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Synthesis of 2'-O,4'-Cα-Dimethyl Ribonucleoside Analogs and Their Effects on RNA and Modulation of ADAR Editing. Chemistry. 2026 Jan 02; 32(1):e02958. Jauregui-Matos V, Brinkman HF, Salvador PJ, Jacobs O, Cheng J, Mozumder S, Vu T, Fisher AJ, Beal PA. PMID: 41318945.
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Discovery and Tuning of RNA Editing Guides via High-Throughput Screening and Chemical Modification. Chembiochem. 2025 Dec 11; 26(24):e202500735. Salvador PJ, Lin S, Chinn MM, Jauregui-Matos V, Manjunath A, Yang I, Jacobsen CS, Beal PA. PMID: 41272938.
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Clickable RNA via 4'-C-Ethynyl Cytidine─A Novel Design for Metabolically Stable Guide RNAs in RNA Editing. Bioconjug Chem. 2025 Dec 17; 36(12):2637-2644. Bereiter R, Manjunath A, Beal PA. PMID: 41250994.
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Control of ADAR2 Dimerization and RNA Editing Efficiency by Site-Specific 2'-Fluoro Modification of Guide RNAs. ACS Chem Biol. 2025 Nov 21; 20(11):2637-2648. Campbell KB, Ouye RB, Wong BL, Jiang A, Okada K, McKenney RJ, Fisher AJ, Beal PA. PMID: 41131871.
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Phylogenetic and structural analysis of Hydra ADAR. Arch Biochem Biophys. 2025 May; 767:110353. Wilcox XE, Zhang H, Mah JL, Cazet JF, Mozumder S, Venkatesh S, Juliano CE, Beal PA, Fisher AJ. PMID: 39986343; PMCID: PMC12904996.
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En masse evaluation of RNA guides (EMERGe) for ADARs. Methods Enzymol. 2025; 710:131-152. Salvador PJ, Dugan NM, Ouye R, Beal PA. PMID: 39870442; PMCID: PMC12014283.
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Structural analysis of human ADAR2-RNA complexes by X-ray crystallography. Methods Enzymol. 2025; 710:19-53. Campbell KB, Cheng J, Mendoza HG, Karki A, Beal PA, Fisher AJ. PMID: 39870445; PMCID: PMC11881785.
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Nucleoside Analogs in ADAR Guide Strands Enable Editing at 5'-GA Sites. Biomolecules. 2024 Sep 29; 14(10). Manjunath A, Cheng J, Campbell KB, Jacobsen CS, Mendoza HG, Bierbaum L, Jauregui-Matos V, Doherty EE, Fisher AJ, Beal PA. PMID: 39456162; PMCID: PMC11506087.
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Structural perspectives on adenosine to inosine RNA editing by ADARs. Mol Ther Nucleic Acids. 2024 Sep 10; 35(3):102284. Fisher AJ, Beal PA. PMID: 39165563; PMCID: PMC11334849.
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Site-specific regulation of RNA editing with ribose-modified nucleoside analogs in ADAR guide strands. Nucleic Acids Res. 2024 Jul 08; 52(12):6733-6747. Jauregui-Matos V, Jacobs O, Ouye R, Mozumder S, Salvador PJ, Fink KD, Beal PA. PMID: 38828787; PMCID: PMC11229365.
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Non-Targeted Detection of Synthetic Oligonucleotides in Equine Serum Using Liquid Chromatography-High-Resolution Mass Spectrometry. Int J Mol Sci. 2024 May 25; 25(11). Helmes E, Montgomery J, Alarcio G, Mendoza HG, Blea JA, Beal PA, Moeller BC. PMID: 38891955; PMCID: PMC11172053.
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Structural and functional effects of inosine modification in mRNA. RNA. 2024 04 16; 30(5):512-520. Mendoza HG, Beal PA. PMID: 38531652; PMCID: PMC11019749.
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RNA sequences that direct selective ADAR editing from a SELEX library bearing 8-azanebularine. Bioorg Med Chem. 2024 Apr 15; 104:117700. Wong BL, Mendoza HG, Jacobsen CS, Beal PA. PMID: 38583236; PMCID: PMC12009006.
