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Multiplexed smFISH Reveals the Spatial Organization of Neuropil Localized mRNAs Is Linked to Abundance. eNeuro. 2025 Dec; 12(12). Tarannum R, Mun G, Quddos F, Swanger SA, Steward O, Farris S. PMID: 41271436; PMCID: PMC12700706.
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Aging Accelerates Degradation of Human Neuromuscular Junction Following Peripheral Nerve Injury. Muscle Nerve. 2025 Nov; 72(5):1161-1167. Gonzales LP, Chen VY, Tedesco A, Andalib S, Lee C, Wright DJ, Johnston TR, Mozaffar T, Steward O, Gupta R. PMID: 41097942.
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Multiplexed smFISH reveals the spatial organization of neuropil localized mRNAs is linked to abundance. bioRxiv. 2025 May 05. Tarannum R, Mun G, Quddos F, Swanger SA, Steward O, Farris S. PMID: 39071419; PMCID: PMC11275876.
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Novel Approaches to Track Neurodegeneration in Murine Models of Alzheimer's Disease Reveal Previously Unknown Aspects of Extracellular Aggregate Deposition. bioRxiv. 2025 Apr 05. Gallardo D, Steward O. PMID: 40236040; PMCID: PMC11996464.
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A modular platform for bioluminescent RNA tracking. Nat Commun. 2024 11 18; 15(1):9992. Halbers LP, Cole KH, Ng KK, Fuller EB, Chan CET, Callicoatte C, Metcalfe M, Chen CC, Barhoosh AA, Reid-McLaughlin E, Kent AD, Torrey ZR, Steward O, Lupták A, Prescher JA. PMID: 39557883; PMCID: PMC11574019.
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PTEN deletion in the adult dentate gyrus induces epilepsy. Neurobiol Dis. 2024 12; 203:106736. Yonan JM, Chen KD, Baram TZ, Steward O. PMID: 39547478; PMCID: PMC11756830.
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Spontaneously regenerative corticospinal neurons in mice. bioRxiv. 2024 Sep 12. Fait BW, Cotto B, Murakami TC, Hagemann-Jensen M, Zhan H, Freivald C, Turbek I, Gao Y, Yao Z, Way SW, Zeng H, Tasic B, Steward O, Heintz N, Schmidt EF. PMID: 39314356; PMCID: PMC11419066.
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PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY. bioRxiv. 2024 Aug 09. Yonan JM, Chen KD, Baram TZ, Steward O. PMID: 39149280; PMCID: PMC11326251.
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Human Motor Endplate Survival after Chronic Peripheral Nerve Injury. medRxiv. 2023 Oct 14. Gupta R, Johnston TR, Chen VY, Gonzales LP, Steward O. PMID: 37873401; PMCID: PMC10592993.
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PTEN deletion in spinal pathways via retrograde transduction with AAV-RG enhances forelimb motor recovery after cervical spinal cord injury; Sex differences and late-onset pathophysiologies. Exp Neurol. 2023 12; 370:114551. Metcalfe M, Steward O. PMID: 37778650.
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Synergistic effect of chemogenetic activation of corticospinal motoneurons and physical exercise in promoting functional recovery after spinal cord injury. Exp Neurol. 2023 12; 370:114549. Lin X, Wang X, Zhang Y, Chu G, Liang J, Zhang B, Lu Y, Steward O, Luo J. PMID: 37774765.
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PTEN deletion in spinal pathways via retrograde transduction with AAV-rg enhances forelimb motor recovery after cervical spinal cord injury; sex differences and late-onset pathophysiologies. bioRxiv. 2023 Jul 24. Metcalfe M, Steward O. PMID: 36993317; PMCID: PMC10055283.
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Vector-mediated PTEN deletion in the adult dentate gyrus initiates new growth of granule cell bodies and dendrites and expansion of mossy fiber terminal fields that continues for months. Neurobiol Dis. 2023 08; 184:106190. Yonan JM, Steward O. PMID: 37290578.
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Preoperative Muscle Biopsy to Assess Motor End Plate Integrity as a Predictor for Successful Nerve Transfer: A Case Report. JBJS Case Connect. 2023 Jan 01; 13(1). Chen VY, Gonzales LP, Johnston TR, Steward O, Gupta R. PMID: 36795913.
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Tribute to the Outgoing Editor-in-Chief. J Neurosci. 2022 12 14; 42(50):9296-9297. Everitt B, Turrigiano G, Steward O. PMID: 36517249; PMCID: PMC9794364.
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Gene modification after spinal cord injury: Mechanisms and therapeutics. Exp Neurol. 2022 10; 356:114156. Smith GM, Steward O, Bradbury EJ. PMID: 35792382; PMCID: PMC9749756.
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Harnessing rAAV-retro for gene manipulations in multiple pathways that are interrupted after spinal cord injury. Exp Neurol. 2022 04; 350:113965. Metcalfe M, Yee KM, Luo J, Martin-Thompson JH, Gandhi SP, Steward O. PMID: 34973965; PMCID: PMC9055973.
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AAV vectors accumulate in the pineal gland after injections into the brain or spinal cord. Mol Ther Methods Clin Dev. 2021 Dec 10; 23:406-417. Steward O, Coulibaly AP, Metcalfe M, Dam JM, Yee KM. PMID: 34761054; PMCID: PMC8560646.
