Philip Rosenthal | UCSF Profiles

Accuracy of Plasmodium falciparum genetic data for estimating parasite prevalence and malaria incidence in Uganda. Malar J. 2026 Feb 21.
Kiyaga S, Mbabazi M, Katairo T, Kabbale KD, Asua V, Nsengimaana B, Wiringilimaana I, Semakuba FD, Mwubaha C, Nakasaanya J, Watyekele E, Ayitewala A, Tukwasibwe S, Mulondo J, Nsobya SL, Agaba B, Maiteki-Sebuguzi C, Kamya MR, Kateete DP, Nabende JN, Jjingo D, Mboowa G, Batte C, Ssewanyana I, Aranda-Díaz A, Dorsey G,
Rosenthal PJ
, Conrad M,
Greenhouse B
Briggs J
. PMID: 41723456.
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PubMed
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Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. J Infect Dis. 2026 Feb 13.
Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD,
Gerlovina I
Hathaway N
Briggs J
, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI,
Dorsey G
Rosenthal PJ
. PMID: 41679334.
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Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomized trial in Uganda. Int J Epidemiol. 2026 Jan 02; 55(1).
Adrama H, Dela Cruz EJ,
Ozarslan N
, Kakuru A, Odongo B,
Gaw SL
, Benjamin-Chung J, Kizza J, Aguti M, Ategeka J, Olwoch P, Nakalembe M, Opira B,
Clark TD
, Kamya MR,
Rosenthal PJ
Dorsey G
Roh ME
. PMID: 41657027.
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PubMed
Mentions:
Optimization of Prodiginines as Single-Dose Curative Antimalarials. J Med Chem. 2025 Nov 27; 68(22):24469-24501.
Kumar A, Li Y, Zhang X, Gaddam M, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Blount C, DeLuca J, Vuong C, Kudyba K, Roncal N, Ashraf K, Lee PJ, Pannone K, Leed S, Dinh HT, Mdaki K, Navarrete K, Charlton J, Binauhan AJ, Qahash T, Kibe KM, Shoue DA, Checkley L, Ferdig MT, Chim-Ong A, Cui L, Orena S, Byaruhanga O, Assimwe J, Tibagambirwa I, Chithanna S, Dodean RA, Legac J,
Kreutzfeld O
Rosenthal PJ
, Cooper RA, Reynolds KA, Roth A, Kelly JX, Kancharla P. PMID: 41253140; PMCID:
PMC12649828
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PubMed
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Humans
Animals
Is Seasonal Malaria Chemoprevention with Sulfadoxine-Pyrimethamine/Amodiaquine Appropriate in East Africa? Clin Infect Dis. 2025 Nov 13.
Rosenthal PJ
. PMID: 41231735.
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PubMed
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Recurrent Plasmodium falciparum parasitemia and drug resistance mutations during intermittent preventive treatment of malaria in pregnancy in Uganda. medRxiv. 2025 Oct 20.
Kizza J, Katairo T, Kakuru A, Nsengimaana B, Esilu T, Wiringilimaana I, Semakuba FD,
Gerlovina I
Hathaway N
, Briggs J, Tukwasibwe S, Kiwuwa SM, Kamya MR, Nankabirwa JI, Dorsey G,
Rosenthal PJ
. PMID: 41282777; PMCID:
PMC12633580
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PubMed
Mentions:
Characterization of β-Carboline Derivatives Reveals a High Barrier to Resistance and Potent Activity against Ring-Stage and DHA-Induced Dormant Plasmodium falciparum. ACS Infect Dis. 2025 Nov 14; 11(11):3310-3322.
Haney RS, Butler JH, Wardlaw LA, Merino EF, Mendiola V, Cooper CA, Mathew J, Tumwebaze PK,
Rosenthal PJ
, Cooper RA, Kyle DE, Rizopoulos Z, Baud D, Brand S, Totrov M, Carlier PR, Cassera MB. PMID: 41105262; PMCID:
PMC12624827
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PubMed
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Humans
Animals
Improving antimalarial therapeutic efficacy studies. Lancet Infect Dis. 2025 Sep 30.
Rosenthal PJ
. PMID: 41043440.
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PubMed
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Plasma proteome correlations with liver stiffness in pediatric cholestasis implicate epithelial to mesenchymal transition. Hepatol Commun. 2025 Oct 01; 9(10).
Shneider BL, Kanchi RS, Grimm SL, Devaraj S, Emamaullee J, Schraw J, Lupo PJ, Bezerra JA, Loomes KM, Magee JC, Sokol RJ, Wang KS, Kriegmeier A, Hsu E, Molleston JP,
Rosenthal P
Kohli R
, Karpen SJ, Horslen SP, Jensen MK, Barbetta A, Coarfa C, Childhood Liver Disease Research Network. PMID: 41021277; PMCID:
PMC12483069
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PubMed
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Humans
Dihydroartemisinin-piperaquine plus sulfadoxine-pyrimethamine versus either drug alone for intermittent preventive treatment of malaria in pregnancy: A double-blind, randomized, controlled phase 3 trial from Uganda. PLoS Med. 2025 Sep; 22(9):e1004582.
Kakuru A, Kizza J, Aguti M, Adrama H, Ategeka J, Olwoch P, Nakalembe M, Nankabirwa JI, Opira B,
Ozarslan N
Ranjit A
, Dela Cruz E,
Clark TD
Roh ME
Gaw SL
, Jagannathan P,
Rosenthal PJ
, Kamya MR, Dorsey G. PMID: 40966190; PMCID:
PMC12445490
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PubMed
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Humans
CT
Clinical Trials
Maternal and household risk factors for malaria in pregnancy and low birthweight: a prospective cohort study from Uganda. Res Sq. 2025 Sep 17.
Aguti M, Kizza J, Kakuru A, Nakalembe M, Nankabirwa JI,
Gaw SL
, Opira B, Ssemukuye T,
Ozarslan N
Ranjit A
, Cruz E,
Clark TD
Roh ME
, Jagannathan P,
Rosenthal PJ
, Adrama H, Olwoch P, Mayende J, Odongo B, John A, Kamya MR, Dorsey G. PMID: 41001541; PMCID:
PMC12458556
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PubMed
Mentions:
Remoscope: a label-free imaging cytometer for malaria diagnostics. Trans R Soc Trop Med Hyg. 2025 Sep 02; 119(9):1100-1111.
Lebel PM, Jeyakumar I, Khoo MWL, Emorut J, Charlton C, Saxena A, Jacobsen A, Huynh E, Wu W, Courville G, Fu PC, Raghavan M, Puccinelli R, Olwoch P,
Dorsey G
Rosenthal PJ
DeRisi J
Gomez-Sjoberg R
. PMID: 40631413.
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PubMed
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Humans
Animals
Cells
Prospective Multicenter Longitudinal Measurement of Liver Stiffness in School-Age Children With Cholestatic Liver Disease. Gastro Hep Adv. 2025; 4(10):100788.
Shneider BL, Goodrich NP, Ye W, Molleston JP, Leung DH, Sokol RJ, Cavallo L, Wang K, Valentino PL, Teckman JH, Squires JE, Sundaram SS,
Rosenthal P
, Romero R, Miethke AG, Loomes KM,
Kohli R
, Karpen SJ, Kamath BM, Jensen MK, Bezerra JA, Bass LM, Magee JC, ChiLDReN. PMID: 41142527; PMCID:
PMC12547242
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PubMed
Mentions:
Efficacies of artemether-lumefantrine, artesunate-amodiaquine, dihydroartemisinin-piperaquine, and artesunate-pyronaridine for the treatment of uncomplicated Plasmodium falciparum malaria in children aged 6 months to 10 years in Uganda: a randomised, open-label, phase 4 clinical trial. Lancet Infect Dis. 2026 Jan; 26(1):67-78.
Kamya MR, Nankabirwa JI, Ebong C, Asua V, Kiggundu M, Orena S, Okitwi M, Tukwasibwe S, Agaba B, Kyabayinze D, Opigo J, Rutazana D, Binagwa B, Mugwanya E, Babirye S, Sebikaari G, Condo PM, Appiah G, Nsobya SL, Conrad MD,
Rosenthal PJ
, Moriarty LF, Yeka A. PMID: 40845863.
