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Chronic cannabis use in people with bipolar disorder is associated with comparable decision-making and functional outcome to healthy participants. Transl Psychiatry. 2025 Nov 27; 15(1):506. Miranda A, Roberts BZ, Holloway BM, Peek E, Rosberg H, Ayoub SM, Piomelli D, Jung KM, Barnes SA, Rossi S, Geyer MA, Perry W, Minassian A, Young JW. PMID: 41309543; PMCID: PMC12660854.
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Quantifying Exploratory Behavior In The Human Behavioral Pattern Monitor Using Automated Video Tracking. Meth Psychol. 2025 Dec; 13. Rosberg H, Miranda A, Holloway BM, Zhang Z, Peek E, Sharp RF, Geyer MA, Young JW, Perry W, Minassian A. PMID: 41311559; PMCID: PMC12657035.
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Effect of blast exposure on sensorimotor gating and fear memory. Physiol Behav. 2025 Oct 15; 300:115029. Vaughn MN, Geyer MA, Powell SB, Ng L, Risbrough VB, Halberstadt AL. PMID: 40659104.
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Prospective ECG-gated High-Pitch Photon-Counting CT Angiography: Evaluation of measurement accuracy for aortic annulus sizing in TAVR planning. Eur J Radiol. 2024 Sep; 178:111604. Yang Y, Richter R, Halfmann MC, Graafen D, Hell M, Vecsey-Nagy M, Laux G, Kavermann L, Jorg T, Geyer M, Varga-Szemes A, Emrich T. PMID: 38996738.
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A Brief Historical Overview of Psychedelic Research. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 May; 9(5):464-471. Geyer MA. PMID: 38000715.
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Modulation of ventromedial orbitofrontal cortical glutamatergic activity affects the explore-exploit balance and influences value-based decision-making. Cereb Cortex. 2023 05 09; 33(10):5783-5796. Barnes SA, Dillon DG, Young JW, Thomas ML, Faget L, Yoo JH, Der-Avakian A, Hnasko TS, Geyer MA, Ramanathan DS. PMID: 36472411; PMCID: PMC10183731.
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Past, Present, and Future of Psychedelics: A Psychedelic Medicine Roundtable Discussion. Psychedelic Med (New Rochelle). 2023 Mar; 1(1):2-11. Hendricks PS, Nichols CD, Cunningham KA, Geyer MA, Griffiths R, Nichols D. PMID: 40047012; PMCID: PMC11658641.
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iTat transgenic mice exhibit hyper-locomotion in the behavioral pattern monitor after chronic exposure to methamphetamine but are unaffected by Tat expression. Pharmacol Biochem Behav. 2023 01; 222:173499. Ayoub S, Kenton JA, Milienne-Petiot M, Deben DS, Achim C, Geyer MA, Perry W, Grant IE, Young JW, Minassian A, TMARC. PMID: 36462584; PMCID: PMC10014034.
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Combining targeted and systematic prostate biopsy improves prostate cancer detection and correlation with the whole mount histopathology in biopsy naïve and previous negative biopsy patients. Front Surg. 2022; 9:1013389. Mischinger J, Schöllnast H, Zurl H, Geyer M, Fischereder K, Adelsmayr G, Igrec J, Fritz G, Merdzo-Hörmann M, Elstner J, Schmid J, Triebl A, Trimmel V, Reiter C, Steiner J, Rosenlechner D, Seles M, Pichler GP, Pichler M, Riedl J, Schöpfer-Schwab S, Strobl J, Hutterer GC, Zigeuner R, Pummer K, Augustin H, Ahyai S, Mannweiler S, Fuchsjäger M, Talakic E. PMID: 36277287; PMCID: PMC9582510.
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Prospective longitudinal assessment of sensorimotor gating as a risk/resiliency factor for posttraumatic stress disorder. Neuropsychopharmacology. 2022 12; 47(13):2238-2244. Acheson DT, Baker DG, Nievergelt CM, Yurgil KA, Geyer MA, Risbrough VB. PMID: 36192631; PMCID: PMC9630259.
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Chronic methamphetamine exposure exerts few effects on the iTat mouse model of HIV, but blocks Tat expression-induced slowed reward retrieval. Behav Brain Res. 2023 02 02; 437:114109. Young JW, Kenton JA, Milienne-Petiot M, Deben D, Achim C, Geyer MA, Perry W, Grant IE, Minassian A, TMARC. PMID: 36108778; PMCID: PMC10878174.
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The contribution of intermolecular spin interactions to the London dispersion forces between chiral molecules. J Chem Phys. 2022 Jun 21; 156(23):234106. Geyer M, Gutierrez R, Mujica V, Silva JFR, Dianat A, Cuniberti G. PMID: 35732515.
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NCCN Guidelines® Insights: Hematopoietic Growth Factors, Version 1.2022. J Natl Compr Canc Netw. 2022 05; 20(5):436-442. Griffiths EA, Roy V, Alwan L, Bachiashvili K, Baird J, Cool R, Dinner S, Geyer M, Glaspy J, Gojo I, Hicks A, Kallam A, Kidwai WZ, Kloth DD, Kraut EH, Landsburg D, Lyman GH, Mahajan A, Miller R, Nachar V, Patel S, Patel S, Perez LE, Poust A, Riaz F, Rosovsky R, Rugo HS, Simon S, Vasu S, Wadleigh M, Westbrook K, Westervelt P, Berardi RA, Pluchino L. PMID: 35545171.
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Mechanisms of Resistance to Noncovalent Bruton's Tyrosine Kinase Inhibitors. N Engl J Med. 2022 02 24; 386(8):735-743. Wang E, Mi X, Thompson MC, Montoya S, Notti RQ, Afaghani J, Durham BH, Penson A, Witkowski MT, Lu SX, Bourcier J, Hogg SJ, Erickson C, Cui D, Cho H, Singer M, Totiger TM, Chaudhry S, Geyer M, Alencar A, Linley AJ, Palomba ML, Coombs CC, Park JH, Zelenetz A, Roeker L, Rosendahl M, Tsai DE, Ebata K, Brandhuber B, Hyman DM, Aifantis I, Mato A, Taylor J, Abdel-Wahab O. PMID: 35196427; PMCID: PMC9074143.
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HIV Transgenic Rats Demonstrate Impaired Sensorimotor Gating But Are Insensitive to Cannabinoid (Δ9-Tetrahydrocannabinol)-Induced Deficits. Int J Neuropsychopharmacol. 2021 11 12; 24(11):894-906. Roberts BZ, Minassian A, Halberstadt AL, He YV, Chatha M, Geyer MA, Grant I, Young JW. PMID: 34338765; PMCID: PMC8598295.
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The Effects of Cannabis Use on Cognitive Function in Healthy Aging: A Systematic Scoping Review. Arch Clin Neuropsychol. 2021 Jul 19; 36(5):673-685. Pocuca N, Walter TJ, Minassian A, Young JW, Geyer MA, Perry W. PMID: 33159510; PMCID: PMC8296849.
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Computational identification of variables in neonatal vocalizations predictive for postpubertal social behaviors in a mouse model of 16p11.2 deletion. Mol Psychiatry. 2021 11; 26(11):6578-6588. Nakamura M, Ye K, E Silva MB, Yamauchi T, Hoeppner DJ, Fayyazuddin A, Kang G, Yuda EA, Nagashima M, Enomoto S, Hiramoto T, Sharp R, Kaneko I, Tajinda K, Adachi M, Mihara T, Tokuno S, Geyer MA, Broin PÓ, Matsumoto M, Hiroi N. PMID: 33859357; PMCID: PMC8517042.
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Chronic antipsychotic treatment exerts limited effects on the mania-like behavior of dopamine transporter knockdown mice. Behav Brain Res. 2021 05 07; 405:113167. Cope ZA, Kenton JA, Minassian A, Martin MV, Perry W, Bundgaard C, Arnt J, van Enkhuizen J, Geyer MA, Young JW. PMID: 33577882; PMCID: PMC10729608.
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The relationship between cannabis use and cognition in people with bipolar disorder: A systematic scoping review. Psychiatry Res. 2021 03; 297:113695. Jordan Walter T, Pocuca N, Young JW, Geyer MA, Minassian A, Perry W. PMID: 33545431; PMCID: PMC7914198.
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Sustained attention and vigilance deficits associated with HIV and a history of methamphetamine dependence. Drug Alcohol Depend. 2020 10 01; 215:108245. Pocuca N, Young JW, MacQueen DA, Letendre S, Heaton RK, Geyer MA, Perry W, Grant I, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC). PMID: 32871507; PMCID: PMC7811354.
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Analysis of Genetically Regulated Gene Expression Identifies a Prefrontal PTSD Gene, SNRNP35, Specific to Military Cohorts. Cell Rep. 2020 06 02; 31(9):107716. Huckins LM, Chatzinakos C, Breen MS, Hartmann J, Klengel T, da Silva Almeida AC, Dobbyn A, Girdhar K, Hoffman GE, Klengel C, Logue MW, Lori A, Maihofer AX, Morrison FG, Nguyen HT, Park Y, Ruderfer D, Sloofman LG, van Rooij SJH, PTSD Working Group of Psychiatric Genomics Consortium, Baker DG, Chen CY, Cox N, Duncan LE, Geyer MA, Glatt SJ, Im HK, Risbrough VB, Smoller JW, Stein DJ, Yehuda R, Liberzon I, Koenen KC, Jovanovic T, Kellis M, Miller MW, Bacanu SA, Nievergelt CM, Buxbaum JD, Sklar P, Ressler KJ, Stahl EA, Daskalakis NP. PMID: 32492425; PMCID: PMC7359754.
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Convergent neural substrates of inattention in bipolar disorder patients and dopamine transporter-deficient mice using the 5-choice CPT. Bipolar Disord. 2020 02; 22(1):46-58. Young JW, Geyer MA, Halberstadt AL, van Enkhuizen J, Minassian A, Khan A, Perry W, Eyler LT. PMID: 31025493; PMCID: PMC6815232.
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Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen. Psychopharmacology (Berl). 2019 Feb; 236(2):821-830. Halberstadt AL, van der Zee JVF, Chatha M, Geyer MA, Powell SB. PMID: 30448990; PMCID: PMC6778591.
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Nicotine improves probabilistic reward learning in wildtype but not alpha7 nAChR null mutants, yet alpha7 nAChR agonists do not improve probabilistic learning. Eur Neuropsychopharmacol. 2018 11; 28(11):1217-1231. Milienne-Petiot M, Higa KK, Grim A, Deben D, Groenink L, Twamley EW, Geyer MA, Young JW. PMID: 30213668; PMCID: PMC6344043.
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Amphetamine improves mouse and human attention in the 5-choice continuous performance test. Neuropharmacology. 2018 08; 138:87-96. MacQueen DA, Minassian A, Kenton JA, Geyer MA, Perry W, Brigman JL, Young JW. PMID: 29859849; PMCID: PMC6340711.
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Effective Use of Animal Models for Therapeutic Development in Psychiatric and Substance Use Disorders. Biol Psychiatry. 2018 06 01; 83(11):915-923. Phillips AG, Geyer MA, Robbins TW. PMID: 29478700.
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Individual variation in working memory is associated with fear extinction performance. Behav Res Ther. 2018 03; 102:52-59. Stout DM, Acheson DT, Moore TM, Gur RC, Baker DG, Geyer MA, Risbrough VB, MRS Team. PMID: 29331727; PMCID: PMC6182776.
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Effect of Hallucinogens on Unconditioned Behavior. Curr Top Behav Neurosci. 2018; 36:159-199. Halberstadt AL, Geyer MA. PMID: 28224459; PMCID: PMC5787039.
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Dopamine transporter knockdown mice in the behavioral pattern monitor: A robust, reproducible model for mania-relevant behaviors. Pharmacol Biochem Behav. 2019 03; 178:42-50. Kwiatkowski MA, Hellemann G, Sugar CA, Cope ZA, Minassian A, Perry W, Geyer MA, Young JW. PMID: 29289701; PMCID: PMC10014035.
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Amphetamine Modestly Improves Conners' Continuous Performance Test Performance in Healthy Adults. J Int Neuropsychol Soc. 2018 03; 24(3):283-293. MacQueen DA, Minassian A, Henry BL, Geyer MA, Young JW, Perry W. PMID: 29032769; PMCID: PMC5820221.
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Erratum: Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017 08 02; 8:16140. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. PMID: 28767105; PMCID: PMC5543301.
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Modafinil improves attentional performance in healthy, non-sleep deprived humans at doses not inducing hyperarousal across species. Neuropharmacology. 2017 Oct; 125:254-262. Cope ZA, Minassian A, Kreitner D, MacQueen DA, Milienne-Petiot M, Geyer MA, Perry W, Young JW. PMID: 28774856; PMCID: PMC6472902.
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Genetic loci associated with heart rate variability and their effects on cardiac disease risk. Nat Commun. 2017 06 14; 8:15805. Nolte IM, Munoz ML, Tragante V, Amare AT, Jansen R, Vaez A, von der Heyde B, Avery CL, Bis JC, Dierckx B, van Dongen J, Gogarten SM, Goyette P, Hernesniemi J, Huikari V, Hwang SJ, Jaju D, Kerr KF, Kluttig A, Krijthe BP, Kumar J, van der Laan SW, Lyytikäinen LP, Maihofer AX, Minassian A, van der Most PJ, Müller-Nurasyid M, Nivard M, Salvi E, Stewart JD, Thayer JF, Verweij N, Wong A, Zabaneh D, Zafarmand MH, Abdellaoui A, Albarwani S, Albert C, Alonso A, Ashar F, Auvinen J, Axelsson T, Baker DG, de Bakker PIW, Barcella M, Bayoumi R, Bieringa RJ, Boomsma D, Boucher G, Britton AR, Christophersen I, Dietrich A, Ehret GB, Ellinor PT, Eskola M, Felix JF, Floras JS, Franco OH, Friberg P, Gademan MGJ, Geyer MA, Giedraitis V, Hartman CA, Hemerich D, Hofman A, Hottenga JJ, Huikuri H, Hutri-Kähönen N, Jouven X, Junttila J, Juonala M, Kiviniemi AM, Kors JA, Kumari M, Kuznetsova T, Laurie CC, Lefrandt JD, Li Y, Li Y, Liao D, Limacher MC, Lin HJ, Lindgren CM, Lubitz SA, Mahajan A, McKnight B, Zu Schwabedissen HM, Milaneschi Y, Mononen N, Morris AP, Nalls MA, Navis G, Neijts M, Nikus K, North KE, O'Connor DT, Ormel J, Perz S, Peters A, Psaty BM, Raitakari OT, Risbrough VB, Sinner MF, Siscovick D, Smit JH, Smith NL, Soliman EZ, Sotoodehnia N, Staessen JA, Stein PK, Stilp AM, Stolarz-Skrzypek K, Strauch K, Sundström J, Swenne CA, Syvänen AC, Tardif JC, Taylor KD, Teumer A, Thornton TA, Tinker LE, Uitterlinden AG, van Setten J, Voss A, Waldenberger M, Wilhelmsen KC, Willemsen G, Wong Q, Zhang ZM, Zonderman AB, Cusi D, Evans MK, Greiser HK, van der Harst P, Hassan M, Ingelsson E, Järvelin MR, Kääb S, Kähönen M, Kivimaki M, Kooperberg C, Kuh D, Lehtimäki T, Lind L, Nievergelt CM, O'Donnell CJ, Oldehinkel AJ, Penninx B, Reiner AP, Riese H, van Roon AM, Rioux JD, Rotter JI, Sofer T, Stricker BH, Tiemeier H, Vrijkotte TGM, Asselbergs FW, Brundel BJJM, Heckbert SR, Whitsel EA, den Hoed M, Snieder H, de Geus EJC. PMID: 28613276; PMCID: PMC5474732.
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Fear learning alterations after traumatic brain injury and their role in development of posttraumatic stress symptoms. Depress Anxiety. 2017 08; 34(8):723-733. Glenn DE, Acheson DT, Geyer MA, Nievergelt CM, Baker DG, Risbrough VB, MRS-II Team. PMID: 28489272; PMCID: PMC12128915.
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Nicotine withdrawal-induced inattention is absent in alpha7 nAChR knockout mice. Psychopharmacology (Berl). 2017 05; 234(9-10):1573-1586. Higa KK, Grim A, Kamenski ME, van Enkhuizen J, Zhou X, Li K, Naviaux JC, Wang L, Naviaux RK, Geyer MA, Markou A, Young JW. PMID: 28243714; PMCID: PMC5420484.
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Brexpiprazole reduces hyperactivity, impulsivity, and risk-preference behavior in mice with dopamine transporter knockdown-a model of mania. Psychopharmacology (Berl). 2017 Mar; 234(6):1017-1028. Milienne-Petiot M, Geyer MA, Arnt J, Young JW. PMID: 28160035; PMCID: PMC5391249.
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Effects of LPS-induced immune activation prior to trauma exposure on PTSD-like symptoms in mice. Behav Brain Res. 2017 04 14; 323:117-123. Deslauriers J, van Wijngaarde M, Geyer MA, Powell S, Risbrough VB. PMID: 28159589; PMCID: PMC12161152.
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Athina Markou. Neuropsychopharmacology. 2016 Dec; 41(13):3121-3122. Geyer MA. PMID: 27818512; PMCID: PMC5101559.
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Prepulse Inhibition Deficits in Obsessive-Compulsive Disorder are More Pronounced in Females. Neuropsychopharmacology. 2016 12; 41(13):2963-2964. Ahmari SE, Risbrough VB, Geyer MA, Simpson HB. PMID: 27818517; PMCID: PMC5101545.
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The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania. Neuropharmacology. 2017 02; 113(Pt A):260-270. Milienne-Petiot M, Kesby JP, Graves M, van Enkhuizen J, Semenova S, Minassian A, Markou A, Geyer MA, Young JW. PMID: 27732870; PMCID: PMC5148687.
