, Selwan E, Fransson R, Fallegger D, Huwiler A, Kleinman MT, Edinger AL, Hanessian S. PMID: 26653336; PMCID: PMC4862402.
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Targeting cancer metabolism at the plasma membrane by limiting amino acid access through SLC6A14. Biochem J. 2015 Sep 15; 470(3):e17-9. McCracken AN, Edinger AL. PMID: 26341486; PMCID: PMC4613721.
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Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus aureus. Chem Biol. 2015 Jun 18; 22(6):785-92. Holden JK, Kang S, Beasley FC, Cinelli MA, Li H, Roy SG, Dejam D, Edinger AL, Nizet V, Silverman RB, Poulos TL. PMID: 26091171; PMCID: PMC4475277.
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B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses. J Immunol. 2015 Apr 01; 194(7):3065-78. Pone EJ, Lam T, Lou Z, Wang R, Chen Y, Liu D, Edinger AL, Xu Z, Casali P. PMID: 25740947; PMCID: PMC4643723.
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Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya). ACS Med Chem Lett. 2013 Oct 10; 4(10). Fransson R, McCracken AN, Chen B, McMonigle RJ, Edinger AL, Hanessian S. PMID: 24273632; PMCID: PMC3834958.
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Loss of TSC2 confers resistance to ceramide and nutrient deprivation. Oncogene. 2014 Apr 03; 33(14):1776-87. Guenther GG, Liu G, Ramirez MU, McMonigle RJ, Kim SM, McCracken AN, Joo Y, Ushach I, Nguyen NL, Edinger AL. PMID: 23604129; PMCID: PMC3858574.
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Reciprocal effects of rab7 deletion in activated and neglected T cells. Autophagy. 2013 Jul; 9(7):1009-23. Roy SG, Stevens MW, So L, Edinger AL. PMID: 23615463; PMCID: PMC3722312.
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Nutrient transporters: the Achilles' heel of anabolism. Trends Endocrinol Metab. 2013 Apr; 24(4):200-8. McCracken AN, Edinger AL. PMID: 23402769; PMCID: PMC3617053.
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Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, et al. PMID: 22966490; PMCID: PMC3404883.
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Flow injection tandem mass spectrometric measurement of ceramides of multiple chain lengths in biological samples. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Feb 01; 883-884:136-40. Chen J, Narayan SB, Edinger AL, Bennett MJ. PMID: 22138588; PMCID: PMC3491661.
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Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteins. Biochem J. 2011 Oct 15; 439(2):299-311. Romero Rosales K, Singh G, Wu K, Chen J, Janes MR, Lilly MB, Peralta ER, Siskind LJ, Bennett MJ, Fruman DA, Edinger AL. PMID: 21767261; PMCID: PMC3454501.
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Unequal in the absence of death: a novel screen identifies cytotoxic compounds selective for cells with activated Akt. Cancer Biol Ther. 2010 Dec 15; 10(12):1262-5. Edinger AL. PMID: 20935459.
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The complex interplay between autophagy, apoptosis, and necrotic signals promotes T-cell homeostasis. Immunol Rev. 2010 Jul; 236:95-109. Walsh CM, Edinger AL. PMID: 20636811; PMCID: PMC2966323.
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Differential effects of TBC1D15 and mammalian Vps39 on Rab7 activation state, lysosomal morphology, and growth factor dependence. J Biol Chem. 2010 May 28; 285(22):16814-21. Peralta ER, Martin BC, Edinger AL. PMID: 20363736; PMCID: PMC2878074.
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The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis. J Biol Chem. 2010 Apr 16; 285(16):11818-26. Siskind LJ, Mullen TD, Romero Rosales K, Clarke CJ, Hernandez-Corbacho MJ, Edinger AL, Obeid LM. PMID: 20172858; PMCID: PMC2852918.
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Rab7 activation by growth factor withdrawal contributes to the induction of apoptosis. Mol Biol Cell. 2009 Jun; 20(12):2831-40. Romero Rosales K, Peralta ER, Guenther GG, Wong SY, Edinger AL. PMID: 19386765; PMCID: PMC2695791.
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A new take on ceramide: starving cells by cutting off the nutrient supply. Cell Cycle. 2009 Apr 15; 8(8):1122-6. Guenther GG, Edinger AL. PMID: 19282666.