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PubMed
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Humans
Animals
CT
Clinical Trials
Weight gain in infancy and metabolic dysfunction-associated steatotic liver disease (MASLD) in a prospective birth cohort of Latino children. Matern Health Neonatol Perinatol. 2025 Aug 15; 11(1):25.
Maxwell SL
Price JC
Perito ER
Rosenthal P
Wojcicki JM
. PMID: 40814062; PMCID:
PMC12355774
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PubMed
Mentions:
Relating household entomological measures to individual malaria risk. Malar J. 2025 Aug 14; 24(1):261.
McClure M, Arinaitwe E, Kamya MR,
Rosenthal PJ
, Nankabirwa J, Kilama M, Musiime A, Dorsey G,
Greenhouse B
Rodriguez-Barraquer I
. PMID: 40804728; PMCID:
PMC12352003
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PubMed
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Humans
Animals
PH
Public Health
Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024. Nat Commun. 2025 Aug 09; 16(1):7353.
Okitwi M, Orena S, Tumwebaze PK, Katairo T, Taremwa Y, Byaruhanga O, Tukwasibwe S, Nsobya SL, Legac J, Bailey JA, Cooper RA, Conrad MD,
Rosenthal PJ
. PMID: 40783405; PMCID:
PMC12335539
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PubMed
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Humans
Animals
Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance. Sci Adv. 2025 Aug 08; 11(32):eads9168.
Klope MT, Talukder P, Blank BR, Chelebieva S, Chen J, Fontaine SD, Gonciarz RL,
Jaishankar P
, Lee GJ, Legac J, Mathur V, Narayan A, Okitwi M, Orena S, Settineri NS, Tapia JA, Taremwa Y, Tumwebaze PK, Vinod A, Burrows JN,
Rosenthal PJ
, Cooper RA,
Renslo AR
. PMID: 40779626; PMCID:
PMC12333675
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PubMed
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Humans
Animals
Cells
Regulatory KIR+CD8+ T cells are elevated during human pregnancy. Sci Transl Med. 2025 Aug 06; 17(810):eadm7697.
Li J, Wang X, Lackner AI, Narasimhan P,
Li L
, Mallajosyula V, Johnson MM, Höbler AL, Kirosingh AS, Braun AE, Nankya F, Musinguzi K, Kakuru A, Kamya M,
Rosenthal PJ
Dorsey G
, Jagannathan P, Angelo M, Pollheimer J,
Gaw SL
, Winn VD, Nadeau KC, Davis MM. PMID: 40768597; PMCID:
PMC12696559
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PubMed
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Humans
Cells
Biannual Mass Azithromycin Distributions for Preschool Children and Malaria Parasitemia: A Secondary Analysis of the MORDOR Cluster Randomized Trial. JAMA Netw Open. 2025 Aug 01; 8(8):e2527148.
Arzika AM, Abdou A, Maliki R, Lebas E, Cook C, Vanderschelden B,
O'Brien KS
, Cotter SY, Varnado NE, Callahan EK, Bailey RL, West SK,
Rosenthal PJ
Porco TC
Lietman TM
Keenan JD
, MORDOR-Niger Study Group. PMID: 40824641; PMCID:
PMC12362227
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PubMed
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Translation:
Humans
PH
Public Health
CT
Clinical Trials
Plasmodiumfalciparum protein kinase 6 and hemozoin formation are inhibited by a type II human kinase inhibitor exhibiting antimalarial activity. Cell Chem Biol. 2025 Jul 17; 32(7):926-941.e23.
Nardella F, Jiang T, Wang L, Bohmer MJ, Chakraborty S, Okombo J, Calla J, Silva TM, Pazicky S, Che J, Jeon J, Vincent E, Boonyalai N, Coyle R, Buchanan MJ, Schaefer S, Chen D, Khan A, Mayville E, De Souza ML, Treat M, Charlton J, Tumwebaze PK, Tjia S, Montejo L, Cover K,
Rosenthal PJ
, Cooper RA, Bozdech Z, Lee MCS, Chakrabarti R, Desai SA, Fidock DA, Wang J, Gray NS,
Winzeler EA
, Chakrabarti D. PMID: 40628257; PMCID:
PMC12406260
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PubMed
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Humans
Animals
Impact of intermittent preventive treatment of malaria in pregnancy with sulfadoxine-pyrimethamine on sexually transmitted and reproductive tract infections: results from a randomised trial in Uganda. medRxiv. 2025 Jul 03.
Adrama H, Dela Cruz EJ,
Ozarslan N
, Kakuru A, Odongo B,
Gaw SL
, Benjamin-Chung J, Kizza J, Aguti M, Ategeka J, Olwoch P, Nakalembe M, Opira B,
Clark TD
, Kamya MR,
Rosenthal PJ
, Dorsey G, Roh ME. PMID: 40630588; PMCID:
PMC12236864
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PubMed
Mentions:
Potent Acridone Antimalarial against All Three Life Stages of Plasmodium. Res Sq. 2025 Jun 27.
Kancharla P, Dodean RA, Li Y, Zhang X, Kelly S, Charlton J, Binauhan A, Garcia L, Caridha D, Madejczyk MS, Jin X, Dennis WE, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Chimong A, Cui L, Vega-Rodriguez J, Okitwi M,
Kreutzfeld O
, Docan C, Green C, Liu Y, Agulay A, Mirsalis J, Farrell SN, McFadden GI, Goodman CD, Probst AS, Nilsen A, Catteruccia F,
Rosenthal PJ
, Riscoe M, Cooper R, Roth A, Kelly J. PMID: 40678217; PMCID:
PMC12270210
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PubMed
Mentions:
Performance of molecular inversion probe DR23K and Paragon MAD4HatTeR Amplicon sequencing panels for detection of Plasmodium falciparum mutations associated with antimalarial drug resistance. Malar J. 2025 Jun 12; 24(1):188.
Katairo T, Asua V, Nsengimaana B, Tukwasibwe S, Semakuba FD, Wiringilimaana I, Kagurusi BA, Mwubaha C, Nakasaanya J, Garg S, Kiyaga S, Mbabazi M, Kabbale KD, Ayitewala A, Nsobya SL, Kamya MR, Ssewanyana I, Bailey JA, Aranda-Díaz A,
Rosenthal PJ
Greenhouse B
Briggs J
, Conrad MD. PMID: 40506703; PMCID:
PMC12164144
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PubMed
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Humans
Animals
Highly multiplexed molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole-genome sequencing assessments for selection and relatedness. Front Genet. 2025; 16:1526049.
Niaré K, Crudale R, Fola AA, Wernsman Young N, Asua V, Conrad MD, Gashema P, Ghansah A, Hangi S, Ishengoma DS, Mazarati JB, Zeleke AJ,
Rosenthal PJ
, Djimdé AA, Juliano JJ, Bailey JA. PMID: 40574802; PMCID:
PMC12198981
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PubMed
Mentions:
Optimization of Tambjamines Active against Multiple Stages of Malaria Parasites. J Med Chem. 2025 Jun 12; 68(11):11746-11785.
Kumar A, Li Y, Zhang X, Jin X, Dennis WE, Chetree R, Blount C, Caridha D, Madejczyk MS, Lee PJ, Pannone K, DeLuca J, Vuong C, Leed S, Dinh HT, Mdaki K, Mahato R, Sen P, Mondal T, Phukan K, Saha A, Chim-Ong A, Cui L, Valmon R, Chithanna S, Dodean RA, Peyton DH, Orena S, Assimwe J, Tibagambirwa I, Angutoko P, Legac J,
Kreutzfeld O
Rosenthal PJ
, Chenu E, Duffy J, Roth A, Reynolds KA, Kelly JX, Kancharla P. PMID: 40450579; PMCID:
PMC12163703
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PubMed
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Humans
Animals
Slowing the spread of treatment failure to artemisinin-based combination therapies in Uganda. medRxiv. 2025 May 18.