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Sensorimotor gating of the startle reflex: what we said 25 years ago, what has happened since then, and what comes next. J Psychopharmacol. 2016 11; 30(11):1072-1081. Swerdlow NR, Braff DL, Geyer MA. PMID: 27539931; PMCID: PMC6036900.
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Premature responses in the five-choice serial reaction time task reflect rodents' temporal strategies: evidence from no-light and pharmacological challenges. Psychopharmacology (Berl). 2016 Oct; 233(19-20):3513-25. Cope ZA, Halberstadt AL, van Enkhuizen J, Flynn AD, Breier M, Swerdlow NR, Geyer MA, Young JW. PMID: 27534540; PMCID: PMC5023490.
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Failed trials for central nervous system disorders do not necessarily invalidate preclinical models and drug targets. Nat Rev Drug Discov. 2016 Jul; 15(7):516. Bespalov A, Steckler T, Altevogt B, Koustova E, Skolnick P, Deaver D, Millan MJ, Bastlund JF, Doller D, Witkin J, Moser P, O'Donnell P, Ebert U, Geyer MA, Prinssen E, Ballard T, Macleod M. PMID: 27312728.
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Effect of 5-HT2A and 5-HT2C receptors on temporal discrimination by mice. Neuropharmacology. 2016 08; 107:364-375. Halberstadt AL, Sindhunata IS, Scheffers K, Flynn AD, Sharp RF, Geyer MA, Young JW. PMID: 27020041; PMCID: PMC5403251.
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PREPULSE INHIBITION DEFICITS ONLY IN FEMALES WITH OBSESSIVE-COMPULSIVE DISORDER. Depress Anxiety. 2016 Mar; 33(3):238-46. Steinman SA, Ahmari SE, Choo T, Kimeldorf MB, Feit R, Loh S, Risbrough V, Geyer MA, Steinglass JE, Wall M, Schneier FR, Fyer AJ, Simpson HB. PMID: 26878422; PMCID: PMC4806386.
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HIGH AND LOW THRESHOLD FOR STARTLE REACTIVITY ASSOCIATED WITH PTSD SYMPTOMS BUT NOT PTSD RISK: EVIDENCE FROM A PROSPECTIVE STUDY OF ACTIVE DUTY MARINES. Depress Anxiety. 2016 Mar; 33(3):192-202. Glenn DE, Acheson DT, Geyer MA, Nievergelt CM, Baker DG, Risbrough VB, MRS Team. PMID: 26878585.
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Wet or dry: translatable "water mazes" for mice and humans. J Clin Invest. 2016 Feb; 126(2):477-9. Higa KK, Young JW, Geyer MA. PMID: 26784538; PMCID: PMC4731183.
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Locomotor Profiling from Rodents to the Clinic and Back Again. Curr Top Behav Neurosci. 2016; 28:287-303. Young JW, Minassian A, Geyer MA. PMID: 27418071.
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Prospective Associations Between Traumatic Brain Injury and Postdeployment Tinnitus in Active-Duty Marines. J Head Trauma Rehabil. 2016 Jan-Feb; 31(1):30-9. Yurgil KA, Clifford RE, Risbrough VB, Geyer MA, Huang M, Barkauskas DA, Vasterling JJ, MRS Team, Baker DG. PMID: 25699623.
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Overexpression of Forebrain CRH During Early Life Increases Trauma Susceptibility in Adulthood. Neuropsychopharmacology. 2016 May; 41(6):1681-90. Toth M, Flandreau EI, Deslauriers J, Geyer MA, Mansuy IM, Merlo Pich E, Risbrough VB. PMID: 26538448; PMCID: PMC4832031.
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Lysergic Acid Diethylamide and Psilocybin Revisited. Biol Psychiatry. 2015 Oct 15; 78(8):516-8. Geyer MA. PMID: 26386624.
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Association of Predeployment Heart Rate Variability With Risk of Postdeployment Posttraumatic Stress Disorder in Active-Duty Marines. JAMA Psychiatry. 2015 Oct; 72(10):979-86. Minassian A, Maihofer AX, Baker DG, Nievergelt CM, Geyer MA, Risbrough VB, Marine Resiliency Study Team. PMID: 26353072.
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Investigating the underlying mechanisms of aberrant behaviors in bipolar disorder from patients to models: Rodent and human studies. Neurosci Biobehav Rev. 2015 Nov; 58:4-18. van Enkhuizen J, Geyer MA, Minassian A, Perry W, Henry BL, Young JW. PMID: 26297513; PMCID: PMC4684462.
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Modeling bipolar disorder in mice by increasing acetylcholine or dopamine: chronic lithium treats most, but not all features. Psychopharmacology (Berl). 2015 Sep; 232(18):3455-67. van Enkhuizen J, Milienne-Petiot M, Geyer MA, Young JW. PMID: 26141192; PMCID: PMC4537820.
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Restoration of Sp4 in Forebrain GABAergic Neurons Rescues Hypersensitivity to Ketamine in Sp4 Hypomorphic Mice. Int J Neuropsychopharmacol. 2015 Jun 02; 18(11):pyv063. Higa KK, Ji B, Buell MR, Risbrough VB, Powell SB, Young JW, Geyer MA, Zhou X. PMID: 26037489; PMCID: PMC4756721.
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Early Adolescent Emergence of Reversal Learning Impairments in Isolation-Reared Rats. Dev Neurosci. 2015; 37(3):253-62. Powell SB, Khan A, Young JW, Scott CN, Buell MR, Caldwell S, Tsan E, de Jong LA, Acheson DT, Lucero J, Geyer MA, Behrens MM. PMID: 26022788; PMCID: PMC4644772.
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GlyT-1 Inhibition Attenuates Attentional But Not Learning or Motivational Deficits of the Sp4 Hypomorphic Mouse Model Relevant to Psychiatric Disorders. Neuropsychopharmacology. 2015 Nov; 40(12):2715-26. Young JW, Kamenski ME, Higa KK, Light GA, Geyer MA, Zhou X. PMID: 25907107; PMCID: PMC4864647.
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Developing treatments for cognitive deficits in schizophrenia: the challenge of translation. J Psychopharmacol. 2015 Feb; 29(2):178-96. Young JW, Geyer MA. PMID: 25516372; PMCID: PMC4670265.
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Cell type-specific modifications of corticotropin-releasing factor (CRF) and its type 1 receptor (CRF1) on startle behavior and sensorimotor gating. Psychoneuroendocrinology. 2015 Mar; 53:16-28. Flandreau E, Risbrough V, Lu A, Ableitner M, Geyer MA, Holsboer F, Deussing JM. PMID: 25575243; PMCID: PMC4364548.
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Genomic predictors of combat stress vulnerability and resilience in U.S. Marines: A genome-wide association study across multiple ancestries implicates PRTFDC1 as a potential PTSD gene. Psychoneuroendocrinology. 2015 Jan; 51:459-71. Nievergelt CM, Maihofer AX, Mustapic M, Yurgil KA, Schork NJ, Miller MW, Logue MW, Geyer MA, Risbrough VB, O'Connor DT, Baker DG. PMID: 25456346.
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Conditioned fear and extinction learning performance and its association with psychiatric symptoms in active duty Marines. Psychoneuroendocrinology. 2015 Jan; 51:495-505. Acheson DT, Geyer MA, Baker DG, Nievergelt CM, Yurgil K, Risbrough VB, MRS-II Team. PMID: 25444643; PMCID: PMC4345165.
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The catecholaminergic-cholinergic balance hypothesis of bipolar disorder revisited. Eur J Pharmacol. 2015 Apr 15; 753:114-26. van Enkhuizen J, Janowsky DS, Olivier B, Minassian A, Perry W, Young JW, Geyer MA. PMID: 25107282; PMCID: PMC4318788.
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Reduced dopamine transporter functioning induces high-reward risk-preference consistent with bipolar disorder. Neuropsychopharmacology. 2014 Dec; 39(13):3112-22. van Enkhuizen J, Henry BL, Minassian A, Perry W, Milienne-Petiot M, Higa KK, Geyer MA, Young JW. PMID: 25005251; PMCID: PMC4229584.
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Inhibition of protein translation by the DISC1-Boymaw fusion gene from a Scottish family with major psychiatric disorders. Hum Mol Genet. 2014 Nov 01; 23(21):5683-705. Ji B, Higa KK, Kim M, Zhou L, Young JW, Geyer MA, Zhou X. PMID: 24908665; PMCID: PMC4189903.
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Influence of aripiprazole, risperidone, and amisulpride on sensory and sensorimotor gating in healthy 'low and high gating' humans and relation to psychometry. Neuropsychopharmacology. 2014 Sep; 39(10):2485-96. Csomor PA, Preller KH, Geyer MA, Studerus E, Huber T, Vollenweider FX. PMID: 24801767; PMCID: PMC4138738.
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Heart rate variability characteristics in a large group of active-duty marines and relationship to posttraumatic stress. Psychosom Med. 2014 May; 76(4):292-301. Minassian A, Geyer MA, Baker DG, Nievergelt CM, O'Connor DT, Risbrough VB, Marine Resiliency Study Team. PMID: 24804881; PMCID: PMC4062545.
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Altered exploration and sensorimotor gating of the chakragati mouse model of schizophrenia. Behav Neurosci. 2014 Aug; 128(4):460-7. Young JW, Ratty A, Dawe GS, Geyer MA. PMID: 24708299; PMCID: PMC4107138.
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Isolation rearing effects on probabilistic learning and cognitive flexibility in rats. Cogn Affect Behav Neurosci. 2014 Mar; 14(1):388-406. Amitai N, Young JW, Higa K, Sharp RF, Geyer MA, Powell SB. PMID: 23943516; PMCID: PMC3923850.
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Disentangling working memory processes during spatial span assessment: a modeling analysis of preferred eye movement strategies. J Clin Exp Neuropsychol. 2014; 36(2):186-204. Patt VM, Thomas ML, Minassian A, Geyer MA, Brown GG, Perry W. PMID: 24499103; PMCID: PMC3970432.
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Prepulse inhibition in HIV-1 gp120 transgenic mice after withdrawal from chronic methamphetamine. Behav Pharmacol. 2014 Feb; 25(1):12-22. Henry BL, Geyer MA, Buell MR, Perry W, Young JW, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 24281153; PMCID: PMC3926694.
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Psychophysiology in the study of psychological trauma: where are we now and where do we need to be? Curr Top Behav Neurosci. 2014; 21:157-83. Acheson DT, Geyer MA, Risbrough VB. PMID: 25158622.
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Sleep deprivation impairs performance in the 5-choice continuous performance test: similarities between humans and mice. Behav Brain Res. 2014 Mar 15; 261:40-8. van Enkhuizen J, Acheson D, Risbrough V, Drummond S, Geyer MA, Young JW. PMID: 24333377; PMCID: PMC3937379.
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Forebrain-specific CRF overproduction during development is sufficient to induce enduring anxiety and startle abnormalities in adult mice. Neuropsychopharmacology. 2014 May; 39(6):1409-19. Toth M, Gresack JE, Bangasser DA, Plona Z, Valentino RJ, Flandreau EI, Mansuy IM, Merlo-Pich E, Geyer MA, Risbrough VB. PMID: 24326400; PMCID: PMC3988544.
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Dopamine depletion attenuates some behavioral abnormalities in a hyperdopaminergic mouse model of bipolar disorder. J Affect Disord. 2014 Feb; 155:247-54. van Enkhuizen J, Geyer MA, Halberstadt AL, Zhuang X, Young JW. PMID: 24287168; PMCID: PMC3924859.
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Reverse translation of the rodent 5C-CPT reveals that the impaired attention of people with schizophrenia is similar to scopolamine-induced deficits in mice. Transl Psychiatry. 2013 Nov 12; 3:e324. Young JW, Geyer MA, Rissling AJ, Sharp RF, Eyler LT, Asgaard GL, Light GA. PMID: 24217494; PMCID: PMC3849961.
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The challenge of connecting the dots in the B.R.A.I.N. Neuron. 2013 Oct 16; 80(2):270-4. Devor A, Bandettini PA, Boas DA, Bower JM, Buxton RB, Cohen LB, Dale AM, Einevoll GT, Fox PT, Franceschini MA, Friston KJ, Fujimoto JG, Geyer MA, Greenberg JH, Halgren E, Hämäläinen MS, Helmchen F, Hyman BT, Jasanoff A, Jernigan TL, Judd LL, Kim SG, Kleinfeld D, Kopell NJ, Kutas M, Kwong KK, Larkum ME, Lo EH, Magistretti PJ, Mandeville JB, Masliah E, Mitra PP, Mobley WC, Moskowitz MA, Nimmerjahn A, Reynolds JH, Rosen BR, Salzberg BM, Schaffer CB, Silva GA, So PT, Spitzer NC, Tootell RB, Van Essen DC, Vanduffel W, Vinogradov SA, Wald LL, Wang LV, Weber B, Yodh AG. PMID: 24139032; PMCID: PMC3864648.
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Harnessing cognitive neuroscience to develop new treatments for improving cognition in schizophrenia: CNTRICS selected cognitive paradigms for animal models. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt B):2087-91. Moore H, Geyer MA, Carter CS, Barch DM. PMID: 24090823; PMCID: PMC3965347.
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Problems and solutions to filling the drying drug pipeline for psychiatric disorders: a report from the inaugural 2012 CINP Think Tank. Int J Neuropsychopharmacol. 2014 Jan; 17(1):137-48. Dean B, Moller HJ, Svensson TH, Geyer MA, Rujescu D, Scarr E, Millan MJ. PMID: 24063634.
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Effects of the hallucinogen 2,5-dimethoxy-4-iodophenethylamine (2C-I) and superpotent N-benzyl derivatives on the head twitch response. Neuropharmacology. 2014 Feb; 77:200-7. Halberstadt AL, Geyer MA. PMID: 24012658; PMCID: PMC3866097.
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Serotonergic hallucinogens as translational models relevant to schizophrenia. Int J Neuropsychopharmacol. 2013 Nov; 16(10):2165-80. Halberstadt AL, Geyer MA. PMID: 23942028; PMCID: PMC3928979.
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Animal models and measures of perceptual processing in schizophrenia. Neurosci Biobehav Rev. 2013 Nov; 37(9 Pt B):2092-8. Siegel SJ, Talpos JC, Geyer MA. PMID: 23867801; PMCID: PMC3849201.
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Evaluating the role of the alpha-7 nicotinic acetylcholine receptor in the pathophysiology and treatment of schizophrenia. Biochem Pharmacol. 2013 Oct 15; 86(8):1122-32. Young JW, Geyer MA. PMID: 23856289; PMCID: PMC3797190.
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Prolonged Ketamine Effects in Sp4 Hypomorphic Mice: Mimicking Phenotypes of Schizophrenia. PLoS One. 2013; 8(6):e66327. Ji B, Wang X, Pinto-Duarte A, Kim M, Caldwell S, Young JW, Behrens MM, Sejnowski TJ, Geyer MA, Zhou X. PMID: 23823008; PMCID: PMC3688895.
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Inhibitory deficits in euthymic bipolar disorder patients assessed in the human behavioral pattern monitor. J Affect Disord. 2013 Sep 25; 150(3):948-54. Henry BL, Minassian A, Patt VM, Hua J, Young JW, Geyer MA, Perry W. PMID: 23759280; PMCID: PMC3759601.
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Prepulse inhibition in HIV-associated neurocognitive disorders. J Int Neuropsychol Soc. 2013 Jul; 19(6):709-17. Minassian A, Henry BL, Woods SP, Vaida F, Grant I, Geyer MA, Perry W, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 23552464; PMCID: PMC3729041.
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The ameliorating effects of 5,7-dihydroxy-6-methoxy-2(4-phenoxyphenyl)-4H-chromene-4-one, an oroxylin A derivative, against memory impairment and sensorimotor gating deficit in mice. Arch Pharm Res. 2013 Jul; 36(7):854-63. Liu X, Hong SI, Park SJ, Dela Peña JB, Che H, Yoon SY, Kim DH, Kim JM, Cai M, Risbrough V, Geyer MA, Shin CY, Cheong JH, Park H, Lew JH, Ryu JH. PMID: 23543630.
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Characterization of the head-twitch response induced by hallucinogens in mice: detection of the behavior based on the dynamics of head movement. Psychopharmacology (Berl). 2013 Jun; 227(4):727-39. Halberstadt AL, Geyer MA. PMID: 23407781; PMCID: PMC3866102.
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Role of the 5-HT₂A receptor in the locomotor hyperactivity produced by phenylalkylamine hallucinogens in mice. Neuropharmacology. 2013 Jul; 70:218-27. Halberstadt AL, Powell SB, Geyer MA. PMID: 23376711; PMCID: PMC3934507.
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Nicotinic agonist-induced improvement of vigilance in mice in the 5-choice continuous performance test. Behav Brain Res. 2013 Mar 01; 240:119-33. Young JW, Meves JM, Geyer MA. PMID: 23201359; PMCID: PMC3538919.
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Chronic valproate attenuates some, but not all, facets of mania-like behaviour in mice. Int J Neuropsychopharmacol. 2013 Jun; 16(5):1021-31. van Enkhuizen J, Geyer MA, Kooistra K, Young JW. PMID: 23164454; PMCID: PMC3920978.
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Sensory and sensorimotor gating in adult attention-deficit/hyperactivity disorder (ADHD). Psychiatry Res. 2013 Jan 30; 205(1-2):117-26. Holstein DH, Vollenweider FX, Geyer MA, Csomor PA, Belser N, Eich D. PMID: 23017654.
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Differential effects of dopamine transporter inhibitors in the rodent Iowa gambling task: relevance to mania. Psychopharmacology (Berl). 2013 Feb; 225(3):661-74. van Enkhuizen J, Geyer MA, Young JW. PMID: 22945515; PMCID: PMC3537839.
