Frontiers | Fad Diets: Facts and Fiction

Frontiers | Fad Diets: Facts and Fiction
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Front. Nutr.
, 05 July 2022
Sec. Nutrition and Sustainable Diets
Volume 9 - 2022 |
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REVIEW article
Front. Nutr.
, 05 July 2022
Sec. Nutrition and Sustainable Diets
Volume 9 - 2022 |
Fad Diets: Facts and Fiction
Aaiza Tahreem
Allah Rakha
Roshina Rabail
Aqsa Nazir
Claudia Terezia Socol
Cristina Maria Maerescu
Rana Muhammad Aadil
1.
National Institute of Food Science and Technology, University of Agriculture, Faisalabad, Pakistan
2.
Department of Genetics, University of Oradea, Oradea, Romania
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Abstract
The global prevalence of obesity is alarmingly high and is impacting both developed and underdeveloped countries, beyond the borders of ethnicity, sex, and age. On the other hand, the global interest in dieting has increased, and people are obsessed with certain fad diets, assuming them as a magic bullet for their long-term problems. A fad diet is a popular dietary pattern known to be a quick fix for obesity. These diets are quite appealing due to the proposed claims, but the lack of scientific evidence is a big question mark. Such diets are often marketed with specific claims that defy the basic principles of biochemistry and nutritional adequacy. These diets may have protective effects against obesity and certain chronic diseases like cardiovascular diseases, metabolic syndrome, and certain cancers. Limited evidence exists to support the proposed claims; rather certain studies suggest the negative health consequences of long-term adherence to such dietary patterns. Many fad diets have emerged in the previous few decades. This review article will explore the current evidence related to the health impacts of some most popular diets: Atkins diet, ketogenic diet, Paleolithic diet, Mediterranean diet, vegetarian diet, intermittent fasting and detox diet.
Introduction
Obesity is one of the major public health concerns in this modern era. It is now considered a global epidemic due to the gradual but continuous increase in its prevalence. The global prevalence of obesity is alarmingly high and is impacting both developed and underdeveloped countries, beyond the borders of ethnicity, sex, and age. Worldwide obesity has tripled from 1975 to 2016, while childhood obesity is increasing dramatically (
). Excessive calories from fats and sugars, large portions of food, routinely junk food intake, availability of fast foods at the doorstep and limited physical activity are some of the contributing factors to obesity (
). Obesity is an independent risk factor for morbidity and mortality. Being obese or overweight puts a person at greater risk of developing cardiovascular diseases, hypertension, insulin resistance, diabetes, reproductive issues, liver and kidney diseases (
).
Despite the growing global prevalence of obesity, there is always a group that is highly obsessed with dieting. The global interest in dieting has increased in the last two decades. A study indicated that internet searches related to weight loss queries had immensely increased between the years 2004 to 2018 (
). In the meantime, people rush toward certain fad diets (FD), assuming them as a magic bullet for their long-term problems. FD is not a scientific terminology but rather a popular or trendy dietary pattern that is known to be a quick fix for obesity (
). FD can be easily differentiated from a healthy and balanced diet based on its characteristic features: (i) promises rapid weight loss (ii) absence of physical activity guidelines (iii) promotes short-term changes rather than achieving lifelong sustainable goals (iv) focuses on one type of food or eliminates any food group (v) cannot be maintained for life long period (vi) nutritional adequacy is questionable (vii) fails to provide health warnings for those with chronic diseases (viii) lacks scientific evidence to support the claims (
) (
Figure 1
).
FIGURE 1
Aim of the Study
A wide range of FDs has been proposed to date, ranging from low carbohydrate diets to low-fat diets, high-fats to high-protein diets, those with detoxification claims, and others of the Mediterranean or Paleolithic origin. These diets are followed blindly but are associated with certain negative health outcomes as one size does not fit all. This review article will explore the current evidence related to the health impacts of some popular diets, including Atkins diet, ketogenic diet, Paleolithic diet, Mediterranean diet, vegetarian diet, intermittent fasting, and detox diet.
Atkins Diet (AD)
In the 1970s, a low carbohydrate, high protein (LCHP) regimen was developed by cardiologist Dr. Robert Atkins, which was published in his book “Dr. Atkins’ New Diet Revolution” (
). This diet was promoted as a quick weight loss plan based on a lifetime change in eating habits. Atkins believed that metabolic imbalance resulting from carbohydrate consumption is the major cause of obesity. He claimed that this is the easiest, high-energy diet that mobilizes fats more than any other diet for weight loss maintenance. The AD involves an extreme reduction of carbohydrates, i.e., less than 5% of total calorie intake,
ad libitum
intake of proteins and fats, adequate fluid intake with vitamin and mineral supplementation, and regular exercise (
).
The diet has four phases: induction phase, ongoing weight loss phase, pre-maintenance phase, and lifetime maintenance phase (
Table 1
). The modified version of the AD (MAD) is currently available with the same four phases but slightly modified net carbs consumption in each phase. The MAD is less restrictive, allowing the person to choose the number of net carbs in phase 1, i.e., 20, 40, or 100 g of carbs and fats are not just allowed but encouraged. The primary goal is not weight loss rather it has shown promising results in seizure reduction in intractable epilepsy (
13
).
TABLE 1
Phases
Duration
Major considerations
Food sources allowed
Reference
Phase 1: Induction
2 weeks
Carbs restriction to
<20 g/day
Protein-rich foods: beef, poultry, fish, egg, etc., good fats: olive oil, etc.
Phase 2: Ongoing weight loss
Variable
(until weight loss cease)
Gradual increase in carbs intake at a rate of 5 g per week
Nutrient dense carbs, proteins and fats
Phase 3: Pre-maintenance
Variable
(Addition phase till weight loss continues, cut back until weight loss resumes)
Additional 10 g carbs per week
Cut back 5 to 10 g carbs when weight loss resumes
Nutrient dense carbs, proteins and fats
Phase 4: Lifetime maintenance
Lifetime
Addition of a wide range of foods while keeping carbs in check, i.e., 40–90 g net carbs a day
Nutrient-dense carbs, proteins and fats
Phases of the Atkins diet.
Effectiveness of Atkins Diet
There is substantial evidence suggesting that AD promotes more weight loss than conventional diets. One of the first AD research was published in The New England Journal of Medicine in 2003. Brehm et al. (
14
) in a study allocated 53 healthy, obese women to two groups, i.e., low carbohydrate ketogenic diet (LCKD) or energy-restricted low-fat diet (LFD) (carbs: 55%, protein: 15%, fats: 30%). Over 6 months, the LCKD subjects lost 8.5 kg versus 4.2 kg in the LFD group. There were no comparable differences between the groups in serum glucose, lipids, leptin, and insulin excluding triglycerides that showed a significant reduction in the LCKD group.
In another randomized trial, 132 severely obese individuals (43% had metabolic syndrome while 39% had type 2 diabetes) were assigned to two groups. One group followed AD and the other followed LFD for 6 months. The results showed that LCD individuals lost 3.8 kg more weight than those on LFD. No significant difference was observed in both groups after 12 months (
15
). In another controlled trial of 1 year, 63 obese participants were randomly assigned to either the AD or conventional LFD. After 6 months, results showed that the LFD group lost less weight, i.e., 3.2 ± 5.6% than the AD group, i.e., 7.0 ± 6.5%. The AD group lost 4% more weight, had higher levels of high-density lipoprotein cholesterol (HDL-c) and lower levels of triglycerides (TG) than the other group. No significant differences between groups were noted in low-density lipoprotein cholesterol LDL-c (
16
).
Several meta-analyses and systemic reviews reported the promising effects of low carbohydrate diets on weight loss and cardiometabolic risk factors. Mansoor et al. (
17
) demonstrated that the LCD group had a significant increase in HDL-c and LDL-c, and had a greater weight loss and TG reduction in contrast to those following LFD. Hashimoto et al. (
18
) reported that LCD resulted in a greater reduction of body weight and body fat mass than the control diet. LCD was linked with moderately more significant advancement in weight loss and reduction of atherosclerotic cardiovascular diseases (ASCVD) risk, compared to LFD (
19
).
Naude et al. (
20
) concluded that both LCD and balanced diets had shown weight loss. After 2 years of follow-up, there was no significant difference between the diets in terms of cardiovascular and diabetes risk factors. Bueno et al. (
21
) found that after 12 months or more, the individuals that followed an energy-restricted very low carbohydrate diet (VLCD) (carbs: <50 g/day or 10%) compared to LFD (fats: <30%) had a more significant improvement in HDL-c, LDL-c, TG and diastolic blood pressure (DBP) as well as the reduction in body weight. Hu et al. (
22
) compared LCD and LFD and concluded that both diets were efficient at reducing waist circumference, body weight, total cholesterol (TC), total to HDL-c ratio, LDL-c, TG, blood glucose, serum insulin, and blood pressure. LCD showed a greater decrease in TG, and less reduction in LDL-c and TC but increased HDL-c in comparison with LFD.
Health Consequences
Atkins diet has not been extensively studied while those studies that have been mentioned earlier have high dropout rates and are sometimes non-conclusive. Despite the rapid weight reduction, there are some concerns for those with comorbidities. There are some considerable potential complications associated with LCHP diets. There is conflicting evidence on the urinary stone formation tendency of LCHP diets (
23
). A short-term study showed that healthy subjects followed the LCHP diet for 6 weeks, decreased urine pH, increased urinary-acid excretion, and decreased calcium balance was observed in them. Therefore, they had a greater risk of stone formation (
24
). A prospective cohort study was conducted in Iran, involving 1,797 participants that were followed up for almost 6 years. Results showed that a higher tertile of LCHP diet correlates with a greater risk of chronic kidney disease (CKD) (
25
).
Metabolic acidosis is a common complication of LCHP diets. A case of 40 years old obese woman was reported, who was presented with nausea, vomiting, dehydration, and dyspnea. Investigations revealed that she was following AD, lost 9 kg in 1 month, and laboratory findings were consistent with ketoacidosis Chen et al. (
26
). Pregnant and lactating mothers should be cautious when following such a diet as there is a reported case of LCD-associated ketoacidosis in a non-diabetic lactating mother (
27
). AD provides several benefits including weight reduction and cardio-metabolic health improvement, but limited evidence exists as compliance is the major barrier to this dietary regimen. Strict supervision by health professionals is advised as adverse metabolic sequelae can result from this type of diet.