Nguyen TD, Zupko RJ, Conrad MD, Rukundo GB, Farinha CC, Asua VD, Tran KT, Grace DM,
Rosenthal PJ
, Agaba BB, Kamya MR, Opigo J, Boni MF. PMID: 40463542; PMCID:
PMC12132124
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PubMed
Mentions:
Development of Next-Generation Antimalarial Acridones with Radical Cure Potential. J Med Chem. 2025 Apr 24; 68(8):8817-8840.
Dodean RA, Li Y, Zhang X, Caridha D, Madejczyk MS, Jin X, Dennis WE, Chetree R, Kudyba K, McEnearney S, Lee PJ, Blount C, DeLuca J, Vuong C, Pannone K, Dinh HT, Mdaki K, Leed S, Martin ML, Pybus BS, Pou S, Winter RW, Liebman KM, Williams R, Kumar A, Chim-Ong A, Cui L, Orena S, Assimwe J, Tibagambirwa I, Byaruhanga O, Angutoko P, Legac J,
Kreutzfeld O
Rosenthal PJ
, Cooper RA, Nilsen A, Riscoe MK, Roth A, Kancharla P, Kelly JX. PMID: 40179277; PMCID:
PMC12021554
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PubMed
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Humans
Animals
Long-term efficacy and safety of sofosbuvir-based direct-acting antiviral regimens in paediatric patients with hepatitis C virus infection: an international registry study. Lancet Child Adolesc Health. 2025 04; 9(4):248-254.
Gonzalez-Peralta RP, Wen JW, Hardikar W, Karnsakul WW, Whitworth S, Lin CH, Indolfi G,
Rosenthal P
, Balistreri W,
Schwarz KB
, Honegger JR, Zhang X, Svarovskaia EC, Suri V, Kersey K, Leung DH. PMID: 40113366.
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PubMed
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Humans
Selection of Plasmodium falciparum kelch13 mutations in Uganda in comparison with southeast Asia: a modelling study. Lancet Microbe. 2025 May; 6(5):101027.
Meier-Scherling CPG, Watson OJ, Asua V, Ghinai I, Katairo T, Garg S, Conrad MD,
Rosenthal PJ
, Okell LC, Bailey JA. PMID: 40112841; PMCID:
PMC12128186
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PubMed
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Humans
Animals
US Public Health and Biomedical Research Institutions Help Keep the World Safe and Deserve Continued Strong Support. Am J Trop Med Hyg. 2025 May 07; 112(5):943-944.
Rosenthal PJ
, Hamer DH, Bausch DG, Nishi JB, Fidock DA. PMID: 40080909; PMCID:
PMC12062666
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PubMed
Mentions:
Fields:
Highly multiplex molecular inversion probe panel in Plasmodium falciparum targeting common SNPs approximates whole genome sequencing assessments for selection and relatedness. medRxiv. 2025 Mar 13.
Niaré K, Crudale R, Fola AA, Wernsman Young N, Asua V, Conrad M, Gashema P, Ghansah A, Hangi S, Ishengoma DS, Mazarati JB, Zeleke AJ,
Rosenthal PJ
, Djimdé AA, Juliano JJ, Bailey JA. PMID: 40162260; PMCID:
PMC11952476
View in:
PubMed
Mentions:
Placental malaria induces a unique methylation profile associated with fetal growth restriction. Epigenetics. 2025 Dec; 20(1):2475276.
Ozarslan N
, Mong C, Ategeka J,
Li L
, Buarpung S,
Robinson JF
, Kizza J, Kakuru A, Kamya MR,
Dorsey G
Rosenthal PJ
Gaw SL
. PMID: 40051167; PMCID:
PMC11901535
View in:
PubMed
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Humans
Cells
Relating household entomological measures to individual malaria risk. Res Sq. 2025 Feb 04.
McClure M, Arinaitwe E, Kamya MR,
Rosenthal PJ
, Nankabirwa J, Maxwell K, Musiime A,
Dorsey G
Greenhouse B
, Rodriguez-Barraquer I. PMID: 39975909; PMCID:
PMC11838747
View in:
PubMed
Mentions:
Increased serum GM-CSF at diagnosis of biliary atresia is associated with improved biliary drainage. Pediatr Res. 2025 Oct; 98(4):1386-1394.
Taylor SA, Harpavat S, Gromer KD, Andreev V, Loomes KM, Bezerra JA, Jarasvaraparn C, Wang K, Horslen S,
Rosenthal P
, Teckman J, Valentino PL, Ng VL, Karpen SJ, Sokol RJ, Alonso EM, Mack CL, Childhood Liver Disease Research Network (ChiLDReN). PMID: 39881181; PMCID:
PMC12304249
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PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Performance of Molecular Inversion Probe DR23K and Paragon MAD4HatTeR Amplicon Sequencing Panels for Detection of Plasmodium falciparum Mutations Associated with Antimalarial Drug Resistance. Res Sq. 2025 Jan 21.
Katairo T, Asua V, Nsengimaana B, Tukwasibwe S, Semakuba FD, Wiringilimaana I, Garg S, Kiyaga S, Mbabazi M, Kabbale KD, Ayitewala A, Nsobya SL, Kamya MR, Ssewanyana I, Bailey JA, Aranda-Díaz A,
Rosenthal PJ
Greenhouse B
Briggs J
, Conrad MD. PMID: 39975885; PMCID:
PMC11838754
View in:
PubMed
Mentions:
Artemisinin Partial Resistance and the Treatment of Severe Malaria. JAMA. 2025 Jan 07; 333(1):37-38.
Rosenthal PJ
. PMID: 39540803.
View in:
PubMed
Mentions:
Fields:
Changes in susceptibility of Plasmodium falciparum to antimalarial drugs in Uganda over time: 2019-2024. medRxiv. 2025 Jan 01.
Okitwi M, Orena S, Tumwebaze PK, Katairo T, Taremwa Y, Byaruhanga O, Tukwasibwe S, Nsobya SL, Legac J, Cooper RA, Conrad MD,
Rosenthal PJ
. PMID: 39802777; PMCID:
PMC11722467
View in:
PubMed
Mentions:
Regional action needed to halt antimalarial drug resistance in Africa. Lancet. 2025 Jan 04; 405(10472):7-10.
Martinez-Vega R, Ishengoma DS,
Gosling R
Rosenthal PJ
, Dondorp A, Barnes KI, Nsanzabana C, Djimde AA, Ochola-Oyier LI, Tibenderana J, Chimumbwa J, Golassa L, Kapologwe NA, Mbacham WF, Kamya MR, Fidock DA, Komatsu R, von Seidlein L, Dhorda M. PMID: 39674185; PMCID:
PMC11838165
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PubMed
Mentions:
Fields:
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission. Sci Adv. 2024 Dec 06; 10(49):eadq1383.
Gomez-Gonzalez PJ, Gupta A, Drought LG, Patel A, Okombo J, van der Watt M, Walker-Gray R, Schindler KA, Burkhard AY, Yeo T, Narwal SK, Bloxham TS, Flueck C, Walker EM, Rey JA, Fairhurst KJ, Reader J, Park H, Pollard HG, Stewart LB, Brandner-Garrod L, Kristan M, Sterk GJ, van Nuland YM, Manko E, van Schalkwyk DA, Zheng Y, Leurs R, Dechering KJ, Aguiar ACC, Guido RVC, Pereira DB, Tumwebaze PK, Nosbya SL,
Rosenthal PJ
, Cooper RA, Palmer M, Parkinson T, Burrows JN, Uhlemann AC, Birkholtz LM, Small-Saunders JL, Duffy J, Fidock DA, Brown A, Gardner M, Baker DA. PMID: 39642214; PMCID:
PMC11623267
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PubMed
Mentions:
Fields:
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Humans
Animals
Systematic in vitro evolution in Plasmodium falciparum reveals key determinants of drug resistance. Science. 2024 11 29; 386(6725):eadk9893.