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Behavioral effects of chronic methamphetamine treatment in HIV-1 gp120 transgenic mice. Behav Brain Res. 2013 Jan 01; 236(1):210-220. Henry BL, Geyer MA, Buell M, Perry W, Young JW, Minassian A, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 22960458; PMCID: PMC3482284.
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From antipsychotic to anti-schizophrenia drugs: role of animal models. Trends Pharmacol Sci. 2012 Oct; 33(10):515-21. Geyer MA, Olivier B, Joëls M, Kahn RS. PMID: 22810174; PMCID: PMC3461097.
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Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophrenia. PLoS One. 2012; 7(7):e39434. Light GA, Swerdlow NR, Rissling AJ, Radant A, Sugar CA, Sprock J, Pela M, Geyer MA, Braff DL. PMID: 22802938; PMCID: PMC3389010.
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Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction. Mol Psychiatry. 2012 Sep; 17(9):887-905. Ayalew M, Le-Niculescu H, Levey DF, Jain N, Changala B, Patel SD, Winiger E, Breier A, Shekhar A, Amdur R, Koller D, Nurnberger JI, Corvin A, Geyer M, Tsuang MT, Salomon D, Schork NJ, Fanous AH, O'Donovan MC, Niculescu AB. PMID: 22584867; PMCID: PMC3427857.
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Predictors of risk and resilience for posttraumatic stress disorder among ground combat Marines: methods of the Marine Resiliency Study. Prev Chronic Dis. 2012; 9:E97. Baker DG, Nash WP, Litz BT, Geyer MA, Risbrough VB, Nievergelt CM, O'Connor DT, Larson GE, Schork NJ, Vasterling JJ, Hammer PS, Webb-Murphy JA, MRS Team. PMID: 22575082; PMCID: PMC3431952.
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Sensory and sensorimotor gating deficits after neonatal ventral hippocampal lesions in rats. Dev Neurosci. 2012; 34(2-3):240-9. Swerdlow NR, Light GA, Breier MR, Shoemaker JM, Saint Marie RL, Neary AC, Geyer MA, Stevens KE, Powell SB. PMID: 22572564.
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Four factors underlying mouse behavior in an open field. Behav Brain Res. 2012 Jul 15; 233(1):55-61. Tanaka S, Young JW, Halberstadt AL, Masten VL, Geyer MA. PMID: 22569582; PMCID: PMC3866095.
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Differences in the locomotor-activating effects of indirect serotonin agonists in habituated and non-habituated rats. Pharmacol Biochem Behav. 2012 Jul; 102(1):88-94. Halberstadt AL, Buell MR, Price DL, Geyer MA. PMID: 22487771; PMCID: PMC3354037.
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Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nat Rev Drug Discov. 2012 Feb 01; 11(2):141-68. Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, Connor R, Davis S, Deakin B, DeRubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Joëls M, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls E, Saletu B, Spedding M, Sweeney J, Whittington M, Young LJ. PMID: 22293568.
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Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor. Psychopharmacology (Berl). 2012 Jun; 221(4):709-18. Halberstadt AL, Nichols DE, Geyer MA. PMID: 22222861; PMCID: PMC3796951.
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Impaired sensorimotor gating in unmedicated adults with obsessive-compulsive disorder. Neuropsychopharmacology. 2012 Apr; 37(5):1216-23. Ahmari SE, Risbrough VB, Geyer MA, Simpson HB. PMID: 22218093; PMCID: PMC3306882.
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Behavioral animal models to assess pro-cognitive treatments for schizophrenia. Handb Exp Pharmacol. 2012; (213):39-79. Young JW, Amitai N, Geyer MA. PMID: 23027412.
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Genetic models of sensorimotor gating: relevance to neuropsychiatric disorders. Curr Top Behav Neurosci. 2012; 12:251-318. Powell SB, Weber M, Geyer MA. PMID: 22367921; PMCID: PMC3357439.
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Adenovirus infection in paediatric allogeneic stem cell transplantation recipients is a major independent factor for significantly increasing the risk of treatment related mortality. Br J Haematol. 2012 Jan; 156(1):99-108. George D, El-Mallawany NK, Jin Z, Geyer M, Della-Latta P, Satwani P, Garvin JH, Bradley MB, Bhatia M, van de Ven C, Morris E, Schwartz J, Cairo MS. PMID: 22008222.
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Advancing drug discovery for schizophrenia. Ann N Y Acad Sci. 2011 Oct; 1236:30-43. Marder SR, Roth B, Sullivan PF, Scolnick EM, Nestler EJ, Geyer MA, Welnberger DR, Karayiorgou M, Guidotti A, Gingrich J, Akbarian S, Buchanan RW, Lieberman JA, Conn PJ, Haggarty SJ, Law AJ, Campbell B, Krystal JH, Moghaddam B, Sawa A, Saw A, Caron MG, George SR, Allen JA, Solis M. PMID: 22032400; PMCID: PMC3787879.
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Predictive animal models of mania: hits, misses and future directions. Br J Pharmacol. 2011 Oct; 164(4):1263-84. Young JW, Henry BL, Geyer MA. PMID: 21410454; PMCID: PMC3229761.
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Psilocybin-induced deficits in automatic and controlled inhibition are attenuated by ketanserin in healthy human volunteers. Neuropsychopharmacology. 2012 Feb; 37(3):630-40. Quednow BB, Kometer M, Geyer MA, Vollenweider FX. PMID: 21956447; PMCID: PMC3260978.
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The effects of sertindole on sensory gating, sensorimotor gating, and cognition in healthy volunteers. J Psychopharmacol. 2011 Dec; 25(12):1600-13. Holstein DH, Csomor PA, Geyer MA, Huber T, Brugger N, Studerus E, Vollenweider FX. PMID: 21890590.
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Perceptual measurement in schizophrenia: promising electrophysiology and neuroimaging paradigms from CNTRICS. Schizophr Bull. 2012 Jan; 38(1):81-91. Butler PD, Chen Y, Ford JM, Geyer MA, Silverstein SM, Green MF. PMID: 21890745; PMCID: PMC3245585.
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Repeated assessment of exploration and novelty seeking in the human behavioral pattern monitor in bipolar disorder patients and healthy individuals. PLoS One. 2011; 6(8):e24185. Minassian A, Henry BL, Young JW, Masten V, Geyer MA, Perry W. PMID: 21912623; PMCID: PMC3166173.
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Factor analysis of attentional set-shifting performance in young and aged mice. Behav Brain Funct. 2011 Aug 12; 7:33. Tanaka S, Young JW, Gresack JE, Geyer MA, Risbrough VB. PMID: 21838910; PMCID: PMC3174878.
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The melanin-concentrating hormone (MCH) system modulates behaviors associated with psychiatric disorders. PLoS One. 2011; 6(7):e19286. Chung S, Verheij MM, Hesseling P, van Vugt RW, Buell M, Belluzzi JD, Geyer MA, Martens GJ, Civelli O. PMID: 21818251; PMCID: PMC3139593.
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Delayed procedural learning in α7-nicotinic acetylcholine receptor knockout mice. Genes Brain Behav. 2011 Oct; 10(7):720-33. Young JW, Meves JM, Tarantino IS, Caldwell S, Geyer MA. PMID: 21679297; PMCID: PMC3918170.
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Mouse pharmacological models of cognitive disruption relevant to schizophrenia. Neuropharmacology. 2012 Mar; 62(3):1381-90. Young JW, Powell SB, Geyer MA. PMID: 21726569; PMCID: PMC3217063.
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Convergent functional genomics of anxiety disorders: translational identification of genes, biomarkers, pathways and mechanisms. Transl Psychiatry. 2011 May 24; 1:e9. Le-Niculescu H, Balaraman Y, Patel SD, Ayalew M, Gupta J, Kuczenski R, Shekhar A, Schork N, Geyer MA, Niculescu AB. PMID: 22832404; PMCID: PMC3309477.
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Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia II: developing imaging biomarkers to enhance treatment development for schizophrenia and related disorders. Biol Psychiatry. 2011 Jul 01; 70(1):7-12. Carter CS, Barch DM, Bullmore E, Breiling J, Buchanan RW, Butler P, Cohen JD, Geyer M, Gollub R, Green MF, Jaeger J, Krystal JH, Moore H, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T. PMID: 21529781; PMCID: PMC3116022.
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Convergent functional genomic studies of ω-3 fatty acids in stress reactivity, bipolar disorder and alcoholism. Transl Psychiatry. 2011 Apr 26; 1:e4. Le-Niculescu H, Case NJ, Hulvershorn L, Patel SD, Bowker D, Gupta J, Bell R, Edenberg HJ, Tsuang MT, Kuczenski R, Geyer MA, Rodd ZA, Niculescu AB. PMID: 22832392; PMCID: PMC3309466.
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The effect of reduced dopamine D4 receptor expression in the 5-choice continuous performance task: Separating response inhibition from premature responding. Behav Brain Res. 2011 Sep 12; 222(1):183-92. Young JW, Powell SB, Scott CN, Zhou X, Geyer MA. PMID: 21458500; PMCID: PMC3531561.
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Increased risk-taking behavior in dopamine transporter knockdown mice: further support for a mouse model of mania. J Psychopharmacol. 2011 Jul; 25(7):934-43. Young JW, van Enkhuizen J, Winstanley CA, Geyer MA. PMID: 21421642; PMCID: PMC3568506.
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Dopamine receptor mediation of the exploratory/hyperactivity effects of modafinil. Neuropsychopharmacology. 2011 Jun; 36(7):1385-96. Young JW, Kooistra K, Geyer MA. PMID: 21412225; PMCID: PMC3096808.
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Differences in drug consumption, comorbidity and health service use of opioid addicts across six European urban regions (TREAT-project). Eur Psychiatry. 2012 Aug; 27(6):455-62. Reissner V, Kokkevi A, Schifano F, Room R, Storbjörk J, Stohler R, DiFuria L, Rehm J, Geyer M, Hölscher F, Scherbaum N. PMID: 21277750.
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Effect of methamphetamine dependence on inhibitory deficits in a novel human open-field paradigm. Psychopharmacology (Berl). 2011 Jun; 215(4):697-707. Henry BL, Minassian A, van Rhenen M, Young JW, Geyer MA, Perry W, Translational Methamphetamine AIDS Research Center (TMARC) Group. PMID: 21279333; PMCID: PMC3102201.
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Multiple receptors contribute to the behavioral effects of indoleamine hallucinogens. Neuropharmacology. 2011 Sep; 61(3):364-81. Halberstadt AL, Geyer MA. PMID: 21256140; PMCID: PMC3110631.
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Working memory span capacity improved by a D2 but not D1 receptor family agonist. Behav Brain Res. 2011 Jun 01; 219(2):181-8. Tarantino IS, Sharp RF, Geyer MA, Meves JM, Young JW. PMID: 21232557; PMCID: PMC3073724.
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Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. Psychopharmacology (Berl). 2011 May; 215(1):81-92. Halberstadt AL, Lehmann-Masten VD, Geyer MA, Powell SB. PMID: 21153406; PMCID: PMC3072483.
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Differential contributions of serotonin receptors to the behavioral effects of indoleamine hallucinogens in mice. J Psychopharmacol. 2011 Nov; 25(11):1548-61. Halberstadt AL, Koedood L, Powell SB, Geyer MA. PMID: 21148021; PMCID: PMC3531560.
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Initial evidence linking synaptic superoxide production with poor short-term memory in aged mice. Brain Res. 2011 Jan 12; 1368:65-70. Ali SS, Young JW, Wallace CK, Gresack J, Jeste DV, Geyer MA, Dugan LL, Risbrough VB. PMID: 21075081; PMCID: PMC3018762.
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Somatostatin-28 modulates prepulse inhibition of the acoustic startle response, reward processes and spontaneous locomotor activity in rats. Neuropeptides. 2010 Oct; 44(5):421-9. Semenova S, Hoyer D, Geyer MA, Markou A. PMID: 20537385; PMCID: PMC3215674.
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5-HT₁A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups. Int J Eat Disord. 2011 Sep; 44(6):477-87. Bailer UF, Bloss CS, Frank GK, Price JC, Meltzer CC, Mathis CA, Geyer MA, Wagner A, Becker CR, Schork NJ, Kaye WH. PMID: 20872754; PMCID: PMC4286242.
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Studies in genetically modified mice suggest novel mechanisms of mood regulation. Biol Psychiatry. 2010 Sep 15; 68(6):500-2. Markou A, Geyer MA. PMID: 20797461; PMCID: PMC2929529.
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Reduced NMDAR1 expression in the Sp4 hypomorphic mouse may contribute to endophenotypes of human psychiatric disorders. Hum Mol Genet. 2010 Oct 01; 19(19):3797-805. Zhou X, Nie Z, Roberts A, Zhang D, Sebat J, Malhotra D, Kelsoe JR, Geyer MA. PMID: 20634195; PMCID: PMC2935857.
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Quantifying over-activity in bipolar and schizophrenia patients in a human open field paradigm. Psychiatry Res. 2010 Jun 30; 178(1):84-91. Perry W, Minassian A, Henry B, Kincaid M, Young JW, Geyer MA. PMID: 20471103; PMCID: PMC2914139.
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CRF2 null mutation increases sensitivity to isolation rearing effects on locomotor activity in mice. Neuropeptides. 2010 Aug; 44(4):349-53. Gresack J, Powell S, Geyer M, Poore MS, Coste S, Risbrough V. PMID: 20466421; PMCID: PMC2888500.
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The mouse attentional-set-shifting task: a method for assaying successful cognitive aging? Cogn Affect Behav Neurosci. 2010 May; 10(2):243-51. Young JW, Powell SB, Geyer MA, Jeste DV, Risbrough VB. PMID: 20498348; PMCID: PMC2877277.
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Cross-species assessments of motor and exploratory behavior related to bipolar disorder. Neurosci Biobehav Rev. 2010 Jul; 34(8):1296-306. Henry BL, Minassian A, Young JW, Paulus MP, Geyer MA, Perry W. PMID: 20398694; PMCID: PMC2900445.
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The mania-like exploratory profile in genetic dopamine transporter mouse models is diminished in a familiar environment and reinstated by subthreshold psychostimulant administration. Pharmacol Biochem Behav. 2010 Jul; 96(1):7-15. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. PMID: 20363246; PMCID: PMC2878916.
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Insoluble DISC1-Boymaw fusion proteins generated by DISC1 translocation. Mol Psychiatry. 2010 Jul; 15(7):669-72. Zhou X, Chen Q, Schaukowitch K, Kelsoe JR, Geyer MA. PMID: 20351725; PMCID: PMC2891102.
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The effects of pramipexole on prepulse inhibition and locomotor activity in C57BL/6J mice. Behav Pharmacol. 2010 Mar; 21(2):135-43. Chang WL, Geyer MA, Buell MR, Weber M, Swerdlow NR. PMID: 20215963; PMCID: PMC2890261.
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Action of modafinil--increased motivation via the dopamine transporter inhibition and D1 receptors? Biol Psychiatry. 2010 Apr 15; 67(8):784-7. Young JW, Geyer MA. PMID: 20132929; PMCID: PMC2849918.
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Age-associated improvements in cross-modal prepulse inhibition in mice. Behav Neurosci. 2010 Feb; 124(1):133-140. Young JW, Wallace CK, Geyer MA, Risbrough VB. PMID: 20141288; PMCID: PMC3088993.
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Isolation rearing-induced deficits in contextual fear learning do not require CRF(2) receptors. Behav Brain Res. 2010 May 01; 209(1):80-4. Gresack JE, Risbrough VB, Scott CN, Coste S, Stenzel-Poore M, Geyer MA, Powell SB. PMID: 20097235; PMCID: PMC2832092.
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GBR 12909 administration as a mouse model of bipolar disorder mania: mimicking quantitative assessment of manic behavior. Psychopharmacology (Berl). 2010 Feb; 208(3):443-54. Young JW, Goey AK, Minassian A, Perry W, Paulus MP, Geyer MA. PMID: 20020109; PMCID: PMC2806531.
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Sustained attention and planning deficits but intact attentional set-shifting in neuroleptic-naïve first-episode schizophrenia patients. Neuropsychobiology. 2010; 61(2):79-86. Hilti CC, Delko T, Orosz AT, Thomann K, Ludewig S, Geyer MA, Vollenweider FX, Feldon J, Cattapan-Ludewig K. PMID: 20016226; PMCID: PMC2837882.
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LSD but not lisuride disrupts prepulse inhibition in rats by activating the 5-HT(2A) receptor. Psychopharmacology (Berl). 2010 Feb; 208(2):179-89. Halberstadt AL, Geyer MA. PMID: 19937319; PMCID: PMC2797624.
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Identification of blood biomarkers for psychosis using convergent functional genomics. Mol Psychiatry. 2011 Jan; 16(1):37-58. Kurian SM, Le-Niculescu H, Patel SD, Bertram D, Davis J, Dike C, Yehyawi N, Lysaker P, Dustin J, Caligiuri M, Lohr J, Lahiri DK, Nurnberger JI, Faraone SV, Geyer MA, Tsuang MT, Schork NJ, Salomon DR, Niculescu AB. PMID: 19935739.
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A reverse-translational study of dysfunctional exploration in psychiatric disorders: from mice to men. Arch Gen Psychiatry. 2009 Oct; 66(10):1072-80. Perry W, Minassian A, Paulus MP, Young JW, Kincaid MJ, Ferguson EJ, Henry BL, Zhuang X, Masten VL, Sharp RF, Geyer MA. PMID: 19805697; PMCID: PMC2897252.
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Heart rate variability in bipolar mania and schizophrenia. J Psychiatr Res. 2010 Feb; 44(3):168-76. Henry BL, Minassian A, Paulus MP, Geyer MA, Perry W. PMID: 19700172; PMCID: PMC2822123.
