New Approach Methods (NAMs) Training | US EPA

New Approach Methods (NAMs) Training | US EPA
Official websites use .gov
.gov
website belongs to an official government organization in the United States.
Secure .gov websites use HTTPS
lock
) or
means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.
New Approach Methods (NAMs) Training
NAMs Training Resources
New to NAMs?
Read background information on NAMs training resources.
Have questions?
Contact us.
New Training Materials
httK R Package Virtual Training
CompTox Chemicals Dashboard Virtual Training
ToxCast Continuing Education Course
Related Resources
EPA New Approach Methods
EPA Chemical Research
EPA Computational Toxicology and Exposure Online Resources
Access training resources from the table below. Filter by Topic, Sub-Topic, or Training Material type by using the dropdown filter. Use the search option to look for keywords or specific presenters/authors.
Year
Topic
Subtopic
Type
Title
Description
2025
Toxicokinetics and Dosimetry
httk
Video
httk R Package Training
Virtual training took place July 31, 2025. The presentation focused on the httk R software package and how it can be used to evaluate how effective a NAM is for predicting
in vivo
toxicity.
Presenter: John Wambaugh
2025
Toxicokinetics and Dosimetry
httk
Slide Deck
httk R Package Training (pdf)
(7.71 MB)
Virtual training took place July 31, 2025. The presentation focused on the httk R software package and how it can be used to evaluate how effective a NAM is for predicting
in vivo
toxicity.
Presenter: John Wambaugh
2025
CompTox Chemicals Dashboard
Dashboard
Video
Comptox Chemicals Dashboard Virtual Training
Virtual training took place June 12, 2025.
The presentation focused on an overview of the dashboard along with its risk evaluation components, navigation, and a case study.
Presenter: Nisha Sipes
2025
CompTox Chemicals Dashboard
Dashboard
Slide Deck
CompTox Chemicals Dashboard Virtual Training (pdf)
(10.51 MB)
Virtual training took place June 12, 2025.
The presentation focused on an overview of the dashboard along with its risk evaluation components, navigation, and a case study.
Presenter: Nisha Sipes
2025
Ecotoxicology
SeqAPASS
Video
SeqAPASS Virtual Training Recording
Virtual training took place on May 1, 2025. This training gave an overview of SeqAPASS functions offered a demonstration of the user-interface.
Presenters: Carlie LaLone and Peter Schumann
2025
Ecotoxicology
SeqAPASS
Slide Deck
SeqAPASS Virtual Training Slides 2025 (pdf)
(8.54 MB, 5/9/2025)
Virtual training took place on May 1, 2025. This training gave an overview of SeqAPASS functions offered a demonstration of the user-interface.
Presenters: Carlie LaLone and Peter Schumann
2025
Ecotoxicology
SeqAPASS
Worksheet
SeqAPASS Training Worksheet 2025 (pdf)
(200.58 KB, 5/9/2025)
Worksheet developed for the May 2025 virtual training session for SeqAPASS.
2025
Toxicity and Bioactivity
ToxCast
Video
ToxCast Continuing Education Course: Navigating Software and Database Updates to ToxCast
This is a comprehensive training on accessing ToxCast data, the open-source R packages associated with the ToxCast Pipeline, EPA’s CompTox and Exposure APIs, and supporting information pages and vignettes. Additionally, there are example use cases provided that demonstrate the various applications of ToxCast Tools.
2024
CompTox Chemicals Dashboard
Dashboard
Slide Deck
US EPA’s CompTox Chemicals Dashboard: Exploring the Chemical Data Landscape
Presentation to Personal Care Products Council in October 8th, 2024 in Arlington, VA.
2024
Ecotoxicology
ECOTOX
Tool Tips
ECOTOX Knowledgebase Tool Tips
Series of short videos to inform new users about the basic functionality of the ECOTOX Knowledgebase
2024
Exposure
ChemExpo
Tool Webpage
ChemExpo Knowledgebase
ChemExpo is a publicly available web-based data search and visualization tool for exposure-relevant data on chemical use in commerce.
2024
Ecotoxicology
Web-ICE
Tool Webpage
Web-ICE v4.0: Interspecies Correlation Estimation
The Web-based Interspecies Correlation Estimation (Web-ICE) application estimates acute toxicity to aquatic and terrestrial organisms for use in risk assessment.
2024
Ecotoxicology
Web-ICE
User Guide
Web-ICE v4.0: Interspecies Correlation Estimation User Manual
An online user guide for Web-ICE v4.0, provide an overview of the models, available data, and instructions for each using module.
2024
Chemistry
Chemical Transformation Simulator
Video
The Chemical Transformation Simulator
This Webinar, recorded June 27, 2024 provides an overview of the Chemical Transformation Simulator (CTS). The CCTS is a web-based tool for predicting transformation pathways and physicochemical properties of organic chemicals. CTS predictions can address data gaps associated with chemical registration and assessment, support alternative assessment activities for manufactured chemicals, and help identify transformation products detected during nontargeted analysis of environmental samples. Furthermore, CTS can be used as a parameterization tool for more complex exposure assessment models for environmental fate, transport, bioaccumulation, and dose estimation.
Presenter: Caroline Stevens
2024
Exposure
ChemExpo
User Guide
ChemExpo Knowledgebase User Guide
An online user guide for ChemExpo, provide an overview of the available data, functionality, use cases and FAQS.