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The Curious Anti-Pathology of the Wlds Mutation: Paradoxical Postsynaptic Spine Growth Accompanies Delayed Presynaptic Wallerian Degeneration. Front Mol Neurosci. 2021; 14:735919. Steward O, Yonan JM, Falk PM. PMID: 34566580; PMCID: PMC8461245.
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Intercellular Arc Signaling Regulates Vasodilation. J Neurosci. 2021 09 15; 41(37):7712-7726. de la Peña JB, Barragan-Iglesias P, Lou TF, Kunder N, Loerch S, Shukla T, Basavarajappa L, Song J, James DN, Megat S, Moy JK, Wanghzou A, Ray PR, Hoyt K, Steward O, Price TJ, Shepherd J, Campbell ZT. PMID: 34326146; PMCID: PMC8445061.
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Rostro-Caudal Specificity of Corticospinal Tract Projections in Mice. Cereb Cortex. 2021 03 31; 31(5):2322-2344. Steward O, Yee KM, Metcalfe M, Willenberg R, Luo J, Azevedo R, Martin-Thompson JH, Gandhi SP. PMID: 33350438; PMCID: PMC8023844.
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Overnight Caloric Restriction Prior to Cardiac Arrest and Resuscitation Leads to Improved Survival and Neurological Outcome in a Rodent Model. Front Neurosci. 2020; 14:609670. Azadian M, Tian G, Bazrafkan A, Maki N, Rafi M, Chetty N, Desai M, Otarola I, Aguirre F, Zaher SM, Khan A, Suri Y, Wang M, Lopour BA, Steward O, Akbari Y. PMID: 33510613; PMCID: PMC7835645.
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Recognizing Team Science Contributions in Academic Hiring, Promotion, and Tenure. J Neurosci. 2020 08 26; 40(35):6662-6663. Cline H, Coolen L, de Vries S, Hyman S, Segal R, Steward O. PMID: 32847999; PMCID: PMC7455215.
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Non-invasive High Frequency Repetitive Transcranial Magnetic Stimulation (hfrTMS) Robustly Activates Molecular Pathways Implicated in Neuronal Growth and Synaptic Plasticity in Select Populations of Neurons. Front Neurosci. 2020; 14:558. Fujiki M, Yee KM, Steward O. PMID: 32612497; PMCID: PMC7308563.
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Regulatory T cells promote remyelination in the murine experimental autoimmune encephalomyelitis model of multiple sclerosis following human neural stem cell transplant. Neurobiol Dis. 2020 07; 140:104868. McIntyre LL, Greilach SA, Othy S, Sears-Kraxberger I, Wi B, Ayala-Angulo J, Vu E, Pham Q, Silva J, Dang K, Rezk F, Steward O, Cahalan MD, Lane TE, Walsh CM. PMID: 32276110; PMCID: PMC7253332.
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Intravenous delivery of microRNA-133b along with Argonaute-2 enhances spinal cord recovery following cervical contusion in mice. Spine J. 2020 07; 20(7):1138-1151. Danilov CA, Gu Y, Punj V, Wu Z, Steward O, Schönthal AH, Tahara SM, Hofman FM, Chen TC. PMID: 32145360.
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Examination of the human motor endplate after brachial plexus injury with two-photon microscopy. Muscle Nerve. 2020 03; 61(3):390-395. Chan JP, Clune J, Shah SB, Ward SR, Kocsis JD, Mozaffar T, Steward O, Gupta R. PMID: 31820462.
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AAVshRNA-mediated PTEN knockdown in adult neurons attenuates activity-dependent immediate early gene induction. Exp Neurol. 2020 04; 326:113098. Steward O, Coulibaly AP, Metcalfe M, Yonan JM, Yee KM. PMID: 31707081; PMCID: PMC7943064.
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Modest enhancement of sensory axon regeneration in the sciatic nerve with conditional co-deletion of PTEN and SOCS3 in the dorsal root ganglia of adult mice. Exp Neurol. 2018 05; 303:120-133. Gallaher ZR, Steward O. PMID: 29458059; PMCID: PMC5864562.
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Delayed Degradation and Impaired Dendritic Delivery of Intron-Lacking EGFP-Arc/Arg3.1 mRNA in EGFP-Arc Transgenic Mice. Front Mol Neurosci. 2017; 10:435. Steward O, Matsudaira Yee K, Farris S, Pirbhoy PS, Worley P, Okamura K, Okuno H, Bito H. PMID: 29445324; PMCID: PMC5797788.
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Neuronal PTEN deletion in adult cortical neurons triggers progressive growth of cell bodies, dendrites, and axons. Exp Neurol. 2018 05; 303:12-28. Gallent EA, Steward O. PMID: 29337147; PMCID: PMC5864555.
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Synaptically driven phosphorylation of ribosomal protein S6 is differentially regulated at active synapses versus dendrites and cell bodies by MAPK and PI3K/mTOR signaling pathways. Learn Mem. 2017 08; 24(8):341-357. Pirbhoy PS, Farris S, Steward O. PMID: 28716954; PMCID: PMC5516686.
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Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway. J Neurotrauma. 2017 10 01; 34(19):2823-2832. Kang YJ, Tian G, Bazrafkan A, Farahabadi MH, Azadian M, Abbasi H, Shamaoun BE, Steward O, Akbari Y. PMID: 28447885; PMCID: PMC5647501.