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Impact of Disease-Associated Mutations on the Deaminase Activity of ADAR1. Biochemistry. 2024 02 06; 63(3):282-293. Karki A, Campbell KB, Mozumder S, Fisher AJ, Beal PA. PMID: 38190734; PMCID: PMC10872254.
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Chemical Modifications in RNA: Elucidating the Chemistry of dsRNA-Specific Adenosine Deaminases (ADARs). Acc Chem Res. 2023 09 19; 56(18):2489-2499. Mendoza HG, Beal PA. PMID: 37665999; PMCID: PMC10826463.
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Library Screening Reveals Sequence Motifs That Enable ADAR2 Editing at Recalcitrant Sites. ACS Chem Biol. 2023 10 20; 18(10):2188-2199. Jacobsen CS, Salvador P, Yung JF, Kragness S, Mendoza HG, Mandel G, Beal PA. PMID: 37040436; PMCID: PMC10581013.
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Selective Inhibition of ADAR1 Using 8-Azanebularine-Modified RNA Duplexes. Biochemistry. 2023 04 18; 62(8):1376-1387. Mendoza HG, Matos VJ, Park S, Pham KM, Beal PA. PMID: 36972568; PMCID: PMC10804918.
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Nucleoside analogs in ADAR guide strands targeting 5'-UA̲ sites. RSC Chem Biol. 2023 Jan 04; 4(1):74-83. Brinkman HF, Jauregui Matos V, Mendoza HG, Doherty EE, Beal PA. PMID: 36685257; PMCID: PMC9811522.
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ADAR activation by inducing a syn conformation at guanosine adjacent to an editing site. Nucleic Acids Res. 2022 10 28; 50(19):10857-10868. Doherty EE, Karki A, Wilcox XE, Mendoza HG, Manjunath A, Matos VJ, Fisher AJ, Beal PA. PMID: 36243986; PMCID: PMC9638939.
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Oligonucleotide-directed RNA editing in primates. Mol Ther. 2022 06 01; 30(6):2117-2119. Doherty EE, Beal PA. PMID: 35460609; PMCID: PMC9171251.
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Rational Design of RNA Editing Guide Strands: Cytidine Analogs at the Orphan Position. J Am Chem Soc. 2021 05 12; 143(18):6865-6876. Doherty EE, Wilcox XE, van Sint Fiet L, Kemmel C, Turunen JJ, Klein B, Tantillo DJ, Fisher AJ, Beal PA. PMID: 33939417; PMCID: PMC8608393.
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Regulation of RNA editing by intracellular acidification. Nucleic Acids Res. 2021 04 19; 49(7):4020-4036. Malik TN, Doherty EE, Gaded VM, Hill TM, Beal PA, Emeson RB. PMID: 33721028; PMCID: PMC8053123.
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Ester modification at the 3' end of anti-microRNA oligonucleotides increases potency of microRNA inhibition. Bioorg Med Chem. 2021 01 01; 29:115894. Pham KM, Suter SR, Lu SS, Beal PA. PMID: 33290908; PMCID: PMC8610567.
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High-throughput mutagenesis reveals unique structural features of human ADAR1. Nat Commun. 2020 10 12; 11(1):5130. Park S, Doherty EE, Xie Y, Padyana AK, Fang F, Zhang Y, Karki A, Lebrilla CB, Siegel JB, Beal PA. PMID: 33046702; PMCID: PMC7550611.
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Asymmetric dimerization of adenosine deaminase acting on RNA facilitates substrate recognition. Nucleic Acids Res. 2020 08 20; 48(14):7958-7972. Thuy-Boun AS, Thomas JM, Grajo HL, Palumbo CM, Park S, Nguyen LT, Fisher AJ, Beal PA. PMID: 32597966; PMCID: PMC7641318.
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DNA capture by a CRISPR-Cas9-guided adenine base editor. Science. 2020 07 31; 369(6503):566-571. Lapinaite A, Knott GJ, Palumbo CM, Lin-Shiao E, Richter MF, Zhao KT, Beal PA, Liu DR, Doudna JA. PMID: 32732424; PMCID: PMC8598131.