2024
Exposure
ChemExpo
Poster
Development of the Public-Facing ChemExpo Knowledgebase Web Application to Support Delivery of Chemical Use and Consumer Product Data
Poster presentation given at Society of Toxicology 2023 Annual Meeting.
Presenter: Sakshi Handa
2024
Toxicity and Bioactivity
invitroDB
Slide Deck
Software and Database Enhancements to ToxCast for Accessible Bioactivity Data for Toxicology (pdf)
(3.12 MB)
Presenters: Madison Feshuk, Jason Brown, Sarah Davidson-Fritz , and Katie Paul Friedman for CompTox Communities of Practice webinar
Related: Database
2024
Toxicity and Bioactivity
invitroDB
Video
Software and Database Enhancements to ToxCast for Accessible Bioactivity Data for Toxicology
Presenters: Madison Feshuk, Jason Brown, Sarah Davidson-Fritz , and Katie Paul Friedman presenting on new updates to invitroDB and the ToxCast data pipeline (Length 47 minutes)
Related: Database
2024
Exposure
ChemExpo
Slide Deck
ChemExpo Knowledgebase NAMs Workshop (pdf)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Katherine Phillips, Sakshi Handa, Kristin Isaacs
2024
Ecotoxicology
SeqAPASS
Training/Resource Webpage
SeqAPASS V8 User Guide
A user guide for SeqAPASS,  a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species.
2024
Chemistry
Cheminformatics
Slide Deck
Cheminformatics Analysis Modules - NAMs Workshop (pdf)
(4 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams
2024
Ecotoxicology
ECOTOX
Slide Deck
ECOTOX Knowledgebase - NAMs Workshop (pdf)
(2.6 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Jennifer Olker
2024
Ecotoxicology
SeqAPASS
Slide Deck
SeqAPASS (pdf)
(10.94 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Carlie LaLone, Marissa Brickley
2024
Toxicokinetics and Dosimetry
Bioactivity:Exposure Ratio
Slide Deck
Bioactivity:Exposure Ratios and SEEM [Part 1] (pdf)
(5.27 MB, April 2024)
Bioactivity:Exposure Ratios and SEEM [Part 2] (pdf)
(3.14 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop. Using SEEM, predictors of exposure are combined according to calibrated weights reflecting estimates of their predictive ability based on monitoring data. This session will focus on a multi-tool case study for the use of SEEM, building on introductions to httk and ToxCast from previous sessions.
Presenters: Katie Paul Friedman and John Wambaugh
Related: ToxCast, SEEM3
2024
Exposure
SHEDS-HT
Slide Deck
SHEDS-HT - NAMs Workshop (pdf)
(4.48 MB, April 2024)
Stochastic Human Exposure and Dose Simulation Models. Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Kristin Isaacs
2024
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Slide Deck
Toxicity Estimation Software Tool (TEST) - NAMs Workshop (pdf)
(2.48 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop. TEST software can predict measures of toxicity from physical characteristics of the structure of the chemical, as it contains a compilation of QSAR models.
Presenters: Todd Martin
2024
Ecotoxicology
ToxCast
Slide Deck
ToxCast / SeqAPASS / ECOTOX Case Study - NAMs Workshop (pdf)
(10.2 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Madison Feshuk, Carlie LaLone, Marissa Brickley, Jennifer Olker
2024
CompTox Chemicals Dashboard
Hazard
Slide Deck
CompTox Chemicals Dashboard & Hazard Data (pdf)
(2.3 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Nisha Sipes, Risa Sayre, and Madison Feshuk
Related: ToxRefDB, ToxValDB, Database
2024
CompTox Chemicals Dashboard
DSSTox
Slide Deck
DSSTox Database - NAMs Workshop (pdf)
(3.91 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams and Charles Lowe
Related: Chemistry
2024
Ecotoxicology
SeqAPASS
Slide Deck
Introduction to SeqAPASS (pdf)
(2.14 MB, July 2024
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Carlie LaLone
2024
Ecotoxicology
SeqAPASS
Video
Introduction to SeqAPASS
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Carlie LaLone
2024
Ecotoxicology
ECOTOX
Slide Deck
Introduction to ECOTOX Knowledgebase (pdf)
(1.53 MB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Jennifer Olker
2024
Ecotoxicology
ECOTOX
Video
Introduction to ECOTOX Knowledgebase
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Jennifer Olker
2024
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Slide Deck
Introduction to the Toxicity Estimation Software Tool (TEST) (pdf)
(639.49 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Todd Martin
2024
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Video
Toxicity Estimation Software Tool (TEST) - NAMs Workshop
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Todd Martin
2024
Chemistry
Cheminformatics
Slide Deck
Introduction to Cheminformatics Analysis Modules (pdf)
(821.24 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams
2024
Chemistry
Cheminformatics
Video
Introduction to Cheminformatics Analysis Modules
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams
2024
Exposure
ChemExpo
Slide Deck
Introduction to ChemExpo Knowledgebase (pdf)
(957.79 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Kristin Isaacs
2024
Exposure
ChemExpo
Video
Introduction to ChemExpo Knowledgebase
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Kristin Isaacs
2024
Adverse Outcome Pathways
AOP-Wiki
Slide Deck
Introduction to the AOP-Wiki (pdf)
(2.38 MB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Steve Edwards
2024
Adverse Outcome Pathways
AOP-Wiki
Video
Introduction to the AOP-Wiki
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Steve Edwards
2024
Adverse Outcome Pathways
AOP-Wiki
Video
AOP-Wiki Virtual Training Recording
Virtual training took place on September 18, 2024. This training gave an overview of AOP-Wiki functions offered a demonstration of the user-interface.