Ketogenic Diet (KD)
In 1923, Dr. Russell Wilder designed the classic KD for the treatment of epilepsy. The classic keto is a strict regime comprised of a 4:1 ratio, which means one part of carbs and proteins combined for four parts of fats. The use of KD for treating different diseases has increased over the past few decades. All the currently available versions are modified forms of classic KD. There are five types of KD published in the medical literature: (i) classic keto (ii) modified keto (iii) Medium-chain triglycerides oil (iv) Low glycemic index treatment (v) Modified Atkins diet. The macronutrient ratio is the major difference between these diets. In a nutshell, KD is a VLCD that relies on a moderate amount of proteins, high fat, and low carbohydrates that provide approximately 5–10% of calories from carbohydrates, 20–25% of calories from proteins, and 65–80% of calories from fats (
28
). KD includes fasting, proper hydration, physical activity, and intake of electrolytes and nutritional supplements (
29
).
The KD works by bringing certain metabolic changes to the body. Glucose is the body’s primary energy source. Carbohydrate deprivation resulting from KD causes a metabolic shift toward gluconeogenesis and ketogenesis. The preliminary shortage is managed by endogenous production of glucose from glycerol, glutamine, alanine, and lactic acid (gluconeogenesis). To keep up with the needs of the body, ketone bodies come into play and serve as an alternate energy source for the body (ketogenesis). At this stage due to low blood glucose feedback, secretion of insulin is also low, which further reduces the stimulus for fat and glucose storage. This ketotic state remains active until the body’s carbohydrates needs are fulfilled (
30
).
Effectiveness of Ketogenic Diet
Literature is consistent with these findings that KD is an effective intervention for improving quality of life, seizure severity, and seizure frequency in epileptic patients (
13
31
). KD is known for its neuroprotective action in various neurological illnesses like Alzheimer’s disease, amyotrophic lateral sclerosis, Parkinson’s disease, ischemic brain injury, traumatic brain injury, depression, autism, and narcolepsy (
32
). In the modern era, KD is recognized as a weight loss intervention but studies suggest mixed findings. A study compared the weight loss, appetite, and hunger responses of obese men who were fed a medium carbohydrate (35%) non-ketogenic diet (MCNKD) and low carbohydrates (4%) ketogenic diet (LCKD) in a crossover manner. After 4 weeks period, significantly greater weight loss and lower
ad libitum
energy intake were observed in the LCKD group because of reduced hunger (
33
).
A meta-analysis concluded that KD contributes to greater long-term weight loss than LFD (
21
). Another study compared the impact of KD and hypocaloric diet (HCD) on metabolic parameters in obese subjects. Fifty-eight subjects followed either of the two diets for 6 months. Greater differences in fat mass, weight, waist circumference, and fasting insulin were observed in the KD group as compared to the HCD group and only KD group showed significantly increased high molecular weight (HMW) adiponectin (
34
). The mechanism behind successful weight loss by KD is still a scientific debate. However, certain mechanisms have been hypothesized including appetite reduction due to the action of appetite-regulating hormones, fulfilling the effect of proteins, or appetite suppressing effect of ketone bodies (
33
35
37
). Weight loss can also be due to the increase in lipolysis, reduction in lipogenesis, and ease in utilizing fats due to the increased metabolic efficiency as indicated by a reduction in the respiratory quotient at rest (
38
42
).
In a non-randomized controlled trial, type 2 diabetes mellitus patients received either an intervention diet (KD) or served as controls. The KD group lost 10–15% of body weight, had a reduction in inflammatory markers like hsCRP, decreased WBCs, and increased TGs, HDL-c, and LDL-c (
43
). A recent review summarized that despite the efficacy of KD for rapid weight reduction and improved HbA1c values, KD raise LDL-c and had no superiority over other diets in terms of safety, effectivity, and sustainability (
44
).
In a prospective study, KD promoted negative changes in lipoprotein sub-fractions. After 6 months, KD contributed to increasing the small LDL-c and decreasing the small HDL-c, thus increasing atherogenic risk in patients (
45
). In another study, 12 months of KD treatment was found to be associated with decreased carotid distensibility and increased LDL-c, TC:LDL-c, and LDL-c:HDL-c ratios. No significant changes were observed in hsCRP and BMI (
46
). Khodabakhshi et al. (
47
) evaluated the effect of KD on physical activity (PA), quality of life (QOL), and biomarkers in 80 metastatic breast cancer patients. In the 12-week trial, subjects were randomly allocated to either control or KD group. No significant differences in PA and QOL scores between the groups were reported. However, the KD group showed decreases in ALP and lactate levels.
Health Consequences
Short-term minor side effects of KD are quite common, that include vomiting, nausea, gastrointestinal discomfort, fatigue, dizziness, feeling faint, decreased energy, and heartbeat alterations (
48
). KD initiation mostly results in hypoglycemia and lethargy (
49
). KD should be initiated with caution in combination with other treatments. A case report showed that the use of Valproate along with KD resulted in the development of hepatic dysfunction in a patient. The hepatotoxic effect was completely reversible as discontinuation of Valproate normalized the liver enzymes (
50
).
Ketogenic diet may negatively impact the lipid profile. A case report showed that following strict KD for 30–40 days, resulted in a rapid increase in LDL-c and TC. Fasting lipid profile showed HDL-c of 59 mg/dL, LDL-c of 199 mg/dL, TC of 283 mg/dL, and TG of 124 mg/dL. After discontinuation of KD and the use of statins for 4 weeks, there was a significant improvement in LDL-c (106 mg/dL) and TC (190 mg/dL). Furthermore, the patient maintained the optimal LDL-c levels after the discontinuation of statin therapy (
51
).
A recent case report demonstrated KD induced severe hyperlipidemia in an overweight 41 year old male. The patient had normal baseline values of lipid panel, i.e., LDL-c 99 mg/dL, HDL-c 49 mg/dL, TC 171 mg/dL, and TG 145 mg/dL. Following KD for 7 months resulted in severe hyperlipidemia as indicated by lab values, i.e., LDL-c 393 mg/dL, VLDL-c 41.5 mg/dL, HDL-c 54.4 mg/dL, TC 488.7 mg/dL, and TG 207.5 md/dL. Increasing the carbohydrates intake for 2 weeks, lipid panel showed remarkable improvement: LDL-c 279.0 mg/dL, VLDL-c 42.26 mg/dL, HDL-c 49.7 mg/dL, TC 371.2 mg/dL, and TG 211.3 mg/dL (
52
).
A retrospective cohort study showed that those on KD therapy had low normal bone mineral density, 8.8% of study subjects got kidney stones and 8.8% got a fracture during treatment (
53
). A newly recognized complication of KD is hypercalcemia. A series of case studies described the development of acute hypercalcemia about 2.1 years after initiating KD. Out of 14 patients, 13 had low levels of 1, 25-dihydroxyvitamin D, while all had low parathyroid hormone levels. Moreover, low alkaline phosphate (ALP) levels were noted in all subjects except the two oldest, while seven had impaired renal function (
54
).
Paleolithic Diet (PD)
The PD also referred to as the Stone Age, caveman, or hunter-gatherer diet was initially introduced in 1985 by Eaton and Konner, and published by Dr. Loren Cordain in 2010 (
55
). It is marketed with the claims to improve health and cure diseases like obesity, cardiovascular disease, diabetes, cancer, and osteoporosis. Proponents of this dietary pattern believe that the modern diet (mainly processed foods, dairy products, grains, and legumes) is the cause of modern diseases and the obesity epidemic. Moreover, humans have evolved before agricultural development while the human diet has revolutionized more rapidly than our genetics; thus Paleolithic foods are more suited to our genetic makeup than the current modern diet (
55
56
). Apart from this theory, anthropological research provides evidence that Paleolithic people used to eat a varied diet comprising of plants, grains, legumes, and game meats (
57
58
).
Cordain’s PD has a basic set of rules, i.e., there is no restriction on the consumption of lean meats, fruits, and non-starchy vegetables while dairy products, legumes, cereals, and processed foods are strictly restricted (
Table 2
). There is little to no focus on portions, and calories. There are three adherence levels to the PD: entry-level, maintenance level, and maximal weight loss level (
Table 3
). One has a choice not to advance to the next level if satisfied with the results of this level (
55
).
TABLE 2
Food groups
Foods allowed/restricted
Reference
Lean meat
About half of daily calories from lean animal foods are encouraged
55
Eggs
6–12 per week
Fruits
All fruits are allowed
Obese should be mindful of calories from high-sugar fruits
Vegetables
All non-starchy vegetables are allowed
Drinks and beverages
Mainly water
Sugary beverages should be avoided
Limited consumption of alcoholic beverages, i.e., two 4-oz servings of wine, 12-oz serving of beer or one 4-oz serving of spirits daily
No tea or coffee
Fats, oils and nuts
Unsaturated fats are allowed in moderation
4 Tbsp of oils per day
4 oz of nuts per day
Vitamin and mineral supplements
Can be taken as per need
Foods in the Paleolithic diet.
TABLE 3
Levels
Description
Reference
Level 1: Entry level
3 open meals*/week
Addition of some transitional foods
**
for the sake of improving compliance
Level 2: Maintenance level
2 open meals/week
No transitional foods allowed
Level 3: Maximal weight loss level
1 open meal/week
Levels of Paleolithic diet.
*Open meal; flexible meals including foods from not avoid list, intended to improve the adherence to diet **transitional foods; food items that don’t meet Paleo rules.
Effectiveness of Paleolithic Diet
Metabolic syndrome and insulin resistance are the prime focused areas in most of the literature related to PD. It does provide benefits but only to specific groups, i.e., eliminating dairy products can help people with digestive disorders. ‘Liberal consumption of fruits and vegetables can have a preventive effect for inflammatory bowel diseases (IBD). At the same time, this diet being high in meat increases the risk of IBD (
59
).
Paleolithic diet is powerful at advancing weight reduction for the time being, even at the point when the weight reduction is unintentional (
60
62
). Initially, weight loss is due to the loss of water weight as this diet is low in carbohydrates. Previous studies suggest that the study participants lost 4–6% of total body weight within 10–12 weeks (
63
64
). Most of the studies are based on short-term interventions and there is only one study that followed the subjects for over 2 years. In a randomized trial, 70 post-menopausal obese women were divided into the
ad libitum
PD group or Nordic Nutrition Recommendations (NNR) diet group. After 24 months, the reductions in waist circumference, fat mass, and weight were observed in both groups irrespective of the dietary regimen followed (
65
).