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Ceramide-induced starvation triggers homeostatic autophagy. Autophagy. 2009 Apr; 5(3):407-9. Peralta ER, Edinger AL. PMID: 19202357.
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Starvation in the midst of plenty: making sense of ceramide-induced autophagy by analysing nutrient transporter expression. Biochem Soc Trans. 2009 Feb; 37(Pt 1):253-8. Edinger AL. PMID: 19143642.
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Ceramide starves cells to death by downregulating nutrient transporter proteins. Proc Natl Acad Sci U S A. 2008 Nov 11; 105(45):17402-7. Guenther GG, Peralta ER, Rosales KR, Wong SY, Siskind LJ, Edinger AL. PMID: 18981422; PMCID: PMC2582319.
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Cancer therapy: staying current with AMPK. Biochem J. 2008 Jun 01; 412(2):e3-5. Fruman DA, Edinger AL. PMID: 18466113.
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Controlling cell growth and survival through regulated nutrient transporter expression. Biochem J. 2007 Aug 15; 406(1):1-12. Edinger AL. PMID: 17645414.
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Growth factors regulate cell survival by controlling nutrient transporter expression. Biochem Soc Trans. 2005 Feb; 33(Pt 1):225-7. Edinger AL. PMID: 15667313.
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Death by design: apoptosis, necrosis and autophagy. Curr Opin Cell Biol. 2004 Dec; 16(6):663-9. Edinger AL, Thompson CB. PMID: 15530778.
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An activated mTOR mutant supports growth factor-independent, nutrient-dependent cell survival. Oncogene. 2004 Jul 22; 23(33):5654-63. Edinger AL, Thompson CB. PMID: 15133498.
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Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res. 2003 Dec 01; 63(23):8451-60. Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. PMID: 14679009.
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Defective autophagy leads to cancer. Cancer Cell. 2003 Dec; 4(6):422-4. Edinger AL, Thompson CB. PMID: 14706333.
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Rab7 prevents growth factor-independent survival by inhibiting cell-autonomous nutrient transporter expression. Dev Cell. 2003 Oct; 5(4):571-82. Edinger AL, Cinalli RM, Thompson CB. PMID: 14536059.
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Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake. Mol Biol Cell. 2002 Jul; 13(7):2276-88. Edinger AL, Thompson CB. PMID: 12134068; PMCID: PMC117312.
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CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity. J Virol. 2002 Mar; 76(6):2595-605. Puffer BA, Pöhlmann S, Edinger AL, Carlin D, Sanchez MD, Reitter J, Watry DD, Fox HS, Desrosiers RC, Doms RW. PMID: 11861825; PMCID: PMC135960.
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Antigen-presenting cells control T cell proliferation by regulating amino acid availability. Proc Natl Acad Sci U S A. 2002 Feb 05; 99(3):1107-9. Edinger AL, Thompson CB. PMID: 11830651; PMCID: PMC122151.
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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J Biol Chem. 2001 Apr 13; 276(15):12041-8. Plas DR, Talapatra S, Edinger AL, Rathmell JC, Thompson CB. PMID: 11278698.
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Characterization and epitope mapping of neutralizing monoclonal antibodies produced by immunization with oligomeric simian immunodeficiency virus envelope protein. J Virol. 2000 Sep; 74(17):7922-35. Edinger AL, Ahuja M, Sung T, Baxter KC, Haggarty B, Doms RW, Hoxie JA. PMID: 10933700; PMCID: PMC112323.
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Chemokine and orphan receptors in HIV-2 and SIV tropism and pathogenesis. Virology. 1999 Aug 01; 260(2):211-21. Edinger AL, Clements JE, Doms RW. PMID: 10417256.
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Functional dissection of CCR5 coreceptor function through the use of CD4-independent simian immunodeficiency virus strains. J Virol. 1999 May; 73(5):4062-73. Edinger AL, Blanpain C, Kunstman KJ, Wolinsky SM, Parmentier M, Doms RW. PMID: 10196302; PMCID: PMC104185.
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Leukotriene binding, signaling, and analysis of HIV coreceptor function in mouse and human leukotriene B4 receptor-transfected cells. J Biol Chem. 1999 Mar 26; 274(13):8597-603. Martin V, Ronde P, Unett D, Wong A, Hoffman TL, Edinger AL, Doms RW, Funk CD. PMID: 10085095.