Presenter: Dan Villeneuve
2024
Adverse Outcome Pathways
AOP-Wiki
Worksheet
AOP-Wiki Training Worksheet (pdf)
(282.66 KB, September 2024)
Worksheet developed for the September 2024 virtual training session for AOP-Wiki.
2024
CompTox Chemicals Dashboard
Dashboard
Video
Introduction to the CompTox Chemicals Dashboard
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Nisha Sipes
2024
CompTox Chemicals Dashboard
GenRA
Video
Introduction to the Generalized Read Across (GenRA)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Dr. Esra Mutlu
2024
Toxicokinetics and Dosimetry
httk
Video
Introduction to the High-Throughput Toxicokinetics (httk) R Package
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: John Wambaugh
2023
Adverse Outcome Pathways
AOP-Wiki
Slide Deck
Combining new approach methodologies and adverse outcome pathways for ecological risk-based screening and prioritization (pdf)
(9.82 MB)
Presenter: Dan Villeneuve. Slide deck for CompTox Communities of Practice webinar
Related: Ecotoxicity
2023
Adverse Outcome Pathways
AOP-Wiki
Video
Combining NAMs and adverse outcome pathways for ecological risk-based screening and prioritization
Presenter: Dan Villeneuve presenting on research applying NAMs to adverse outcome pathways (Length 63 minutes)
Related: Ecotoxicity
2023
Exposure
ChemExpo
Video
Chemical Exposure Knowledgebase (ChemExpo)
Presenters: Katherine Phillips and Sakshi Handa providing a demo of the Chemical Exposure Knowledgebase. (Length 44 minutes)
2023
Non-Targeted Analysis
NTA
Video
Introduction to Non-Targeted Analysis
5-minute video giving an introduction to Non-Targeted Analysis research at EPA.
2023
Non-Targeted Analysis
NTA
Video
Assessing Performance of Non-targeted Analysis (NTA) Methods video
4-minute instructional video summarizing existing performance assessment metrics for targeted analyses to provide context and clarify terminology that may be shared between targeted and NTA methods (e.g., terms such as accuracy, precision, sensitivity, and selectivity).
2023
Non-Targeted Analysis
NTA
Video
NTA Study Reporting Tool (SRT) Instructional Video
3-minute instructional video about how and why to use the Study Reporting Tool (SRT). This video covers: How to download the SRT; Use the SRT for peer review; Added functionality available for editors (auto-plot function)
2023
Non-Targeted Analysis
NTA
Video
Advanced Techniques for Identifying Novel Contaminants in Drinking Water using Non-Targeted Analysis
Presenter: John Sloop providing an overview of ongoing collaborative efforts to use non-targeted analysis to sample drinking water.(Length 56 minutes)
2023
CompTox Chemicals Dashboard
Dashboard
Video
CompTox Chemicals Dashboard V2.2 and Data Availability Using APIs
Presenters: Nisha Sipes and Asif Rashid providing an overview of new features in version 2.2 of the CompTox Chemicals Dashboard and how users can access it through API's. (Length 58 minutes)
2023
Chemistry
Cheminformatics
Video
Using Cheminformatics Approaches to Develop a Structure Searchable Database of Analytical Methods
Presenter: Antony Williams providing an overview of efforts to create a structure searchable database of analytical methods. (Length 57 minutes)
Related: Dashboard, Database
2023
Toxicity and Bioactivity
ToxRefDB
Video
Toxicity Reference Database (ToxRefDB): Curating Legacy
in Vivo
Toxicity Data for the Future
Presenter: Madison Feshuk providing an overview of the Toxicity Reference Database, which is a curated source of toxicity data from live organisms. (Length 54 minutes)
Related: Database
2019
CompTox Chemicals Dashboard
invitroDB
Slide Deck
CompTox Chemicals Dashboard and InVitroDB V3.1 (pdf)
(3.03 MB, 3/28/2019)
Presenter: Antony Williams
2023
CompTox Chemicals Dashboard
GenRA
Video
GenRA Case Study: Data Poor Chemical Example
This video is a demonstration of using GenRA for read-across of a data-poor chemical.