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Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide. Chemistry. 2020 Aug 06; 26(44):9874-9878. Knutson SD, Korn MM, Johnson RP, Monteleone LR, Dailey DM, Swenson CS, Beal PA, Heemstra JM. PMID: 32428320; PMCID: PMC7674219.
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Versatile 3' Functionalization of CRISPR Single Guide RNA. Chembiochem. 2020 Jun 02; 21(11):1633-1640. Palumbo CM, Gutierrez-Bujari JM, O'Geen H, Segal DJ, Beal PA. PMID: 31943634; PMCID: PMC7323579.
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RNA binding candidates for human ADAR3 from substrates of a gain of function mutant expressed in neuronal cells. Nucleic Acids Res. 2019 11 18; 47(20):10801-10814. Wang Y, Chung DH, Monteleone LR, Li J, Chiang Y, Toney MD, Beal PA. PMID: 31552420; PMCID: PMC6846710.
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Off-Target Editing by CRISPR-Guided DNA Base Editors. Biochemistry. 2019 Sep 10; 58(36):3727-3734. Park S, Beal PA. PMID: 31433621; PMCID: PMC7309633.
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A Bump-Hole Approach for Directed RNA Editing. Cell Chem Biol. 2019 02 21; 26(2):269-277.e5. Monteleone LR, Matthews MM, Palumbo CM, Thomas JM, Zheng Y, Chiang Y, Fisher AJ, Beal PA. PMID: 30581135; PMCID: PMC6386613.
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Nucleoside analogs in the study of the epitranscriptome. Methods. 2019 03 01; 156:46-52. Palumbo CM, Beal PA. PMID: 30827466; PMCID: PMC6400310.
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Structural basis for eukaryotic mRNA modification. Curr Opin Struct Biol. 2018 12; 53:59-68. Fisher AJ, Beal PA. PMID: 29913347.
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Differentiating Positional Isomers of Nucleoside Modifications by Higher-Energy Collisional Dissociation Mass Spectrometry (HCD MS). J Am Soc Mass Spectrom. 2018 08; 29(8):1745-1756. Jora M, Burns AP, Ross RL, Lobue PA, Zhao R, Palumbo CM, Beal PA, Addepalli B, Limbach PA. PMID: 29949056; PMCID: PMC6062210.
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Selective Recognition of RNA Substrates by ADAR Deaminase Domains. Biochemistry. 2018 03 13; 57(10):1640-1651. Wang Y, Park S, Beal PA. PMID: 29457714; PMCID: PMC5898644.
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Controlling miRNA-like off-target effects of an siRNA with nucleobase modifications. Org Biomol Chem. 2017 Dec 06; 15(47):10029-10036. Suter SR, Ball-Jones A, Mumbleau MM, Valenzuela R, Ibarra-Soza J, Owens H, Fisher AJ, Beal PA. PMID: 29164215; PMCID: PMC5734094.
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Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics. Nat Methods. 2018 01; 15(1):53-56. Lai Z, Tsugawa H, Wohlgemuth G, Mehta S, Mueller M, Zheng Y, Ogiwara A, Meissen J, Showalter M, Takeuchi K, Kind T, Beal P, Arita M, Fiehn O. PMID: 29176591; PMCID: PMC6358022.
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TLR8 activation and inhibition by guanosine analogs in RNA: Importance of functional groups and chain length. Bioorg Med Chem. 2018 01 01; 26(1):77-83. Hu T, Suter SR, Mumbleau MM, Beal PA. PMID: 29174509; PMCID: PMC5733708.
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Adenosine Deaminases That Act on RNA (ADARs). Enzymes. 2017; 41:215-268. Wang Y, Zheng Y, Beal PA. PMID: 28601223.
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DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. Nucleic Acids Res. 2017 04 07; 45(6):3369-3377. Zheng Y, Lorenzo C, Beal PA. PMID: 28132026; PMCID: PMC5389660.
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Synthesis of native-like crosslinked duplex RNA and study of its properties. Bioorg Med Chem. 2017 04 01; 25(7):2191-2199. Onizuka K, Hazemi ME, Thomas JM, Monteleone LR, Yamada K, Imoto S, Beal PA, Nagatsugi F. PMID: 28268052; PMCID: PMC5969911.