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Over-expression of a human chromosome 22q11.2 segment including TXNRD2, COMT and ARVCF developmentally affects incentive learning and working memory in mice. Hum Mol Genet. 2009 Oct 15; 18(20):3914-25. Suzuki G, Harper KM, Hiramoto T, Funke B, Lee M, Kang G, Buell M, Geyer MA, Kucherlapati R, Morrow B, Männistö PT, Agatsuma S, Hiroi N. PMID: 19617637; PMCID: PMC2748897.
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A Kappa Opioid Model of Atypical Altered Consciousness and Psychosis: U50488, DOI, AC90179 Effects on Prepulse Inhibition and Locomotion in Mice. J Young Investig. 2009 Jul 01; 19(13):1-7. Ruderman MA, Powell SB, Geyer MA. PMID: 25346645; PMCID: PMC4208663.
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5-HT1A receptor activation is necessary for 5-MeODMT-dependent potentiation of feeding inhibition. Pharmacol Biochem Behav. 2009 Sep; 93(3):349-53. Duvvuri V, Risbrough VB, Kaye WH, Geyer MA. PMID: 19490926; PMCID: PMC2724836.
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Asenapine effects in animal models of psychosis and cognitive function. Psychopharmacology (Berl). 2009 Nov; 206(4):699-714. Marston HM, Young JW, Martin FD, Serpa KA, Moore CL, Wong EH, Gold L, Meltzer LT, Azar MR, Geyer MA, Shahid M. PMID: 19462162; PMCID: PMC2755103.
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Prepulse inhibition and genetic mouse models of schizophrenia. Behav Brain Res. 2009 Dec 07; 204(2):282-94. Powell SB, Zhou X, Geyer MA. PMID: 19397931; PMCID: PMC2735602.
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Transcription factor SP4 is a susceptibility gene for bipolar disorder. PLoS One. 2009; 4(4):e5196. Zhou X, Tang W, Greenwood TA, Guo S, He L, Geyer MA, Kelsoe JR. PMID: 19401786; PMCID: PMC2674320.
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5-HT(2A) and 5-HT(2C) receptors exert opposing effects on locomotor activity in mice. Neuropsychopharmacology. 2009 Jul; 34(8):1958-67. Halberstadt AL, van der Heijden I, Ruderman MA, Risbrough VB, Gingrich JA, Geyer MA, Powell SB. PMID: 19322172; PMCID: PMC2697271.
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Using the MATRICS to guide development of a preclinical cognitive test battery for research in schizophrenia. Pharmacol Ther. 2009 May; 122(2):150-202. Young JW, Powell SB, Risbrough V, Marston HM, Geyer MA. PMID: 19269307; PMCID: PMC2688712.
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Sept5 deficiency exerts pleiotropic influence on affective behaviors and cognitive functions in mice. Hum Mol Genet. 2009 May 01; 18(9):1652-60. Suzuki G, Harper KM, Hiramoto T, Sawamura T, Lee M, Kang G, Tanigaki K, Buell M, Geyer MA, Trimble WS, Agatsuma S, Hiroi N. PMID: 19240081; PMCID: PMC2733818.
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The 5-choice continuous performance test: evidence for a translational test of vigilance for mice. PLoS One. 2009; 4(1):e4227. Young JW, Light GA, Marston HM, Sharp R, Geyer MA. PMID: 19156216; PMCID: PMC2626630.
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Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting. Schizophr Bull. 2009 Jan; 35(1):109-14. Barch DM, Carter CS, Arnsten A, Buchanan RW, Cohen JD, Geyer M, Green MF, Krystal JH, Nuechterlein K, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. PMID: 19023126; PMCID: PMC2643950.
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Perception measurement in clinical trials of schizophrenia: promising paradigms from CNTRICS. Schizophr Bull. 2009 Jan; 35(1):163-81. Green MF, Butler PD, Chen Y, Geyer MA, Silverstein S, Wynn JK, Yoon JH, Zemon V. PMID: 19023123; PMCID: PMC2635893.
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CRF1 and CRF2 receptors are required for potentiated startle to contextual but not discrete cues. Neuropsychopharmacology. 2009 May; 34(6):1494-503. Risbrough VB, Geyer MA, Hauger RL, Coste S, Stenzel-Poore M, Wurst W, Holsboer F. PMID: 19020499; PMCID: PMC2900918.
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Chronic reductions in serotonin transporter function prevent 5-HT1B-induced behavioral effects in mice. Biol Psychiatry. 2009 Mar 01; 65(5):401-8. Shanahan NA, Holick Pierz KA, Masten VL, Waeber C, Ansorge M, Gingrich JA, Geyer MA, Hen R, Dulawa SC. PMID: 19013555; PMCID: PMC2674010.
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Habituation revisited: an updated and revised description of the behavioral characteristics of habituation. Neurobiol Learn Mem. 2009 Sep; 92(2):135-8. Rankin CH, Abrams T, Barry RJ, Bhatnagar S, Clayton DF, Colombo J, Coppola G, Geyer MA, Glanzman DL, Marsland S, McSweeney FK, Wilson DA, Wu CF, Thompson RF. PMID: 18854219; PMCID: PMC2754195.
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Removing obstacles in neuroscience drug discovery: the future path for animal models. Neuropsychopharmacology. 2009 Jan; 34(1):74-89. Markou A, Chiamulera C, Geyer MA, Tricklebank M, Steckler T. PMID: 18830240; PMCID: PMC2651739.
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Effect of yacon (Smallanthus sonchifolius) on colonic transit time in healthy volunteers. Digestion. 2008; 78(1):30-3. Geyer M, Manrique I, Degen L, Beglinger C. PMID: 18781073.
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Serotonin research: contributions to understanding psychoses. Trends Pharmacol Sci. 2008 Sep; 29(9):445-53. Geyer MA, Vollenweider FX. PMID: 19086254.
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Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. Behav Pharmacol. 2008 Sep; 19(5-6):562-5. Powell SB, Young JW, Ong JC, Caron MG, Geyer MA. PMID: 18690110; PMCID: PMC2693185.
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Developing translational animal models for symptoms of schizophrenia or bipolar mania. Neurotox Res. 2008 Aug; 14(1):71-8. Geyer MA. PMID: 18790726; PMCID: PMC2667110.
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Habituation and sensitization of acoustic startle: opposite influences of dopamine D1 and D2-family receptors. Neurobiol Learn Mem. 2009 Sep; 92(2):243-8. Halberstadt AL, Geyer MA. PMID: 18644244; PMCID: PMC2745310.
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Modification of the effects of 5-methoxy-N,N-dimethyltryptamine on exploratory behavior in rats by monoamine oxidase inhibitors. Psychopharmacology (Berl). 2008 Nov; 201(1):55-66. Halberstadt AL, Buell MR, Masten VL, Risbrough VB, Geyer MA. PMID: 18604652; PMCID: PMC2929165.
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Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative. Biol Psychiatry. 2008 Jul 01; 64(1):4-10. Carter CS, Barch DM, Buchanan RW, Bullmore E, Krystal JH, Cohen J, Geyer M, Green M, Nuechterlein KH, Robbins T, Silverstein S, Smith EE, Strauss M, Wykes T, Heinssen R. PMID: 18466880; PMCID: PMC2577821.
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Does disrupted-in-schizophrenia (DISC1) generate fusion transcripts? Mol Psychiatry. 2008 Apr; 13(4):361-3. Zhou X, Geyer MA, Kelsoe JR. PMID: 18347596; PMCID: PMC2771200.
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Phenomic, convergent functional genomic, and biomarker studies in a stress-reactive genetic animal model of bipolar disorder and co-morbid alcoholism. Am J Med Genet B Neuropsychiatr Genet. 2008 Mar 05; 147B(2):134-66. Le-Niculescu H, McFarland MJ, Ogden CA, Balaraman Y, Patel S, Tan J, Rodd ZA, Paulus M, Geyer MA, Edenberg HJ, Glatt SJ, Faraone SV, Nurnberger JI, Kuczenski R, Tsuang MT, Niculescu AB. PMID: 18247375.
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Prepulse inhibition and "psychosis-proneness" in healthy individuals: an fMRI study. Eur Psychiatry. 2008 Jun; 23(4):274-80. Kumari V, Antonova E, Geyer MA. PMID: 18222069.
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Cortical grey matter volume and sensorimotor gating in schizophrenia. Cortex. 2008 Oct; 44(9):1206-14. Kumari V, Fannon D, Geyer MA, Premkumar P, Antonova E, Simmons A, Kuipers E. PMID: 18761134; PMCID: PMC2845812.
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Contributions of dopamine D1, D2, and D3 receptor subtypes to the disruptive effects of cocaine on prepulse inhibition in mice. Neuropsychopharmacology. 2008 Oct; 33(11):2648-56. Doherty JM, Masten VL, Powell SB, Ralph RJ, Klamer D, Low MJ, Geyer MA. PMID: 18075489.
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Spontaneous nicotine withdrawal potentiates the effects of stress in rats. Neuropsychopharmacology. 2008 Aug; 33(9):2131-8. Jonkman S, Risbrough VB, Geyer MA, Markou A. PMID: 18033237; PMCID: PMC2648847.
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Patients with premenstrual dysphoric disorder have increased startle response across both cycle phases and lower levels of prepulse inhibition during the late luteal phase of the menstrual cycle. Neuropsychopharmacology. 2008 Aug; 33(9):2283-90. Kask K, Gulinello M, Bäckström T, Geyer MA, Sundström-Poromaa I. PMID: 17940552.
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IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007 Sep 27; 449(7161):478-82. Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, Gumaste S, Geyer M, Zarrin AA, Manis JP, Rajewsky K, Alt FW. PMID: 17713479.
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Wayne Fenton's impact on academic neuroscience. Schizophr Bull. 2007 Sep; 33(5):1156-9. Geyer MA, Tamminga CA. PMID: 17617663; PMCID: PMC2632348.
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A reverse-translational approach to bipolar disorder: rodent and human studies in the Behavioral Pattern Monitor. Neurosci Biobehav Rev. 2007; 31(6):882-96. Young JW, Minassian A, Paulus MP, Geyer MA, Perry W. PMID: 17706782; PMCID: PMC2025688.
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Inactivation of the 5-HT(7) receptor partially blocks phencyclidine-induced disruption of prepulse inhibition. Biol Psychiatry. 2008 Jan 01; 63(1):98-105. Semenova S, Geyer MA, Sutcliffe JG, Markou A, Hedlund PB. PMID: 17531208; PMCID: PMC2174622.
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Prepulse inhibition of the startle reflex and its attentional modulation in the human S-ketamine and N,N-dimethyltryptamine (DMT) models of psychosis. J Psychopharmacol. 2007 May; 21(3):312-20. Heekeren K, Neukirch A, Daumann J, Stoll M, Obradovic M, Kovar KA, Geyer MA, Gouzoulis-Mayfrank E. PMID: 17591658.
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Haloperidol differentially modulates prepulse inhibition and p50 suppression in healthy humans stratified for low and high gating levels. Neuropsychopharmacology. 2008 Feb; 33(3):497-512. Csomor PA, Stadler RR, Feldon J, Yee BK, Geyer MA, Vollenweider FX. PMID: 17460616.
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Overview of animal models of schizophrenia. Curr Protoc Neurosci. 2007 Apr; Chapter 9:Unit 9.24. Powell SB, Geyer MA. PMID: 18428667.
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Towards understanding the schizophrenia code: an expanded convergent functional genomics approach. Am J Med Genet B Neuropsychiatr Genet. 2007 Mar 05; 144B(2):129-58. Le-Niculescu H, Balaraman Y, Patel S, Tan J, Sidhu K, Jerome RE, Edenberg HJ, Kuczenski R, Geyer MA, Nurnberger JI, Faraone SV, Tsuang MT, Niculescu AB. PMID: 17266109.
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The indirect serotonergic agonist d-fenfluramine and prepulse inhibition in healthy men. Neuropharmacology. 2007 Mar; 52(4):1088-94. Abel KM, Allin M, van Amelsvoort T, Hemsley D, Geyer MA. PMID: 17306313.
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Deficits in parvalbumin and calbindin immunoreactive cells in the hippocampus of isolation reared rats. J Neural Transm (Vienna). 2007 Jul; 114(7):893-8. Harte MK, Powell SB, Swerdlow NR, Geyer MA, Reynolds GP. PMID: 17594127.
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The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval. Neuropsychopharmacology. 2007 Sep; 32(9):1876-87. Vollenweider FX, Csomor PA, Knappe B, Geyer MA, Quednow BB. PMID: 17299516.
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Role of dopamine D1 and D2 receptors in CRF-induced disruption of sensorimotor gating. Pharmacol Biochem Behav. 2007 Mar; 86(3):550-8. Vinkers CH, Risbrough VB, Geyer MA, Caldwell S, Low MJ, Hauger RL. PMID: 17324452; PMCID: PMC1892615.
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The family of sensorimotor gating disorders: comorbidities or diagnostic overlaps? Neurotox Res. 2006 Dec; 10(3-4):211-20. Geyer MA. PMID: 17197371; PMCID: PMC2667105.
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Primary mouse hepatocytes for systems biology approaches: a standardized in vitro system for modelling of signal transduction pathways. Syst Biol (Stevenage). 2006 Nov; 153(6):433-47. Klingmüller U, Bauer A, Bohl S, Nickel PJ, Breitkopf K, Dooley S, Zellmer S, Kern C, Merfort I, Sparna T, Donauer J, Walz G, Geyer M, Kreutz C, Hermes M, Götschel F, Hecht A, Walter D, Egger L, Neubert K, Borner C, Brulport M, Schormann W, Sauer C, Baumann F, Preiss R, MacNelly S, Godoy P, Wiercinska E, Ciuclan L, Edelmann J, Zeilinger K, Heinrich M, Zanger UM, Gebhardt R, Maiwald T, Heinrich R, Timmer J, von Weizsäcker F, Hengstler JG. PMID: 17186705.
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The roles of 5-HT1A and 5-HT2 receptors in the effects of 5-MeO-DMT on locomotor activity and prepulse inhibition in rats. Psychopharmacology (Berl). 2006 Dec; 189(3):319-29. Krebs-Thomson K, Ruiz EM, Masten V, Buell M, Geyer MA. PMID: 17013638.
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The neural correlates of habituation of response to startling tactile stimuli presented in a functional magnetic resonance imaging environment. Psychiatry Res. 2006 Nov 22; 148(1):1-10. McDowell JE, Brown GG, Lazar N, Camchong J, Sharp R, Krebs-Thomson K, Eyler LT, Braff DL, Geyer MA. PMID: 17000088.
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A fMRI investigation of startle gating deficits in schizophrenia patients treated with typical or atypical antipsychotics. Int J Neuropsychopharmacol. 2007 Aug; 10(4):463-77. Kumari V, Antonova E, Geyer MA, Ffytche D, Williams SC, Sharma T. PMID: 16923324.
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Prepulse inhibition and P50 suppression: commonalities and dissociations. Psychiatry Res. 2006 Aug 30; 143(2-3):147-58. Oranje B, Geyer MA, Bocker KB, Leon Kenemans J, Verbaten MN. PMID: 16879870.
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Differential contributions of dopamine D1, D2, and D3 receptors to MDMA-induced effects on locomotor behavior patterns in mice. Neuropsychopharmacology. 2006 Nov; 31(11):2349-58. Risbrough VB, Masten VL, Caldwell S, Paulus MP, Low MJ, Geyer MA. PMID: 16855533.
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Iloperidone reduces sensorimotor gating deficits in pharmacological models, but not a developmental model, of disrupted prepulse inhibition in rats. Neuropharmacology. 2006 Sep; 51(3):457-65. Barr AM, Powell SB, Markou A, Geyer MA. PMID: 16762376.
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A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia. Biol Psychiatry. 2006 Aug 01; 60(3):253-64. Moore H, Jentsch JD, Ghajarnia M, Geyer MA, Grace AA. PMID: 16581031; PMCID: PMC3396156.
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Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in rats. Neuropsychopharmacology. 2006 Mar; 31(3):506-15. Swerdlow NR, Geyer MA, Shoemaker JM, Light GA, Braff DL, Stevens KE, Sharp R, Breier M, Neary A, Auerbach PP. PMID: 16123772; PMCID: PMC1373667.
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Pharmacological and behavioral profile of N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N'-(4-(2-methylpropyloxy)phenylmethyl) carbamide (2R,3R)-dihydroxybutanedioate (2:1) (ACP-103), a novel 5-hydroxytryptamine(2A) receptor inverse agonist. J Pharmacol Exp Ther. 2006 May; 317(2):910-8. Vanover KE, Weiner DM, Makhay M, Veinbergs I, Gardell LR, Lameh J, Del Tredici AL, Piu F, Schiffer HH, Ott TR, Burstein ES, Uldam AK, Thygesen MB, Schlienger N, Andersson CM, Son TY, Harvey SC, Powell SB, Geyer MA, Tolf BR, Brann MR, Davis RE. PMID: 16469866.
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A behavioural and functional neuroimaging investigation into the effects of nicotine on sensorimotor gating in healthy subjects and persons with schizophrenia. Psychopharmacology (Berl). 2006 Mar; 184(3-4):589-99. Postma P, Gray JA, Sharma T, Geyer M, Mehrotra R, Das M, Zachariah E, Hines M, Williams SC, Kumari V. PMID: 16456657.
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Isolation rearing of mice induces deficits in prepulse inhibition of the startle response. Behav Brain Res. 2006 Apr 25; 169(1):162-7. Varty GB, Powell SB, Lehmann-Masten V, Buell MR, Geyer MA. PMID: 16406103.
