About this Seminar
Increased activity of ventral hippocampal neurons that project to the medial prefrontal cortex causes deficits of social memory in autism mice. Reducing the activity of these neurons in the autism mice specifically rescued their social memory, but did not influence any other ways they interacted with other mice. In wildtype mice, this projection regulated social memory in a fashion that was specific to the ventral hippocampal to medial prefrontal projection as opposed to other hippocampal projections, and selective to social interactions as opposed to interactions with objects or spatial memory.