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How do ADARs bind RNA? New protein-RNA structures illuminate substrate recognition by the RNA editing ADARs. Bioessays. 2017 04; 39(4). Thomas JM, Beal PA. PMID: 28217931; PMCID: PMC5501306.
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Effects of Aicardi-Goutières syndrome mutations predicted from ADAR-RNA structures. RNA Biol. 2017 02; 14(2):164-170. Fisher AJ, Beal PA. PMID: 27937139; PMCID: PMC5324757.
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Guide Strand 3'-End Modifications Regulate siRNA Specificity. Chembiochem. 2016 Dec 14; 17(24):2340-2345. Valenzuela RA, Onizuka K, Ball-Jones AA, Hu T, Suter SR, Beal PA. PMID: 27731539; PMCID: PMC5161629.
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Probing RNA recognition by human ADAR2 using a high-throughput mutagenesis method. Nucleic Acids Res. 2016 Nov 16; 44(20):9872-9880. Wang Y, Beal PA. PMID: 27614075; PMCID: PMC5175354.
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Structure-Guided Control of siRNA Off-Target Effects. J Am Chem Soc. 2016 07 20; 138(28):8667-9. Suter SR, Sheu-Gruttadauria J, Schirle NT, Valenzuela R, Ball-Jones AA, Onizuka K, MacRae IJ, Beal PA. PMID: 27387838; PMCID: PMC4962782.
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Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity. Nat Struct Mol Biol. 2016 05; 23(5):426-33. Matthews MM, Thomas JM, Zheng Y, Tran K, Phelps KJ, Scott AI, Havel J, Fisher AJ, Beal PA. PMID: 27065196; PMCID: PMC4918759.
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Synthesis and evaluation of an alkyne-modified ATP analog for enzymatic incorporation into RNA. Bioorg Med Chem Lett. 2016 Apr 01; 26(7):1799-802. Zheng Y, Beal PA. PMID: 26927424; PMCID: PMC4785081.
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A Phenotypic Screen for Functional Mutants of Human Adenosine Deaminase Acting on RNA 1. ACS Chem Biol. 2015 Nov 20; 10(11):2512-9. Wang Y, Havel J, Beal PA. PMID: 26372505; PMCID: PMC4900682.
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A Fluorescent Adenosine Analogue as a Substrate for an A-to-I RNA Editing Enzyme. Angew Chem Int Ed Engl. 2015 Jul 20; 54(30):8713-6. Mizrahi RA, Shin D, Sinkeldam RW, Phelps KJ, Fin A, Tantillo DJ, Tor Y, Beal PA. PMID: 26095193; PMCID: PMC4532316.
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Tethering in RNA: an RNA-binding fragment discovery tool. Molecules. 2015 Mar 04; 20(3):4148-61. Tran K, Arkin MR, Beal PA. PMID: 25749683; PMCID: PMC4760646.
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On-enzyme refolding permits small RNA and tRNA surveillance by the CCA-adding enzyme. Cell. 2015 Feb 12; 160(4):644-658. Kuhn CD, Wilusz JE, Zheng Y, Beal PA, Joshua-Tor L. PMID: 25640237; PMCID: PMC4329729.
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Recognition of duplex RNA by the deaminase domain of the RNA editing enzyme ADAR2. Nucleic Acids Res. 2015 Jan; 43(2):1123-32. Phelps KJ, Tran K, Eifler T, Erickson AI, Fisher AJ, Beal PA. PMID: 25564529; PMCID: PMC4333395.
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Base modification strategies to modulate immune stimulation by an siRNA. Chembiochem. 2015 Jan 19; 16(2):262-7. Valenzuela RA, Suter SR, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Beal PA. PMID: 25487859; PMCID: PMC4337945.
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Click modification of RNA at adenosine: structure and reactivity of 7-ethynyl- and 7-triazolyl-8-aza-7-deazaadenosine in RNA. ACS Chem Biol. 2014 Aug 15; 9(8):1780-7. Phelps KJ, Ibarra-Soza JM, Tran K, Fisher AJ, Beal PA. PMID: 24896732; PMCID: PMC4136661.