Most of the studies reported the TC reduction properties of this diet while there are mixed results for HDL-c (
61
62
64
66
). A study was conducted to evaluate the physiological and metabolic impacts of PD in healthy adults. After 10 days of intervention, reduction in TC, LDL-c, TG, and mean arterial pressure were observed (
66
). In another trial, participants were randomized to PD and reference diet groups. After 2 weeks of intervention, there were greater reductions in TC, TG, and diastolic blood pressure in the PD group (
61
).
In another study, healthy subjects followed this dietary intervention for 10 weeks, which resulted in increased LDL-c, TC, TC:HDL-c, along with a decline in HDL-c values (
64
). No significant changes in fasting blood glucose were seen in most studies (
65
66
). While, some studies were short-term, where HbA1c was not measured as per protocol (
67
). Modest reduction, i.e., 3–4 mmHg in systolic or diastolic blood pressure was reported in most studies (
60
61
66
67
). No significant change in inflammatory markers (CRP) was reported (
61
67
).
Health Consequences
The PD not only requires a big budget but is also very challenging to follow as compared to other diets (
68
69
). Despite weight reduction and some favorable impact on cardiometabolic profile, this diet can have long-term consequences. Some studies suggest that this diet is not nutritionally balanced as it discourages certain food groups like whole grains, legumes, and dairy products. The micronutrient deficiencies can have long-term adverse outcomes. Those who follow PD have inadequate calcium intake. A study was conducted to check the nutritional adequacy of this diet. In addition to a low intake of carbs, fats, and total calories that could have promoted weight loss, this diet provided about 50% less calcium than the daily requirement (
60
).
Decreased HDL-c has also been observed among healthy adults and those with comorbidities. In a study comprising 28 type 2 diabetic patients, 14 followed the PD and 10 followed the American Diabetes Association (ADA) guidelines. Results showed that there was a significant reduction in HDL-c in the PD group (
62
). In another study, healthy subjects followed this dietary intervention for 10 weeks, which resulted in increased LDL-c, TC, TC:HDL-c, along with a decline in HDL-c values (
64
). More randomized trials need to be done to highlight the consequences of such diets that eliminate one or more food groups. PD is powerful at advancing weight reduction for the time being but its efficacy in cardiovascular events is not well established as limited long-term data is available.
Mediterranean Diet (MD)
The concept of the MD emerged in the 1950s by Dr. Ancel Keys. In one of the first research that related diet and heart health, it was revealed that CVDs associated mortality rates are different in Westerns and Europeans. Lower mortality rates were observed in Europeans, even though they typically consume a moderately high-fat diet (
70
). Their dietary pattern can be linked to lower mortality and incidence of CVDs (
71
).
In 1975, Ancel Keys described this diet in his book as a complex of dietary choices followed by those living in Mediterranean regions. Whole grains, legumes, fruits, vegetables, olive oil, fish, and nuts are key components of this diet with a moderate allowance of alcohol, dairy products, and meat [Keys, (
72
)]. Traditionally, this diet derives its most calories from fish and plant-based foods. Fats account for 30% of calories which are mostly polyunsaturated fatty acid (PUFA) and monounsaturated fatty acids (MUFA), while carbohydrates provide 50–55% of calories from low glycemic index carbohydrates and proteins provide 15–20% of calories (
73
).
Effectiveness of Mediterranean Diet
Mediterranean diet is the most extensively studied diet to date. In a previous review, it has been summarized that MD is nutritionally adequate for the general public and may have the potential of preventing micronutrient deficiencies (
74
). Research shows that it has preventive and therapeutic potential for many chronic diseases like non-alcoholic fatty live disease (NAFLD), CVDs, metabolic syndrome, and certain cancers like colorectal and breast cancer (
75
). In a 2-year trial, weight loss by LFD, AD, and MD was compared and results showed that the AD group had the highest mean weight loss, i.e., – 4.7 ± 6.5 kg, while the MD group stood second with a mean weight loss of – 4.4 ± 6 kg and LFD group lost –2.9 ± 4.2 kg. Following changes were recorded in the MD group: increased molecular adiponectin reduced serum leptin, and CRP levels (
76
).
In another controlled trial, 259 subjects were randomly allocated to American Diabetic Association (ADA) diet, traditional MD, or low carbohydrate Mediterranean diet (LCM) group. After 12 months, the LCM group had the highest weight reduction, increased HDL-c, improved LDL-c, TG and HbA1c (
77
). Another study described the effectiveness of MD in the primary prevention of CVDs [Estruch et al. (
78
)]. A study investigated the protective effect of MD against cancer and found that greater compliance with MD patterns reduces the risk of non-tobacco linked cancers in both men and women (
79
).
Most MD studies are short-duration studies, only a few studies focused on the long-term impacts of following MD. In a study, non-diabetic elderly subjects (
= 3,541) at higher risk of CVD were randomized to three intervention groups: control diet, MD with nuts or MD with extra virgin olive oil. New cases of diabetes were recorded after regular intervals (median follow-up duration = 4.1 years) and results showed that MD with extra virgin olive oil was associated with a reduced risk of diabetes (
80
). In another 5 years clinical trial, subjects (
= 7,447) who were type 2 diabetics or those with risk factors of CVDs, were randomized to three intervention groups: control diet, MD with nuts, or MD with extra virgin olive oil. After the specified period, there was no significant weight reduction in all the groups, while the MD group had a significant reduction in central obesity [Estruch et al. (
81
)].
Health Consequences
No evidence of adverse effects associated with MD is available in the literature. Rather, MD has preventive and therapeutic potential for many chronic diseases. It is highly suitable for the general public for the prevention of micronutrient deficiencies and specifically for those patients who are more health-conscious than just weight loss oriented.
Vegetarian Diet (VD)
The VD is a dietary pattern characterized by no consumption of meat and meat products, seafood, poultry, and sometimes other animal products like eggs, animal milk, and honey. Some studies have linked meat intake with an increased risk of chronic diseases, while others indicate a positive association between low meat intake and life expectancy (
82
83
). VD are of four main types: (i) a lacto-ovo-vegetarian does not consume any meat product but consumes eggs and dairy products (ii) a lactovegetarian does take dairy products but does not consume eggs and meat products (iii) an ovo-vegetarian does not eat meat products and dairy products and are free to consume eggs (iv) a vegan does not consume any animal products, including meat, eggs, dairy products, and honey (
84
). Vegan diets include different subtypes: raw vegan, vegan (general), and whole-food vegan (
Figure 2
). Each subtype has its own set of foods allowed and restricted with one thing in common, i.e., meat products restriction. This dietary pattern is gaining much popularity in the general population, especially in the Western world (
85
). There are various reasons for adopting this dietary profile, including religious beliefs, ethical motivation, cultural aspects, and health considerations (
85
86
).
FIGURE 2
Effectiveness of Vegetarian Diet
Several epidemiological studies reported a lower cardiometabolic risk in the vegan population. A study concluded that non-vegetarians have a higher type 2 diabetes prevalence (7.6%) than vegetarians (2.9%). While, the prevalence rate also varies with the type of VD, i.e., 3.2% in lacto-ovo vegetarians, 4.8% in pesco-vegetarians and 6.1% in semi-vegetarians. This can be explained by the low-glycemic-response associated with these diets as vegetarian diets typically include foods that have a low glycemic index such as beans, legumes, nuts, some fruits and vegetables (
87
). Glycemic control via a VD is quite controversial, as these are high carbohydrate diets. Some studies have shown that vegetarians also have increased life expectancy (
82
). Generally, vegetarians are more health-conscious and have lower BMI than the general population (
88
). The Seventh Day Adventist study showed a lower mean BMI, i.e., 23.6 kg/m
in the vegan population (
89
). In a 5-year prospective study, 22,000 subjects having different dietary patterns were checked for their weight gain during this period. Vegans had the lowest weight gain as compared to meat-eaters and fish eaters (
90
).
Red meat and poultry intake were most strongly linked to increased risk of esophageal adenocarcinoma and gastric cardia or non-cardia adenocarcinoma, respectively (
91
). On the other hand, lower rates of heart diseases and cancers have been observed in vegetarians in comparison with those following other dietary patterns (
92
93
). A better cardiometabolic risk profile is generally present in vegetarians, i.e., lower BMI, TC, and LDL-c [Chen et al. (
94
); De Biase et al. (
95
)]. A cross-sectional study investigated the lipid profile of fish-eaters, meat-eaters, and vegetarians. Not only the vegans have a lower BMI but also favorable serum lipid levels: lower LDL-c, TC, and apolipoproteins (
96
).
In a study, out of 26,346 participants, 1,079 cases of prostate cancer were identified and results showed the protective effect of vegan diets against prostate cancer in the white population (
97
). This protective effect against prostate cancer may be due to the higher fiber intake. Some other studies are either short-term or have a very small sample size, showing mixed findings related to colorectal cancer and breast cancer. In a study, 2,304 patients from 10 European countries were assessed for their dietary intake to find the impact of diet on the risk of cancers. Not poultry but red meat intake was found to be associated with an increased risk of esophageal cancer and upper aerodigestive tract (UADT) cancer. Furthermore, vegetable and fruit intake are significantly associated with a reduced risk of UADT cancer (
98
).
Butler et al. (
99
) demonstrated that the higher the intake of vegetable-fruit -soy dietary pattern, the lower the breast cancer hazard ratio among postmenopausal women. Another study showed a significant association between consumption of vegetables and risk of esophageal adenocarcinoma. Elimination of potentially harmful dietary components like animal protein, saturated fats, and cholesterol can be the reason for these benefits. These benefits can also be due to the addition of dietary fiber, phytochemicals, and antioxidants rich in beneficial dietary components like whole grains, legumes, nuts, fruits, and vegetables (
91
).
Health Consequences
This diet is associated with fluctuations in micronutrients intake because of the day-to-day variation in the menu. Depending upon the type of VD, vegetarians are potentially at increased risk of micronutrient deficiencies such as calcium, zinc, iron, vitamin E, vitamin B12, essential fatty acids, docosahexaenoic acid (DHA), and eicosapentaenoic acid (EPA) (
100
). A study reported that half of the vegan participants were micronutrient deficient as compared to omnivores (
101
). Vegetarians have lower serum vitamin B12 levels as plant sources are deficient in this vitamin (
101
102
). As VD is generally low in calcium due to the suboptimal intake of dairy, vegetarians are at greater risk of bone fractures due to the lower bone mineral density (
103
).