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Are cross-species measures of sensorimotor gating useful for the discovery of procognitive cotreatments for schizophrenia? Dialogues Clin Neurosci. 2006; 8(1):9-16. Geyer MA. PMID: 16640109; PMCID: PMC3181759.
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[The emotional sensitivity of elderly people--validation of the Profile of Mood States for people over 60 years]. Z Gerontol Geriatr. 2005 Dec; 38(6):431-40. Albani C, Gunzelmann T, Schmutzer G, Grulke N, Bailer H, Blaser G, Geyer M, Brähler E. PMID: 16362559.
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New approaches to measurement and treatment research to improve cognition in schizophrenia. Schizophr Bull. 2005 Oct; 31(4):806-9. Geyer MA, Heinssen R. PMID: 16166608.
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An investigation of the efficacy of mood stabilizers in rodent models of prepulse inhibition. J Pharmacol Exp Ther. 2005 Dec; 315(3):1163-71. Ong JC, Brody SA, Large CH, Geyer MA. PMID: 16123308.
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Developing predictive animal models and establishing a preclinical trials network for assessing treatment effects on cognition in schizophrenia. Schizophr Bull. 2005 Oct; 31(4):888-94. Floresco SB, Geyer MA, Gold LH, Grace AA. PMID: 16079387.
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The effects of sex and neonatal maternal separation on fear-potentiated and light-enhanced startle. Behav Brain Res. 2005 Jun 20; 161(2):190-6. de Jongh R, Geyer MA, Olivier B, Groenink L. PMID: 15878207.
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A developmental influence of the N-methyl-D-aspartate receptor NR3A subunit on prepulse inhibition of startle. Biol Psychiatry. 2005 May 15; 57(10):1147-52. Brody SA, Nakanishi N, Tu S, Lipton SA, Geyer MA. PMID: 15866554.
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Yohimbine disrupts prepulse inhibition in rats via action at 5-HT1A receptors, not alpha2-adrenoceptors. Psychopharmacology (Berl). 2005 Jul; 180(3):491-500. Powell SB, Palomo J, Carasso BS, Bakshi VP, Geyer MA. PMID: 15719216.
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Information-processing deficits and cognitive dysfunction in panic disorder. J Psychiatry Neurosci. 2005 Jan; 30(1):37-43. Ludewig S, Geyer MA, Ramseier M, Vollenweider FX, Rechsteiner E, Cattapan-Ludewig K. PMID: 15644996; PMCID: PMC543839.
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Anxiogenic treatments do not increase fear-potentiated startle in mice. Biol Psychiatry. 2005 Jan 01; 57(1):33-43. Risbrough VB, Geyer MA. PMID: 15607298.
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Prepulse inhibition of the acoustically evoked startle reflex in patients with an acute schizophrenic psychosis--a longitudinal study. Eur Arch Psychiatry Clin Neurosci. 2004 Dec; 254(6):415-21. Meincke U, Mörth D, Voss T, Thelen B, Geyer MA, Gouzoulis-Mayfrank E. PMID: 15538598.
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Reduced N-acetylaspartate in the temporal cortex of rats reared in isolation. Biol Psychiatry. 2004 Aug 15; 56(4):296-9. Harte MK, Powell SB, Reynolds LM, Swerdlow NR, Geyer MA, Reynolds GP. PMID: 15312819.
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Endogenous kynurenic acid disrupts prepulse inhibition. Biol Psychiatry. 2004 Aug 15; 56(4):255-60. Erhardt S, Schwieler L, Emanuelsson C, Geyer M. PMID: 15312813.
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Corticotropin-releasing factor receptors CRF1 and CRF2 exert both additive and opposing influences on defensive startle behavior. J Neurosci. 2004 Jul 21; 24(29):6545-52. Risbrough VB, Hauger RL, Roberts AL, Vale WW, Geyer MA. PMID: 15269266; PMCID: PMC6729883.
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The influence of schizotypy traits on prepulse inhibition in young healthy controls. J Psychopharmacol. 2004 Jun; 18(2):181-8. Abel KM, Jolley S, Hemsley DR, Geyer MA. PMID: 15260905.
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The selective serotonin-2A receptor antagonist M100907 reverses behavioral deficits in dopamine transporter knockout mice. Neuropsychopharmacology. 2004 Feb; 29(2):221-8. Barr AM, Lehmann-Masten V, Paulus M, Gainetdinov RR, Caron MG, Geyer MA. PMID: 14603268.
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Plasticity of the acoustic startle reflex in currently abstinent ecstasy (MDMA) users. Psychopharmacology (Berl). 2004 May; 173(3-4):418-24. Heekeren K, Daumann J, Geyer MA, Gouzoulis-Mayfrank E. PMID: 14722707.
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Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice. Neurotox Res. 2004; 6(1):79-90. Brody SA, Geyer MA. PMID: 15184109.
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Attentional modulation of prepulse inhibition: a new startle paradigm. Neuropsychobiology. 2004; 49(2):88-93. Heekeren K, Meincke U, Geyer MA, Gouzoulis-Mayfrank E. PMID: 14981340.
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Disruption of prepulse inhibition in mice lacking mGluR1. Eur J Neurosci. 2003 Dec; 18(12):3361-6. Brody SA, Conquet F, Geyer MA. PMID: 14686909.
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Effect of antipsychotic treatment on the prepulse inhibition deficit of mGluR5 knockout mice. Psychopharmacology (Berl). 2004 Mar; 172(2):187-95. Brody SA, Conquet F, Geyer MA. PMID: 14615875.
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Assessment of murine startle reactivity, prepulse inhibition, and habituation. Curr Protoc Neurosci. 2003 Nov; Chapter 8:Unit 8.17. Geyer MA, Dulawa SC. PMID: 18428584.
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Animal behavior models of the mechanisms underlying antipsychotic atypicality. Prog Neuropsychopharmacol Biol Psychiatry. 2003 Oct; 27(7):1071-9. Geyer MA, Ellenbroek B. PMID: 14642967.
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Reversal of startle gating deficits in transgenic mice overexpressing corticotropin-releasing factor by antipsychotic drugs. Neuropsychopharmacology. 2003 Oct; 28(10):1790-8. Dirks A, Groenink L, Westphal KG, Olivier JD, Verdouw PM, van der Gugten J, Geyer MA, Olivier B. PMID: 12865891.
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Cognition in schizophrenia: from basic science to clinical treatment. Psychopharmacology (Berl). 2003 Sep; 169(3-4):213-4. Harvey PD, Geyer MA, Robbins TW, Krystal JH. PMID: 12955286.
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[Somatoform complaints in elderly of Germany]. Z Gerontol Geriatr. 2003 Aug; 36(4):287-96. Hessel A, Geyer M, Gunzelmann T, Schumacher J, Brähler E. PMID: 12937934.
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Deficits in prepulse inhibition and habituation in never-medicated, first-episode schizophrenia. Biol Psychiatry. 2003 Jul 15; 54(2):121-8. Ludewig K, Geyer MA, Vollenweider FX. PMID: 12873801.
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Role of corticotropin releasing factor (CRF) receptors 1 and 2 in CRF-potentiated acoustic startle in mice. Psychopharmacology (Berl). 2003 Nov; 170(2):178-87. Risbrough VB, Hauger RL, Pelleymounter MA, Geyer MA. PMID: 12845406.
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The acoustic startle reflex and its modulation: effects of age and gender in humans. Biol Psychol. 2003 Jul; 63(3):311-23. Ludewig K, Ludewig S, Seitz A, Obrist M, Geyer MA, Vollenweider FX. PMID: 12853174.
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Low dose ketamine increases prepulse inhibition in healthy men. Neuropharmacology. 2003 May; 44(6):729-37. Abel KM, Allin MP, Hemsley DR, Geyer MA. PMID: 12681371.
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Lamotrigine prevents ketamine but not amphetamine-induced deficits in prepulse inhibition in mice. Psychopharmacology (Berl). 2003 Sep; 169(3-4):240-6. Brody SA, Geyer MA, Large CH. PMID: 12698229.
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The relationship of age to prepulse inhibition and habituation of the acoustic startle response. Biol Psychol. 2003 Mar; 62(3):175-95. Ellwanger J, Geyer MA, Braff DL. PMID: 12633977.
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Valproate attenuates hyperactive and perseverative behaviors in mutant mice with a dysregulated dopamine system. Biol Psychiatry. 2003 Feb 15; 53(4):352-9. Ralph-Williams RJ, Paulus MP, Zhuang X, Hen R, Geyer MA. PMID: 12586455.
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Neural correlates of tactile prepulse inhibition: a functional MRI study in normal and schizophrenic subjects. Psychiatry Res. 2003 Feb 15; 122(2):99-113. Kumari V, Gray JA, Geyer MA, ffytche D, Soni W, Mitterschiffthaler MT, Vythelingum GN, Simmons A, Williams SC, Sharma T. PMID: 12714174.
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Dopamine depletion of the nucleus accumbens reverses isolation-induced deficits in prepulse inhibition in rats. Neuroscience. 2003; 119(1):233-40. Powell SB, Geyer MA, Preece MA, Pitcher LK, Reynolds GP, Swerdlow NR. PMID: 12763084.
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Dopamine D1 rather than D2 receptor agonists disrupt prepulse inhibition of startle in mice. Neuropsychopharmacology. 2003 Jan; 28(1):108-18. Ralph-Williams RJ, Lehmann-Masten V, Geyer MA. PMID: 12496946.
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The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. Neuropharmacology. 2002 Dec; 43(8):1199-209. Henry SA, Lehmann-Masten V, Gasparini F, Geyer MA, Markou A. PMID: 12527469.
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Differential effects of direct and indirect dopamine agonists on prepulse inhibition: a study in D1 and D2 receptor knock-out mice. J Neurosci. 2002 Nov 01; 22(21):9604-11. Ralph-Williams RJ, Lehmann-Masten V, Otero-Corchon V, Low MJ, Geyer MA. PMID: 12417685; PMCID: PMC6758013.
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GABA-A and 5-HT1A receptor agonists block expression of fear-potentiated startle in mice. Neuropsychopharmacology. 2003 Apr; 28(4):654-63. Risbrough VB, Brodkin JD, Geyer MA. PMID: 12655310.
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Isolation rearing-induced deficits in prepulse inhibition and locomotor habituation are not potentiated by water deprivation. Physiol Behav. 2002 Sep; 77(1):55-64. Powell SB, Swerdlow NR, Pitcher LK, Geyer MA. PMID: 12213502.
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Prestimulus effects on startle magnitude: sensory or motor? Behav Neurosci. 2002 Aug; 116(4):672-81. Swerdlow NR, Shoemaker JM, Stephany N, Wasserman L, Ro HJ, Geyer MA. PMID: 12148934.
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Developmental markers of psychiatric disorders as identified by sensorimotor gating. Neurotox Res. 2002 Aug-Sep; 4(5-6):489-502. Powell SB, Geyer MA. PMID: 12754162.
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Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype? Am J Psychiatry. 2002 May; 159(5):869-71. Cadenhead KS, Light GA, Geyer MA, McDowell JE, Braff DL. PMID: 11986147.
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Stability of the acoustic startle reflex, prepulse inhibition, and habituation in schizophrenia. Schizophr Res. 2002 May 01; 55(1-2):129-37. Ludewig K, Geyer MA, Etzensberger M, Vollenweider FX. PMID: 11955972.
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Subthalamic 5-HT(1A) and 5-HT(1B) receptor modulation of RU 24969-induced behavioral profile in rats. Pharmacol Biochem Behav. 2002 Apr; 71(4):569-80. Martinez-Price DL, Geyer MA. PMID: 11888548.
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Acute psychological and neurophysiological effects of MDMA in humans. J Psychoactive Drugs. 2002 Apr-Jun; 34(2):171-84. Vollenweider FX, Liechti ME, Gamma A, Greer G, Geyer M. PMID: 12691207.
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Reduced startle reactivity and plasticity in transgenic mice overexpressing corticotropin-releasing hormone. Biol Psychiatry. 2002 Apr 01; 51(7):583-90. Dirks A, Groenink L, Schipholt MI, van der Gugten J, Hijzen TH, Geyer MA, Olivier B. PMID: 11950460.
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Dopamine agonist effects on startle and sensorimotor gating in normal male subjects: time course studies. Psychopharmacology (Berl). 2002 May; 161(2):189-201. Swerdlow NR, Eastvold A, Karban B, Ploum Y, Stephany N, Geyer MA, Cadenhead K, Auerbach PP. PMID: 11981599.
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"Typical" but not "atypical" antipsychotic effects on startle gating deficits in prepubertal rats. Psychopharmacology (Berl). 2002 Apr; 161(1):38-46. Martinez ZA, Platten A, Pollack E, Shoemaker J, Ro H, Pitcher L, Geyer MA, Swerdlow NR. PMID: 11967629.
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Prepulse inhibition deficits in patients with panic disorder. Depress Anxiety. 2002; 15(2):55-60. Ludewig S, Ludewig K, Geyer MA, Hell D, Vollenweider FX. PMID: 11891993.
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Mouse genetic models for prepulse inhibition: an early review. Mol Psychiatry. 2002; 7(10):1039-53. Geyer MA, McIlwain KL, Paylor R. PMID: 12476318.
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A systems model of altered consciousness: integrating natural and drug-induced psychoses. Brain Res Bull. 2001 Nov 15; 56(5):495-507. Vollenweider FX, Geyer MA. PMID: 11750795.
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Tactile prepuff inhibition of startle in children with Tourette's syndrome: in search of an "fMRI-friendly" startle paradigm. Biol Psychiatry. 2001 Oct 15; 50(8):578-85. Swerdlow NR, Karban B, Ploum Y, Sharp R, Geyer MA, Eastvold A. PMID: 11690592.
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5-hydroxytryptamine2A receptor inverse agonists as antipsychotics. J Pharmacol Exp Ther. 2001 Oct; 299(1):268-76. Weiner DM, Burstein ES, Nash N, Croston GE, Currier EA, Vanover KE, Harvey SC, Donohue E, Hansen HC, Andersson CM, Spalding TA, Gibson DF, Krebs-Thomson K, Powell SB, Geyer MA, Hacksell U, Brann MR. PMID: 11561089.
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Pharmacological studies of prepulse inhibition models of sensorimotor gating deficits in schizophrenia: a decade in review. Psychopharmacology (Berl). 2001 Jul; 156(2-3):117-54. Geyer MA, Krebs-Thomson K, Braff DL, Swerdlow NR. PMID: 11549216.
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Strain-specific effects of amphetamine on prepulse inhibition and patterns of locomotor behavior in mice. J Pharmacol Exp Ther. 2001 Jul; 298(1):148-55. Ralph RJ, Paulus MP, Geyer MA. PMID: 11408536.
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Neural circuit regulation of prepulse inhibition of startle in the rat: current knowledge and future challenges. Psychopharmacology (Berl). 2001 Jul; 156(2-3):194-215. Swerdlow NR, Geyer MA, Braff DL. PMID: 11549223.
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Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl). 2001 Jul; 156(2-3):234-58. Braff DL, Geyer MA, Swerdlow NR. PMID: 11549226.
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Measurement of startle response, prepulse inhibition, and habituation. Curr Protoc Neurosci. 2001 May; Chapter 8:Unit 8.7. Geyer MA, Swerdlow NR. PMID: 18428548.
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Post-weaning handling attenuates isolation-rearing induced disruptions of prepulse inhibition in rats. Behav Brain Res. 2001 May; 120(2):221-4. Krebs-Thomson K, Giracello D, Solis A, Geyer MA. PMID: 11182170.
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Impact of prepulse characteristics on the detection of sensorimotor gating deficits in schizophrenia. Schizophr Res. 2001 Apr 15; 49(1-2):171-8. Braff DL, Geyer MA, Light GA, Sprock J, Perry W, Cadenhead KS, Swerdlow NR. PMID: 11343875.
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Effects of MDMA (ecstasy) on prepulse inhibition and habituation of startle in humans after pretreatment with citalopram, haloperidol, or ketanserin. Neuropsychopharmacology. 2001 Mar; 24(3):240-52. Liechti ME, Geyer MA, Hell D, Vollenweider FX. PMID: 11166515.
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5-HT1B receptor knockout, but not 5-HT1A receptor knockout mice, show reduced startle reactivity and footshock-induced sensitization, as measured with the acoustic startle response. Behav Brain Res. 2001 Jan 29; 118(2):169-78. Dirks A, Pattij T, Bouwknecht JA, Westphal TT, Hijzen TH, Groenink L, van der Gugten J, Oosting RS, Hen R, Geyer MA, Olivier B. PMID: 11164514.
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Prepulse inhibition deficits and perseverative motor patterns in dopamine transporter knock-out mice: differential effects of D1 and D2 receptor antagonists. J Neurosci. 2001 Jan 01; 21(1):305-13. Ralph RJ, Paulus MP, Fumagalli F, Caron MG, Geyer MA. PMID: 11150348; PMCID: PMC6762423.
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Startle responses, heart rate, and temperature in 5-HT1B receptor knockout mice. Neuroreport. 2000 Dec 18; 11(18):4097-102. Bouwknecht JA, Hijzen TH, van der Gugten J, Dirks A, Maes RA, Hen R, Geyer MA, Olivier B. PMID: 11192635.
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Regulation of sensorimotor gating of the startle reflex by serotonin 2A receptors. Ontogeny and strain differences. Neuropsychopharmacology. 2000 Dec; 23(6):623-32. Farid M, Martinez ZA, Geyer MA, Swerdlow NR. PMID: 11063918.
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"Early" and "late" effects of sustained haloperidol on apomorphine- and phencyclidine-induced sensorimotor gating deficits. Neuropsychopharmacology. 2000 Nov; 23(5):517-27. Martinez ZA, Oostwegel J, Geyer MA, Ellison GD, Swerdlow NR. PMID: 11027917.