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Short interfering RNA guide strand modifiers from computational screening. J Am Chem Soc. 2013 Nov 13; 135(45):17069-77. Onizuka K, Harrison JG, Ball-Jones AA, Ibarra-Soza JM, Zheng Y, Ly D, Lam W, Mac S, Tantillo DJ, Beal PA. PMID: 24152142; PMCID: PMC3884816.
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RNA-Seq analysis identifies a novel set of editing substrates for human ADAR2 present in Saccharomyces cerevisiae. Biochemistry. 2013 Nov 12; 52(45):7857-69. Eifler T, Pokharel S, Beal PA. PMID: 24124932; PMCID: PMC3856204.
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Computational approaches to predicting the impact of novel bases on RNA structure and stability. ACS Chem Biol. 2013 Nov 15; 8(11):2354-9. Harrison JG, Zheng YB, Beal PA, Tantillo DJ. PMID: 24063428; PMCID: PMC3856235.
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Potent and selective inhibition of A-to-I RNA editing with 2'-O-methyl/locked nucleic acid-containing antisense oligoribonucleotides. ACS Chem Biol. 2013 Apr 19; 8(4):832-9. Mizrahi RA, Schirle NT, Beal PA. PMID: 23394403; PMCID: PMC3631459.
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A screening protocol for identification of functional mutants of RNA editing adenosine deaminases. Curr Protoc Chem Biol. 2012 Dec 01; 4(4):357-69. Eifler T, Chan D, Beal PA. PMID: 23788559; PMCID: PMC3690185.
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Promiscuous 8-alkoxyadenosines in the guide strand of an siRNA: modulation of silencing efficacy and off-pathway protein binding. J Am Chem Soc. 2012 Oct 24; 134(42):17643-52. Ghanty U, Fostvedt E, Valenzuela R, Beal PA, Burrows CJ. PMID: 23030736; PMCID: PMC3491887.
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Nucleoside analog studies indicate mechanistic differences between RNA-editing adenosine deaminases. Nucleic Acids Res. 2012 Oct; 40(19):9825-35. Mizrahi RA, Phelps KJ, Ching AY, Beal PA. PMID: 22885375; PMCID: PMC3479202.
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7-Substituted 8-aza-7-deazaadenosines for modification of the siRNA major groove. Org Biomol Chem. 2012 Aug 28; 10(32):6491-7. Ibarra-Soza JM, Morris AA, Jayalath P, Peacock H, Conrad WE, Donald MB, Kurth MJ, Beal PA. PMID: 22766576; PMCID: PMC3417767.
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NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing. Chembiochem. 2012 Jun 18; 13(9):1338-48. Onizuka K, Yeo J, David SS, Beal PA. PMID: 22639086; PMCID: PMC3454477.
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ADAR proteins: structure and catalytic mechanism. Curr Top Microbiol Immunol. 2012; 353:1-33. Goodman RA, Macbeth MR, Beal PA. PMID: 21769729.
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Novel modifications in RNA. ACS Chem Biol. 2012 Jan 20; 7(1):100-9. Phelps K, Morris A, Beal PA. PMID: 22148740; PMCID: PMC3270579.
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Chemical modification of siRNA bases to probe and enhance RNA interference. J Org Chem. 2011 Sep 16; 76(18):7295-300. Peacock H, Kannan A, Beal PA, Burrows CJ. PMID: 21834582; PMCID: PMC3170502.
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Nucleobase and ribose modifications control immunostimulation by a microRNA-122-mimetic RNA. J Am Chem Soc. 2011 Jun 22; 133(24):9200-3. Peacock H, Fucini RV, Jayalath P, Ibarra-Soza JM, Haringsma HJ, Flanagan WM, Willingham A, Beal PA. PMID: 21612237; PMCID: PMC3116021.
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Covalent stabilization of a small molecule-RNA complex. Bioorg Med Chem Lett. 2011 Sep 01; 21(17):5002-5. Peacock H, Bachu R, Beal PA. PMID: 21601451; PMCID: PMC3156283.