Thus supplementation of certain vitamins like vitamin B12 and vitamin D is needed to avoid these deficiencies among vegetarians (
84
). Vitamin B12 supplements are especially important for vegan pregnant and lactating mothers as a preventive therapy for deficiency in their babies (
104
). VD can be nutritionally adequate, so it may be helpful in chronic disease prevention and treatment. Benefits and harms depend upon the dietary choices so the individualized plan fulfilling the micronutrient requirements must be carefully developed by a professional.
Intermittent Fasting (IF)
The IF is gaining much popularity and is widely adopted as an effective weight loss intervention. Contrary to the conventional weight loss programs that are based on calorie restriction, IF is more about scheduled eating. Some of the key features of IF are abstinence from food for a certain period, followed by a period of normal eating. There are various versions of IF but the most popular of these are alternate day fasting (ADF), 5:2 diet or periodic fasting (PF), and time-restricted feeding (TRF). The frequency and duration of fast cycles may differ among all types (
Table 4
).
TABLE 4
Types
Description
Fasting definition
Normal eating
Reference
Alternate day fasting
Fasting alternated with a day of normal eating
0–25% of TCN
ad libitum
105
5:2 diet or periodic fasting
Fasting for 2 days with normal eating for 5 days
0–25% of TCN
ad libitum
Time-restricted feeding
Normal eating within a window of < 8 h per day
ad libitum
Types of intermittent fasting.
*TCN, total caloric needs.
Effectiveness of Intermittent Fasting
The alternate-day fasting (ADF) approach has been tested for its metabolic effects. In a study, healthy young men (
= 8) were subjected to ADF for 20 h/day for 15 days. After the specified study period, weight remained unchanged (86.4 ± 2.3 kg) while the increase in glucose uptake, i.e., 7.3 ± 0.3 mg/kg/min that was previously 6.3 ± 0.6 mg/kg/min, and prominent increase in lipolysis of adipose tissues were observed (
106
). Another study showed that when non-obese subjects (8 women and 8 men) fasted for 22 days on alternate days, they lost 4 ± 1% of their initial fat mass and 2.5 ± 0.5% of their initial body weight. However, a decrease in fasting insulin and non-significant change in glucose and ghrelin were also reported (
107
).
A randomized crossover trial was conducted to evaluate the fasting-induced acute changes in biomarkers. Healthy volunteers (
= 30) were randomized into two groups: (i) normal eating for 28 ± 4 h then water-only fasting for 28 ± 4 h (ii) 28 ± 4 h of water-only fasting then 28 ± 4 h of normal eating. Blood samples were drawn and analyzed at baseline, day 1 and day 2. Laboratory findings suggested that the fasting intervention acutely increased hemoglobin, hematocrit, red blood cell count, human growth hormone, and HDL-c; on the other hand, decreased body weight, bicarbonates, and TGs, as compared to the normal eating day. Moreover, cholesterol and human growth hormone returned to baseline after 48 h (
108
).
Night-time fasting (NTF) has been linked to lower energy intake, consequently resulting in weight loss. In a study, twenty-nine healthy young men were subjected to 9 h of NTF for 2 weeks, then 1 week washout period followed by 2 weeks of controlled conditions. Results showed that the participants had less total calorie intake in the NTF phase as compared to controlled conditions. Significant differences in weight change were also reported, i.e., – 0.4 kg for NTF and + 0.6 kg for control (
109
).
In a randomized trial of 3 months, young overweight premenopausal women (
= 107) were randomly assigned to two groups: two consecutive days of fasting (25% energy restriction)/week or fasting for all days of the week. Both interventions were found to be equally good at a weight and showed improvement in risk markers of CVDs, cancer, and diabetes for example reduction in leptin, leptin to adiponectin ratio, inflammatory markers, fasting insulin, insulin resistance, blood pressure, and lipids (
110
).
Fasting also impacts the appetite by influencing the appetite-regulating hormones (
110
111
). A previous systematic review summarized that IF may have the potential to provide metabolic benefits in terms of improving insulin resistance, thus providing better glycemic control as IF showed a significant decline in fasting glucose levels as compared to controls. Moreover, IF was associated with a decline in BMI, fat mass, and leptin while an increase in adiponectin (
112
). Headland et al. (
113
) evaluated the effectiveness of intermittent energy restriction (IER) in improving weight and biological markers in long-term studies. Irrespective of duration, IER was associated with weight loss. However, IER was not found to be superior to continuous energy restriction (CER) in terms of weight loss, blood lipids, glucose, and insulin levels.
Health Consequences
Some short-term studies highlighted the potential harms posed by IF among normal-weight subjects. IF induces lipolysis, resulting in increased free fatty acids (FFA). So whether it be ADF, periodic fasting, or else, a prolonged course of fasting can lead to large fluctuations in FFA in normal-weight individuals. A study showed that these fluctuations were three times greater than those typically seen after an overnight fast. Furthermore, it induced reductions in insulin sensitivity and acute glucose-simulated insulin response (
114
). Despite the effectiveness of IF in weight loss as indicated by several studies, the current evidence is non-conclusive. The prime focus of available literature is weight loss but little is known about its sustainability and long-term health effects. More long-term trials should be conducted to draw a clear conclusion.
Detox Diets (DD)
The popularity of detoxification dates back to Greek, Roman, Indian, and Native American cultures. Many effective approaches that are still used for the removal of toxins include fasting, saunas, herbs, rebounding, dry brush, water, rest, exercise, and meditation (
115
). However, detoxification or DD are interventional diets specifically designed for toxins elimination, health promotion, and weight management. These short-term dietary interventions involve multiple approaches, including total calorie restriction, dietary modification, or juice fasts, and often involve the use of additional minerals, vitamins, diuretics, laxatives, or cleansing foods. Some commercial DDs have been listed in
Table 5
. These are most commonly prescribed by naturopathic doctors to prevent or treat a number of conditions like gastrointestinal disorders, inflammation, autoimmune disorders, chronic fatigue syndrome, fibromyalgia, and weight loss (
116
).
TABLE 5
Diet type
Duration
Foods allowed
Proposed claims
References
Liver cleansing diet
8 weeks
Plant-based, dairy-free, low fat, high fiber, unprocessed foods are allowed.
Epsom salt and liver tonics are also consumed.
Improved energy levels and liver function
Toxins removal
Improved immune response
Efficient metabolism of fats and better weight control
117
Lemon detox diet/Master cleanser
10 days
A liquid only diet based on purified water, lemon juice, tree syrup and cayenne pepper.
A mild laxative herbal tea and sea salt water is also incorporated.
Toxins removal
Shiny hair, glowing skin and strong nails
Weight loss
118
The clean cleanse
21 days
Breakfast and dinner comprise probiotic capsules, cleanse supplements and cleanse shakes.
A solid meal in lunch while avoiding gluten, dairy, corn, soy, pork, beef, refined sugars, some fruits and vegetables.
Toxins removal
Improved energy, digestion, sleep and mental health
Reduction in joint pains, headaches, constipation and bloating
119
Martha’s vineyard detox diet
21 days
Herbal teas, vegetable soups and juices, specially formulated tablets, powders and digestive enzymes are on the menu.
Weight loss up to 9.5 kg
Toxins removal
Improved energy levels
120
Weekend wonder detox
48 h
Protein-rich meals salads, detox-promoting super foods and beverages.
Healthy lifestyle, spa treatments and herbal remedies.
Toxins removal
Improved organs’ function
Strengthen body
Enhance beauty
121
Fat flush
2 weeks
Large meals are replaced with dilute cranberries, hot water with lemon, pre-prepared cocktails, supplements and small meals
Toxins removal
Reduced stress
Weight loss
Improved liver function
122
Blue print cleanse
3 days
Consumption of six pre-prepared vegetable and fruit juices is allowed per day.
Toxins removal
123
The Hubbard purification rundown
Several weeks
Niacin doses along with sustained consumption of vitamin-A, B, C, D, and E.
Daily exercise with balanced meals.
Restriction of alcohol and drugs.
Sitting in a sauna for ≤ 5 h each day.
Toxins removal from fat stores
Improved memory and intelligence quotient
Better blood pressure and cholesterol levels
124
Commercial detox diets.
The DDs have not been extensively investigated; however, the handful of available studies have methodological limitations like sampling bias, small sample sizes, relying on self-reporting, and absence of control groups. Despite the emerging popularity, these diets fail to identify the mechanisms of eliminating toxins or even the specific toxins removed by a particular diet. Detox approaches defy the general principles of human physiology as the liver and kidneys are quite efficient in removing both exogenous and endogenous toxins from our body, along with extra-renal excretion of toxins in sebum and sweat (
125
).
Effectiveness of Detox Diets
Currently, there is no clinical evidence confirming or negating the effectiveness of commercially available detox regimes for losing weight. Because of its emerging popularity, this area needs attention. So, in the absence of scientific evidence, results can be extrapolated from other closely related studies. It is known that the success rate of dieting, in general, is only 20% (
126
). This may be possible because humans and animals have natural mechanisms to counter the weight loss as starvation can have negative health consequences like reduced fertility and even death. Calorie restriction alters the neuropeptides’ expression in the hypothalamus; which reduces metabolic rate and stimulates appetite, resulting in a weight loss plateau (
127
).
Furthermore, studies in mice have shown binge eating followed by a period of energy restriction, though this phenomenon is not established in humans yet (
128
). A study conducted by Mazurak et al. (
129
) showed that fasting raised cortisol levels in young healthy women. Another study reported an increase in stress hormone levels in females due to the restricted intake of 1,200 kcal/day (
130
). There is considerable evidence that stress stimulates appetite, thus promoting weight gain via elevations of cortisol (
131
).
Many of the DD are liquid-based, low-calorie, and nutrient-poor. For example, a part of BluePrint Cleanse, Excavation Cleanse, provides only 19 g protein and 860 kcal/day which is far below the actual requirement. Food and Agriculture Organization (FAO) recommends a minimum of 0.83 g/kg body weight of high-quality protein and 1,680 kcal/day for an adult (
132
133
). Based on the previous work, DD may induce stress, raise cortisol levels and increase appetite, resulting in difficulty in losing weight, followed by binge eating and weight gain (
128
130
).