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Selective neuronal PTEN deletion: can we take the brakes off of growth without losing control? Neural Regen Res. 2016 Aug; 11(8):1201-3. Gutilla EA, Steward O. PMID: 27651754; PMCID: PMC5020805.
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A Rhumba of "R's": Replication, Reproducibility, Rigor, Robustness: What Does a Failure to Replicate Mean? eNeuro. 2016 Jul-Aug; 3(4). Steward O. PMID: 27419220; PMCID: PMC4937130.
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Rodent spinal cord injury models for studies of axon regeneration. Exp Neurol. 2017 Jan; 287(Pt 3):374-383. Steward O, Willenberg R. PMID: 27374113.
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Synaptic activation of ribosomal protein S6 phosphorylation occurs locally in activated dendritic domains. Learn Mem. 2016 06; 23(6):255-69. Pirbhoy PS, Farris S, Steward O. PMID: 27194793; PMCID: PMC4880148.
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Central Mechanisms Mediating Thrombospondin-4-induced Pain States. J Biol Chem. 2016 Jun 17; 291(25):13335-48. Park J, Yu YP, Zhou CY, Li KW, Wang D, Chang E, Kim DS, Vo B, Zhang X, Gong N, Sharp K, Steward O, Vitko I, Perez-Reyes E, Eroglu C, Barres B, Zaucke F, Feng G, Luo ZD. PMID: 27129212; PMCID: PMC4933243.
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Variable laterality of corticospinal tract axons that regenerate after spinal cord injury as a result of PTEN deletion or knock-down. J Comp Neurol. 2016 09 01; 524(13):2654-76. Willenberg R, Zukor K, Liu K, He Z, Steward O. PMID: 26878190; PMCID: PMC4935643.
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Long-term consequences of conditional genetic deletion of PTEN in the sensorimotor cortex of neonatal mice. Exp Neurol. 2016 May; 279:27-39. Gutilla EA, Buyukozturk MM, Steward O. PMID: 26896833; PMCID: PMC4957975.
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Robotic Rehabilitator of the Rodent Upper Extremity: A System and Method for Assessing and Training Forelimb Force Production after Neurological Injury. J Neurotrauma. 2016 Mar 01; 33(5):460-7. Sharp KG, Duarte JE, Gebrekristos B, Perez S, Steward O, Reinkensmeyer DJ. PMID: 26414700; PMCID: PMC4779318.
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Sphingosine-1-phosphate receptor antagonism enhances proliferation and migration of engrafted neural progenitor cells in a model of viral-induced demyelination. Am J Pathol. 2015 Oct; 185(10):2819-32. Blanc CA, Grist JJ, Rosen H, Sears-Kraxberger I, Steward O, Lane TE. PMID: 26435414; PMCID: PMC4607760.
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Nonspecific labeling limits the utility of Cre-Lox bred CST-YFP mice for studies of corticospinal tract regeneration. J Comp Neurol. 2015 Dec 15; 523(18):2665-82. Willenberg R, Steward O. PMID: 25976033; PMCID: PMC4607560.
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Synaptic ultrastructure changes in trigeminocervical complex posttrigeminal nerve injury. J Comp Neurol. 2016 Feb 01; 524(2):309-22. Park J, Trinh VN, Sears-Kraxberger I, Li KW, Steward O, Luo ZD. PMID: 26132987; PMCID: PMC4675675.
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Large animal and primate models of spinal cord injury for the testing of novel therapies. Exp Neurol. 2015 Jul; 269:154-68. Kwon BK, Streijger F, Hill CE, Anderson AJ, Bacon M, Beattie MS, Blesch A, Bradbury EJ, Brown A, Bresnahan JC, Case CC, Colburn RW, David S, Fawcett JW, Ferguson AR, Fischer I, Floyd CL, Gensel JC, Houle JD, Jakeman LB, Jeffery ND, Jones LA, Kleitman N, Kocsis J, Lu P, Magnuson DS, Marsala M, Moore SW, Mothe AJ, Oudega M, Plant GW, Rabchevsky AS, Schwab JM, Silver J, Steward O, Xu XM, Guest JD, Tetzlaff W. PMID: 25902036.
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Conditional genetic deletion of PTEN after a spinal cord injury enhances regenerative growth of CST axons and motor function recovery in mice. Exp Neurol. 2015 Apr; 266:147-60. Danilov CA, Steward O. PMID: 25704959; PMCID: PMC4382431.
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Repair of spinal cord injury with neuronal relays: From fetal grafts to neural stem cells. Brain Res. 2015 Sep 04; 1619:115-23. Bonner JF, Steward O. PMID: 25591483; PMCID: PMC4499497.
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Localization and local translation of Arc/Arg3.1 mRNA at synapses: some observations and paradoxes. Front Mol Neurosci. 2014; 7:101. Steward O, Farris S, Pirbhoy PS, Darnell J, Driesche SJ. PMID: 25628532; PMCID: PMC4290588.
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Rigor or mortis: best practices for preclinical research in neuroscience. Neuron. 2014 Nov 05; 84(3):572-81. Steward O, Balice-Gordon R. PMID: 25442936.