2019
CompTox Chemicals Dashboard
invitroDB
Video
CompTox Chemicals Dashboard and InVitroDB V3 - YouTube
Presenter: Antony Williams
2020
CompTox Chemicals Dashboard
Dashboard
Slide Deck
Where are we now? Celebrating the 10th Incremental Release of the CompTox Chemicals Dashboard
Presenter: Antony Williams
2022
Toxicokinetics and Dosimetry
ToxCast
Video
Computational Biology and Predictive Toxicology of Neurovascular Morphogenesis
Presenter: Thomas Knudsen
2022
CompTox Chemicals Dashboard
NTA
Poster
Targeted Lists of Chemicals to Support Non-Targeted Analysis via the US-EPA CompTox Chemicals Dashboard
Presenter: Antony Williams
2020
CompTox Chemicals Dashboard
Dashboard
Video
Where are we now? Celebrating the 10th Incremental Release of the CompTox Chemicals Dashboard
Presenter: Antony Williams
2021
Ecotoxicology
ECOTOX
Slide Deck
EPA Tools & Resources Training Webinar: ECOTOX Knowledgebase
Presenter: Jennifer Olker; Colleen Elonen
2021
Ecotoxicology
ECOTOX
Video
ECOTOXicology Knowledgebase Training - YouTube
Presenter: Jennifer Olker; Colleen Elonen
2021
Chemistry
NTA
Slide Deck
Computational Toxicology and Exposure Communities of Practice: Semi-Quantitative Non-Targeted Analysis as a Rapid Risk Prioritization Tool: A Proof of Concept Using Activated Carbon Drinking Water Filter slides (pdf)
(4.97 MB)
Presenter: Louis Groff
Related: TSCA proof of concept
2023
Ecotoxicology
SeqAPASS
Video
SeqAPASS Version 7
Presenter: Carlie LaLone giving an overview of new features in SeqAPASS Version 7. (Length 59 minutes)
2024
Ecotoxicology
SeqAPASS
Training/Resource Webpage
SeqAPASS V8 User Guide
A user guide for SeqAPASS,  a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species.
2020
Ecotoxicology
SeqAPASS
Slide Deck
SeqAPASS version 5.0: An emphasis on rapid data synthesis and interpretation slides (pdf)
(5.39 MB)
Presenter: Carlie LaLone
2020
Ecotoxicology
SeqAPASS
Video
SeqAPASS version 5.0: An emphasis on rapid data synthesis and interpretation - YouTube
Presenter: Carlie LaLone
2020
Ecotoxicology
SeqAPASS
Video
The Evolution of the Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS) Tool - YouTube
Presenter: Carlie LaLone
2020
Ecotoxicology
SeqAPASS
Slide Deck
The Evolution of the Sequence Alignment to Predict Across Species Susceptibility Tool slides (pdf)
(8.15 MB)
Presenter: Carlie LaLone
2021
Exposure
SEEM3
Slide Deck
High Throughput Exposure Models and the Systematic Empirical Evaluation of Models (SEEM) Framework
Presenter: John Wambaugh
2019
Exposure
NTA
Slide Deck
EPA’s Non-Targeted Analysis Research Program: Building Tools to Enable Rapid Exposure Surveillance
Presenter: Jon Sobus
2019
Toxicity and Bioactivity
ToxVal
Video
ToxValDB: A comprehensive database of quantitative in vivo study results from over 25,000 chemicals - YouTube
Presenter: Richard Judson
Related: Database
2018
Toxicity and Bioactivity
ToxVal
Slide Deck
ToxValDB: A comprehensive database of quantitative in vivo study results from over 25,000 chemicals (pdf)
(2.63 MB, 12/20/2018)
Presenter: Richard Judson
Related: Database
2018
Exposure
Expocast
Slide Deck
EPA's Rapid Exposure and Dosimetry (RED) Project
Presenter: John Wambaugh
Related: Toxicokinetics and Dosimetry, Httk, NTA, CPDAT
2022
Exposure
SEEM3
Training/Resource Webpage
Systematic Empirical Evaluation of Models (SEEM) User Guide
A webpage describing the function of the Systematic Empirical Evaluation Models (SEEM) R package.
2019
Exposure
SEEM3
Slide Deck
The Systematic Empirical Evaluation of Models (SEEM) framework (pdf)
(3.88 MB, 2/28/2019)
Presenter: John Wambaugh
2019
Exposure
SEEM3
Video
The Systematic Empirical Evaluation of Models (SEEM) framework - YouTube
Presenter: John Wambaugh
2019
Chemical Safety Proof of Concept (POC) Workflows
Bioactivity:Exposure Ratio
Slide Deck
Accelerating the Pace of Chemical Risk Assessment (APCRA) Through International Collaborative Case Studies slides (pdf)
(5.08 MB)
Presenter: Maureen Gwinn
2019
Chemical Safety Proof of Concept (POC) Workflows
Bioactivity:Exposure Ratio
Video
Accelerating the Pace of Chemical Risk Assessment Through International Collaborative Case Studies - YouTube
Presenter: Maureen Gwinn
2018
Chemical Safety Proof of Concept (POC) Workflows
Bioactivity:Exposure Ratio
Slide Deck
Bioactivity Exposure Ratio (BER) Analysis Using High Throughput Transcriptomics (HTTr) Chemical Screening Data
Presenter: Joshua Harrill
2018
Chemistry
GenRA
Slide Deck
Generalized Read-Across (GenRA) (pdf)
(2.41 MB)
Presenter: Grace Patlewicz
2018
Chemistry
GenRA
Video
Generalized Read-Across (GenRA) - YouTube
Presenter: Grace Patlewicz
2020
CompTox Chemicals Dashboard
Dashboard
Slide Deck
Introduction to the US EPA CompTox Chemicals Dashboard (figshare.com)
Presenter: Antony Williams
2020
CompTox Chemicals Dashboard
Dashboard
Slide Deck
Introduction to the US EPA CompTox Chemicals Dashboard (figshare.com)
Presenter: Antony Williams
2021
CompTox Chemicals Dashboard
ToxCast
Training/Resource Webpage
ToxCast Owner's Manual
A user guide for ToxCast, a Toxicity Forecaster that uses automated chemical screening technologies called high-throughput screening assays to expose living cells, isolated proteins, or other biological molecules to chemicals to generate data and predictive models.