It is quite alarming that the components of detox products may not be according to the labels as there is no regulatory authority that approves such products. A case was reported in Spain that a 50 year old man with no history of relevant medical illness, presented with diffuse abdominal pain, lethargy, profuse diarrhea, and vomiting after ingesting Epsom salt during a liver cleansing diet. That person died within 72 h from the onset of symptoms. Forensic and clinical investigations concluded that instead of magnesium sulfate heptahydrate, the supplier had mistakenly added hydrated manganese sulfate resulted in manganese intoxication (
134
).
Energy-restricted DDs are capable of short-term weight loss. But still, there is a high likelihood of health risks from detox products because of their nutritional inadequacy. As no convincing evidence exists in this domain so such diets and products need to be discouraged by health professionals and must be subjected to regulatory review and monitoring.
Conclusion
Fad diets facilitate fast and easy weight loss, improve appearance, and do not require a longer time to achieve the results. These diets are effective in improving health to some extent. However, compliance is always a significant concern because of the unrealistic combinations and nutritional inadequacy due to the complete elimination of one or more essential food groups. Despite the rapid weight reduction, there are some concerns for those with comorbidities. All these diets have not been extensively studied while those studies that have been mentioned in the literature have high dropout rates and are sometimes non-conclusive. More randomized controlled trials of prolonged duration need to be done to establish the safety of FDs for the public and to make people aware of the possible consequences of long-term adherence to such dietary patterns.
Publisher’s Note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher.
Statements
Author contributions
AT and AR: conceptualization. AT: writing – original draft preparation. AT, AN, RR, AR, RA, CS, and CM: writing – review and editing. AR and RA: supervision. All authors have read and agreed to the published version of the manuscript.
Acknowledgments
We are thankful to the University of Agriculture, Faisalabad, Pakistan for their support. We also address thanks to the University of Oradea.
Conflict of interest
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
1.
World Health Organization [WHO].
WHO Obesity and Overweight.
2021
). Available online at:
(Accessed September 12, 2021)
Google Scholar
2.
Wright
SM
Aronne
LJ
Causes of obesity.
Abdom Imaging.
2012
37
730
10.1007/s00261-012-9862-x
Pubmed Abstract
CrossRef
Google Scholar
3.
Uzogara
SG
Obesity epidemic, medical and quality of life consequences: a review.
Int J Public Health Res.
2017
12
Google Scholar
4.
Teng
Huang
Li
Xie
Zhang
Lou
et al
Seasonal variation and trends in the internet searches for losing weight: an infodemiological study.
Obes Res Clin Pract.
2020
14
225
33
10.1016/j.orcp.2020.04.001
Pubmed Abstract
CrossRef
Google Scholar
5.
Gui
Fad diets, fats & weight management.
Singapore Fam Physician.
2008
34
14
Google Scholar
6.
Bastin
S.
Fad Diets.
Lexington, KY
University of Kentucky
2004
).
Google Scholar
7.
Atkins
RC.
Dr. Atkins’ Diet Revolution: The High Calorie Way to Stay Thin Forever.
New York, NY
McKay
1973
).
Google Scholar
8.
Apovian
Brouillard
Young
L.
Clinical Guide to Popular Diets.
New York
CRC Press
2018
).
Google Scholar
9.
Chen
Kossoff
EH
Long-term follow-up of children treated with the modified atkins diet.
J Child Neurol.
2012
27
754
10.1177/0883073812441062
Pubmed Abstract
CrossRef
Google Scholar
10.
Kang
Lee
HS
You
SJ
Kang
DC
Ko
Kim
HD
Use of a modified atkins diet in intractable childhood epilepsy.
Epilepsia.
2007
48
182
10.1111/j.1528-1167.2006.00910.x
Pubmed Abstract
CrossRef
Google Scholar
11.
Kossoff
EH
Turner
Bluml
RM
Pyzik
PL
Vining
EPGA
Randomized, crossover comparison of daily carbohydrate limits using the modified atkins diet.
Epilepsy Behav.
2007
10
432
10.1016/j.yebeh.2007.01.012
Pubmed Abstract
CrossRef
Google Scholar
12.
Kossoff
EH
Rowley
Sinha
SR
Vining
EPGA
Prospective study of the modified atkins diet for intractable epilepsy in adults.
Epilepsia.
2008
49
316
10.1111/j.1528-1167.2007.01256.x
Pubmed Abstract
CrossRef
Google Scholar
13.
Kverneland
Molteberg
Iversen
PO
Veierød
MB
Taubøll
Selmer
KK
et al
Effect of modified atkins diet in adults with drug-resistant focal epilepsy: a randomized clinical trial.
Epilepsia.
2018
59
1567
76
10.1111/epi.14457
Pubmed Abstract
CrossRef
Google Scholar
14.
Brehm
BJ
Seeley
RJ
Daniels
SR
D’alessio
DAA
Randomized trial comparing a very low carbohydrate diet and a calorie-restricted low fat diet on body weight and cardiovascular risk factors in healthy women.
J Clin Endocrinol Metab.
2003
88
1617
23
10.1210/jc.2002-021480
Pubmed Abstract
CrossRef
Google Scholar
15.
Samaha
FF
Iqbal
Seshadri
Chicano
KL
Daily
DA
McGrory
et al
Low-carbohydrate as compared with a low-fat diet in severe obesity.
N Engl J Med.
2003
348
2074
81
10.1056/NEJMoa022637
Pubmed Abstract
CrossRef
Google Scholar
16.
Foster
GD
Wyatt
HR
Hill
JO
McGuckin
BG
Brill
Mohammed
BS
et al
Randomized trial of a low-carbohydrate diet for obesity.
N Engl J Med.
2003
348
2082
90
10.1056/NEJMoa022207
Pubmed Abstract
CrossRef
Google Scholar
17.
Mansoor
Vinknes
KJ
Veierød
MB
Retterstøl
Effects of low-carbohydrate diets v. low-fat diets on body weight and cardiovascular risk factors: a meta-analysis of randomised controlled trials.
Br J Nutr.
2016
115
466
79
10.1017/S0007114515004699
Pubmed Abstract
CrossRef
Google Scholar
18.
Hashimoto
Fukuda
Oyabu
Tanaka
Asano
Yamazaki
et al
Impact of low-carbohydrate diet on body composition: meta-analysis of randomized controlled studies.
Obes Rev.
2016
17
499
509
10.1111/obr.12405
Pubmed Abstract
CrossRef
Google Scholar
19.
Sackner-bernstein
Kanter
Kaul
Dietary intervention for overweight and obese adults: comparison of low-carbohydrate and low-fat diets. A meta-analysis.
PLoS One.
2015
10
e0139817
10.1371/journal.pone.0139817
Pubmed Abstract
CrossRef
Google Scholar
20.
Naude
CE
Schoonees
Senekal
Young
Garner
Volmink
Low carbohydrate versus isoenergetic balanced diets for reducing weight and cardiovascular risk: a systematic review and meta-analysis.
PLoS One.
2014
e100552
10.1371/journal.pone.0100652
Pubmed Abstract
CrossRef
Google Scholar
21.
Bueno
NB
de Melo
SIV
De Oliveira
SL
da Rocha Ataide
Very-low-carbohydrate ketogenic diet v. low-fat diet for long-term weight loss: a meta-analysis of randomised controlled trials.
Br J Nutr.
2013
110
1178
87
10.1017/S0007114513000548
Pubmed Abstract
CrossRef
Google Scholar
22.
Hu
Mills
KT
Yao
Demanelis
Eloustaz
Yancy
WS
et al
Systematic reviews and meta- and pooled analyses effects of low-carbohydrate diets versus low-fat diets on metabolic risk factors: a meta-analysis of randomized controlled clinical trials.
Am J Epidemiol.
2012
176
S44
54
10.1093/aje/kws264
Pubmed Abstract
CrossRef
Google Scholar
23.
Nouvenne
Ticinesi
Morelli
Guida
Borghi
Meschi
Fad diets and their effect on urinary stone formation.
Transl Androl Urol.
2014
303
12
10.3978/j.issn.2223-4683.2014.06.01
Pubmed Abstract
CrossRef
Google Scholar
24.
Reddy
ST
Wang
Sakhaee
Brinkley
Pak
CYC
Effect of low-carbohydrate high-protein diets on acid-base balance, stone-forming propensity, and calcium metabolism.
Am J Kidney Dis.
2002
40
265
74
10.1053/ajkd.2002.34504
Pubmed Abstract
CrossRef
Google Scholar
25.
Farhadnejad
Asghari
Emamat
Mirmiran
Azizi
Low-carbohydrate high-protein diet is associated with increased risk of incident chronic kidney diseases among Tehranian adults.
J Ren Nutr.
2018
29
343
10.1053/j.jrn.2018.10.007
Pubmed Abstract
CrossRef
Google Scholar
26.
Chen
Smith
Rosenstock
JL
Lessnau
KA
Life-threatening complication of atkins diet.
Lancet.
2006
367
958
10.1016/S0140-6736(06)68394-3
CrossRef
Google Scholar
27.
von Geijer
Ekelund
Ketoacidosis associated with low-carbohydrate diet in a non-diabetic lactating woman: a case report.
J Med Case Rep.
2015
224
10.1186/s13256-015-0709-2
Pubmed Abstract
CrossRef
Google Scholar
28.
Gershuni
VM
Yan
SL
Medici
Nutritional ketosis for weight management and reversal of metabolic syndrome.
Curr Nutr Rep.
2018
97
106
10.1007/s13668-018-0235-0
Pubmed Abstract
CrossRef
Google Scholar
29.
Neal
EG
Zupec-kania
Pfeifer
HH
Carnitine, nutritional supplementation and discontinuation of ketogenic diet therapies.
Epilepsy Res.
2012
100
267
71
10.1016/j.eplepsyres.2012.04.021
Pubmed Abstract
CrossRef
Google Scholar
30.
Dąbek
Wojtala
Pirola
Balcerczyk
Modulation of cellular biochemistry, epigenetics and metabolomics by ketone bodies. implications of the ketogenic diet in the physiology of the organism and pathological states.
Nutrients.
2020
12
788
801
10.3390/nu12030788
Pubmed Abstract
CrossRef
Google Scholar
31.
Roehl
Falco-walter
Ouyang
Balabanov
Modified ketogenic diets in adults with refractory epilepsy: efficacious improvements in seizure frequency, seizure severity, and quality of life.