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Leveraging biomedical informatics for assessing plasticity and repair in primate spinal cord injury. Brain Res. 2015 Sep 04; 1619:124-38. Nielson JL, Haefeli J, Salegio EA, Liu AW, Guandique CF, Stück ED, Hawbecker S, Moseanko R, Strand SC, Zdunowski S, Brock JH, Roy RR, Rosenzweig ES, Nout-Lomas YS, Courtine G, Havton LA, Steward O, Reggie Edgerton V, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. PMID: 25451131; PMCID: PMC4418964.
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Characterization of ectopic colonies that form in widespread areas of the nervous system with neural stem cell transplants into the site of a severe spinal cord injury. J Neurosci. 2014 Oct 15; 34(42):14013-21. Steward O, Sharp KG, Yee KM, Hatch MN, Bonner JF. PMID: 25319698; PMCID: PMC4198542.
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Development of a database for translational spinal cord injury research. J Neurotrauma. 2014 Nov 01; 31(21):1789-99. Nielson JL, Guandique CF, Liu AW, Burke DA, Lash AT, Moseanko R, Hawbecker S, Strand SC, Zdunowski S, Irvine KA, Brock JH, Nout-Lomas YS, Gensel JC, Anderson KD, Segal MR, Rosenzweig ES, Magnuson DS, Whittemore SR, McTigue DM, Popovich PG, Rabchevsky AG, Scheff SW, Steward O, Courtine G, Edgerton VR, Tuszynski MH, Beattie MS, Bresnahan JC, Ferguson AR. PMID: 25077610; PMCID: PMC4186058.
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Rapamycin and interleukin-1β impair brain-derived neurotrophic factor-dependent neuron survival by modulating autophagy. J Biol Chem. 2014 Jul 25; 289(30):20615-29. Smith ED, Prieto GA, Tong L, Sears-Kraxberger I, Rice JD, Steward O, Cotman CW. PMID: 24917666; PMCID: PMC4110274.
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AAVshRNA-mediated suppression of PTEN in adult rats in combination with salmon fibrin administration enables regenerative growth of corticospinal axons and enhances recovery of voluntary motor function after cervical spinal cord injury. J Neurosci. 2014 Jul 23; 34(30):9951-62. Lewandowski G, Steward O. PMID: 25057197; PMCID: PMC4107411.
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Human neural precursor cells promote neurologic recovery in a viral model of multiple sclerosis. Stem Cell Reports. 2014 Jun 03; 2(6):825-37. Chen L, Coleman R, Leang R, Tran H, Kopf A, Walsh CM, Sears-Kraxberger I, Steward O, Macklin WB, Loring JF, Lane TE. PMID: 24936469; PMCID: PMC4050357.
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A re-assessment of long distance growth and connectivity of neural stem cells after severe spinal cord injury. Exp Neurol. 2014 Jul; 257:186-204. Sharp KG, Yee KM, Steward O. PMID: 24747827; PMCID: PMC4123968.
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Selective localization of arc mRNA in dendrites involves activity- and translation-dependent mRNA degradation. J Neurosci. 2014 Mar 26; 34(13):4481-93. Farris S, Lewandowski G, Cox CD, Steward O. PMID: 24671994; PMCID: PMC3965778.
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Long-distance migration and colonization of transplanted neural stem cells. Cell. 2014 Jan 30; 156(3):385-7. Steward O, Sharp KG, Matsudaira Yee K. PMID: 24485444.
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Calcium channel α2δ1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis. J Biol Chem. 2014 Mar 07; 289(10):7025-7037. Li KW, Yu YP, Zhou C, Kim DS, Lin B, Sharp K, Steward O, Luo ZD. PMID: 24459143; PMCID: PMC3945363.
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A re-assessment of treatment with a tyrosine kinase inhibitor (imatinib) on tissue sparing and functional recovery after spinal cord injury. Exp Neurol. 2014 Apr; 254:1-11. Sharp KG, Yee KM, Steward O. PMID: 24440639.
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A re-assessment of the effects of treatment with a non-steroidal anti-inflammatory (ibuprofen) on promoting axon regeneration via RhoA inhibition after spinal cord injury. Exp Neurol. 2013 Oct; 248:321-37. Sharp KG, Yee KM, Stiles TL, Aguilar RM, Steward O. PMID: 23830951.
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Thrombospondin-4 contributes to spinal cord injury-induced changes in nociception. Eur J Pain. 2013 Nov; 17(10):1458-64. Zeng J, Kim D, Li KW, Sharp K, Steward O, Zaucke F, Luo ZD. PMID: 23649982; PMCID: PMC3762950.
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Matrix metalloproteinase 3 deletion preserves denervated motor endplates after traumatic nerve injury. Ann Neurol. 2013 Feb; 73(2):210-23. Chao T, Frump D, Lin M, Caiozzo VJ, Mozaffar T, Steward O, Gupta R. PMID: 23281061.
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A call for transparent reporting to optimize the predictive value of preclinical research. Nature. 2012 Oct 11; 490(7419):187-91. Landis SC, Amara SG, Asadullah K, Austin CP, Blumenstein R, Bradley EW, Crystal RG, Darnell RB, Ferrante RJ, Fillit H, Finkelstein R, Fisher M, Gendelman HE, Golub RM, Goudreau JL, Gross RA, Gubitz AK, Hesterlee SE, Howells DW, Huguenard J, Kelner K, Koroshetz W, Krainc D, Lazic SE, Levine MS, Macleod MR, McCall JM, Moxley RT, Narasimhan K, Noble LJ, Perrin S, Porter JD, Steward O, Unger E, Utz U, Silberberg SD. PMID: 23060188; PMCID: PMC3511845.