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8-Oxoguanosine switches modulate the activity of alkylated siRNAs by controlling steric effects in the major versus minor grooves. J Am Chem Soc. 2011 Apr 27; 133(16):6343-51. Kannan A, Fostvedt E, Beal PA, Burrows CJ. PMID: 21452817; PMCID: PMC3086133.
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RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1. Proc Natl Acad Sci U S A. 2010 Nov 30; 107(48):20715-9. Yeo J, Goodman RA, Schirle NT, David SS, Beal PA. PMID: 21068368; PMCID: PMC2996456.
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Minor-groove-modulating adenosine replacements control protein binding and RNAi activity in siRNAs. ACS Chem Biol. 2010 Dec 17; 5(12):1115-24. Peacock H, Fostvedt E, Beal PA. PMID: 20863128; PMCID: PMC3003776.
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Selective inhibition of ADAR2-catalyzed editing of the serotonin 2c receptor pre-mRNA by a helix-threading peptide. Org Biomol Chem. 2010 Nov 07; 8(21):4898-904. Schirle NT, Goodman RA, Krishnamurthy M, Beal PA. PMID: 20820662.
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N(2)-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA. Org Lett. 2010 Mar 05; 12(5):1044-7. Peacock H, Maydanovych O, Beal PA. PMID: 20108910; PMCID: PMC2830388.
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Covalent hydration energies for purine analogs by quantum chemical methods. J Comput Chem. 2010 Mar; 31(4):721-5. Wang SC, Beal PA, Tantillo DJ. PMID: 19569207.
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Matching active site and substrate structures for an RNA editing reaction. J Am Chem Soc. 2009 Aug 26; 131(33):11882-91. Pokharel S, Jayalath P, Maydanovych O, Goodman RA, Wang SC, Tantillo DJ, Beal PA. PMID: 19642681.
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Synthesis and evaluation of an RNA editing substrate bearing 2'-deoxy-2'-mercaptoadenosine. Nucleosides Nucleotides Nucleic Acids. 2009 Feb; 28(2):78-88. Jayalath P, Pokharel S, Véliz E, Beal PA. PMID: 19219738; PMCID: PMC2747504.
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Screening helix-threading peptides for RNA binding using a thiazole orange displacement assay. Bioorg Med Chem. 2008 Oct 01; 16(19):8914-21. Krishnamurthy M, Schirle NT, Beal PA. PMID: 18789700; PMCID: PMC2585546.
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The chemistry and biology of RNA editing by adenosine deaminases. Nucleic Acids Symp Ser (Oxf). 2007; (51):83-4. Beal PA, Maydanovych O, Pokharel S. PMID: 18029597.
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Macrocyclic helix-threading peptides for targeting RNA. Angew Chem Int Ed Engl. 2007; 46(37):7044-7. Krishnamurthy M, Simon K, Orendt AM, Beal PA. PMID: 17691090.
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Probing adenosine-to-inosine editing reactions using RNA-containing nucleoside analogs. Methods Enzymol. 2007; 424:369-86. Maydanovych O, Easterwood LM, Cui T, Véliz EA, Pokharel S, Beal PA. PMID: 17662850.
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High-throughput screening for functional adenosine to inosine RNA editing systems. ACS Chem Biol. 2006 Dec 15; 1(12):761-5. Pokharel S, Beal PA. PMID: 17240974.
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Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification. Nucleic Acids Res. 2006; 34(17):4900-11. Puthenveetil S, Whitby L, Ren J, Kelnar K, Krebs JF, Beal PA. PMID: 16982647; PMCID: PMC1635244.
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C6-substituted analogues of 8-azanebularine: probes of an RNA-editing enzyme active site. Org Lett. 2006 Aug 17; 8(17):3753-6. Maydanovych O, Beal PA. PMID: 16898809.
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Breaking the central dogma by RNA editing. Chem Rev. 2006 Aug; 106(8):3397-411. Maydanovych O, Beal PA. PMID: 16895334.
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RNA binding and thiolytic stability of a quinoline-containing helix-threading peptide. Org Biomol Chem. 2006 Feb 21; 4(4):639-45. Krishnamurthy M, Gooch BD, Beal PA. PMID: 16467938.