Epilepsy Behav.
2019
93
113
10.1016/j.yebeh.2018.12.010
Pubmed Abstract
CrossRef
Google Scholar
32.
Stafstrom
CE
Rho
JM
The ketogenic diet as a treatment paradigm for diverse neurological disorders.
Front Pharmacol.
2012
59
10.3389/fphar.2012.00059
Pubmed Abstract
CrossRef
Google Scholar
33.
Johnstone
AM
Horgan
GW
Murison
SD
Bremner
DM
Lobley
GE
Effects of a high-protein ketogenic diet on hunger, appetite, and weight loss in obese men feeding ad libitum.
Am J Clin Nutr.
2008
87
44
55
10.1093/ajcn/87.1.44
Pubmed Abstract
CrossRef
Google Scholar
34.
Partsalaki
Karvela
Spiliotis
BE
Metabolic impact of a ketogenic diet compared to a hypocaloric diet in obese children and adolescents.
J Pediatr Endocrinol Metab.
2012
25
697
704
10.1515/jpem-2012-0131
Pubmed Abstract
CrossRef
Google Scholar
35.
Veldhorst
Smeets
Soenen
Hochstenbach-Waelen
Hursel
Diepvens
et al
Protein-induced satiety: effects and mechanisms of different proteins.
Physiol Behav.
2008
94
300
10.1016/j.physbeh.2008.01.003
Pubmed Abstract
CrossRef
Google Scholar
36.
Westerterp-Plantenga
MS
Nieuwenhuizen
Tome
Soenen
Westerterp
KR
Dietary protein, weight loss, and weight maintenance.
Annu Rev Nutr.
2009
29
21
41
10.1146/annurev-nutr-080508-141056
Pubmed Abstract
CrossRef
Google Scholar
37.
Sumithran
Prendergast
LA
Delbridge
Purcell
Shulkes
Kriketos
et al
Ketosis and appetite-mediating nutrients and hormones after weight loss.
Eur J Clin Nutr.
2013
67
759
64
10.1038/ejcn.2013.90
Pubmed Abstract
CrossRef
Google Scholar
38.
Cahill
GF
Fuel metabolism in starvation.
Annu RevNutr.
2006
26
22
10.1146/annurev.nutr.26.061505.111258
Pubmed Abstract
CrossRef
Google Scholar
39.
Veldhorst
MA
Westerterp-plantenga
MS
Westerterp
KR
Gluconeogenesis and energy expenditure after a high-protein, carbohydrate-free diet.
Am J Clin Nutr.
2009
90
519
26
10.3945/ajcn.2009.27834.1
CrossRef
Google Scholar
40.
Paoli
Cenci
Fancelli
Parmagnani
Fratter
Cucchi
et al
Ketogenic diet and phytoextracts comparison of the efficacy of mediterranean, zone and Tisanoreica diet on some health risk factors.
Agro Food Ind Hi Tech.
2010
21
24
Google Scholar
41.
Paoli
Grimaldi
Bianco
Lodi
Cenci
Parmagnani
Medium term effects of a ketogenic diet and a mediterranean diet on resting energy expenditure and respiratory ratio.
BMC Proc.
2012
37
10.1186/1753-6561-6-S3-P37
CrossRef
Google Scholar
42.
Tagliabue
Bertoli
Trentani
Borrelli
Veggiotti
Effects of the ketogenic diet on nutritional status, resting energy expenditure, and substrate oxidation in patients with medically refractory epilepsy: a 6-month prospective observational study.
Clin Nutr.
2012
31
246
10.1016/j.clnu.2011.09.012
Pubmed Abstract
CrossRef
Google Scholar
43.
Hallberg
SJ
Mckenzie
AL
Williams
PT
Bhanpuri
NH
Peters
AL
Campbell
WW
et al
Effectiveness and safety of a novel care model for the management of type 2 diabetes at 1 year: an open-label, non-randomized, controlled study.
Diabetes Ther.
2018
583
612
10.1007/s13300-018-0373-9
Pubmed Abstract
CrossRef
Google Scholar
44.
O’Neill
Raggi
The ketogenic diet: pros and cons.
Atherosclerosis.
2020
292
119
26
10.1016/j.atherosclerosis.2019.11.021
Pubmed Abstract
CrossRef
Google Scholar
45.
Azevedo de Lima
Baldini Prudêncio
Murakami
DK
Pereira de Brito Sampaio
Figueiredo Neto
AM
Teixeira Damasceno
NR
Effect of classic ketogenic diet treatment on lipoprotein subfractions in children and adolescents with refractory epilepsy.
Nutrition.
2017
33
271
10.1016/j.nut.2016.06.016
Pubmed Abstract
CrossRef
Google Scholar
46.
Kapetanakis
Liuba
Odermarsky
Lundgren
Hallbo
Effects of Ketogenic Diet on Vascular Function.
Eur J Paediatr Neurol.
2014
18
489
94
10.1016/j.ejpn.2014.03.006
Pubmed Abstract
CrossRef
Google Scholar
47.
Khodabakhshi
Seyfried
TN
Kalamian
Beheshti
Davoodi
SH
Does a ketogenic diet have beneficial effects on quality of life, physical activity or biomarkers in patients with breast cancer: a randomized controlled.
Nutr J.
2020
19
87
96
10.21203/rs.3.rs-19350/v2
CrossRef
Google Scholar
48.
Bostock
ECS
Kirkby
KC
Taylor
BV
Hawrelak
JA
Consumer reports of “Keto Flu” associated with the ketogenic diet.
Front Nutr.
2020
20
10.3389/fnut.2020.00020
Pubmed Abstract
CrossRef
Google Scholar
49.
Lin
Turner
Doerrer
SC
Stanfield
Kossoff
EH
Complications during ketogenic diet initiation: prevalence, treatment and influence on seizure outcomes.
Pediatr Neurol.
2017
68
35
10.1016/j.pediatrneurol.2017.01.007
Pubmed Abstract
CrossRef
Google Scholar
50.
Stevens
CE
Turner
Kossoff
EH
Hepatic dysfunction as a complication of combined valproate and ketogenic diet.
Pediatr Neurol.
2016
54
82
10.1016/j.pediatrneurol.2015.10.006
Pubmed Abstract
CrossRef
Google Scholar
51.
Noain
JS
Minupuri
Kulkarni
Zheng
Significant impact of the ketogenic diet on low-density lipoprotein cholesterol levels.
Cureus.
2020
12
10
10.7759/cureus.9418
Pubmed Abstract
CrossRef
Google Scholar
52.
Swaid
Severe hyperlipidemia with LDL cholesterol of 393 Milligrams per decilitre after 7 months of high fat ketogenic diet: a rare case report.
J Endocr Soc.
2021
A37
10.1210/jendso/bvab048
CrossRef
Google Scholar
53.
Draaisma
JMT
Hampsink
BM
Janssen
van Houdt
NBM
Linders
ETAM
Willemsen
MA
The ketogenic diet and its effect on bone mineral density: a retrospective observational cohort study.
Neuropediatrics.
2019
50
353
10.1055/s-0039-1693059
Pubmed Abstract
CrossRef
Google Scholar
54.
Hawkes
CP
Roy
SM
Dekelbab
Frazier
Grover
Haidet
et al
hypercalcemia in children using the ketogenic diet: a multicenter study.
J Clin Endocrinol Metab.
2021
106
e485
95
10.1210/clinem/dgaa759
Pubmed Abstract
CrossRef
Google Scholar
55.
Cordain
L.
The Paelo Diet.
Hoboken
John Wiley & Sons
2010
).
Google Scholar
56.
Eaton
SB
Konner
MJ
Cordain
Diet-dependent acid load, paleolithic nutrition, and evolutionary health promotion.
Am J Clin Nutr.
2010
91
295
10.3945/ajcn.2009.29058.Am
CrossRef
Google Scholar
57.
Katz
SH
Weaver
WW.
Game.
New York
Scribner
2003
).
Google Scholar
58.
Eisenstein
Evolution: the first supper.
Nature.
2010
468
S8
10.1038/468S8a
Pubmed Abstract
CrossRef
Google Scholar
59.
Hou
JK
Abraham
El-serag
Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.
Am J Gastroenterol.
2011
106
563
73
10.1038/ajg.2011.44
Pubmed Abstract
CrossRef
Google Scholar
60.
Osterdahl
Kocturk
Koochek
Wandell
PE
Effects of a short-term intervention with a paleolithic diet in healthy volunteers.
Eur J Clin Nutr.
2008
62
682
10.1038/sj.ejcn.1602790
Pubmed Abstract
CrossRef
Google Scholar
61.
Boers
Muskiet
FAJ
Berkelaar
Schut
Penders
Hoenderdos
et al
Favourable effects of consuming a palaeolithic-type diet on characteristics of the metabolic syndrome: a randomized controlled pilot-study.
Lipids Health Dis.
2014
13
160
72
10.1186/1476-511X-13-160
Pubmed Abstract
CrossRef
Google Scholar
62.
Masharani
Sherchan
Schloetter
Stratford
Xiao
Sebastian
et al
Metabolic and physiologic effects from consuming a hunter-gatherer (paleolithic)-type diet in type 2 diabetes.
Eur J Clin Nutr.
2015
69
944
10.1038/ejcn.2015.39
Pubmed Abstract
CrossRef
Google Scholar
63.
Lindeberg
Jönsson
Granfeldt
Borgstrand
Soffman
Sjöström
et al
Palaeolithic diet improves glucose tolerance more than a mediterranean-like diet in individuals with ischaemic heart disease.
Diabetologia.
2007
50
1795
807
10.1007/s00125-007-0716-y
Pubmed Abstract
CrossRef
Google Scholar
64.
Smith
MM
Trexler
ET
Sommer
AJ
Starkoff
BE
Devor
ST
Unrestricted paleolithic diet is associated with unfavorable changes to blood lipids in healthy subjects.
Int J Exerc Sci.
2014
128
39
Google Scholar
65.
Mellberg
Sandberg
Ryberg
Eriksson
Brage
Larsson
et al
Long-term effects of a palaeolithic-type diet in obese postmenopausal women: a 2-year randomized trial.
Eur J Clin Nutr.
2014
68
350
10.1038/ejcn.2013.290
Pubmed Abstract
CrossRef
Google Scholar
66.
Frassetto
LA
Schloetter
Mietus-Synder
Morris
RC
Sebastian
Metabolic and Physiologic Improvements from Consuming a Paleolithic, Hunter-Gatherer Type Diet.