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A Cell-Cell Fusion Assay to Monitor HIV-1 Env Interactions with Chemokine Receptors. Methods Mol Med. 1999; 17:41-9. Edinger AL, Doms RW. PMID: 21380656.
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An orphan seven-transmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol. 1998 Oct; 72(10):7934-40. Edinger AL, Hoffman TL, Sharron M, Lee B, Yi Y, Choe W, Kolson DL, Mitrovic B, Zhou Y, Faulds D, Collman RG, Hesselgesser J, Horuk R, Doms RW. PMID: 9733831; PMCID: PMC110125.
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Use of GPR1, GPR15, and STRL33 as coreceptors by diverse human immunodeficiency virus type 1 and simian immunodeficiency virus envelope proteins. Virology. 1998 Sep 30; 249(2):367-78. Edinger AL, Hoffman TL, Sharron M, Lee B, O'Dowd B, Doms RW. PMID: 9791028.
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ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur J Immunol. 1998 May; 28(5):1689-700. Samson M, Edinger AL, Stordeur P, Rucker J, Verhasselt V, Sharron M, Govaerts C, Mollereau C, Vassart G, Doms RW, Parmentier M. PMID: 9603476.
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CD4-independent, CCR5-dependent infection of brain capillary endothelial cells by a neurovirulent simian immunodeficiency virus strain. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14742-7. Edinger AL, Mankowski JL, Doranz BJ, Margulies BJ, Lee B, Rucker J, Sharron M, Hoffman TL, Berson JF, Zink MC, Hirsch VM, Clements JE, Doms RW. PMID: 9405683; PMCID: PMC25107.
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Utilization of chemokine receptors, orphan receptors, and herpesvirus-encoded receptors by diverse human and simian immunodeficiency viruses. J Virol. 1997 Dec; 71(12):8999-9007. Rucker J, Edinger AL, Sharron M, Samson M, Lee B, Berson JF, Yi Y, Margulies B, Collman RG, Doranz BJ, Parmentier M, Doms RW. PMID: 9371556; PMCID: PMC230200.
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Role of basic residues in the subgroup-determining region of the subgroup A avian sarcoma and leukosis virus envelope in receptor binding and infection. J Virol. 1997 May; 71(5):3458-65. Rong L, Edinger A, Bates P. PMID: 9094617; PMCID: PMC191492.
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Differential utilization of CCR5 by macrophage and T cell tropic simian immunodeficiency virus strains. Proc Natl Acad Sci U S A. 1997 Apr 15; 94(8):4005-10. Edinger AL, Amedee A, Miller K, Doranz BJ, Endres M, Sharron M, Samson M, Lu ZH, Clements JE, Murphey-Corb M, Peiper SC, Parmentier M, Broder CC, Doms RW. PMID: 9108095; PMCID: PMC20558.
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Cell-cell fusion assay to study role of chemokine receptors in human immunodeficiency virus type 1 entry. Methods Enzymol. 1997; 288:118-33. Rucker J, Doranz BJ, Edinger AL, Long D, Berson JF, Doms RW. PMID: 9356991.
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Mycosis fungoides skin lesions contain CD8+ tumor-infiltrating lymphocytes expressing an activated, MHC-restricted cytotoxic T-lymphocyte phenotype. J Cutan Pathol. 1994 Apr; 21(2):151-6. Wood GS, Edinger A, Hoppe RT, Warnke RA. PMID: 8040463.
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CD45 epitope mapping of human CD1a+ dendritic cells and peripheral blood dendritic cells. Am J Pathol. 1991 Jun; 138(6):1451-9. Wood GS, Freudenthal PS, Edinger A, Steinman RM, Warnke RA. PMID: 1711291; PMCID: PMC1886385.
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Most CD8+ cells in skin lesions of CD3+ CD4+ mycosis fungoides are CD3+ T cells that lack CD11b, CD16, CD56, CD57, and human Hanukah factor mRNA. Am J Pathol. 1991 Jun; 138(6):1545-52. Wood GS, Dubiel C, Mueller C, Abel EA, Hoppe RT, Edinger A, Weissman I, Warnke RA. PMID: 1828937; PMCID: PMC1886408.
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