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Effects of strain and serotonergic agents on prepulse inhibition and habituation in mice. Neuropharmacology. 2000 Aug 23; 39(11):2170-9. Dulawa SC, Geyer MA. PMID: 10963760.
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Knockout mice reveal opposite roles for serotonin 1A and 1B receptors in prepulse inhibition. Neuropsychopharmacology. 2000 Jun; 22(6):650-9. Dulawa SC, Gross C, Stark KL, Hen R, Geyer MA. PMID: 10788764.
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Animal models of deficient sensorimotor gating: what we know, what we think we know, and what we hope to know soon. Behav Pharmacol. 2000 Jun; 11(3-4):185-204. Swerdlow NR, Braff DL, Geyer MA. PMID: 11103873.
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Toward understanding the biology of a complex phenotype: rat strain and substrain differences in the sensorimotor gating-disruptive effects of dopamine agonists. J Neurosci. 2000 Jun 01; 20(11):4325-36. Swerdlow NR, Martinez ZA, Hanlon FM, Platten A, Farid M, Auerbach P, Braff DL, Geyer MA. PMID: 10818168; PMCID: PMC6772622.
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Environmental enrichment and isolation rearing in the rat: effects on locomotor behavior and startle response plasticity. Biol Psychiatry. 2000 May 15; 47(10):864-73. Varty GB, Paulus MP, Braff DL, Geyer MA. PMID: 10807959.
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Normal P50 suppression in schizophrenia patients treated with atypical antipsychotic medications. Am J Psychiatry. 2000 May; 157(5):767-71. Light GA, Geyer MA, Clementz BA, Cadenhead KS, Braff DL. PMID: 10784470.
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Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice. Psychopharmacology (Berl). 2000 Apr; 149(3):306-12. Dulawa SC, Scearce-Levie KA, Hen R, Geyer MA. PMID: 10823412.
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Ontogeny of phencyclidine and apomorphine-induced startle gating deficits in rats. Pharmacol Biochem Behav. 2000 Mar; 65(3):449-57. Martinez ZA, Halim ND, Oostwegel JL, Geyer MA, Swerdlow NR. PMID: 10683485.
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Sensory gating deficits assessed by the P50 event-related potential in subjects with schizotypal personality disorder. Am J Psychiatry. 2000 Jan; 157(1):55-9. Cadenhead KS, Light GA, Geyer MA, Braff DL. PMID: 10618013.
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The genetic liability to stress and postweaning isolation have a competitive influence on behavioral organization in rats. Physiol Behav. 2000 Jan; 68(3):389-94. Paulus MP, Varty GB, Geyer MA. PMID: 10716550.
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Interactions between equine cyclin T1, Tat, and TAR are disrupted by a leucine-to-valine substitution found in human cyclin T1. J Virol. 2000 Jan; 74(2):892-8. Taube R, Fujinaga K, Irwin D, Wimmer J, Geyer M, Peterlin BM. PMID: 10623752; PMCID: PMC111610.
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Assessing prepulse inhibition of startle in wild-type and knockout mice. Psychopharmacology (Berl). 1999 Nov; 147(1):11-3. Geyer MA. PMID: 10591857.
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Dopamine D4 receptor-knock-out mice exhibit reduced exploration of novel stimuli. J Neurosci. 1999 Nov 01; 19(21):9550-6. Dulawa SC, Grandy DK, Low MJ, Paulus MP, Geyer MA. PMID: 10531457; PMCID: PMC6782928.
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Amphetamine disrupts P50 suppression in normal subjects. Biol Psychiatry. 1999 Oct 01; 46(7):990-6. Light GA, Malaspina D, Geyer MA, Luber BM, Coleman EA, Sackeim HA, Braff DL. PMID: 10509182.
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Sex differences in sensorimotor gating of the human startle reflex: all smoke? Psychopharmacology (Berl). 1999 Sep; 146(2):228-32. Swerdlow NR, Geyer MA, Hartman PL, Sprock J, Auerbach PP, Cadenhead K, Perry W, Braff DL. PMID: 10525760.
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Ontogeny of isolation rearing-induced deficits in sensorimotor gating in rats. Physiol Behav. 1999 Sep; 67(3):385-92. Bakshi VP, Geyer MA. PMID: 10497957.
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Effects of LU-111995 in three models of disrupted prepulse inhibition in rats. J Pharmacol Exp Ther. 1999 Aug; 290(2):716-24. Geyer MA, Swerdlow NR, Lehmann-Masten V, Teschendorf HJ, Traut M, Gross G. PMID: 10411583.
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Effects of sustained phencyclidine exposure on sensorimotor gating of startle in rats. Neuropsychopharmacology. 1999 Jul; 21(1):28-39. Martinez ZA, Ellison GD, Geyer MA, Swerdlow NR. PMID: 10379517.
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Cross-species studies of sensorimotor gating of the startle reflex. Ann N Y Acad Sci. 1999 Jun 29; 877:202-16. Swerdlow NR, Braff DL, Geyer MA. PMID: 10415651.
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The dopamine D2, but not D3 or D4, receptor subtype is essential for the disruption of prepulse inhibition produced by amphetamine in mice. J Neurosci. 1999 Jun 01; 19(11):4627-33. Ralph RJ, Varty GB, Kelly MA, Wang YM, Caron MG, Rubinstein M, Grandy DK, Low MJ, Geyer MA. PMID: 10341260; PMCID: PMC6782596.
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Is there a critical developmental 'window' for isolation rearing-induced changes in prepulse inhibition of the acoustic startle response? Behav Brain Res. 1999 Apr; 100(1-2):177-83. Varty GB, Braff DL, Geyer MA. PMID: 10212065.
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Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans. Psychopharmacology (Berl). 1999 Apr; 143(4):365-72. Vollenweider FX, Remensberger S, Hell D, Geyer MA. PMID: 10367553.
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M100907, a serotonin 5-HT2A receptor antagonist and putative antipsychotic, blocks dizocilpine-induced prepulse inhibition deficits in Sprague-Dawley and Wistar rats. Neuropsychopharmacology. 1999 Apr; 20(4):311-21. Varty GB, Bakshi VP, Geyer MA. PMID: 10088132.
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Symptom correlates of prepulse inhibition deficits in male schizophrenic patients. Am J Psychiatry. 1999 Apr; 156(4):596-602. Braff DL, Swerdlow NR, Geyer MA. PMID: 10200740.
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Increased exploratory activity and altered response to LSD in mice lacking the 5-HT(5A) receptor. Neuron. 1999 Mar; 22(3):581-91. Grailhe R, Waeber C, Dulawa SC, Hornung JP, Zhuang X, Brunner D, Geyer MA, Hen R. PMID: 10197537.
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Effects of sustained cocaine exposure on sensorimotor gating of startle in rats. Psychopharmacology (Berl). 1999 Mar; 142(3):253-60. Martinez ZA, Ellison GD, Geyer MA, Swerdlow NR. PMID: 10208317.
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Sensorimotor gating and thought disturbance measured in close temporal proximity in schizophrenic patients. Arch Gen Psychiatry. 1999 Mar; 56(3):277-81. Perry W, Geyer MA, Braff DL. PMID: 10078506.
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Prepulse inhibition and habituation of the startle response are stable neurobiological measures in a normal male population. Biol Psychiatry. 1999 Feb 01; 45(3):360-4. Cadenhead KS, Carasso BS, Swerdlow NR, Geyer MA, Braff DL. PMID: 10023514.
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Disruption of prepulse inhibition and increases in locomotor activity by competitive N-methyl-D-aspartate receptor antagonists in rats. J Pharmacol Exp Ther. 1999 Feb; 288(2):643-52. Bakshi VP, Tricklebank M, Neijt HC, Lehmann-Masten V, Geyer MA. PMID: 9918570.
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Long-range correlations in choice sequences of schizophrenic patients. Schizophr Res. 1999 Jan 04; 35(1):69-75. Paulus MP, Geyer MA, Braff DL. PMID: 9988842.
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Alpha-1-adrenergic receptors mediate sensorimotor gating deficits produced by intracerebral dizocilpine administration in rats. Neuroscience. 1999; 92(1):113-21. Bakshi VP, Geyer MA. PMID: 10392835.
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5-HT1B receptor modulation of prepulse inhibition: recent findings in wild-type and 5-HT1B knockout mice. Ann N Y Acad Sci. 1998 Dec 15; 861:79-84. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA. PMID: 9928242.
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Differential movement patterns but not amount of activity in unconditioned motor behavior of Fischer, Lewis, and Sprague-Dawley rats. Physiol Behav. 1998 Dec 01; 65(3):601-6. Paulus MP, Geyer MA, Sternberg E. PMID: 9877429.
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Effects of isolation rearing on startle reactivity, habituation, and prepulse inhibition in male Lewis, Sprague-Dawley, and Fischer F344 rats. Behav Neurosci. 1998 Dec; 112(6):1450-7. Varty GB, Geyer MA. PMID: 9926827.
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Poor P50 suppression among schizophrenia patients and their first-degree biological relatives. Am J Psychiatry. 1998 Dec; 155(12):1691-4. Clementz BA, Geyer MA, Braff DL. PMID: 9842777.
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Evidence for a functional interaction between 5-HT1A and 5-HT2 receptors in rats. Psychopharmacology (Berl). 1998 Nov; 140(1):69-74. Krebs-Thomson K, Geyer MA. PMID: 9862404.
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Effects of the hallucinogen psilocybin on habituation and prepulse inhibition of the startle reflex in humans. Behav Pharmacol. 1998 Nov; 9(7):561-6. Gouzoulis-Mayfrank E, Heekeren K, Thelen B, Lindenblatt H, Kovar KA, Sass H, Geyer MA. PMID: 9862081.
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Seroquel, clozapine and chlorpromazine restore sensorimotor gating in ketamine-treated rats. Psychopharmacology (Berl). 1998 Nov; 140(1):75-80. Swerdlow NR, Bakshi V, Waikar M, Taaid N, Geyer MA. PMID: 9862405.
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Multiple limbic regions mediate the disruption of prepulse inhibition produced in rats by the noncompetitive NMDA antagonist dizocilpine. J Neurosci. 1998 Oct 15; 18(20):8394-401. Bakshi VP, Geyer MA. PMID: 9763482; PMCID: PMC6792827.
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Expression of vascular endothelial growth factor during the development of cardiac hypertrophy in spontaneously hypertensive rats. Mol Cell Biochem. 1998 Oct; 187(1-2):141-6. McAinsh AM, Geyer M, Fandrey J, Rüegg JC, Wiesner RJ. PMID: 9788751.
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Towards a cross-species pharmacology of sensorimotor gating: effects of amantadine, bromocriptine, pergolide and ropinirole on prepulse inhibition of acoustic startle in rats. Behav Pharmacol. 1998 Sep; 9(5-6):389-96. Swerdlow NR, Taaid N, Oostwegel JL, Randolph E, Geyer MA. PMID: 9832924.
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Isolation rearing affects sequential organization of motor behavior in post-pubertal but not pre-pubertal Lister and Sprague-Dawley rats. Behav Brain Res. 1998 Aug; 94(2):271-80. Paulus MP, Bakshi VP, Geyer MA. PMID: 9722278.
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Behavioral studies of hallucinogenic drugs in animals: implications for schizophrenia research. Pharmacopsychiatry. 1998 Jul; 31 Suppl 2:73-9. Geyer MA. PMID: 9754837.
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Effects of hallucinogens on locomotor and investigatory activity and patterns: influence of 5-HT2A and 5-HT2C receptors. Neuropsychopharmacology. 1998 May; 18(5):339-51. Krebs-Thomson K, Paulus MP, Geyer MA. PMID: 9536447.
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Aging effects on the startle response and startle plasticity in Fischer F344 rats. Neurobiol Aging. 1998 May-Jun; 19(3):243-51. Varty GB, Hauger RL, Geyer MA. PMID: 9661999.
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Reversal of isolation rearing-induced deficits in prepulse inhibition by Seroquel and olanzapine. Biol Psychiatry. 1998 Mar 15; 43(6):436-45. Bakshi VP, Swerdlow NR, Braff DL, Geyer MA. PMID: 9532349.
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Multiple site evaluation of P50 suppression among schizophrenia and normal comparison subjects. Schizophr Res. 1998 Feb 27; 30(1):71-80. Clementz BA, Geyer MA, Braff DL. PMID: 9542790.
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Modulation of phencyclidine-induced changes in locomotor activity and patterns in rats by serotonin. Eur J Pharmacol. 1998 Feb 19; 343(2-3):135-43. Krebs-Thomson K, Lehmann-Masten V, Naiem S, Paulus MP, Geyer MA. PMID: 9570460.
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Lack of sensitization to the effects of d-amphetamine and apomorphine on sensorimotor gating in rats. Psychopharmacology (Berl). 1998 Feb; 135(3):296-304. Druhan JP, Geyer MA, Valentino RJ. PMID: 9498734.
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Using an animal model of deficient sensorimotor gating to study the pathophysiology and new treatments of schizophrenia. Schizophr Bull. 1998; 24(2):285-301. Swerdlow NR, Geyer MA. PMID: 9613626.
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Discrepant findings of clozapine effects on prepulse inhibition of startle: is it the route or the rat? Neuropsychopharmacology. 1998 Jan; 18(1):50-6. Swerdlow NR, Varty GB, Geyer MA. PMID: 9408918.
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Disruption in prepulse inhibition after alpha-1 adrenoceptor stimulation in rats. Neuropharmacology. 1998; 37(3):401-4. Carasso BS, Bakshi VP, Geyer MA. PMID: 9681939.
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Repeated testing of prepulse inhibition and habituation of the startle reflex: a study in healthy human controls. J Psychopharmacol. 1998; 12(4):330-7. Abel K, Waikar M, Pedro B, Hemsley D, Geyer M. PMID: 10065906.
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Information processing deficits of schizophrenia patients: relationship to clinical ratings, gender and medication status. Schizophr Res. 1997 Nov 07; 28(1):51-62. Cadenhead KS, Geyer MA, Butler RW, Perry W, Sprock J, Braff DL. PMID: 9428064.
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Phencyclidine-induced deficits in prepulse inhibition of startle are blocked by prazosin, an alpha-1 noradrenergic antagonist. J Pharmacol Exp Ther. 1997 Nov; 283(2):666-74. Bakshi VP, Geyer MA. PMID: 9353384.
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Serotonin1B receptor modulation of startle reactivity, habituation, and prepulse inhibition in wild-type and serotonin1B knockout mice. Psychopharmacology (Berl). 1997 Jul; 132(2):125-34. Dulawa SC, Hen R, Scearce-Levie K, Geyer MA. PMID: 9266609.
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DOI disrupts prepulse inhibition of startle in rats via 5-HT2A receptors in the ventral pallidum. Brain Res. 1997 Jun 27; 761(1):97-104. Sipes TE, Geyer MA. PMID: 9247071.
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P50 suppression among schizophrenia and normal comparison subjects: a methodological analysis. Biol Psychiatry. 1997 May 15; 41(10):1035-44. Clementz BA, Geyer MA, Braff DL. PMID: 9129784.
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Characterization of the disruptions of prepulse inhibition and habituation of startle induced by alpha-ethyltryptamine. Neuropsychopharmacology. 1997 Mar; 16(3):246-55. Martinez DL, Geyer MA. PMID: 9138441.
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Seroquel restores sensorimotor gating in phencyclidine-treated rats. J Pharmacol Exp Ther. 1996 Dec; 279(3):1290-9. Swerdlow NR, Bakshi V, Geyer MA. PMID: 8968353.
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The role of 5-HT(1A) receptors in the locomotor-suppressant effects of LSD: WAY-100635 studies of 8-OH-DPAT, DOI and LSD in rats. Behav Pharmacol. 1996 Nov; 7(6):551-559. Krebs-Thomson K, Geyer MA. PMID: 11224452.
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Polyamine spider toxins and mammalian N-methyl-D-aspartate receptors. Structural basis for channel blocking and binding of argiotoxin636. Eur J Biochem. 1996 Sep 01; 240(2):416-26. Raditsch M, Geyer M, Kalbitzer HR, Jahn W, Ruppersberg JP, Witzemann V. PMID: 8841407.
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Functional behavioral homology between rat 5-HT1B and guinea pig 5-HT1D receptors in the modulation of prepulse inhibition of startle. Psychopharmacology (Berl). 1996 Jun; 125(3):231-7. Sipes TE, Geyer MA. PMID: 8815958.
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Latent inhibition in schizophrenia. Schizophr Res. 1996 May; 20(1-2):91-103. Swerdlow NR, Braff DL, Hartston H, Perry W, Geyer MA. PMID: 8794497.
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Use of methods from chaos theory to quantify a fundamental dysfunction in the behavioral organization of schizophrenic patients. Am J Psychiatry. 1996 May; 153(5):714-7. Paulus MP, Geyer MA, Braff DL. PMID: 8615422.
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Prepulses inhibit startle-induced reductions of extracellular dopamine in the nucleus accumbens of rat. J Neurosci. 1996 Mar 15; 16(6):2149-56. Humby T, Wilkinson LS, Robbins TW, Geyer MA. PMID: 8604058; PMCID: PMC6578511.
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Psychopharmacology of prepulse inhibition in mice. Chin J Physiol. 1996; 39(3):139-46. Dulawa SC, Geyer MA. PMID: 8955560.
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Serotonergic functions in arousal and motor activity. Behav Brain Res. 1996; 73(1-2):31-5. Geyer MA. PMID: 8788473.
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A comparison of the effects of amphetamine, strychnine and caffeine on prepulse inhibition and latent inhibition. Behav Pharmacol. 1995 Dec; 6(8):801-809. Bakshi VP, Geyer MA, Taaid N, Swerdlow NR. PMID: 11224383.
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DOI disruption of prepulse inhibition of startle in the rat is mediated by 5-HT(2A) and not by 5-HT(2C) receptors. Behav Pharmacol. 1995 Dec; 6(8):839-842. Sipes TE, Geyer MA. PMID: 11224388.