Eur J Clin Nutr.
2009
63
947
55
10.1038/ejcn.2009.4
Pubmed Abstract
CrossRef
Google Scholar
67.
Jönsson
Granfeldt
Ahrén
Branell
U-C
Pålsson
Hansson
et al
Beneficial effects of a paleolithic diet on cardiovascular risk factors in type 2 diabetes: a randomized cross-over pilot study.
Cardiovasc Diabetol.
2009
35
48
10.1186/1475-2840-8-35
Pubmed Abstract
CrossRef
Google Scholar
68.
Jönsson
Granfeldt
Lindeberg
Hallberg
Subjective satiety and other experiences of a paleolithic diet compared to a diabetes diet in patients with Type 2 diabetes.
Nutr J.
2013
12
105
11
10.1186/1475-2891-12-105
Pubmed Abstract
CrossRef
Google Scholar
69.
Manheimer
EW
Van Zuuren
EJ
Fedorowicz
Pijl
Paleolithic nutrition for metabolic syndrome: systematic review and meta-analysis.
Am J Clin Nutr.
2015
102
922
32
10.3945/ajcn.115.113613.1
CrossRef
Google Scholar
70.
Keys
Grande
Role of dietary fat in human nutrition.
Am J Public Health.
1957
47
1520
30
10.2105/ajph.47.12.1530
Pubmed Abstract
CrossRef
Google Scholar
71.
Martınez-Gonzalez
MA
Sanchez-Villegas
The emerging role of mediterranean diets in cardiovascular epidemiology: monounsaturated fats, olive oil, red wine or the whole pattern?
Eur J Epidemiol.
2004
19
13
10.1023/b:ejep.0000013351.60227.7b
CrossRef
Google Scholar
72.
Keys
AB.
How to Eat Well and Stay Well the Mediterranean Way.
New York, NY
Doubleday
1975
).
Google Scholar
73.
Kromhout
Keys
Aravanis
Buzina
Fidanza
Giampaoli
et al
Food Consumption Patterns in the 1960s in Seven Countries.
Am J Clin Nutr.
1989
49
889
94
10.1093/ajcn/49.5.889
Pubmed Abstract
CrossRef
Google Scholar
74.
Castro-Quezada
Román-Viñas
Serra-Majem
The mediterranean diet and nutritional adequacy: a review.
Nutrients.
2014
231
48
10.3390/nu6010231
Pubmed Abstract
CrossRef
Google Scholar
75.
Romagnolo
DF
Selmin
OI
Mediterranean diet and prevention of chronic diseases.
Nutr Today.
2017
52
208
22
10.1097/NT.0000000000000228
Pubmed Abstract
CrossRef
Google Scholar
76.
Shai
Schwarzfuchs
Henkin
Shahar
DR
Witkow
Greenberg
et al
Weight loss with a low-carbohydrate, mediterranean, or low-fat diet.
N Engl J Med.
2008
359
229
41
10.1056/NEJMoa0708681
Pubmed Abstract
CrossRef
Google Scholar
77.
Elhayany
Lustman
Abel
Attal-Singer
Vinker
A low carbohydrate mediterranean diet improves cardiovascular risk factors and diabetes control among prospective randomized intervention study.
Diabetes Obes Metab.
2010
12
204
10.1111/j.1463-1326.2009.01151.x
Pubmed Abstract
CrossRef
Google Scholar
78.
Estruch
Ros
Salas-Salvadó
Covas
MI
Corella
Arós
et al
Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts.
N Engl J Med.
2018
378
e34
10.1056/NEJMoa1800389
Pubmed Abstract
CrossRef
Google Scholar
79.
Couto
Boffetta
Lagiou
Ferrari
Buckland
Overvad
et al
Mediterranean dietary pattern and cancer risk in the EPIC cohort.
Br J Cancer.
2011
104
1493
10.1038/bjc.2011.106
Pubmed Abstract
CrossRef
Google Scholar
80.
Salas-Salvado
Bullo
Estruch
Ros
Covas
M-I
Ibarrola-Jurado
et al
Prevention of diabetes with mediterranean diets: a subgroup analysis of a randomized trial.
Ann Intern Med.
2014
160
10
10.7326/M13-1725
Pubmed Abstract
CrossRef
Google Scholar
81.
Estruch
Martínez-gonzález
MA
Corella
Salas-salvadó
Chiva-blanch
Fiol
Effect of a high-fat mediterranean diet on bodyweight and waist circumference : a prespecified secondary outcomes analysis of the PREDIMED randomised controlled trial.
Lancet Diabetes Endocrinol.
2019
e6
17
10.1016/S2213-8587(19)30074-9
CrossRef
Google Scholar
82.
Singh
PN
Sabaté
Fraser
GE
Does low meat consumption increase life expectancy in humans?
Am J Clin Nutr.
2003
78
S526
32
10.1093/ajcn/78.3.526S
Pubmed Abstract
CrossRef
Google Scholar
83.
Sinha
Cross
AJ
Graubard
BI
Leitzmann
MF
Schatzkin
Meat intake and mortality: a prospective study of over half a million people.
Arch Intern Med.
2009
169
562
71
10.1001/archinternmed.2009.6.Meat
CrossRef
Google Scholar
84.
Marsh
Zeuschner
Saunders
Health implications of a vegetarian diet: a review.
Am J Lifestyle Med.
2012
250
67
10.1177/1559827611425762
CrossRef
Google Scholar
85.
Leitzmann
Vegetarian nutrition: past, present, future.
Am J Clin Nutr.
2014
100
S496
502
10.3945/ajcn.113.071365.496S
CrossRef
Google Scholar
86.
Craig
WJ
Health effects of vegan diets.
Am J Clin Nutr.
2009
89
S1627
33
10.3945/ajcn.2009.26736N
Pubmed Abstract
CrossRef
Google Scholar
87.
Tonstad
Yan
Butler
Fraser
GE
Type of vegetarian diet, body weight, and prevalence of type 2 diabetes.
Diabetes Care.
2009
32
791
10.2337/dc08-1886
Pubmed Abstract
CrossRef
Google Scholar
88.
Bedford
JL
Barr
SI
Diets and selected lifestyle practices of self-defined adult vegetarians from a population-based sample suggest they are more “health conscious“.
Int J Behav Nutr Phys Act.
2005
14
10.1186/1479-5868-2-4
Pubmed Abstract
CrossRef
Google Scholar
89.
Roberts
SB
Urban
LE
Das
SK
Effects of dietary factors on energy regulation: consideration of multiple- versus single-dietary-factor models.
Physiol Behav.
2014
134
15
10.1016/j.physbeh.2014.04.024
Pubmed Abstract
CrossRef
Google Scholar
90.
Rosell
Appleby
Spencer
Key
Weight gain over 5 years in 21966 meat-eating, fish-eating, vegetarian, and vegan men and women in EPIC-Oxford.
Int J Obes.
2006
30
1389
96
10.1038/sj.ijo.0803305
Pubmed Abstract
CrossRef
Google Scholar
91.
Silvera
SAN
Mayne
ST
Risch
Gammon
MD
Vaughan
TL
Chow
W-H
et al
Food group intake and risk of subtypes of esophageal and gastric cancer.
Int J Cancer.
2008
123
852
60
10.1002/ijc.23544
Pubmed Abstract
CrossRef
Google Scholar
92.
Bosetti
Negri
Franceschi
Pelucchi
Talamini
La Montelle
et al
Diet and ovarian cancer risk: a case-control study in Italy.
Int J Cancer.
2001
93
911
10.1002/ijc.1422
Pubmed Abstract
CrossRef
Google Scholar
93.
Norat
Bingham
Ferrari
Slimani
Jenab
Mazuir
et al
Meat, fish, and colorectal cancer risk: the European prospective investigation into cancer and nutrition.
J Natl Cancer Inst.
2005
97
906
16
10.1093/jnci/dji164
Pubmed Abstract
CrossRef
Google Scholar
94.
Chen
CW
Lin
YL
Lin
TK
Lin
CT
Chen
BC
Lin
CL
Total cardiovascular risk profile of taiwanese vegetarians.
Eur J Clin Nutr.
2008
62
138
44
10.1038/sj.ejcn.1602689
Pubmed Abstract
CrossRef
Google Scholar
95.
de Biase
SG
Fernandes
SFC
Gianini
RJ
Duarte
JLG
Vegetarian diet and cholesterol and triglycerides levels.
Arq Bras Cardiol.
2007
88
32
10.1590/S0066-782X2007000100006
Pubmed Abstract
CrossRef
Google Scholar
96.
Bradbury
KE
Crowe
FL
Appleby
PN
Schmidt
JA
Travis
RC
Key
TJ
Serum concentrations of cholesterol, apolipoprotein A-I and apolipoprotein B in a total of 1694 meat-eaters, fish-eaters, vegetarians and vegans.
Eur J Clin Nutr.
2014
68
178
83
10.1038/ejcn.2013.248
Pubmed Abstract
CrossRef
Google Scholar
97.
Cross
AJ
Ferrucci
LM
Risch
Graubard
BI
Ward
MH
Park
et al
Large prospective study of meat consumption and colorectal cancer risk: an investigation of potential mechanisms underlying this association.
Cancer Res.
2010
70
2406
14
10.1158/0008-5472.CAN-09-3929.A
CrossRef
Google Scholar
98.
Lagiou
Talamini
Samoli
Lagiou
Ahrens
Pohlabeln
et al
Diet and upper-aerodigestive tract cancer in Europe: the ARCAGE study.
Int J Cancer.
2009
124
2671
10.1002/ijc.24246
Pubmed Abstract
CrossRef
Google Scholar
99.
Butler
LM
Wu
AH
Wang
Koh
W-P
Yuan
J-M
Yu
MC
A vegetable-fruit-soy dietary pattern protects against breast cancer among postmenopausal Singapore Chinese women.
Am J Clin Nutr.
2010
91
1013
10.3945/ajcn.2009.28572
Pubmed Abstract
CrossRef
Google Scholar
100.
Craig
W.J.
Mangels
A.R
Position of the American dietetic association: vegetarian diets.
J Am Diet Assoc.
2009
109
1266
82
10.1016/j.jada.2009.05.027
Pubmed Abstract
CrossRef
Google Scholar
101.
Gilsing
A.M.J.
Crowe
F.L.