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Binding of helix-threading peptides to E. coli 16S ribosomal RNA and inhibition of the S15-16S complex. Chembiochem. 2005 Dec; 6(12):2247-54. Gooch BD, Krishnamurthy M, Shadid M, Beal PA. PMID: 16245373.
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Duplex RNA-binding enzymes: headliners from neurobiology, virology, and development. Chembiochem. 2005 Feb; 6(2):257-66. Beal PA. PMID: 15645515.
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Inhibitory properties of nucleic acid-binding ligands on protein synthesis. FEBS Lett. 2005 Jan 03; 579(1):79-89. Malina A, Khan S, Carlson CB, Svitkin Y, Harvey I, Sonenberg N, Beal PA, Pelletier J. PMID: 15620694.
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A transition state analogue for an RNA-editing reaction. J Am Chem Soc. 2004 Sep 15; 126(36):11213-9. Haudenschild BL, Maydanovych O, Véliz EA, Macbeth MR, Bass BL, Beal PA. PMID: 15355102; PMCID: PMC1823040.
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Recognition of duplex RNA by helix-threading peptides. J Am Chem Soc. 2004 Sep 01; 126(34):10603-10. Gooch BD, Beal PA. PMID: 15327318.
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The binding selectivity of ADAR2's dsRBMs contributes to RNA-editing selectivity. Chem Biol. 2004 Sep; 11(9):1239-50. Stephens OM, Haudenschild BL, Beal PA. PMID: 15380184.
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Site-specific modification of Epstein-Barr virus-encoded RNA 1 with N2-benzylguanosine limits the binding sites occupied by PKR. Chembiochem. 2004 Mar 05; 5(3):383-6. Puthenveetil S, Véliz EA, Beal PA. PMID: 14997533.
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Peptide quinoline conjugates: a new class of RNA-binding molecules. Org Lett. 2004 Jan 08; 6(1):63-6. Krishnamurthy M, Gooch BD, Beal PA. PMID: 14703351.
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Substrate analogues for an RNA-editing adenosine deaminase: mechanistic investigation and inhibitor design. J Am Chem Soc. 2003 Sep 10; 125(36):10867-76. Véliz EA, Easterwood LM, Beal PA. PMID: 12952466.
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Recognition of double-stranded RNA by proteins and small molecules. Biopolymers. 2003 Sep; 70(1):86-102. Carlson CB, Stephens OM, Beal PA. PMID: 12925995.
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Small molecule inhibitors of the RNA-dependent protein kinase. Biochem Biophys Res Commun. 2003 Aug 15; 308(1):50-7. Jammi NV, Whitby LR, Beal PA. PMID: 12890478.
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Preferred RNA binding sites for a threading intercalator revealed by in vitro evolution. Chem Biol. 2003 Jul; 10(7):663-72. Carlson CB, Vuyisich M, Gooch BD, Beal PA. PMID: 12890540.
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Selection of small-molecule mediators of the RNA regulation of PKR, the RNA-dependent protein kinase. Chembiochem. 2002 Sep 02; 3(9):859-65. Carlson CB, Spanggord RJ, Beal PA. PMID: 12210987.
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Controlling protein activity with ligand-regulated RNA aptamers. Chem Biol. 2002 Aug; 9(8):907-13. Vuyisich M, Beal PA. PMID: 12204690.
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Point of attachment and sequence of immobilized peptide-acridine conjugates control affinity for nucleic acids. J Am Chem Soc. 2002 Jul 24; 124(29):8510-1. Carlson CB, Beal PA. PMID: 12121075.
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The binding site of the RNA-dependent protein kinase (PKR) on EBER1 RNA from Epstein-Barr virus. EMBO Rep. 2002 Jul; 3(7):622-7. Vuyisich M, Spanggord RJ, Beal PA. PMID: 12101093; PMCID: PMC1084191.
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Identification of binding sites for both dsRBMs of PKR on kinase-activating and kinase-inhibiting RNA ligands. Biochemistry. 2002 Apr 09; 41(14):4511-20. Spanggord RJ, Vuyisich M, Beal PA. PMID: 11926812.
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