Luth MR, Godinez-Macias KP, Chen D, Okombo J, Thathy V, Cheng X, Daggupati S, Davies H, Dhingra SK,
Economy JM
, Edgar RCS, Gomez-Lorenzo MG, Istvan ES, Jado JC, LaMonte GM, Melillo B, Mok S, Narwal SK, Ndiaye T, Ottilie S, Palomo Diaz S, Park H, Peña S,
Rocamora F
, Sakata-Kato T, Small-Saunders JL, Summers RL, Tumwebaze PK, Vanaerschot M, Xia G, Yeo T, You A, Gamo FJ, Goldberg DE, Lee MCS, McNamara CW, Ndiaye D,
Rosenthal PJ
, Schreiber SL, Serra G, De Siqueira-Neto JL, Skinner-Adams TS, Uhlemann AC, Kato N, Lukens AK, Wirth DF, Fidock DA,
Winzeler EA
. PMID: 39607932; PMCID:
PMC11809290
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PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
The extended recovery ring-stage survival assay is a scalable alternative for artemisinin susceptibility phenotyping of fresh Plasmodium falciparum isolates. Antimicrob Agents Chemother. 2024 12 05; 68(12):e0118324.
Okitwi M, Shoue DA, Checkley LA, Orena S, Ceja FG, Taremwa Y, Tumwebaze PK, Katairo T, Byaruhanga O, Sievert MA, Garg S,
Kreutzfeld OK
, Legac J, Bailey JA, Nsobya SL, Conrad MD,
Rosenthal PJ
, Ferdig MT, Cooper RA. PMID: 39545737; PMCID:
PMC11619366
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PubMed
Mentions:
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Translation:
Humans
Animals
Remoscope: a label-free imaging cytometer for malaria diagnostics. medRxiv. 2024 Nov 13.
Lebel PM, Jeyakumar I, Khoo MWL, Charlton C, Saxena A, Jacobsen A, James E, Huynh E, Wu W, Courville G, Fu PC, Raghavan M, Puccinelli R, Peter O,
Dorsey G
Rosenthal P
DeRisi J
Gomez-Sjoberg R
. PMID: 39606416; PMCID:
PMC11601755
View in:
PubMed
Mentions:
Tambjamines as Fast-Acting Multistage Antimalarials. ACS Infect Dis. 2024 12 13; 10(12):4291-4300.
Kumar A, Li Y, Dodean RA, Roth A, Caridha D, Madejczyk MS, Jin X, Dennis WE, Lee PJ, Pybus BS, Martin M, Pannone K, Dinh HT, Blount C, Chetree R, DeLuca J, Evans M, Nadeau R, Vuong C, Leed S, Black C, Sousa J, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK,
Rosenthal PJ
, Cooper RA, Rottmann M, Orjuela-Sanchez P, Meister S,
Winzeler EA
, Delves MJ, Matthews H, Baum J, Kirby RW, Burrows JN, Duffy J, Peyton DH, Reynolds KA, Kelly JX, Kancharla P. PMID: 39526703; PMCID:
PMC11645189
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Refugees. Am J Trop Med Hyg. 2024 Dec 04; 111(6):1159-1160.
Rosenthal PJ
. PMID: 39499950; PMCID:
PMC11619497
View in:
PubMed
Mentions:
Fields:
Natural killer cell antibody-dependent cellular cytotoxicity to Plasmodium falciparum is impacted by cellular phenotypes, erythrocyte polymorphisms, parasite diversity and intensity of transmission. Clin Transl Immunology. 2024; 13(11):e70005.
Tukwasibwe S, Lewis SN, Taremwa Y, van der Ploeg K, Press KD, Ty M, Namirimu Nankya F, Musinguzi K, Nansubuga E, Bach F, Chamai M, Okitwi M, Tumusiime G, Nakimuli A, Colucci F, Kamya MR, Nankabirwa JI, Arinaitwe E,
Greenhouse B
Dorsey G
Rosenthal PJ
, Ssewanyana I, Jagannathan P. PMID: 39493859; PMCID:
PMC11528551
View in:
PubMed
Mentions:
The 2024 Public Health Emergency of International Concern: A Global Failure to Control Mpox. Am J Trop Med Hyg. 2025 Jan 08; 112(1):17-20.
Zumla A,
Rosenthal PJ
, Sam-Agudu NA, Ogoina D, Mbala-Kingebeni P, Ntoumi F, Nakouné E, Njouom R, Ndembi N, Mills EJ, Muyembe-Tamfum JJ, Nachega JB. PMID: 39406210; PMCID:
PMC11720770
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Drug-Drug Interaction Between Dihydroartemisinin-Piperaquine and Sulfadoxine-Pyrimethamine During Malaria Chemoprevention in Pregnant Women. Clin Pharmacol Ther. 2025 Feb; 117(2):506-514.
Mwebaza N,
Roh ME
, Geng YZ, Opio L, Opira B, Marzan F, Mwima MW, Ssemukuye T, Guo K, Gingrich D, Fotaki N, Kakuru A, Kizza J, Aguti M, Adrama H, Kamya M, Dorsey G,
Rosenthal PJ
Aweeka FT
Huang L
. PMID: 39402742; PMCID:
PMC11747899
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
CT
Clinical Trials
Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction. bioRxiv. 2024 Oct 04.
Ozarslan N
, Mong C, Ategeka J, Li L, Buarpung S,
Robinson JF
, Kizza J, Kakuru A, Kamya MR, Dorsey G,
Rosenthal PJ
Gaw SL
. PMID: 38798500; PMCID:
PMC11118523
View in:
PubMed
Mentions:
Gestational SARS-CoV-2 Infection in a Ugandan Birth Cohort: High Incidence, Mild Maternal Disease, and Evidence of Association with Transient Infant Stunting. Am J Trop Med Hyg. 2024 Nov 06; 111(5):1107-1117.
Jacobson KB, Röltgen K, Lam B, Nayebare P, Kakuru A, Kizza J, Aguti M, Nankya F,
Briggs J
, Takahashi S,
Greenhouse B
Rodriguez-Barraquer I
, van der Ploeg K, Wohlstadter JN, Sigal GB,
Roh ME
, Nankabirwa JI, Cuu G,
Gaw SL
Rosenthal PJ
, Kamya MR, Ssewanyana I, Dorsey G, Boyd SD, Jagannathan P. PMID: 39288758; PMCID:
PMC11542540
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Environmental toxicants modulate disease severity in pediatric metabolic dysfunction-associated steatohepatitis. J Pediatr Gastroenterol Nutr. 2024 Nov; 79(5):943-953.
Jain AK
, Busgang SA, Gennings C, Yates KP,
Schwimmer JB
Rosenthal P
, Murray KF, Molleston JP, Scheimann A, Xanthakos SA,
Behling CA
, Carpenter D, Fishbein M, Neuschwander-Tetri BA, Tonasia J, Vos MB. PMID: 39282813; PMCID:
PMC11955998
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Synthesis and In Vivo Profiling of Desymmetrized Antimalarial Trioxolanes with Diverse Carbamate Side Chains. ACS Med Chem Lett. 2024 Oct 10; 15(10):1764-1770.
Klope MT, Tapia Cardona JA, Chen J, Gonciarz RL,
Cheng K
Jaishankar P
, Kim J, Legac J,
Rosenthal PJ
Renslo AR
. PMID: 39411530; PMCID:
PMC11472393
View in:
PubMed
Mentions:
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. PLOS Glob Public Health. 2024; 4(8):e0003254.
Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ,
Greenhouse B
Briggs J
Krezanoski PJ
, Bousema T,
Rosenthal PJ
, Olwoch P, Jagannathan P,
Rodriguez-Barraquer I
, Dorsey G. PMID: 39208072; PMCID:
PMC11361418
View in:
PubMed
Mentions:
11
Varied Prevalence of Antimalarial Drug Resistance Markers in Different Populations of Newly Arrived Refugees in Uganda. J Infect Dis. 2024 Aug 16; 230(2):497-504.