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Increased sensitivity to the sensorimotor gating-disruptive effects of apomorphine after lesions of medial prefrontal cortex or ventral hippocampus in adult rats. Psychopharmacology (Berl). 1995 Nov; 122(1):27-34. Swerdlow NR, Lipska BK, Weinberger DR, Braff DL, Jaskiw GE, Geyer MA. PMID: 8711061.
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Neonatal excitotoxic hippocampal damage in rats causes post-pubertal changes in prepulse inhibition of startle and its disruption by apomorphine. Psychopharmacology (Berl). 1995 Nov; 122(1):35-43. Lipska BK, Swerdlow NR, Geyer MA, Jaskiw GE, Braff DL, Weinberger DR. PMID: 8711062.
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Antagonism of phencyclidine-induced deficits in prepulse inhibition by the putative atypical antipsychotic olanzapine. Psychopharmacology (Berl). 1995 Nov; 122(2):198-201. Bakshi VP, Geyer MA. PMID: 8848537.
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The behavior of APO-SUS rats in animal models with construct validity for schizophrenia. J Neurosci. 1995 Nov; 15(11):7604-11. Ellenbroek BA, Geyer MA, Cools AR. PMID: 7472511; PMCID: PMC6578060.
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Presynaptic dopamine-glutamate interactions in the nucleus accumbens regulate sensorimotor gating. Psychopharmacology (Berl). 1995 Aug; 120(4):433-41. Wan FJ, Geyer MA, Swerdlow NR. PMID: 8539324.
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Drug screening in "normal" controls. Biol Psychiatry. 1995 Jul 15; 38(2):123-4. Swerdlow NR, Geyer MA, Perry W, Cadenhead K, Braff DL. PMID: 7578645.
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Effects of D3/D2 dopamine receptor agonists and antagonists on prepulse inhibition of acoustic startle in the rat. Neuropsychopharmacology. 1995 Apr; 12(2):139-45. Caine SB, Geyer MA, Swerdlow NR. PMID: 7779242.
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"Normal" personality correlates of sensorimotor, cognitive, and visuospatial gating. Biol Psychiatry. 1995 Mar 01; 37(5):286-99. Swerdlow NR, Filion D, Geyer MA, Braff DL. PMID: 7748980.
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Impaired prepulse inhibition of acoustic and tactile startle response in patients with Huntington's disease. J Neurol Neurosurg Psychiatry. 1995 Feb; 58(2):192-200. Swerdlow NR, Paulsen J, Braff DL, Butters N, Geyer MA, Swenson MR. PMID: 7876851; PMCID: PMC1073317.
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Gating and habituation deficits in the schizophrenia disorders. Clin Neurosci. 1995; 3(2):131-9. Braff DL, Swerdlow NR, Geyer MA. PMID: 7583619.
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8-OH-DPAT disruption of prepulse inhibition in rats: reversal with (+)WAY 100,135 and localization of site of action. Psychopharmacology (Berl). 1995 Jan; 117(1):41-8. Sipes TA, Geyer MA. PMID: 7724701.
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Flinders resistant hypocholinergic rats exhibit startle sensitization and reduced startle thresholds. Biol Psychiatry. 1994 Nov 15; 36(10):680-8. Markou A, Matthews K, Overstreet DH, Koob GF, Geyer MA. PMID: 7880937.
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The assessment of sequential response organization in schizophrenic and control subjects. Prog Neuropsychopharmacol Biol Psychiatry. 1994 Nov; 18(7):1169-85. Paulus MP, Geyer MA, Braff DL. PMID: 7846287.
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Clozapine antagonizes phencyclidine-induced deficits in sensorimotor gating of the startle response. J Pharmacol Exp Ther. 1994 Nov; 271(2):787-94. Bakshi VP, Swerdlow NR, Geyer MA. PMID: 7965797.
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Accumbens D2 modulation of sensorimotor gating in rats: assessing anatomical localization. Pharmacol Biochem Behav. 1994 Sep; 49(1):155-63. Wan FJ, Geyer MA, Swerdlow NR. PMID: 7816867.
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Multiple serotonin receptor subtypes modulate prepulse inhibition of the startle response in rats. Neuropharmacology. 1994 Mar-Apr; 33(3-4):441-8. Sipes TA, Geyer MA. PMID: 7984282.
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Social isolation in the rat produces developmentally specific deficits in prepulse inhibition of the acoustic startle response without disrupting latent inhibition. Neuropsychopharmacology. 1994 Feb; 10(1):61-72. Wilkinson LS, Killcross SS, Humby T, Hall FS, Geyer MA, Robbins TW. PMID: 8179795.
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Assessing the validity of an animal model of deficient sensorimotor gating in schizophrenic patients. Arch Gen Psychiatry. 1994 Feb; 51(2):139-54. Swerdlow NR, Braff DL, Taaid N, Geyer MA. PMID: 8297213.
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Cross-tolerance studies of serotonin receptors involved in behavioral effects of LSD in rats. Psychopharmacology (Berl). 1994 Jan; 113(3-4):429-37. Krebs KM, Geyer MA. PMID: 7862855.
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Serotonin receptor involvement in an animal model of the acute effects of hallucinogens. NIDA Res Monogr. 1994; 146:124-56. Geyer MA, Krebs KM. PMID: 8742797.
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Impaired startle prepulse inhibition and habituation in patients with schizotypal personality disorder. Am J Psychiatry. 1993 Dec; 150(12):1862-7. Cadenhead KS, Geyer MA, Braff DL. PMID: 8238643.
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Isolation rearing of rats produces a deficit in prepulse inhibition of acoustic startle similar to that in schizophrenia. Biol Psychiatry. 1993 Sep 15; 34(6):361-72. Geyer MA, Wilkinson LS, Humby T, Robbins TW. PMID: 8218603.
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Men are more inhibited than women by weak prepulses. Biol Psychiatry. 1993 Aug 15; 34(4):253-60. Swerdlow NR, Auerbach P, Monroe SM, Hartston H, Geyer MA, Braff DL. PMID: 8399822.
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Serotonin1B receptor activation mimics behavioral effects of presynaptic serotonin release. Neuropsychopharmacology. 1993 May; 8(3):201-11. Rempel NL, Callaway CW, Geyer MA. PMID: 8099482.
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Clozapine and haloperidol in an animal model of sensorimotor gating deficits in schizophrenia. Pharmacol Biochem Behav. 1993 Mar; 44(3):741-4. Swerdlow NR, Geyer MA. PMID: 8451276.
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Three independent factors characterize spontaneous rat motor activity. Behav Brain Res. 1993 Feb 26; 53(1-2):11-20. Paulus MP, Geyer MA. PMID: 8466655.
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A preliminary assessment of sensorimotor gating in patients with obsessive compulsive disorder. Biol Psychiatry. 1993 Feb 15; 33(4):298-301. Swerdlow NR, Benbow CH, Zisook S, Geyer MA, Braff DL. PMID: 8471686.
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Prepulse inhibition of acoustic startle in rats after lesions of the pedunculopontine tegmental nucleus. Behav Neurosci. 1993 Feb; 107(1):104-17. Swerdlow NR, Geyer MA. PMID: 8447948.
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Quantitative assessment of the microstructure of rat behavior: II. Distinctive effects of dopamine releasers and uptake inhibitors. Psychopharmacology (Berl). 1993; 113(2):187-98. Paulus MP, Callaway CW, Geyer MA. PMID: 7855180.
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Behavioral characterization of alpha-ethyltryptamine, a tryptamine derivative with MDMA-like properties in rats. Psychopharmacology (Berl). 1993; 113(2):284-7. Krebs KM, Geyer MA. PMID: 7855195.
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Quantitative assessment of the microstructure of rat behavior: I, f(d), the extension of the scaling hypothesis. Psychopharmacology (Berl). 1993; 113(2):177-86. Paulus MP, Geyer MA. PMID: 7855179.
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Suppression of behavioral activity by norfenfluramine and related drugs in rats is not mediated by serotonin release. Psychopharmacology (Berl). 1993; 111(2):169-78. Callaway CW, Wing LL, Nichols DE, Geyer MA. PMID: 7870948.
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Hippocampal modulation of acoustic startle and prepulse inhibition in the rat. Pharmacol Biochem Behav. 1992 Dec; 43(4):1201-8. Caine SB, Geyer MA, Swerdlow NR. PMID: 1475305.
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Differential startle amplitude and corticosterone response in rats. Neuroendocrinology. 1992 Nov; 56(5):719-23. Glowa JR, Geyer MA, Gold PW, Sternberg EM. PMID: 1488104.
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Tolerance and cross-tolerance to the activating effects of 3,4-methylenedioxymethamphetamine and a 5-hydroxytryptamine1B agonist. J Pharmacol Exp Ther. 1992 Oct; 263(1):318-26. Callaway CW, Geyer MA. PMID: 1357158.
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Serotonin 5-HT1-like receptors mediate hyperactivity in rats induced by 3,4-methylenedioxymethamphetamine. Neuropsychopharmacology. 1992 Sep; 7(2):113-27. Callaway CW, Rempel N, Peng RY, Geyer MA. PMID: 1358088.
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The effects of MDMA and other methylenedioxy-substituted phenylalkylamines on the structure of rat locomotor activity. Neuropsychopharmacology. 1992 Aug; 7(1):15-31. Paulus MP, Geyer MA. PMID: 1355968.
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Stimulant effects of 3,4-methylenedioxymethamphetamine in the nucleus accumbens of rat. Eur J Pharmacol. 1992 Apr 07; 214(1):45-51. Callaway CW, Geyer MA. PMID: 1349861.
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Gating and habituation of the startle reflex in schizophrenic patients. Arch Gen Psychiatry. 1992 Mar; 49(3):206-15. Braff DL, Grillon C, Geyer MA. PMID: 1567275.
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Regionally selective effects of intracerebral dopamine infusion on sensorimotor gating of the startle reflex in rats. Psychopharmacology (Berl). 1992; 108(1-2):189-95. Swerdlow NR, Caine SB, Geyer MA. PMID: 1410139.
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Multivariate and nonlinear approaches to characterizing drug effects on the locomotor and investigatory behavior of rats. NIDA Res Monogr. 1992; 124:203-35. Geyer MA, Paulus MP. PMID: 1470213.
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Responding to acoustic startle during chronic ethanol intoxication and withdrawal. Psychopharmacology (Berl). 1992; 106(3):351-8. Rassnick S, Koob GF, Geyer MA. PMID: 1570382.
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Psychopharmacological models related to schizophrenia. J Psychopharmacol. 1992 Jan; 6(4):550-2. Geyer MA. PMID: 22291414.
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The neural substrates of sensorimotor gating of the startle reflex: a review of recent findings and their implications. J Psychopharmacol. 1992 Jan; 6(2):176-90. Swerdlow NR, Caine SB, Braff DL, Geyer MA. PMID: 22291349.
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Failure of haloperidol to block the effects of phencyclidine and dizocilpine on prepulse inhibition of startle. Biol Psychiatry. 1991 Sep 15; 30(6):557-66. Keith VA, Mansbach RS, Geyer MA. PMID: 1834231.
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Spatial and temporal patterning distinguishes the locomotor activating effects of dizocilpine and phencyclidine in rats. Neuropharmacology. 1991 Jun; 30(6):629-36. Lehmann-Masten VD, Geyer MA. PMID: 1922682.
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Effects of spiperone, raclopride, SCH 23390 and clozapine on apomorphine inhibition of sensorimotor gating of the startle response in the rat. J Pharmacol Exp Ther. 1991 Feb; 256(2):530-6. Swerdlow NR, Keith VA, Braff DL, Geyer MA. PMID: 1825226.
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Opiate-dopamine interactions in the neural substrates of acoustic startle gating in the rat. Prog Neuropsychopharmacol Biol Psychiatry. 1991; 15(3):415-26. Swerdlow NR, Caine SB, Geyer MA. PMID: 1862221.
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A temporal and spatial scaling hypothesis for the behavioral effects of psychostimulants. Psychopharmacology (Berl). 1991; 104(1):6-16. Paulus MP, Geyer MA. PMID: 1679242.
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A scaling approach to find order parameters quantifying the effects of dopaminergic agents on unconditioned motor activity in rats. Prog Neuropsychopharmacol Biol Psychiatry. 1991; 15(6):903-19. Paulus MP, Geyer MA. PMID: 1684875.
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Carbachol infusion into the dentate gyrus disrupts sensorimotor gating of startle in the rat. Psychopharmacology (Berl). 1991; 105(3):347-54. Caine SB, Geyer MA, Swerdlow NR. PMID: 1798831.
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Dissociation of multiple effects of acute LSD on exploratory behavior in rats by ritanserin and propranolol. Psychopharmacology (Berl). 1991; 105(1):69-76. Mittman SM, Geyer MA. PMID: 1745714.
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Parametric determinants in pre-stimulus modification of acoustic startle: interaction with ketamine. Psychopharmacology (Berl). 1991; 105(2):162-8. Mansbach RS, Geyer MA. PMID: 1796122.
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Amphetamine derivatives induce locomotor hyperactivity by acting as indirect serotonin agonists. Psychopharmacology (Berl). 1991; 104(3):293-301. Callaway CW, Johnson MP, Gold LH, Nichols DE, Geyer MA. PMID: 1924637.
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Multiple serotonergic influences on startle responding. J Psychopharmacol. 1991 Jan; 5(4):334-5. Geyer MA. PMID: 22282836.
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GABAergic projection from nucleus accumbens to ventral pallidum mediates dopamine-induced sensorimotor gating deficits of acoustic startle in rats. Brain Res. 1990 Nov 05; 532(1-2):146-50. Swerdlow NR, Braff DL, Geyer MA. PMID: 2282510.
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Physiological evidence of exaggerated startle response in a subgroup of Vietnam veterans with combat-related PTSD. Am J Psychiatry. 1990 Oct; 147(10):1308-12. Butler RW, Braff DL, Rausch JL, Jenkins MA, Sprock J, Geyer MA. PMID: 2399998.
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Startle response models of sensorimotor gating and habituation deficits in schizophrenia. Brain Res Bull. 1990 Sep; 25(3):485-98. Geyer MA, Swerdlow NR, Mansbach RS, Braff DL. PMID: 2292046.
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Direct cerebrospinal fluid delivery of an antiretroviral agent using multivesicular liposomes. J Infect Dis. 1990 Sep; 162(3):750-2. Kim S, Scheerer S, Geyer MA, Howell SB. PMID: 2167343.
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Serotonin release contributes to the locomotor stimulant effects of 3,4-methylenedioxymethamphetamine in rats. J Pharmacol Exp Ther. 1990 Aug; 254(2):456-64. Callaway CW, Wing LL, Geyer MA. PMID: 1974635.
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A D2 dopamine receptor agonist disrupts sensorimotor gating in rats. Implications for dopaminergic abnormalities in schizophrenia. Neuropsychopharmacology. 1990 Jun; 3(3):211-8. Peng RY, Mansbach RS, Braff DL, Geyer MA. PMID: 2141986.
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Sensorimotor gating and schizophrenia. Human and animal model studies. Arch Gen Psychiatry. 1990 Feb; 47(2):181-8. Braff DL, Geyer MA. PMID: 2405807.
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Increased distractibility in schizophrenic patients. Electrophysiologic and behavioral evidence. Arch Gen Psychiatry. 1990 Feb; 47(2):171-9. Grillon C, Courchesne E, Ameli R, Geyer MA, Braff DL. PMID: 2302027.
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Application of entropy measures derived from the ergodic theory of dynamical systems to rat locomotor behavior. Proc Natl Acad Sci U S A. 1990 Jan; 87(2):723-7. Paulus MP, Geyer MA, Gold LH, Mandell AJ. PMID: 1967830; PMCID: PMC53338.
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5HT-2 mediation of acute behavioral effects of hallucinogens in rats. Psychopharmacology (Berl). 1990; 100(3):417-25. Wing LL, Tapson GS, Geyer MA. PMID: 2138338.
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Schizophrenic-like sensorimotor gating abnormalities in rats following dopamine infusion into the nucleus accumbens. Psychopharmacology (Berl). 1990; 101(3):414-20. Swerdlow NR, Braff DL, Masten VL, Geyer MA. PMID: 2114026.
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Apomorphine disrupts the inhibition of acoustic startle induced by weak prepulses in rats. Psychopharmacology (Berl). 1990; 102(1):1-4. Davis M, Mansbach RS, Swerdlow NR, Campeau S, Braff DL, Geyer MA. PMID: 2392496.
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Amphetamine disruption of prepulse inhibition of acoustic startle is reversed by depletion of mesolimbic dopamine. Psychopharmacology (Berl). 1990; 100(3):413-6. Swerdlow NR, Mansbach RS, Geyer MA, Pulvirenti L, Koob GF, Braff DL. PMID: 2315438.
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Effects of phencyclidine and phencyclidine biologs on sensorimotor gating in the rat. Neuropsychopharmacology. 1989 Dec; 2(4):299-308. Mansbach RS, Geyer MA. PMID: 2692589.
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Prepulse inhibition of the acoustic startle response is disrupted by N-ethyl-3,4-methylenedioxyamphetamine (MDEA) in the rat. Eur J Pharmacol. 1989 Aug 11; 167(1):49-55. Mansbach RS, Braff DL, Geyer MA. PMID: 2776841.
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Increases in diversive exploration in rats during hippocampal microinfusions of isoproterenol but not methoxamine. Physiol Behav. 1989 Jan; 45(1):213-7. Geyer MA, Masten VL. PMID: 2543005.
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Psychostimulant properties of MDMA. NIDA Res Monogr. 1989; 95:345-6. Gold LH, Geyer MA, Koob GF. PMID: 2577038.