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Arc mRNA docks precisely at the base of individual dendritic spines indicating the existence of a specialized microdomain for synapse-specific mRNA translation. J Comp Neurol. 2012 Oct 01; 520(14):3105-19. Dynes JL, Steward O. PMID: 22350812; PMCID: PMC5546873.
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Biophysical stimulation induces demyelination via an integrin-dependent mechanism. Ann Neurol. 2012 Jul; 72(1):112-23. Lin MY, Frieboes LS, Forootan M, Palispis WA, Mozaffar T, Jafari M, Steward O, Gall CM, Gupta R. PMID: 22829273.
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Thrombospondin-4 contributes to spinal sensitization and neuropathic pain states. J Neurosci. 2012 Jun 27; 32(26):8977-87. Kim DS, Li KW, Boroujerdi A, Peter Yu Y, Zhou CY, Deng P, Park J, Zhang X, Lee J, Corpe M, Sharp K, Steward O, Eroglu C, Barres B, Zaucke F, Xu ZC, Luo ZD. PMID: 22745497; PMCID: PMC3408211.
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Concepts and methods for the study of axonal regeneration in the CNS. Neuron. 2012 Jun 07; 74(5):777-91. Tuszynski MH, Steward O. PMID: 22681683; PMCID: PMC3387806.
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Chronic spinal cord injury impairs primary antibody responses but spares existing humoral immunity in mice. J Immunol. 2012 Jun 01; 188(11):5257-66. Oropallo MA, Held KS, Goenka R, Ahmad SA, O'Neill PJ, Steward O, Lane TE, Cancro MP. PMID: 22523388; PMCID: PMC3358463.
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Salmon fibrin treatment of spinal cord injury promotes functional recovery and density of serotonergic innervation. Exp Neurol. 2012 May; 235(1):345-56. Sharp KG, Dickson AR, Marchenko SA, Yee KM, Emery PN, Laidmåe I, Uibo R, Sawyer ES, Steward O, Flanagan LA. PMID: 22414309; PMCID: PMC3437931.
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A rat chronic pain model of spinal cord contusion injury. Methods Mol Biol. 2012; 851:195-203. Sharp K, Boroujerdi A, Steward O, Luo ZD. PMID: 22351092.
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Age-Dependent Resistance to Excitotoxicity in Htt CAG140 Mice and the Effect of Strain Background. J Huntingtons Dis. 2012; 1(2):221-41. Strong MK, Southwell AL, Yonan JM, Hayden MR, Macgregor GR, Thompson LM, Steward O. PMID: 23833693; PMCID: PMC3702054.
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One day of motor training with amphetamine impairs motor recovery following spinal cord injury. Exp Neurol. 2012 Feb; 233(2):693-707. Wong JK, Steward O. PMID: 22078754.
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Replication and reproducibility in spinal cord injury research. Exp Neurol. 2012 Feb; 233(2):597-605. Steward O, Popovich PG, Dietrich WD, Kleitman N. PMID: 22078756.
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A re-assessment of the effects of treatment with an epidermal growth factor receptor (EGFR) inhibitor on recovery of bladder and locomotor function following thoracic spinal cord injury in rats. Exp Neurol. 2012 Feb; 233(2):649-59. Sharp K, Yee KM, Steward O. PMID: 22078761.
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A reassessment of whether cortical motor neurons die following spinal cord injury. J Comp Neurol. 2011 Oct 01; 519(14):2852-69. Nielson JL, Strong MK, Steward O. PMID: 21618218; PMCID: PMC3916191.
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A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid. Exp Neurol. 2012 Feb; 233(2):662-73. Steward O, Sharp K, Yee KM. PMID: 21946267; PMCID: PMC3652674.
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Calcium channel alpha-2-delta-1 protein upregulation in dorsal spinal cord mediates spinal cord injury-induced neuropathic pain states. Pain. 2011 Mar; 152(3):649-655. Boroujerdi A, Zeng J, Sharp K, Kim D, Steward O, Luo DZ. PMID: 21239111; PMCID: PMC3039050.
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A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats. Exp Neurol. 2012 Feb; 233(2):625-44. Sharp KG, Flanagan LA, Yee KM, Steward O. PMID: 21195070; PMCID: PMC9191910.
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Synaptic loss and retention of different classic cadherins with LTP-associated synaptic structural remodeling in vivo. Hippocampus. 2012 Jan; 22(1):17-28. Huntley GW, Elste AM, Patil SB, Bozdagi O, Benson DL, Steward O. PMID: 20848607; PMCID: PMC3008765.
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Impaired immune responses following spinal cord injury lead to reduced ability to control viral infection. Exp Neurol. 2010 Nov; 226(1):242-53. Held KS, Steward O, Blanc C, Lane TE. PMID: 20832407; PMCID: PMC5029284.
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Unexpected survival of neurons of origin of the pyramidal tract after spinal cord injury. J Neurosci. 2010 Aug 25; 30(34):11516-28. Nielson JL, Sears-Kraxberger I, Strong MK, Wong JK, Willenberg R, Steward O. PMID: 20739574; PMCID: PMC2941508.