Tukwasibwe S, Garg S, Katairo T, Asua V, Kagurusi BA, Mboowa G, Crudale R, Tumusiime G, Businge J, Alula D, Kasozi J, Wadembere I, Ssewanyana I, Arinaitwe E, Nankabirwa JI, Nsobya SL, Kamya MR,
Greenhouse B
, Dorsey G, Bailey JA,
Briggs J
, Conrad MD,
Rosenthal PJ
. PMID: 38874098; PMCID:
PMC11326807
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Ex vivo susceptibilities to ganaplacide and diversity in potential resistance mediators in Ugandan Plasmodium falciparum isolates. Antimicrob Agents Chemother. 2024 09 04; 68(9):e0046624.
Kreutzfeld O
, Orena S, Okitwi M, Tumwebaze PK, Byaruhanga O, Katairo T, Conrad MD, Legac J, Garg S, Crudale R, Aydemir O, Giesbrecht D, Nsobya SL, Blasco B, Duffey M, Rouillier M, Bailey JA, Cooper RA,
Rosenthal PJ
. PMID: 39136468; PMCID:
PMC11373204
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Artemisinin-resistant malaria in Africa demands urgent action. Science. 2024 07 19; 385(6706):252-254.
Dhorda M, Kaneko A, Komatsu R, Kc A, Mshamu S, Gesase S, Kapologwe N, Assefa A, Opigo J, Adoke Y, Ebong C, Karema C, Uwimana A, Mangara JN, Amaratunga C, Peto TJ, Tripura R, Callery JJ, Adhikari B, Mukaka M, Cheah PY, Mutesa L, Day NPJ, Barnes KI, Dondorp A,
Rosenthal PJ
, White NJ, von Seidlein L. PMID: 39024426.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
Animals
Urgent action is needed to confront artemisinin partial resistance in African malaria parasites. Nat Med. 2024 Jul; 30(7):1807-1808.
Ishengoma DS,
Gosling R
, Martinez-Vega R, Beshir KB, Bailey JA, Chimumbwa J, Sutherland C, Conrad MD, Tadesse FG, Juliano JJ, Kamya MR, Mbacham WF, Ménard D,
Rosenthal PJ
, Raman J,
Tatarsky A
, Tessema SK, Fidock DA, Djimde AA. PMID: 38710833.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Gravidity influences distinct transcriptional profiles of maternal and fetal placental macrophages at term. Front Immunol. 2024; 15:1384361.
Ozarslan N
Robinson JF
, Buarpung S, Kim MY, Ansbro MR, Akram J,
Montoya DJ
, Kamya MR, Kakuru A, Dorsey G,
Rosenthal PJ
, Cheng G,
Feeney ME
Fisher SJ
Gaw SL
. PMID: 38994356; PMCID:
PMC11237841
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Author Correction: Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa. Nat Rev Microbiol. 2024 Jun; 22(6):385.
Rosenthal PJ
, Asua V, Conrad MD. PMID: 38413816.
View in:
PubMed
Mentions:
Fields:
The surge of mpox in Africa: a call for action. Lancet Glob Health. 2024 Jul; 12(7):e1086-e1088.
Nachega JB, Sam-Agudu NA, Ogoina D, Mbala-Kingebeni P, Ntoumi F, Nakouné E, Njouom R, Lewis RF,
Gandhi M
Rosenthal PJ
, Rawat A, Wilson LA, Kindrachuk J, Liesenborghs L, Mills EJ, Preiser W, Rimoin AW, Sullivan NJ, Peeters M, Delaporte E, Baxter C, Harrison L, Hermans MP, Mohr EL, Gonsalves G, Ndembi N, Zumla A, Muyembe-Tamfum JJ, Mpox Research Consortium. PMID: 38735300.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Efficacy and safety of odevixibat in patients with Alagille syndrome (ASSERT): a phase 3, double-blind, randomised, placebo-controlled trial. Lancet Gastroenterol Hepatol. 2024 07; 9(7):632-645.
Ovchinsky N, Aumar M, Baker A, Baumann U, Bufler P, Cananzi M, Czubkowski P, Durmaz Ö, Fischer R, Indolfi G, Karnsakul WW, Lacaille F, Lee WS, Maggiore G,
Rosenthal P
, Ruiz M, Sokal E, Sturm E, van der Woerd W, Verkade HJ, Wehrman A, Clemson C, Yu Q, Ni Q, Ruvido J, Manganaro S, Mattsson JP. PMID: 38670135.
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
CT
Clinical Trials
Sofosbuvir-velpatasvir in children 3-17 years old with hepatitis C virus infection. J Pediatr Gastroenterol Nutr. 2024 Jun; 78(6):1342-1354.
Jonas MM, Romero R,
Rosenthal P
, Lin CH, Verucchi G, Wen J, Balistreri WF, Whitworth S, Bansal S, Leung DH, Narkewicz MR, Gonzalez-Peralta RP, Mangia A, Karnsakul W, Rao GS, Shao J, de Jong J, Parhy B, Osinusi A, Kersey K, Murray KF, Sokal EM,
Schwarz KB
. PMID: 38644678.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
CT
Clinical Trials
Development of Novel Peptidyl Nitriles Targeting Rhodesain and Falcipain-2 for the Treatment of Sleeping Sickness and Malaria. Int J Mol Sci. 2024 Apr 17; 25(8).
Di Chio C, Starvaggi J, Totaro N, Previti S, Natale B, Cosconati S, Bogacz M, Schirmeister T, Legac J,
Rosenthal PJ
, Zappalà M, Ettari R. PMID: 38673995; PMCID:
PMC11050014
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
The emergence of artemisinin partial resistance in Africa: how do we respond? Lancet Infect Dis. 2024 Sep; 24(9):e591-e600.
Rosenthal PJ
, Asua V, Bailey JA, Conrad MD, Ishengoma DS, Kamya MR, Rasmussen C, Tadesse FG, Uwimana A, Fidock DA. PMID: 38552654.
View in:
PubMed
Mentions:
45
Fields:
Translation:
Humans
Animals
Dramatic resurgence of malaria after 7 years of intensive vector control interventions in Eastern Uganda. medRxiv. 2024 Mar 16.
Kamya MR, Nankabirwa JI, Arinaitwe E, Rek J, Zedi M, Maiteki-Sebuguzi C, Opigo J, Staedke SG, Oruni A, Donnelly MJ,
Greenhouse B
, Briggs J,
Krezanoski PJ
, Bousema T,
Rosenthal PJ
, Olwoch P, Jagannathan P,
Rodriguez-Barraquer I
, Dorsey G. PMID: 38559091; PMCID:
PMC10980127
View in:
PubMed
Mentions:
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Diagnostic accuracy of serum matrix metalloproteinase-7 as a biomarker of biliary atresia in a large North American cohort. Hepatology. 2024 07 01; 80(1):152-162.
Pandurangi S, Mourya R, Nalluri S, Fei L, Dong S, Harpavat S, Guthery SL, Molleston JP,
Rosenthal P
, Sokol RJ, Wang KS, Ng V, Alonso EM, Hsu EK, Karpen SJ, Loomes KM, Magee JC, Shneider BL, Horslen SP, Teckman JH, Bezerra JA, Childhood Liver Disease Research Network. PMID: 38446707; PMCID:
PMC11191042
View in:
PubMed
Mentions:
14
Fields:
Translation:
Humans
Ex vivo drug susceptibility and resistance mediating genetic polymorphisms of Plasmodium falciparum in Bobo-Dioulasso, Burkina Faso. Antimicrob Agents Chemother. 2024 04 03; 68(4):e0153423.
Somé AF, Conrad MD, Kabré Z, Fofana A, Yerbanga RS, Bazié T, Neya C, Somé M, Kagambega TJ, Legac J, Garg S, Bailey JA, Ouédraogo J-B,
Rosenthal PJ
, Cooper RA. PMID: 38411062; PMCID:
PMC10989024
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Real-world experience of maralixibat in Alagille syndrome: Novel findings outside of clinical trials. J Pediatr Gastroenterol Nutr. 2024 03; 78(3):506-513.