Lloyd-Wright
Z.
Sanders
T.A.B.
Appleby
P.N.
Allen
N.E.
Key
T.J
Serum concentrations of vitamin B12 and folate in British male omnivores, vegetarians, and vegans: results from a cross-sectional analysis of the EPIC-oxford cohort study.
Eur J Clin Nutr.
2011
64
933
10.1038/ejcn.2010.142.Serum
CrossRef
Google Scholar
102.
Allen
L.H
How common is vitamin B-12 deficiency?
Am J Clin Nutr.
2009
89
S693
10.3945/ajcn.2008.26947A
Pubmed Abstract
CrossRef
Google Scholar
103.
Ho-Pham
L.T.
Nguyen
P.L.T.
Le
T.T.T.
Doan
T.A.T.
Tran
N.T.
Le
T.A.
Nguyen
T. V
Veganism, bone mineral density, and body composition: a study in buddhist nuns.
Osteoporos Int
2009
20
2087
93
10.1007/s00198-009-0916-z
Pubmed Abstract
CrossRef
Google Scholar
104.
Dror
D.K.
Allen
L.H
Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms.
Nutr Rev.
2008
66
250
10.1111/j.1753-4887.2008.00031.x
Pubmed Abstract
CrossRef
Google Scholar
105.
Freire
Scientific evidence of diets for weight loss: different macronutrient composition, intermittent fasting, and popular diets.
Nutrition.
2020
69
110549
59
10.1016/j.nut.2019.07.001
Pubmed Abstract
CrossRef
Google Scholar
106.
Halberg
N.
Henriksen
M.
Söderhamn
N.
Stallknecht
B.
Ploug
T.
Schjerling
P.
Dela
Effect of intermittent fasting and refeeding on insulin action in healthy men.
J Appl Physiol.
2005
99
2128
36
10.1152/japplphysiol.00683.2005
Pubmed Abstract
CrossRef
Google Scholar
107.
Heilbronn
LK
Smith
SR
Martin
CK
Anton
SD
Ravussin
Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism.
Am J Clin Nutr.
2005
81
69
73
10.1093/ajcn/81.1.69
Pubmed Abstract
CrossRef
Google Scholar
108.
Horne
BD
Muhlestein
JB
Lappe
DL
May
HT
Carlquist
JF
Galenko
et al
Randomized cross-over trial of short-term water-only fasting: metabolic and cardiovascular consequences.
Nutr Metab Cardiovasc Dis.
2013
23
1050
10.1016/j.numecd.2012.09.007
Pubmed Abstract
CrossRef
Google Scholar
109.
LeCheminant
JD
Christenson
Bailey
BW
Tucker
LA
Restricting night-time eating reduces daily energy intake in healthy young men: a short-term cross-over study.
Br J Cancer.
2013
110
2108
13
10.1017/S0007114513001359
Pubmed Abstract
CrossRef
Google Scholar
110.
Harvie
MN
Pegington
Mattson
MP
Frystyk
Dillon
Evans
et al
The effects of intermittent or continuous energy restriction on weight loss and metabolic disease risk markers : a randomized trial in young overweight women.
Int J Obes.
2011
35
714
27
10.1038/ijo.2010.171
Pubmed Abstract
CrossRef
Google Scholar
111.
Hoddy
KK
Gibbons
Kroeger
CM
Trepanowski
JF
Barnosky
Bhutani
et al
Changes in hunger and fullness in relation to gut peptides before and after 8 weeks of alternate day fasting.
Clin Nutr.
2016
35
1380
10.1016/j.clnu.2016.03.011
Pubmed Abstract
CrossRef
Google Scholar
112.
Cho
Hong
Kim
Cho
SJ
Lee
Lee
et al
The effectiveness of intermittent fasting to reduce body mass index and glucose metabolism: a systematic review and meta-analysis.
J Clin Med.
2019
1645
55
10.3390/jcm8101645
Pubmed Abstract
CrossRef
Google Scholar
113.
Headland
Clifton
PM
Carter
Keogh
JB
Weight-loss outcomes: a systematic review and meta-analysis of intermittent energy restriction trials lasting a minimum of 6 months.
Nutrients.
2016
354
65
10.3390/nu8060354
Pubmed Abstract
CrossRef
Google Scholar
114.
Salgin
Marcovecchio
ML
Humphreys
SM
Hill
Chassin
LJ
Lunn
DJ
et al
Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.
Am J Physiol Endocrinol Metab.
2009
296
E454
61
10.1152/ajpendo.90613.2008
Pubmed Abstract
CrossRef
Google Scholar
115.
Khalil
MT
Impact of a detox diet paradigm in weight management.
Izzivi Prihodnosti.
2017
237
55
Google Scholar
116.
Allen
Montalto
Lovejoy
Weber
Detoxification in naturopathic medicine: a survey.
J Altern Complement Med.
2011
17
1175
80
10.1089/acm.2010.0572
Pubmed Abstract
CrossRef
Google Scholar
117.
Cabot
S.
The Liver Cleansing Diet: Love Your Liver and Live Longer.
Phoenix, AZ
SCB International
2014
).
Google Scholar
118.
Woloshyn
T.
The Complete Master Cleanse: A Step-by-Step Guide to Maximizing the Benefits of The Lemonade Diet.
Berkeley
Ulysses Press
2021
).
Google Scholar
119.
Junger
A.
Clean: The Revolutionary Program to Restore the Body’s Natural Ability to Heal Itself.
New York, NY
HarperOne
2009
).
Google Scholar
120.
Deluz
Hester
Beard
H.
21 Pounds in 21 Days: The Martha’s Vineyard Diet Detox.
New York, NY
Harper Collins
2009
).
Google Scholar
121.
Cook
MS.
Weekend Wonder Detox: Quick Cleanses to Strengthen Your Body and Enhance Your Beauty.
New York, NY
Da Capo Lifelong Books
2014
).
Google Scholar
122.
Gittleman
AL.
The New Fat Flush Plan.
New York, NY
McGraw Hill
2016
).
Google Scholar
123.
Sakoutis
Huss
E.
The 3-Day Cleanse: Your BluePrint for Fresh Juice, Real Food, and a Total Body Reset.
New York, NY
Grand Central Life & Style
2010
).
Google Scholar
124.
Hubbard
LR.
Clear Body Clear Mind: The Effective Purification Program.
Los Angeles
Bridge Publications
2002
).
Google Scholar
125.
Genuis
SJ
Birkholz
Rodushkin
Beesoon
Blood, urine, and sweat (BUS) study: monitoring and elimination of bioaccumulated toxic elements.
Arch Environ Contam Toxicol.
2011
61
344
57
10.1007/s00244-010-9611-5
Pubmed Abstract
CrossRef
Google Scholar
126.
Wing
RR
Phelan
Long-term weight loss maintenance.
Am J Clin Nutr.
2005
82
S222
10.1093/ajcn/82.1.222s
Pubmed Abstract
CrossRef
Google Scholar
127.
Sainsbury
Zhang
Role of the arcuate nucleus of the hypothalamus in regulation of body weight during energy deficit.
Mol Cell Endocrinol.
2010
316
109
19
10.1016/j.mce.2009.09.025
Pubmed Abstract
CrossRef
Google Scholar
128.
Pankevich
DE
Teegarden
SL
Hedin
AD
Jensen
CL
Bale
TL
Caloric restriction experience reprograms stress and orexigenic pathways and promotes binge eating.
J Neurosci.
2010
30
16399
407
10.1523/JNEUROSCI.1955-10.2010
Pubmed Abstract
CrossRef
Google Scholar
129.
Mazurak
Gunther
Grau
FS
Muth
ER
Pustovoyt
Bischoff
SC
et al
Effects of a 48-h fast on heart rate variability and cortisol levels in healthy female subjects.
Eur J Clin Nutr.
2013
67
401
10.1038/ejcn.2013.32
Pubmed Abstract
CrossRef
Google Scholar
130.
Tomiyama
AJ
Mann
Vinas
Hunger
JM
DeJager
Taylor
SE
Low calorie dieting increases cortisol.
Psychosom Med.
2010
72
357
64
10.1097/PSY.0b013e3181d9523c.Low
CrossRef
Google Scholar
131.
Torres
SJ
Nowson
CA
Relationship between stress, eating behavior, and obesity.
Nutrition.
2007
23
887
94
10.1016/j.nut.2007.08.008
Pubmed Abstract
CrossRef
Google Scholar
132.
Joint WHO/FAO/UNU Expert Consultation.
Protein and Amino Acid Requirements in Human Nutrition.
Geneva
World Health Organization
2007
).
Google Scholar
133.
Food and Agriculture Organization [FAO].
FAO Methodology for the Measurement of Food Deprivation: Updating the Minimum Dietary Energy Requirements.
2008
). Available online at:
(Accessed June 20, 2021)
Google Scholar
134.
Sanchez
Casalots-Casado
Quintana
Arroyo
Martin-Fumadoc
Galtes
Fatal manganese intoxication due to an error in the elaboration of epsom salts for a liver cleansing diet.
Forensic Sci Int.
2012
223
e1
14
10.1016/j.forsciint.2012.07.010
Pubmed Abstract
CrossRef
Google Scholar
Summary
Keywords
fad diets
obesity
weight loss
metabolism
chronic disease
cardiovascular
health
Citation
Tahreem A, Rakha A, Rabail R, Nazir A, Socol CT, Maerescu CM and Aadil RM (2022)
Fad Diets: Facts and Fiction
Front. Nutr.
9:960922. doi:
10.3389/fnut.2022.960922
Received
08 June 2022
Accepted
20 June 2022
Published
05 July 2022
Volume
9 - 2022
Edited by
Monica Trif, Centre for Innovative Process Engineering, Germany
Reviewed by
Seydi Yıkmış, Namik Kemal University, Turkey; Jahan Zaib Ashraf, University of Foggia, Italy
Updates
© 2022 Tahreem, Rakha, Rabail, Nazir, Socol, Maerescu and Aadil.
This is an open-access article distributed under the terms of the
Creative Commons Attribution License (CC BY)
. The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Allah Rakha,
arrehman_ft@uaf.edu.pk
Cristina Maria Maerescu,
cristina_maerescu@yahoo.com
Rana Muhammad Aadil,
muhammad.aadil@uaf.edu.pk
This article was submitted to Nutrition and Sustainable Diets, a section of the journal Frontiers in Nutrition
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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