Related: Toxicity
2020
CompTox Chemicals Dashboard
ToxCast
Slide Deck
Overview of the CompTox Chemicals Dashboard and ToxCast/Tox21 Screening Program: Tools for Users (figshare.com)
Presenter: Katie Paul Friedman
Related: Toxicity
2020
CompTox Chemicals Dashboard
ToxCast
Slide Deck
Overview of the CompTox Chemicals Dashboard and ToxCast/Tox21 Screening Program: Tools for Users (figshare.com)
Presenter: Katie Paul Friedman
Related: Toxicity
2022
Toxicokinetics and Dosimetry
Httk
Training/Resource Webpage
Httk Package Reference Manual (v.2.1.0)
This is a reference manual for Httk, a freely available, open-source R package that allows for forward and reverse dosimetry and other statistical analyses of chemicals.
2020
Toxicokinetics and Dosimetry
Httk
Slide Deck
High Throughput Toxicokinetic Modeling (figshare.com)
Presenter: John Wambaugh
2020
Toxicokinetics and Dosimetry
Httk
Video
High Throughput Toxicokinetic Modeling (video)
Presenter: John Wambaugh
2022
CompTox Chemicals Dashboard
CPDat
Training/Resource Webpage
Chemicals and Products Database (CPDat)
CPDat (Chemical and Products Database) is a database containing information mapping more than 49,000 chemicals to a set of terms categorizing their usage or function in 16,000 consumer products (e.g. shampoo, soap) types based on what chemicals they contain.
2020
Exposure
CPDat
Slide Deck
Data and Models from the ExpoCast Project for Informing Chemical Assessment (figshare.com)
Presenter: Kristin Isaacs
2020
Exposure
CPDat
Slide Deck
Data and Models from the ExpoCast Project for Informing Chemical Assessment (figshare.com)
Presenter: Kristin Isaacs
2019
CompTox Chemicals Dashboard
GenRA
Video
CompTox Chemicals Dashboard Primer: Generalized Read Across (GenRA)
Presenter: Grace Patlewicz
2021
Exposure
NTA
Slide Deck
NAMS for Exposure: Non Targeted Analysis
Presenter: Jon Sobus
2020
Chemistry
phys-chem properties (OPERA models)
Slide Deck
OPERA: A QSAR tool for physicochemical properties and environmental fate predictions (figshare.com)
Presenter: Antony Williams
2017
CompTox Chemicals Dashboard
phys-chem properties (OPERA models)
Slide Deck
Real-time prediction of Physicochemical and Toxicological Endpoints Using the Web-based CompTox Chemistry Dashboard (figshare.com)
Presenter: Antony Williams
2021
CompTox Chemicals Dashboard
Dashboard
Slide Deck
An Introduction (and Demo) of the CompTox Chemicals Dashboard (figshare.com)
Presenter: Antony Williams
Related: GenRA, ToxCast
2021
CompTox Chemicals Dashboard
Dashboard
Slide Deck
Web-based access to data for >600 disinfection by-products via the EPA CompTox Chemicals Dashboard (figshare.com)
Presenter: Antony Williams
2021
CompTox Chemicals Dashboard
Dashboard
Video
Web-based access to data for >600 disinfection by-products via the EPA CompTox Chemicals Dashboard
Presenter: Antony Williams
2022
CompTox Chemicals Dashboard
Dashboard
Training/Resource Webpage
CompTox Chemicals Dashboard Help
The CompTox Chemicals Dashboard provides information regarding chemical compounds and substances of potential interest to environmental scientists. This webpage contains a detailed user guide to the CompTox Chemicals Dashboard.
2019
CompTox Chemicals Dashboard
Dashboard
Overview Training
CompTox Chemicals Dashboard Primer Videos
Explore the wealth of data and features available in the CompTox Chemicals Dashboard with these instructional videos narrated by EPA scientists – recorded in 2019.
2021
CompTox Chemicals Dashboard
ToxCast
Slide Deck
An Update on the ToxCast Data Pipeline: Features for Dataset Development (figshare.com)
Presenter: Katie Paul Friedman
Related: Toxicity
2022
CompTox Chemicals Dashboard
invitroDB
Slide Deck
State of the Science: ToxCast and Tox21 assays and approaches to screening for potential thyroid hormone disruption
Presenter: Katie Paul Friedman
Related: Database
2022
Databases Relevant to Toxicity and Bioactivity
ToxRefDB
Training/Resource Webpage
Toxicity Reference Database (ToxRefDB) User Guide
The ToxRefDB user guide provides information about the database development, database contents, data dictionary for all tables and fields, and sample queries to extract information from the MySQL database.