Himes R,
Rosenthal P
, Dilwali N, Smith K,
Venick R
, Gonzalez-Peralta RP. PMID: 38334237.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Emergence, transmission dynamics and mechanisms of artemisinin partial resistance in malaria parasites in Africa. Nat Rev Microbiol. 2024 Jun; 22(6):373-384.
Rosenthal PJ
, Asua V, Conrad MD. PMID: 38321292.
View in:
PubMed
Mentions:
56
Fields:
Translation:
Humans
Animals
Selection of artemisinin partial resistance Kelch13 mutations in Uganda in 2016-22 was at a rate comparable to that seen previously in South-East Asia. medRxiv. 2024 Feb 04.
Meier-Scherling CPG, Watson OJ, Asua V, Ghinai I, Katairo T, Garg S, Conrad M,
Rosenthal PJ
, Okell LC, Bailey JA. PMID: 38352505; PMCID:
PMC10862983
View in:
PubMed
Mentions:
Determination of sulfadoxine and pyrimethamine in microvolume human plasma using ultra high performance liquid chromatography-tandam mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2024 Feb 15; 1234:124030.
Sok V, Marzan F,
Roh M
, Guo K, Legac J, Mwebaza N, Dorsey G,
Rosenthal PJ
Aweeka FT
Huang L
. PMID: 38309043; PMCID:
PMC11820842
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Discovery of Potent Antimalarial Type II Kinase Inhibitors with Selectivity over Human Kinases. J Med Chem. 2024 01 25; 67(2):1460-1480.
Wang L, Bohmer MJ, Wang J, Nardella F, Calla J, Laureano De Souza M, Schindler KA, Montejo L, Mittal N,
Rocamora F
, Treat M, Charlton JT, Tumwebaze PK,
Rosenthal PJ
, Cooper RA, Chakrabarti R,
Winzeler EA
, Chakrabarti D, Gray NS. PMID: 38214254; PMCID:
PMC10950204
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Protein biomarkers GDF15 and FGF21 to differentiate mitochondrial hepatopathies from other pediatric liver diseases. Hepatol Commun. 2024 01 01; 8(1).
Van Hove JLK, Friederich MW, Strode DK, Van Hove RA, Miller KR, Sharma R, Shah H, Estrella J, Gabel L, Horslen S,
Kohli R
, Lovell MA, Miethke AG, Molleston JP, Romero R, Squires JE, Alonso EM, Guthery SL, Kamath BM, Loomes KM,
Rosenthal P
, Mysore KR, Cavallo LA, Valentino PL, Magee JC, Sundaram SS, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 38180987; PMCID:
PMC10781130
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Diagnosis and management of Alagille and progressive familial intrahepatic cholestasis. Hepatol Commun. 2023 12 01; 7(12).
Cheng K
Rosenthal P
. PMID: 38055640; PMCID:
PMC10984671
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Nutrition assessment and MASH severity in children using the Healthy Eating Index. Hepatol Commun. 2023 12 01; 7(12).
Jain AK
, Buchannan P, Yates KP, Belt P,
Schwimmer JB
Rosenthal P
, Murray KF, Molleston JP, Scheimann A, Xanthakos SA,
Behling CA
, Hertel P, Nilson J, Neuschwander-Tetri BA, Tonascia J, Vos MB, Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN). PMID: 38055641; PMCID:
PMC10984667
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Neonatal cholestasis in children with Alpha-1-AT deficiency is a risk for earlier severe liver disease with male predominance. Hepatol Commun. 2023 12 01; 7(12).
Teckman J,
Rosenthal P
, Ignacio RV, Spino C, Bass LM, Horslen S, Wang K, Magee JC, Karpen S, Asai A, Molleston JP, Squires RH, Kamath BM, Guthery SL, Loomes KM, Shneider BL, Sokol RJ, ChiLDReN (Childhood Liver Disease Research Network). PMID: 38055647; PMCID:
PMC10984655
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Naphthyl bearing 1,3,4-thiadiazoleacetamides targeting the parasitic folate pathway as anti-infectious agents: in silico, synthesis, and biological approach. RSC Med Chem. 2023 Dec 13; 14(12):2768-2781.
Pal K, Lala S, Agarwal P, Patel TS, Legac J, Rahman MA, Ahmedi S, Shahid N, Singh S, Kumari K, Madhav H, Sen A, Manzoor N, Dixit BC, Van Zyl R,
Rosenthal PJ
, Hoda N. PMID: 38107179; PMCID:
PMC10718588
View in:
PubMed
Mentions:
Sarcopenia is associated with osteopenia and impaired quality of life in children with genetic intrahepatic cholestatic liver disease. Hepatol Commun. 2023 11 01; 7(11).
Boster JM, Goodrich NP, Spino C, Loomes KM, Alonso EM, Kamath BM, Sokol RJ, Karpen S, Miethke A, Shneider BL, Molleston JP,
Kohli R
, Horslen SP,
Rosenthal P
, Valentino PL, Teckman JH, Hangartner TN, Sundaram SS, Childhood Liver Disease Research Network (ChiLDReN). PMID: 37902507; PMCID:
PMC10617863
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Seasonal Malaria Chemoprevention Drug Levels and Drug Resistance Markers in Children With or Without Malaria in Burkina Faso: A Case-Control Study. J Infect Dis. 2023 10 03; 228(7):926-935.
Roh ME
, Zongo I, Haro A, Huang L, Somé AF, Yerbanga RS, Conrad MD, Wallender E, Legac J,
Aweeka F
, Ouédraogo JB,
Rosenthal PJ
. PMID: 37221018; PMCID:
PMC10547452
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Distinct transcriptional profiles of maternal and fetal placental macrophages at term are associated with gravidity. bioRxiv. 2023 Sep 28.
Ozarslan N
Robinson JF
, Buarpung S, Kim MY, Ansbro MR, Akram J,
Montoya DJ
, Kamya MR, Kakuru A, Dorsey G,
Rosenthal PJ
, Cheng G,
Feeney ME
Fisher SJ
Gaw SL
. PMID: 37808856; PMCID:
PMC10557660
View in:
PubMed
Mentions:
Change in Health-Related Quality of Life in Youth with Chronic Hepatitis B Living in North America: A 5-Year Cohort Study. J Pediatr Gastroenterol Nutr. 2023 12 01; 77(6):713-719.
Schwarzenberg SJ, King WC, Ling SC, Murray KF, Mogul D,
Rosenthal P
, Rodriguez-Baez N, Teckman J,
Schwarz KB
, Hepatitis B Research Network (HBRN). PMID: 37756340; PMCID:
PMC12462827
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Malaria-specific Type 1 regulatory T cells are more abundant in first pregnancies and associated with placental malaria. EBioMedicine. 2023 Sep; 95:104772.
Kirosingh AS, Delmastro A, Kakuru A, van der Ploeg K, Bhattacharya S, Press KD, Ty M, Parte L, Kizza J, Muhindo M, Devachanne S, Gamain B, Nankya F, Musinguzi K,
Rosenthal PJ
Feeney ME
, Kamya M, Dorsey G, Jagannathan P. PMID: 37634385; PMCID:
PMC10474374
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Evolution of Partial Resistance to Artemisinins in Malaria Parasites in Uganda. N Engl J Med. 2023 08 24; 389(8):722-732.
Conrad MD, Asua V, Garg S, Giesbrecht D, Niaré K, Smith S, Namuganga JF, Katairo T, Legac J, Crudale RM, Tumwebaze PK, Nsobya SL, Cooper RA, Kamya MR, Dorsey G, Bailey JA,
Rosenthal PJ
. PMID: 37611122; PMCID:
PMC10513755
View in:
PubMed
Mentions:
125
Fields:
Translation:
Humans
Animals
The Human Mpox Global Outbreak: Available Control Tools and the Opportunity to Break a Cycle of Neglect in Endemic Countries. Am J Trop Med Hyg. 2023 10 04; 109(4):719-724.