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Deficits in bladder function following spinal cord injury vary depending on the level of the injury. Exp Neurol. 2010 Nov; 226(1):128-35. David BT, Steward O. PMID: 20713043; PMCID: PMC2955760.
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PTEN deletion enhances the regenerative ability of adult corticospinal neurons. Nat Neurosci. 2010 Sep; 13(9):1075-81. Liu K, Lu Y, Lee JK, Samara R, Willenberg R, Sears-Kraxberger I, Tedeschi A, Park KK, Jin D, Cai B, Xu B, Connolly L, Steward O, Zheng B, He Z. PMID: 20694004; PMCID: PMC2928871.
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Examination of axonal injury and regeneration in micropatterned neuronal culture using pulsed laser microbeam dissection. Lab Chip. 2010 Aug 21; 10(16):2083-92. Hellman AN, Vahidi B, Kim HJ, Mismar W, Steward O, Jeon NL, Venugopalan V. PMID: 20532390; PMCID: PMC3380453.
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Role of early surgical decompression of the intradural space after cervical spinal cord injury in an animal model. J Bone Joint Surg Am. 2010 May; 92(5):1206-14. Smith JS, Anderson R, Pham T, Bhatia N, Steward O, Gupta R. PMID: 20439667; PMCID: PMC2859904.
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Assessment of the role of MAP kinase in mediating activity-dependent transcriptional activation of the immediate early gene Arc/Arg3.1 in the dentate gyrus in vivo. Learn Mem. 2010 Feb; 17(2):117-29. Chotiner JK, Nielson J, Farris S, Lewandowski G, Huang F, Banos K, de Leon R, Steward O. PMID: 20154358; PMCID: PMC2825695.
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A bilateral cervical contusion injury model in mice: assessment of gripping strength as a measure of forelimb motor function. Exp Neurol. 2010 Jan; 221(1):38-53. Aguilar RM, Steward O. PMID: 19815010; PMCID: PMC2812629.
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Forelimb locomotor assessment scale (FLAS): novel assessment of forelimb dysfunction after cervical spinal cord injury. Exp Neurol. 2009 Nov; 220(1):23-33. Anderson KD, Sharp KG, Hofstadter M, Irvine KA, Murray M, Steward O. PMID: 19733168; PMCID: PMC2771771.
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Bilateral cervical contusion spinal cord injury in rats. Exp Neurol. 2009 Nov; 220(1):9-22. Anderson KD, Sharp KG, Steward O. PMID: 19559699; PMCID: PMC2761499.
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A straight alley version of the BBB locomotor scale. Exp Neurol. 2009 Jun; 217(2):417-20. Wong JK, Sharp K, Steward O. PMID: 19348792; PMCID: PMC2703578.
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An investigation of the cortical control of forepaw gripping after cervical hemisection injuries in rats. Exp Neurol. 2009 May; 217(1):96-107. Strong MK, Blanco JE, Anderson KD, Lewandowski G, Lewandoski G, Steward O. PMID: 19416669; PMCID: PMC2679860.
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Rapid activation of plasticity-associated gene transcription in hippocampal neurons provides a mechanism for encoding of one-trial experience. J Neurosci. 2009 Jan 28; 29(4):898-906. Miyashita T, Kubik S, Haghighi N, Steward O, Guzowski JF. PMID: 19176799; PMCID: PMC2749324.
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Repulsive Wnt signaling inhibits axon regeneration after CNS injury. J Neurosci. 2008 Aug 13; 28(33):8376-82. Liu Y, Wang X, Lu CC, Kerman R, Steward O, Xu XM, Zou Y. PMID: 18701700; PMCID: PMC3385642.
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Regenerative growth of corticospinal tract axons via the ventral column after spinal cord injury in mice. J Neurosci. 2008 Jul 02; 28(27):6836-47. Steward O, Zheng B, Tessier-Lavigne M, Hofstadter M, Sharp K, Yee KM. PMID: 18596159; PMCID: PMC2745399.
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Chronic nerve compression injury induces a phenotypic switch of neurons within the dorsal root ganglia. J Comp Neurol. 2008 Jan 10; 506(2):180-93. Chao T, Pham K, Steward O, Gupta R. PMID: 18022951.
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A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol. 2008 Feb; 209(2):446-68. Steward O, Sharp K, Yee KM, Hofstadter M. PMID: 18234196; PMCID: PMC2613794.
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Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiol Dis. 2008 Mar; 29(3):391-9. McLin JP, Thompson LM, Lusis AJ, Davis RC, Steward O. PMID: 17996456.
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Actin polymerization and ERK phosphorylation are required for Arc/Arg3.1 mRNA targeting to activated synaptic sites on dendrites. J Neurosci. 2007 Aug 22; 27(34):9054-67. Huang F, Chotiner JK, Steward O. PMID: 17715342; PMCID: PMC6672203.
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A form of perforant path LTP can occur without ERK1/2 phosphorylation or immediate early gene induction. Learn Mem. 2007 Jun; 14(6):433-45. Steward O, Huang F, Guzowski JF. PMID: 17562895; PMCID: PMC1896093.
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Spinal pathways involved in the control of forelimb motor function in rats. Exp Neurol. 2007 Aug; 206(2):318-31. Anderson KD, Gunawan A, Steward O. PMID: 17603042.