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Neurochemical mechanisms involved in behavioral effects of amphetamines and related designer drugs. NIDA Res Monogr. 1989; 94:101-26. Gold LH, Geyer MA, Koob GF. PMID: 2514360.
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Effects of 5HT-1A agonists on locomotor and investigatory behaviors in rats differ from those of hallucinogens. Psychopharmacology (Berl). 1989; 98(3):321-9. Mittman SM, Geyer MA. PMID: 2501811.
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Spatial pattern analysis reveals similarities between amphetamine conditioned and unconditioned locomotion. Behav Pharmacol. 1989; 1(3):209-220. Gold LH, Koob GF, Geyer MA. PMID: 11224032.
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Blockade of potentiated startle responding in rats by 5-hydroxytryptamine1A receptor ligands. Eur J Pharmacol. 1988 Nov 08; 156(3):375-83. Mansbach RS, Geyer MA. PMID: 2975225.
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Stimulant and hallucinogenic behavioral profiles of 3,4-methylenedioxymethamphetamine and N-ethyl-3,4-methylenedioxyamphetamine in rats. J Pharmacol Exp Ther. 1988 Nov; 247(2):547-55. Gold LH, Koob GF, Geyer MA. PMID: 2903234.
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Peripheral mediation of effects of clenbuterol on locomotor and investigatory behavior in rats. Pharmacol Biochem Behav. 1988 Jun; 30(2):417-20. Geyer MA, Frampton SF. PMID: 2845445.
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Habituation of tactile startle is altered by drugs acting on serotonin-2 receptors. Neuropsychopharmacology. 1988 May; 1(2):135-47. Geyer MA, Tapson GS. PMID: 3150805.
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Dopaminergic stimulation disrupts sensorimotor gating in the rat. Psychopharmacology (Berl). 1988; 94(4):507-14. Mansbach RS, Geyer MA, Braff DL. PMID: 3131796.
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Habituation deficits, serotonergic function, and schizophrenia: new animal model data. Psychopharmacol Bull. 1988; 24(3):426-30. Braff DL, Geyer MA. PMID: 3153503.
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Effects of apomorphine and amphetamine on patterns of locomotor and investigatory behavior in rats. Pharmacol Biochem Behav. 1987 Nov; 28(3):393-9. Geyer MA, Russo PV, Segal DS, Kuczenski R. PMID: 3685075.
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Multivesicular liposomes containing 1-beta-D-arabinofuranosylcytosine for slow-release intrathecal therapy. Cancer Res. 1987 Aug 01; 47(15):3935-7. Kim S, Kim DJ, Geyer MA, Howell SB. PMID: 3607740.
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Gabaergic interneurons in the dorsal raphe mediate the effects of apomorphine on serotonergic system. Brain Res Bull. 1987 Mar; 18(3):345-53. Lee EH, Wang FB, Tang YP, Geyer MA. PMID: 2438015.
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Sequential changes in behavior induced by continuous infusions of amphetamine in rats. Psychopharmacology (Berl). 1987; 91(2):217-20. Gately PF, Segal DS, Geyer MA. PMID: 3107035.
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Startle habituation and sensorimotor gating in schizophrenia and related animal models. Schizophr Bull. 1987; 13(4):643-68. Geyer MA, Braff DL. PMID: 3438708.
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Behavioral effects of xylamine-induced depletions of brain norepinephrine: interaction with amphetamine. Behav Brain Res. 1986 Jul; 21(1):55-64. Geyer MA, Masten VL, Segal DS. PMID: 3741596.
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Multivariate assessment of locomotor behavior: pharmacological and behavioral analyses. Pharmacol Biochem Behav. 1986 Jul; 25(1):277-88. Geyer MA, Russo PV, Masten VL. PMID: 2875472.
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Cardiovascular concomitants of tactile and acoustic startle responses in spontaneously hypertensive and normotensive rats. Physiol Behav. 1986; 36(6):1123-8. Rettig R, Geyer MA, Printz MP. PMID: 3725916.
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The behavioral effects of depletions of brain serotonin induced by 5,7-dihydroxytryptamine vary with time after administration. Behav Neural Biol. 1986 Jan; 45(1):31-42. Gately PF, Segal DS, Geyer MA. PMID: 3954713.
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Central dopamine hyperactivity in rats mimics abnormal acoustic startle response in schizophrenics. Biol Psychiatry. 1986 Jan; 21(1):23-33. Swerdlow NR, Braff DL, Geyer MA, Koob GF. PMID: 3080033.
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Corticotropin-releasing factor potentiates acoustic startle in rats: blockade by chlordiazepoxide. Psychopharmacology (Berl). 1986; 88(2):147-52. Swerdlow NR, Geyer MA, Vale WW, Koob GF. PMID: 3081925.
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Collaborative Behavioral Teratology Study: results. Neurobehav Toxicol Teratol. 1985 Nov-Dec; 7(6):591-624. Buelke-Sam J, Kimmel CA, Adams J, Nelson CJ, Vorhees CV, Wright DC, St Omer V, Korol BA, Butcher RE, Geyer MA, et al. PMID: 3835454.
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A study of startle and locomotor activity in rats exposed prenatally to methylmercury. Neurobehav Toxicol Teratol. 1985 Nov-Dec; 7(6):759-65. Geyer MA, Butcher RE, Fite K. PMID: 3835478.
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Strategies for the selection of test methods. Neurobehav Toxicol Teratol. 1985 Nov-Dec; 7(6):661-2. Geyer MA, Reiter LW. PMID: 3835462.
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Behavioral effects of xylamine-induced depletions of brain norepinephrine: interaction with LSD. Pharmacol Biochem Behav. 1985 Oct; 23(4):619-25. Geyer MA, Gordon J, Adams LM. PMID: 3877938.
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A proposed animal model for hallucinogens based on LSD's effects on patterns of exploration in rats. Behav Neurosci. 1985 Oct; 99(5):881-900. Adams LM, Geyer MA. PMID: 3843306.
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Patterns of exploration in rats distinguish lisuride from lysergic acid diethylamide. Pharmacol Biochem Behav. 1985 Sep; 23(3):461-8. Adams LM, Geyer MA. PMID: 4048241.
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Effects of DOM and DMT in a proposed animal model of hallucinogenic activity. Prog Neuropsychopharmacol Biol Psychiatry. 1985; 9(2):121-32. Adams LM, Geyer MA. PMID: 3858911.
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Depletion of brain serotonin by 5,7-dihydroxytryptamine alters the response to amphetamine and the habituation of locomotor activity in rats. Psychopharmacology (Berl). 1985; 87(4):400-5. Gately PF, Poon SL, Segal DS, Geyer MA. PMID: 3936096.
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Effects of clonidine, piperoxane and locus coeruleus lesion on the serotonergic and dopaminergic systems in raphe and caudate nucleus. Biochem Pharmacol. 1984 Nov 01; 33(21):3399-404. Geyer MA, Lee EH. PMID: 6437408.
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Dopamine autoreceptor mediation of the effects of apomorphine on serotonin neurons. Pharmacol Biochem Behav. 1984 Aug; 21(2):301-11. Lee EH, Geyer MA. PMID: 6207549.
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Depletions of central norepinephrine by intraventricular xylamine in rats. Eur J Pharmacol. 1984 Apr 20; 100(2):227-31. Geyer MA, Gordon J, Adams LM. PMID: 6203760.
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Increased startle responding in rats treated with phencyclidine. Neurobehav Toxicol Teratol. 1984 Mar-Apr; 6(2):161-4. Geyer MA, Segal DS, Greenberg BD. PMID: 6472561.
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Indirect effects of apomorphine on serotoninergic neurons in rats. Neuroscience. 1984 Feb; 11(2):437-42. Lee EH, Geyer MA. PMID: 6201781.
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Similarities of the effects of apomorphine and 3-PPP on serotonin neurons. Eur J Pharmacol. 1983 Oct 28; 94(3-4):297-303. Lee EH, Geyer MA. PMID: 6653663.
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Behavior during hippocampal microinfusions: anticholinesterase-induced locomotor activation. Behav Brain Res. 1983 Sep; 9(3):295-304. Zheng S, Berman HA, Geyer MA. PMID: 6639738.
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Selective effects of apomorphine on dorsal raphe neurons: a cytofluorimetric study. Brain Res Bull. 1982 Jul-Dec; 9(1-6):719-25. Lee EH, Geyer MA. PMID: 6184135.
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Effects of tactile startle on serotonin content of midbrain raphe neurons in rats. Behav Brain Res. 1982 Apr; 4(4):369-76. Geyer MA, Flicker CE, Lee EH. PMID: 7073886.
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The hippocampus as a possible site of action for increased locomotion during intracerebral infusions of norepinephrine. Behav Neural Biol. 1982 Apr; 34(4):421-6. Flicker C, Geyer MA. PMID: 7126090.
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Behavior during hippocampal microinfusions. I. Norepinephrine and diversive exploration. Brain Res. 1982 Mar; 257(1):79-103. Flicker C, Geyer MA. PMID: 6277439.
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Behavior during hippocampal microinfusions. IV. Transmitter interactions. Brain Res. 1982 Mar; 257(1):137-47. Flicker C, Geyer MA. PMID: 6120751.
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Behavior during hippocampal microinfusions. II. Muscarinic locomotor activation. Brain Res. 1982 Mar; 257(1):105-27. Flicker C, Geyer MA. PMID: 7059844.
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Behavior during hippocampal microinfusions. III. Lidocaine versus picrotoxin. Brain Res. 1982 Mar; 257(1):129-36. Flicker C, Geyer MA. PMID: 7199365.
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LSD-induced alterations of locomotor patterns and exploration in rats. Psychopharmacology (Berl). 1982; 77(2):179-85. Adams LM, Geyer MA. PMID: 6812137.
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Habituation of the Blink reflex in normals and schizophrenic patients. Psychophysiology. 1982 Jan; 19(1):1-6. Geyer MA, Braff DL. PMID: 7058230.
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Effects of caffeine on tactile startle in rats. Pharmacol Biochem Behav. 1981 Dec; 15(6):875-7. Ward HW, Pollare T, Geyer MA. PMID: 7323112.
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Effects of levonantradol on habituation of startle in rats. J Clin Pharmacol. 1981 Aug-Sep; 21(S1):235S-239S. Geyer MA. PMID: 7298869.
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Effects of 6-hydroxydopamine lesions of locus coeruleus on startle in rats. Psychopharmacology (Berl). 1981; 73(4):394-8. Adams LM, Geyer MA. PMID: 6789365.
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Stimulant-induced psychosis: an evaluation of animal methods. Essays Neurochem Neuropharmacol. 1981; 5:95-129. Segal DS, Geyer MA, Schuckit MA. PMID: 6112147.
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Acute and chronic LSD effects on rat startle: data supporting an LSD--rat model of schizophrenia. Biol Psychiatry. 1980 Dec; 15(6):909-16. Braff DL, Geyer MA. PMID: 7193055.
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Persistent effects of chronic administration of LSD on intracellular serotonin content in rat midbrain. Neuropharmacology. 1980 Oct; 19(10):1005-7. Lee EH, Geyer MA. PMID: 7422071.
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Effects of serotonergic lesions on investigatory responding by rats in a holeboard. Behav Neural Biol. 1980 Oct; 30(2):160-77. Geyer MA, Petersen LR, Rose GJ. PMID: 7447870.
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Decreased startle reactivity in the end-to-side portacaval shunted rat. Pharmacol Biochem Behav. 1980 May; 12(5):739-42. Warbritton JD, Geyer MA, Jeppsson B, Fischer JE. PMID: 7393968.
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Both indoleamine and phenylethylamine hallucinogens increase serotonin in both dorsal and median raphe neurons. Life Sci. 1980 Feb 11; 26(6):431-4. Geyer MA. PMID: 6768945.
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[Prognosis, chronification and therapeutic relations in unsatisfactorily improved secondary faulty developments with cardiovascular affections]. Psychiatr Neurol Med Psychol (Leipz). 1979 Nov; 31(11):681-8. Geyer M, Barthel E, Schröder F, Franke G, Küstner R. PMID: 549043.
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A characteristic effect of hallucinogens on investigatory responding in rats. Psychopharmacology (Berl). 1979 Sep; 65(1):35-40. Geyer MA, Light RK, Rose GJ, Petersen LR, Horwitt DD, Adams LM, Hawkins RL. PMID: 116288.
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LSD-induced alterations of investigatory responding in rats. Psychopharmacology (Berl). 1979 Sep; 65(1):41-7. Geyer MA, Light RK. PMID: 41281.
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Mescaline increases startle responding equally in normal and raphe-lesioned rats. Pharmacol Biochem Behav. 1979 Feb; 10(2):293-8. Geyer MA, Rose GJ, Petersen LR. PMID: 450941.
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Behavioral model of early hepatic encephalopathy in rats. Surg Forum. 1979; 30:394-6. Warbritton JD, Geyer MA, Jeppsson BW, Fischer JE. PMID: 538643.
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The effects of lysergic acid diethylamide and mescaline-derived hallucinogens on sensory-integrative function: tactile startle. J Pharmacol Exp Ther. 1978 Dec; 207(3):837-47. Geyer MA, Petersen LR, Rose GJ, Horwitt DD, Light RK, Adams LM, Zook JA, Hawkins RL, Mandell AJ. PMID: 731434.
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Fading: a new cytofluorimetric measure quantifying serotonin in the presence of catecholamines at the cellular level in brain. J Pharmacol Exp Ther. 1978 Nov; 207(2):650-67. Geyer MA, Dawsey WJ, Mandell AJ. PMID: 309507.
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Prestimulus effects on human startle reflex in normals and schizophrenics. Psychophysiology. 1978 Jul; 15(4):339-43. Braff D, Stone C, Callaway E, Geyer M, Glick I, Bali L. PMID: 693742.
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Pre- and post-junctional supersensitivity: differentiation by intraventricular infusions of norepinephrine and methoxamine. Psychopharmacology (Berl). 1976 Nov 10; 50(2):145-8. Segal DS, Geyer MA. PMID: 188061.
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[Psychophysiological studies in the framework of objective diagnosis of neuroses with factor and discrimination analyses]. Psychiatr Neurol Med Psychol (Leipz). 1976 May; 28(5):267-74. Scholle HC, Zwiener U, Geyer M, Goldammer D. PMID: 940891.
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Behavioral studies following lesions of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):257-69. Geyer MA, Puerto A, Menkes DB, Segal DS, Mandell AJ. PMID: 1276871.
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Histologic and enzymatic studies of the mesolimbic and mesostriatal serotonergic pathways. Brain Res. 1976 Apr 23; 106(2):241-56. Geyer MA, Puerto A, Dawsey WJ, Knapp S, Bullard WP, Mandell AJ. PMID: 6112.
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Extrapineal amine N-acetylation in rat brain. Regional and subcellular distribution and enzyme kinetics. Biochem Pharmacol. 1976 Apr 01; 25(7):815-9. Hsu LL, Geyer MA, Mandell AJ. PMID: 938582.
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Strain differences during intraventricular infusion of norepinephrine: possible role of receptor sensitivity. Science. 1975 Jul 25; 189(4199):301-3. Segal DS, Geyer MA, Weiner BE. PMID: 1145205.
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Opposite effects of intraventricular serotonin and bufotenin on rat startle responses. Pharmacol Biochem Behav. 1975 Jul-Aug; 3(4):687-91. Geyer MA, Warbritton JD, Menkes DB, Zook JA, Mandell AJ. PMID: 1187731.
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Differential effects of caffeine, D-amphetamine and methylphenidate on individual raphe cell fluorescence: a microspectrofluorimetric demonstration. Brain Res. 1975 Feb 21; 85(1):135-9. Geyer MA, Dawsey WJ, Mandell AJ. PMID: 1109692.
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Functional heterogeneity within neurotransmitter systems. Psychopharmacol Commun. 1975; 1(6):675-85. Geyer MA. PMID: 4862.
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[Psychosomatic aspects of cholelithiasis]. Psychiatr Neurol Med Psychol (Leipz). 1974 Aug; 26(8):457-65. Geyer M, Kliem U, Voigtsberger P. PMID: 4449915.
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Effects of amphetamines on regional tryptophan hydroxylase activity and synaptosomal conversion of tryptophan to 5-hydroxytryptamine in rat brain. J Pharmacol Exp Ther. 1974 Jun; 189(3):676-89. Knapp S, Mandell AJ, Geyer MA. PMID: 4843167.
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Shock-induced aggression: opposite effects of intraventricularly infused dopamine and norepinephrine. Behav Biol. 1974 Jan; 10(1):99-104. Geyer MA, Segal DS. PMID: 4856062.
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Ventricular infusion of norepinephrine and amphetamine: direct versus indirect action. Pharmacol Biochem Behav. 1974 Jan-Feb; 2(1):79-86. Segal DS, McAllister C, Geyer MA. PMID: 4857225.
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Regional distribution of 5-methyltetrahydrofolic acid in brain. Nat New Biol. 1973 Oct 24; 245(147):244-5. Korevaar WC, Geyer MA, Knapp S, Hsu LL, Mandell AJ. PMID: 4518367.
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Differential effects of reserpine and alpha-methyl-P-tyrosine on norepinephrine and dopamine induced behavioral activity. Psychopharmacologia. 1973 Mar 16; 29(2):131-40. Geyer MA, Segal DS. PMID: 4709837.
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Effect of intraventricular infusion of dopamine and norepinephrine on motor activity. Physiol Behav. 1972 Apr; 8(4):653-8. Geyer MA, Segal DS, Mandell AJ. PMID: 5038135.
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Localization of depletion-sensitive and depletion-resistant norepinephrine storage sites in autonomic ganglia. J Pharmacol Exp Ther. 1970 Jul; 174(1):56-71. Van Orden LS, Burke JP, Geyer M, Lodoen FV. PMID: 5424704.
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