Nachega JB, Mbala-Kingebeni P,
Rosenthal PJ
, Rimoin AW, Hoff NA, Liesenborghs L, Vanlerberghe V, Andrei G, Rawat A, Wilson LA, Forrest J, Mills EJ, Hermans MP, Mulangu S, Ntoumi F, Zumla A, Muyembe-Tamfum JJ. PMID: 37580027; PMCID:
PMC10551064
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
PH
Public Health
Proteasome inhibitors: The next generation of antimalarial drugs? Cell Chem Biol. 2023 05 18; 30(5):413-415.
Rosenthal PJ
. PMID: 37207628.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Clinical spectrum and genetic causes of mitochondrial hepatopathy phenotype in children. Hepatol Commun. 2023 06 01; 7(6).
Squires JE, Miethke AG, Valencia CA, Hawthorne K, Henn L, Van Hove JLK, Squires RH, Bove K, Horslen S,
Kohli R
, Molleston JP, Romero R, Alonso EM, Bezerra JA, Guthery SL, Hsu E, Karpen SJ, Loomes KM, Ng VL,
Rosenthal P
, Mysore K, Wang KS, Friederich MW, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 37184518; PMCID:
PMC10187840
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Safety and yield of percutaneous liver biopsy in adults and children with chronic hepatitis B: Results from a prospective, multicenter study. Hepatol Commun. 2023 06 01; 7(6).
Ghany MG, Belle SH, Kleiner DE, Smith C, Kelley SS,
Rosenthal P
, Fontana RJ, Hepatitis B Research Network. PMID: 37184524; PMCID:
PMC10187861
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline. Microbiol Spectr. 2023 06 15; 11(3):e0523622.
Kreutzfeld O
, Tumwebaze PK, Okitwi M, Orena S, Byaruhanga O, Katairo T, Conrad MD, Rasmussen SA, Legac J, Aydemir O, Giesbrecht D, Forte B, Campbell P, Smith A, Kano H, Nsobya SL, Blasco B, Duffey M, Bailey JA, Cooper RA,
Rosenthal PJ
. PMID: 37158739; PMCID:
PMC10269555
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Influence of amino acid size at the P3 position of N-Cbz-tripeptide Michael acceptors targeting falcipain-2 and rhodesain for the treatment of malaria and human african trypanosomiasis. Bioorg Chem. 2023 08; 137:106587.
Previti S, Ettari R, Di Chio C, Legac J, Bogacz M, Zimmer C, Schirmeister T,
Rosenthal PJ
, Zappalà M. PMID: 37163812.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Artefenomel Regioisomer RLA-3107 Is a Promising Lead for the Discovery of Next-Generation Endoperoxide Antimalarials. ACS Med Chem Lett. 2023 Apr 13; 14(4):493-498.
Blank BR, Gut J,
Rosenthal PJ
Renslo AR
. PMID: 37077383; PMCID:
PMC10108391
View in:
PubMed
Mentions:
Shorter leukocyte telomere length protects against NAFLD progression in children. Sci Rep. 2023 04 03; 13(1):5446.
Wojcicki JM
Gill RM
, Wilson L, Lin J,
Rosenthal P
. PMID: 37012261; PMCID:
PMC10070244
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Efavirenz-Based Antiretroviral Therapy but Not Pregnancy Increased Unbound Piperaquine Exposure in Women during Malaria Chemoprevention. Antimicrob Agents Chemother. 2023 04 18; 67(4):e0142722.
Hong H, Aslam-Mir U, Kajubi R, Wallender E, Mwebaza N, Dorsey G,
Rosenthal PJ
Aweeka FT
Huang L
. PMID: 36916944; PMCID:
PMC10112216
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Serum bile acids as a prognostic biomarker in biliary atresia following Kasai portoenterostomy. Hepatology. 2023 03 01; 77(3):862-873.
Harpavat S, Hawthorne K, Setchell KDR, Rivas MN, Henn L, Beil CA, Karpen SJ, Ng VL, Alonso EM, Bezerra JA, Guthery SL, Horslen S, Loomes KM, McKiernan P, Magee JC, Merion RM, Molleston JP,
Rosenthal P
, Thompson RJ, Wang KS, Sokol RJ, Shneider BL, for Childhood Liver Disease Research Network (ChiLDReN). PMID: 36131538; PMCID:
PMC9936974
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
Elbasvir/grazoprevir in children aged 3-18 years with chronic HCV genotype 1 or 4 infection: a pharmacokinetic modeling study. Hepatol Commun. 2023 03 01; 7(3):e0031.
Gonzalez-Peralta RP, Wirth S, Squires RH, Mutschler F, Lang T, Pawlowska M, Sluzewski W, Majda-Stanislawska E, Fischler B, Balistreri WF, Jonas MM, Blondet N,
Rosenthal P
, Alkhouri N, Romero R, Grandhi A, Castronuovo P, Caro L, Du L, Rosenbloom DIS, Haber BA. PMID: 36790337; PMCID:
PMC9931032
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Costs of pediatric liver transplantation among commercially insured and Medicaid-insured patients with cholestasis in the US. Liver Transpl. 2023 07 01; 29(7):735-744.
Miloh T, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N,
Rosenthal P
. PMID: 36747344; PMCID:
PMC10270280
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Seroprevalence of Antibodies to SARS-CoV-2 in Rural Households in Eastern Uganda, 2020-2022. JAMA Netw Open. 2023 02 01; 6(2):e2255978.
Briggs J
, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K,
Rosenthal PJ
, Dorsey G,
Greenhouse B
, Ssewanyana I, Rodríguez-Barraquer I. PMID: 36790811; PMCID:
PMC9932849
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Cells
Structure-Activity Relationship Studies of Antimalarial Plasmodium Proteasome Inhibitors─Part II. J Med Chem. 2023 01 26; 66(2):1484-1508.
Zhang H, Ginn J, Zhan W, Leung A, Liu YJ, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Michino M, Yukawa T, Chelebieva S, Tumwebaze PK, Vendome J, Beuming T, Sato K, Aso K,
Rosenthal PJ
, Cooper RA, Liverton N, Foley M, Meinke PT, Nathan CF, Kirkman LA, Lin G. PMID: 36630286; PMCID:
PMC10157299
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Measures of malaria transmission, infection, and disease in an area bordering two districts with and without sustained indoor residual spraying of insecticide in Uganda. PLoS One. 2022; 17(12):e0279464.
Nankabirwa JI, Bousema T, Blanken SL, Rek J, Arinaitwe E,
Greenhouse B
Rosenthal PJ
, Kamya MR, Staedke SG, Dorsey G. PMID: 36584122; PMCID:
PMC9803187
View in:
PubMed
Mentions:
18
Fields:
Translation:
Humans
Animals
PH
Public Health
Identification, in-vitro anti-plasmodial assessment and docking studies of series of tetrahydrobenzothieno[2,3-d]pyrimidine-acetamide molecular hybrids as potential antimalarial agents. Eur J Med Chem. 2023 Feb 15; 248:115055.
Pal K, Raza MK, Legac J, Rahman A, Manzoor S, Bhattacharjee S,
Rosenthal PJ
, Hoda N. PMID: 36621136.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Advancing detection and response capacities for emerging and re-emerging pathogens in Africa. Lancet Infect Dis. 2023 05; 23(5):e185-e189.
Nachega JB, Nsanzimana S, Rawat A, Wilson LA,
Rosenthal PJ
, Siedner MJ, Varma JK, Kilmarx PH, Mutesa L, Tanner M, Binagwaho A, Forrest J, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Ntoumi F, Zumla A, de Oliveira T, Mills EJ. PMID: 36563700; PMCID:
PMC10023168
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
PH
Public Health
Impact of different mosquito collection methods on indicators of Anopheles malaria vectors in Uganda. Malar J. 2022 Dec 19; 21(1):388.
Mawejje HD, Asiimwe JR, Kyagamba P, Kamya MR,
Rosenthal PJ
, Lines J, Dorsey G, Staedke SG. PMID: 36536428; PMCID:
PMC9761930
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
PH
Public Health
Characterizing pyrethroid resistance and mechanisms in Anopheles gambiae (s.s.) and Anopheles arabiensis from 11 districts in Uganda. Curr Res Parasitol Vector Borne Dis. 2023; 3:100106.