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Response to: Kim et al., "axon regeneration in young adult mice lacking Nogo-A/B." Neuron 38, 187-199. Neuron. 2007 Apr 19; 54(2):191-5. Steward O, Zheng B, Banos K, Yee KM. PMID: 17442241.
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Dynamics of bidirectional transport of Arc mRNA in neuronal dendrites. J Comp Neurol. 2007 Jan 20; 500(3):433-47. Dynes JL, Steward O. PMID: 17120280.
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Differential susceptibility to striatal neurodegeneration induced by quinolinic acid and kainate in inbred, outbred and hybrid mouse strains. Eur J Neurosci. 2006 Dec; 24(11):3134-40. McLin JP, Thompson LM, Steward O. PMID: 17156374.
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Recovery of forepaw gripping ability and reorganization of cortical motor control following cervical spinal cord injuries in mice. Exp Neurol. 2007 Feb; 203(2):333-48. Blanco JE, Anderson KD, Steward O. PMID: 17049345.
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Comparison of seizure phenotype and neurodegeneration induced by systemic kainic acid in inbred, outbred, and hybrid mouse strains. Eur J Neurosci. 2006 Oct; 24(8):2191-202. McLin JP, Steward O. PMID: 17074044.
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Synaptic regulation of translation of dendritic mRNAs. J Neurosci. 2006 Jul 05; 26(27):7143-6. Schuman EM, Dynes JL, Steward O. PMID: 16822969; PMCID: PMC6673937.
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Local down-regulation of myelin-associated glycoprotein permits axonal sprouting with chronic nerve compression injury. Exp Neurol. 2006 Aug; 200(2):418-29. Gupta R, Rummler LS, Palispis W, Truong L, Chao T, Rowshan K, Mozaffar T, Steward O. PMID: 16764860.
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Endogenous neurogenesis replaces oligodendrocytes and astrocytes after primate spinal cord injury. J Neurosci. 2006 Feb 22; 26(8):2157-66. Yang H, Lu P, McKay HM, Bernot T, Keirstead H, Steward O, Gage FH, Edgerton VR, Tuszynski MH. PMID: 16495442; PMCID: PMC6674802.
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A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Exp Neurol. 2006 Apr; 198(2):483-99. Steward O, Sharp K, Selvan G, Hadden A, Hofstadter M, Au E, Roskams J. PMID: 16494866.
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Anisomycin infused into the hippocampus fails to block "reconsolidation" but impairs extinction: the role of re-exposure duration. Learn Mem. 2006 Jan-Feb; 13(1):27-34. Power AE, Berlau DJ, McGaugh JL, Steward O. PMID: 16452651; PMCID: PMC1360130.
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Septations in chronic spinal cord injury cavities contain axons. Exp Neurol. 2005 Dec; 196(2):339-41. Radojicic M, Reier PJ, Steward O, Keirstead HS. PMID: 16153640.
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The mRNA for elongation factor 1alpha is localized in dendrites and translated in response to treatments that induce long-term depression. J Neurosci. 2005 Aug 03; 25(31):7199-209. Huang F, Chotiner JK, Steward O. PMID: 16079402; PMCID: PMC6725237.
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Memory-influencing intra-basolateral amygdala drug infusions modulate expression of Arc protein in the hippocampus. Proc Natl Acad Sci U S A. 2005 Jul 26; 102(30):10718-23. McIntyre CK, Miyashita T, Setlow B, Marjon KD, Steward O, Guzowski JF, McGaugh JL. PMID: 16020527; PMCID: PMC1175582.
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A noninvasive ultrasonographic method to evaluate bladder function recovery in spinal cord injured rats. Exp Neurol. 2005 Jul; 194(1):120-7. Keirstead HS, Fedulov V, Cloutier F, Steward O, Duel BP. PMID: 15899249.
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Quantitative assessment of forelimb motor function after cervical spinal cord injury in rats: relationship to the corticospinal tract. Exp Neurol. 2005 Jul; 194(1):161-74. Anderson KD, Gunawan A, Steward O. PMID: 15899253.
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Understanding the biology of compressive neuropathies. Clin Orthop Relat Res. 2005 Jul; (436):251-60. Gupta R, Rummler L, Steward O. PMID: 15995449.
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Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 2005 May 11; 25(19):4694-705. Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, Steward O. PMID: 15888645; PMCID: PMC6724772.
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Genetic deletion of the Nogo receptor does not reduce neurite inhibition in vitro or promote corticospinal tract regeneration in vivo. Proc Natl Acad Sci U S A. 2005 Jan 25; 102(4):1205-10. Zheng B, Atwal J, Ho C, Case L, He XL, Garcia KC, Steward O, Tessier-Lavigne M. PMID: 15647357; PMCID: PMC544342.
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Quantitative assessment of deficits and recovery of forelimb motor function after cervical spinal cord injury in mice. Exp Neurol. 2004 Nov; 190(1):184-91. Anderson KD, Abdul M, Steward O. PMID: 15473991.
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Nitrogen disruption of synaptoneurosomes: an alternative method to isolate brain mitochondria. J Neurosci Methods. 2004 Aug 30; 137(2):299-303. Brown MR, Sullivan PG, Dorenbos KA, Modafferi EA, Geddes JW, Steward O. PMID: 15262074.