Related: Database
2021
Databases Relevant to Toxicity and Bioactivity
ToxRefDB
Slide Deck
ToxRefDB v2.0: Building an enhanced resource for predictive applications and beyond
Presenter: Katie Paul Friedman
Related: Database
2020
Databases Relevant to Toxicity and Bioactivity
ToxRefDB
Slide Deck
Quantitative variability in repeat dose toxicity studies: Implications for scientific confidence in NAMs (figshare.com)
Presenter: Katie Paul Friedman
Related: Database
2021
Toxicokinetics and Dosimetry
Bioactivity:Exposure Ratio
Slide Deck
In vitro to in vivo extrapolation for decision-making (figshare.com)
Presenter: Katie Paul Friedman
Related: Httk
2018
Exposure
ENTACT
Video
EPA's Non-Targeted Analysis Collaborative Trial (ENTACT)
Presenter: Elin Ulrich
Related: NTA, Non-Targeted Analysis
2022
CompTox Chemicals Dashboard
GenRA
Tool Webpage
GenRA
GenRA is an algorithmic automated approach to make reproducible read-across predictions of toxicity.
2021
Toxicity and Bioactivity
ToxVal
Training/Resource Webpage
Chemicals Dashboard Help: Toxicity Values (ToxVal)
A user guide for The Toxicity Values tab, which provides Toxicity Value data that have been assembled from a number of EPA agency resources as well as many other public sources.
Related: Database
2021
Toxicokinetics and Dosimetry
Httk
Slide Deck
Toxicokinetic New Approach Methodologies (NAMs) (pdf)
(12.16 MB, October 2021)
This presentation was given as a continuing education course at the Society of Environmental Toxicology and Chemistry (SETAC) North America conference in October 2021. This course contained four parts:
In vitro measurement of key determinants of toxicokinetics (Barbara A. Wetmore, PhD)
Generic TK models: Parameterization and Evaluation (John Wambaugh, PhD)
Monte Carlo for variability simulation and uncertainty (Caroline L. Ring, PhD)
In vitro to in vivo extrapolation for decision-making (Kathie Paul Friedman, PhD)
2018
Toxicity and Bioactivity
ToxVal
Tool Webpage
ToxVal
The Toxicity Values database is delivered via the Hazard Tab in the CompTox Chemicals Dashboard.
Related: Database
2022
Toxicity and Bioactivity
ToxRefDB
Tool Webpage
ToxRefDB
The Toxicity Reference Database (ToxRefDB) contains in vivo study data from over 5900 guideline or guideline-like studies. ToxRefDB allows scientists and the interested public to access thousands of curated animal toxicity testing results, which is a great resource for many retrospective and predictive toxicology applications.
Related: Database
2020
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Training/Resource Webpage
Toxicity Estimation Software Tool (TEST) User Guide
A user guide for TEST, a Java application to estimate toxicities and physical properties from molecular structure.
2021
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Tool Webpage
Toxicity Estimation Software Tool (TEST)
TEST software can predict measures of toxicity from physical characteristics of the structure of the chemical, as it contains a compilation of QSAR models.
2022
Ecotoxicology
SeqAPASS
Tool Webpage
Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS)
SeqAPASS is a fast, online screening tool that allows researchers and regulators to extrapolate toxicity information across species. SeqAPASS extrapolates from data rich model organisms to thousands of other non-target species to evaluate their specific potential chemical susceptibility.
2020
Exposure
SEEM3
Tool Webpage
SEEM3
For SEEM3 chemical structure and physicochemical properties were used to predict the probability that a chemical might be associated with any of four exposure pathways leading from sources–consumer (near-field), dietary, far-field industrial, and far-field pesticide–to the general population.
2018
CompTox Chemicals Dashboard
phys-chem properties (OPERA models)
Training/Resource Webpage
phys-chem properties (OPERA models) Reference Manual
A user reference manual for OPERA, a free and open-source/open-data suite of QSAR models providing predictions on physicochemical properties, environmental fate, and toxicity endpoints as well as information such as applicability domain and accuracy assessment.
2022
CompTox Chemicals Dashboard
phys-chem properties (OPERA models)
Tool Webpage
phys-chem properties (OPERA models)
OPERA is a free and open-source/open-data suite of QSAR models providing predictions on physicochemical properties, environmental fate, and toxicity endpoints as well as information such as applicability domain and accuracy assessment.
2020
CompTox Chemicals Dashboard
invitroDB
Training/Resource Webpage
invitroDB v.3 Reference Manual
System requirements, description of the contents of the July 2020 ToxCast data release and installation guidance for invtroDB v.3.
Related: Database
2019
CompTox Chemicals Dashboard
invitroDB
Tool Webpage
invitroDB
EPA's Toxicity Forecaster (ToxCast) generates data and predictive models on thousands of chemicals of interest to the EPA. ToxCast uses high-throughput screening methods and computational toxicology approaches to rank and prioritize chemicals.
Related: Database
2022
Toxicokinetics and Dosimetry
Httk
Tool Webpage
Httk
Httk is a freely available, open-source R package that allows for forward and reverse dosimetry and other statistical analyses of chemicals.
2022
CompTox Chemicals Dashboard
Dashboard
Tool Webpage
CompTox Chemicals Dashboard
The Dashboard contains chemistry, toxicity and exposure information for over 1,200,000 chemicals, with over 300 chemical lists based on structure or category.