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Brain-derived neurotrophic factor mRNA and protein are targeted to discrete dendritic laminas by events that trigger epileptogenesis. J Neurosci. 2004 Jul 28; 24(30):6842-52. Tongiorgi E, Armellin M, Giulianini PG, Bregola G, Zucchini S, Paradiso B, Steward O, Cattaneo A, Simonato M. PMID: 15282290; PMCID: PMC6729709.
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Chronic nerve compression induces local demyelination and remyelination in a rat model of carpal tunnel syndrome. Exp Neurol. 2004 Jun; 187(2):500-8. Gupta R, Rowshan K, Chao T, Mozaffar T, Steward O. PMID: 15144876.
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The dorsolateral corticospinal tract in mice: an alternative route for corticospinal input to caudal segments following dorsal column lesions. J Comp Neurol. 2004 May 10; 472(4):463-77. Steward O, Zheng B, Ho C, Anderson K, Tessier-Lavigne M. PMID: 15065120.
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Assessment of factors regulating axon growth between the cortex and spinal cord in organotypic co-cultures: effects of age and neurotrophic factors. J Neurotrauma. 2004 Mar; 21(3):339-56. Oishi Y, Baratta J, Robertson RT, Steward O. PMID: 15115608.
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The successful aging of Carl Cotman: from proteins of the synapse, through sprouting, regeneration, and spinal cord injury to the mechanisms of brain aging. Neurochem Res. 2003 Nov; 28(11):1617-9. Steward O. PMID: 14584814.
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Compartmentalized synthesis and degradation of proteins in neurons. Neuron. 2003 Oct 09; 40(2):347-59. Steward O, Schuman EM. PMID: 14556713.
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Ascending sensory, but not other long-tract axons, regenerate into the connective tissue matrix that forms at the site of a spinal cord injury in mice. J Comp Neurol. 2003 Aug 04; 462(4):431-49. Inman DM, Steward O. PMID: 12811811.
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Chronic nerve compression induces concurrent apoptosis and proliferation of Schwann cells. J Comp Neurol. 2003 Jun 23; 461(2):174-86. Gupta R, Steward O. PMID: 12724836.
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Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003 Jun; 53(6):711-7. Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. PMID: 12783416; PMCID: PMC2930774.
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Lack of enhanced spinal regeneration in Nogo-deficient mice. Neuron. 2003 Apr 24; 38(2):213-24. Zheng B, Ho C, Li S, Keirstead H, Steward O, Tessier-Lavigne M. PMID: 12718856.
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False resurrections: distinguishing regenerated from spared axons in the injured central nervous system. J Comp Neurol. 2003 Apr 21; 459(1):1-8. Steward O, Zheng B, Tessier-Lavigne M. PMID: 12629662.
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Visualizing changes in circuit activity resulting from denervation and reinnervation using immediate early gene expression. J Neurosci. 2003 Apr 01; 23(7):2779-88. Temple MD, Worley PF, Steward O. PMID: 12684464; PMCID: PMC6742062.
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Physical size does not determine the unique histopathological response seen in the injured mouse spinal cord. J Neurotrauma. 2003 Jan; 20(1):33-42. Inman DM, Steward O. PMID: 12614586.
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Local synthesis of proteins at synaptic sites on dendrites: role in synaptic plasticity and memory consolidation? Neurobiol Learn Mem. 2002 Nov; 78(3):508-27. Steward O, Worley P. PMID: 12559831.
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mRNA at synapses, synaptic plasticity, and memory consolidation. Neuron. 2002 Oct 24; 36(3):338-40. Steward O. PMID: 12408837.
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Genetic influences on secondary degeneration and wound healing following spinal cord injury in various strains of mice. J Comp Neurol. 2002 Sep 23; 451(3):225-35. Inman D, Guth L, Steward O. PMID: 12210135.
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Translating axon guidance cues. Cell. 2002 Sep 06; 110(5):537-40. Steward O. PMID: 12230970.
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Spatial learning and memory is preserved in rats after early development in a microgravity environment. Neurobiol Learn Mem. 2002 Sep; 78(2):199-216. Temple MD, Kosik KS, Steward O. PMID: 12431413.
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Zn(2+) induces permeability transition pore opening and release of pro-apoptotic peptides from neuronal mitochondria. J Biol Chem. 2001 Dec 14; 276(50):47524-9. Jiang D, Sullivan PG, Sensi SL, Steward O, Weiss JH. PMID: 11595748.
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A cellular mechanism for targeting newly synthesized mRNAs to synaptic sites on dendrites. Proc Natl Acad Sci U S A. 2001 Jun 19; 98(13):7062-8. Steward O, Worley PF. PMID: 11416188; PMCID: PMC34623.
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Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation. Neuron. 2001 Apr; 30(1):227-40. Steward O, Worley PF. PMID: 11343657.
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Protein synthesis at synaptic sites on dendrites. Annu Rev Neurosci. 2001; 24:299-325. Steward O, Schuman EM. PMID: 11283313.
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Synaptic plasticity in epileptogenesis: cellular mechanisms underlying long-lasting synaptic modifications that require new gene expression. Int Rev Neurobiol. 2001; 45:269-92. Steward O, Wallace CS, Worley PF. PMID: 11130903.
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Localization of mRNAs at synaptic sites on dendrites. Results Probl Cell Differ. 2001; 34:1-26. Steward O, Worley P. PMID: 11288670.
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