2018
Exposure
ENTACT
Slide Deck
Genesis and Study Design for EPA’s Non-Targeted Analysis Collaborative Trial (ENTACT) (pdf)
(2.27 MB)
Presenter: Elin Ulrich
Related: Non-Targeted Analysis (NTA)
2022
Ecotoxicology
ECOTOX
Tool Webpage
ECOTOXicology Knowledgebase (ECOTOX)
ECOTOX is a source for locating single chemical toxicity data for aquatic life, terrestrial plants, and wildlife.
2022
Ecotoxicology
ECOTOX
Slide Deck
ECOTOXicology Knowledgebase Training
Presenter: Jennifer Olker
2021
Ecotoxicology
ECOTOX
Training/Resource Webpage
ECOTOXicology Knowledgebase System User Guide
Prepared by: Colleen Elonen; Jennifer Olker
2022
Ecotoxicology
ECOTOX
Video
ECOTOXicology Knowledgebase Training
Presenter: Jennifer Olker
2022
CompTox Chemicals Dashboard
GenRA
Training/Resource Webpage
Generalized Read-Across (GenRA) User Guide
A user guide for GenRA, an algorithmic automated approach to make reproducible read-across predictions of toxicity.
2022
Non-Targeted Analysis
NTA
Video
NTA Study Reporting Tool (SRT) Informational Video
This 3-minute video provides an overview of why the Study Reporting Tool (SRT) was developed by BP4NTA, a description of the SRT itself, its scoring system, and associated reference content
2022
Non-Targeted Analysis
NTA
Video
The use of non-targeted analysis for rapid and emergency response: Demonstration through mock scenarios
Presenter: Dr. John Sloop
2022
Toxicokinetics and Dosimetry
TSCA proof of concept
Video
NAMs for Estrogenicity and Application of DNT NAMs by US EPA
Drs. Richard Judson and Tim Shafer
2022
Chemistry
phys-chem properties (OPERA models)
Video
Optimizing QSA/PR Model Interpretability, Stability & Performance
Dr. Nathaniel Charest
2022
CompTox Chemicals Dashboard
GenRA
Slide Deck
Primer on New Versions of CompTox Chemicals Dashboard and Generalized Read-Across (GenRA)
This presentation took place February 23rd, 2022.
Presenter: Grace Patlewicz; Antony Williams
2022
Ecotoxicology
ECOTOX
Worksheet
ECOTOX Worksheets
This page houses worksheets developed for training sessions of the ECOTOX Knowledgebase.
2022
CompTox Chemicals Dashboard
Dashboard
Worksheet
CompTox Chemicals Dashboard Worksheets
This page houses worksheets developed for training sessions of the CompTox Chemicals Dashboard.
2022
CompTox Chemicals Dashboard
Dashboard
Slide Deck
CompTox Chemicals Dashboard Training (pdf)
(8.51 MB)
Virtual training took place on October 18th, 2022.
Presenter: Nisha Sipes
2022
CompTox Chemicals Dashboard
Dashboard
Video
CompTox Chemicals Dashboard Training Recording 10/18/2022
Virtual training took place on October 18th, 2022. This training gave an overview of Dashboard functions and highlighted new features from the 2022 update.
Presenter: Nisha Sipes
2023
CompTox Chemicals Dashboard
Dashboard
Tool Tips
CompTox Chemicals Dashboard Tool Tips
Series of helpful videos produced to offer a dynamic user guide for various EPA tools.
2023
Ecotoxicology
ECOTOX
Worksheet
ECOTOX Encore Worksheets
Worksheets developed for the February 2023 virtual training session for the ECOTOX Knowledgebase.
2023
Ecotoxicology
ECOTOX
Video
ECOTOX Knowledgebase Encore Virtual Training
Virtual training took place on February 7, 2023.
Presenter: Bridget Kushiyama (ICF)
2023
CompTox Chemicals Dashboard
Dashboard
Slide Deck
Supporting Chemical Evaluations Using Transparent and Accessible Data
Presentation for Society of Toxicology 2023 Annual Meeting Continuing Education Course: Tools Supporting Open Chemical Evaluations on March 19, 2023
Presenter: Nisha Sipes
Related: GenRA, Toxicity Estimation Software Tool (TEST)
2023
CompTox Chemicals Dashboard
GenRA
Video
GenRA Virtual Training Recording
Virtual training took place on May 23, 2023. This training gave an overview of GenRA functions and a walkthrough of available data in the GenRA tool.
Presenters: Dr. Esra Mutlu & Dr. Grace Patlewicz
2023
CompTox Chemicals Dashboard
GenRA
Slide Deck
GenRA Virtual Training Slides (pdf)
(5.28 MB, May 23, 2023)
Virtual training took place on May 23, 2023. This training gave an overview of GenRA functions and a walkthrough of available data in the GenRA tool.
Presenters: Dr. Esra Mutlu & Dr. Grace Patlewicz
2023
CompTox Chemicals Dashboard
GenRA
Worksheet
GenRA Worksheets
Worksheet developed for the May 2023 virtual training session for GenRA. Case study for data poor chemical.
2023
Toxicokinetics and Dosimetry
Httk
Video
Day 1 Recording
Day 2 Recording
This training included an application-oriented presentation and demonstration (Day 1), as well as opportunities for participatory learning and engagement (Day 2).
2023
Toxicokinetics and Dosimetry
Httk
Video
httk Virtual Training Slides (pdf)
(2.99 MB)
This training included an application-oriented presentation and demonstration (Day 1), as well as opportunities for participatory learning and engagement (Day 2). These slides were presented on Day 1, November 8th by Drs. Marina Evans and Celia Schacht.
2023
Toxicokinetics and Dosimetry
Httk
Worksheet
httk Virtual Training Worksheets
Worksheets developed for the November 2023 virtual training session for httk R Package.
2024
CompTox Chemicals Dashboard
Bioactivity
Slide Deck
CompTox Chemicals Dashboard & Bioactivity Data (pdf)
(4.98 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop. This presentation covers High Throughput Transcriptomics, High Throughput Phenotypic Profiling, and ToxCast.
Presenters: Logan Everett and Madison Feshuk
Related: Database, HTPP
2024
Adverse Outcome Pathways
AOP-Wiki
Slide Deck
Navigating the AOP-Wiki (pdf)
(1.21 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenter: Dan Villeneuve
2024
Exposure
ChemExpo
Slide Deck
ChemExpo Knowledgebase NAMs Workshop (pdf)
(5.94 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Katherine Phillips, Sakshi Handa, Kristin Isaacs
2024
Chemistry
Cheminformatics
Slide Deck
Cheminformatics Analysis Modules - NAMs Workshop (pdf)
(4 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams
2024
Ecotoxicology
ECOTOX
Slide Deck
ECOTOX Knowledgebase - NAMs Workshop (pdf)
(2.6 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Jennifer Olker
2024
Ecotoxicology
SeqAPASS
Slide Deck
SeqAPASS (pdf)
(10.94 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Carlie LaLone, Marissa Brickley
2024
Toxicokinetics and Dosimetry
Bioactivity:Exposure Ratio
Slide Deck
Bioactivity:Exposure Ratios and SEEM [Part 1] (pdf)
(5.27 MB, April 2024)
Bioactivity:Exposure Ratios and SEEM [Part 2] (pdf)
(3.14 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop. Using SEEM, predictors of exposure are combined according to calibrated weights reflecting estimates of their predictive ability based on monitoring data. This session will focus on a multi-tool case study for the use of SEEM, building on introductions to httk and ToxCast from previous sessions.
Presenters: Katie Paul Friedman and John Wambaugh
Related: ToxCast, SEEM3
2024
Exposure
SHEDS-HT
Slide Deck
SHEDS-HT - NAMs Workshop (pdf)
(4.48 MB, April 2024)
Stochastic Human Exposure and Dose Simulation Models. Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Kristin Isaacs
2024
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Slide Deck
Toxicity Estimation Software Tool (TEST) - NAMs Workshop (pdf)
(2.48 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop. TEST software can predict measures of toxicity from physical characteristics of the structure of the chemical, as it contains a compilation of QSAR models.
Presenters: Todd Martin
2024
Ecotoxicology
ToxCast
Slide Deck
ToxCast / SeqAPASS / ECOTOX Case Study - NAMs Workshop (pdf)
(10.2 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Madison Feshuk, Carlie LaLone, Marissa Brickley, Jennifer Olker
2024
CompTox Chemicals Dashboard
Hazard
Slide Deck
CompTox Chemicals Dashboard & Hazard Data (pdf)
(2.3 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Nisha Sipes, Risa Sayre, and Madison Feshuk
Related: ToxRefDB, ToxValDB, Database
2024
CompTox Chemicals Dashboard
DSSTox
Slide Deck
DSSTox Database - NAMs Workshop (pdf)
(3.91 MB, April 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams and Charles Lowe
Related: Chemistry
2024
Ecotoxicology
SeqAPASS
Slide Deck
Introduction to SeqAPASS (pdf)
(2.14 MB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Carlie LaLone
2024
Ecotoxicology
ECOTOX
Slide Deck
Introduction to ECOTOX Knowledgebase (pdf)
(1.53 MB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Jennifer Olker
2024
CompTox Chemicals Dashboard
Toxicity Estimation Software Tool (TEST)
Slide Deck
Introduction to the Toxicity Estimation Software Tool (TEST) (pdf)
(639.49 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Todd Martin
2024
Chemistry
Cheminformatics
Slide Deck
Introduction to Cheminformatics Analysis Modules (pdf)
(821.24 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Tony Williams
2024
Exposure
ChemExpo
Slide Deck
Introduction to ChemExpo Knowledgebase (pdf)
(957.79 KB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Kristin Isaacs
2024
Adverse Outcome Pathways
AOP-Wiki
Slide Deck
Introduction to the AOP-Wiki (pdf)
(2.38 MB, July 2024)
Part of the April 2024 NAMs Tools Training Workshop.
Presenters: Steve Edwards
2024
Adverse Outcome Pathways
AOP-Wiki
Video
AOP-Wiki Virtual Training Recording
Virtual training took place on September 18, 2024. This training gave an overview of AOP-Wiki functions offered a demonstration of the user-interface.
Presenter: Dan Villeneuve
2024
Adverse Outcome Pathways
AOP-Wiki
Worksheet
AOP-Wiki Training Worksheet (pdf)
(282.66 KB, September 2024)
Worksheet developed for the September 2024 virtual training session for AOP-Wiki.
Contact Us About Chemical Safety Research
to ask a question, provide feedback, or report a problem.