Mawejje HD, Weetman D,
Epstein A
, Lynd A, Opigo J, Maiteki-Sebuguzi C, Lines J, Kamya MR,
Rosenthal PJ
, Donnelly MJ, Dorsey G, Staedke SG. PMID: 36590346; PMCID:
PMC9798136
View in:
PubMed
Mentions:
19
Quinoline-based heterocyclic hydrazones: Design, synthesis, anti-plasmodial assessment, and mechanistic insights. Chem Biol Drug Des. 2023 04; 101(4):829-836.
Sharma B, Chowdhary S, Legac J,
Rosenthal PJ
, Kumar V. PMID: 36418231.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Severe Acute Respiratory Syndrome Coronavirus 2 Infection and Pregnancy in Sub-Saharan Africa: A 6-Country Retrospective Cohort Analysis. Clin Infect Dis. 2022 11 30; 75(11):1950-1961.
Nachega JB, Sam-Agudu NA, Machekano RN,
Rosenthal PJ
, Schell S, de Waard L, Bekker A, Gachuno OW, Kinuthia J, Mwongeli N, Budhram S, Vannevel V, Somapillay P, Prozesky HW, Taljaard J, Parker A, Agyare E, Opoku AB, Makarfi AU, Abdullahi AM, Adirieje C, Ishoso DK, Pipo MT, Tshilanda MB, Bongo-Pasi Nswe C, Ditekemena J, Sigwadhi LN, Nyasulu PS, Hermans MP, Sekikubo M, Musoke P, Nsereko C, Agbeno EK, Yeboah MY, Umar LW, Ntakwinja M, Mukwege DM, Birindwa EK, Mushamuka SZ, Smith ER, Mills EJ, Otshudiema JO, Mbala-Kingebeni P, Tamfum JM, Zumla A, Tsegaye A, Mteta A, Sewankambo NK, Suleman F, Adejumo P, Anderson JR, Noormahomed EV, Deckelbaum RJ, Stringer JSA, Mukalay A, Taha TE, Fowler MG, Wasserheit JN, Masekela R, Mellors JW, Siedner MJ, Myer L, Kengne AP, Yotebieng M, Mofenson LM, Langenegger E, AFREhealth Research Collaboration on COVID-19 and Pregnancy. PMID: 36130257; PMCID:
PMC9214158
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Cells
Response to "The Importance of Exercising Caution When Comparing Results from Malaria Vaccines Administered on the EPI Schedule and on a Seasonal Schedule". Am J Trop Med Hyg. 2022 11 21; 107(6):1357.
Rosenthal PJ
. PMID: 36410330; PMCID:
PMC9768280
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Serum biomarkers correlated with liver stiffness assessed in a multicenter study of pediatric cholestatic liver disease. Hepatology. 2023 02 01; 77(2):530-545.
Leung DH, Devaraj S, Goodrich NP, Chen X, Rajapakshe D, Ye W, Andreev V, Minard CG, Guffey D, Molleston JP, Bass LM, Karpen SJ, Kamath BM, Wang KS, Sundaram SS,
Rosenthal P
, McKiernan P, Loomes KM, Jensen MK, Horslen SP, Bezerra JA, Magee JC, Merion RM, Sokol RJ, Shneider BL, Alonso E, Bass L, Kelly S, Riordan M, Melin-Aldana H, Bezerra J, Bove K, Heubi J, Miethke A, Tiao G, Denlinger J, Chapman E, Sokol R, Feldman A, Mack C, Narkewicz M, Suchy F, Sundaram SS, Van Hove J, Garcia B, Kauma M, Kocher K, Steinbeiss M, Lovell M, Loomes KM, Piccoli D, Rand E, Russo P, Spinner N, Erlichman J, Stalford S, Pakstis D, King S, Squires R, Sindhi R, Venkat V, Bukauskas K, McKiernan P, Haberstroh L, Squires J,
Rosenthal P
Bull L
, Curry J, Langlois C, Kim G, Teckman J, Kociela V, Nagy R, Patel S, Cerkoski J, Molleston JP, Bozic M, Subbarao G, Klipsch A, Sawyers C, Cummings O, Horslen SP, Murray K, Hsu E, Cooper K, Young M, Finn L, Kamath BM, Ng V, Quammie C, Putra J, Sharma D, Parmar A, Guthery S, Jensen K, Rutherford A, Lowichik A, Book L, Meyers R, Hall T, Wang KS, Michail S, Thomas D, Goodhue C,
Kohli R
, Wang L,
Soufi N
, Thomas D, Karpen S, Gupta N, Romero R, Vos MB, Tory R, Berauer JP, Abramowsky C, McFall J, Shneider BL, Harpavat S, Hertel P, Leung D, Tessier M, Schady D, Cavallo L, Olvera D, Banks C, Tsai C, Thompson R, Doo E, Hoofnagle J, Sherker A, Torrance R, Hall S, Magee J, Merion R, Spino C, Ye W, Childhood Liver Disease Research Network. PMID: 36069569; PMCID:
PMC10151059
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Decreased susceptibility of Plasmodium falciparum to both dihydroartemisinin and lumefantrine in northern Uganda. Nat Commun. 2022 10 26; 13(1):6353.
Tumwebaze PK, Conrad MD, Okitwi M, Orena S, Byaruhanga O, Katairo T, Legac J, Garg S, Giesbrecht D, Smith SR, Ceja FG, Nsobya SL, Bailey JA, Cooper RA,
Rosenthal PJ
. PMID: 36289202; PMCID:
PMC9605985
View in:
PubMed
Mentions:
70
Fields:
Translation:
Humans
Animals
Prioritizing Pregnant Women for Coronavirus Disease 2019 Vaccination in African Countries. Clin Infect Dis. 2022 10 12; 75(8):1462-1466.
Nachega JB, Sam-Agudu NA, Siedner MJ,
Rosenthal PJ
, Mellors JW, Zumla A, Hermans MP, Ntakwinja MB, Mukwege DM, Langenegger E, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) Research Collaboration on COVID-19 a. PMID: 36130226; PMCID:
PMC9214132
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
PH
Public Health
East Africa International Center of Excellence for Malaria Research: Impact on Malaria Policy in Uganda. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):33-39.
Namuganga JF, Nankabirwa JI, Maiteki-Ssebuguzi C, Gonahasa S, Opigo J, Staedke SG, Rutazaana D, Ebong C, Dorsey G, Tomko SS, Kizza T, Mawejje HD, Arinaitwe E,
Rosenthal PJ
, Kamya MR. PMID: 36228904; PMCID:
PMC9662221
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
East Africa International Center of Excellence for Malaria Research: Summary of Key Research Findings. Am J Trop Med Hyg. 2022 10 11; 107(4_Suppl):21-32.
Nankabirwa JI, Rek J, Arinaitwe E, Namuganga JF, Nsobya SL, Asua V, Mawejje HD,
Epstein A
Greenhouse B
Rodriguez-Barraquer I
Briggs J
Krezanoski PJ
Rosenthal PJ
, Conrad M, Smith D, Staedke SG, Drakeley C, Bousema T, Andolina C, Donnelly MJ, Kamya MR, Dorsey G. PMID: 36228916; PMCID:
PMC9662228
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
PH
Public Health
Simulating the Impacts of Augmenting Intensive Vector Control with Mass Drug Administration or Test-and-Treat Strategies on the Malaria Infectious Reservoir. Am J Trop Med Hyg. 2022 11 14; 107(5):1028-1035.
Nankabirwa JI, Arinaitwe E,
Briggs J
, Rek J,
Rosenthal PJ
, Kamya MR, Olwoch P, Smith DL,
Rodriguez-Barraquer I
, Dorsey G,
Greenhouse B
. PMID: 36191870; PMCID:
PMC9709029
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Health Care Resource Utilization by Patients with Alagille Syndrome. J Pediatr. 2023 02; 253:144-151.e1.
Ebel NH, Goldstein A, Howard R, Mogul DB, Marden JR, Anderson A, Gaburo K, Kirson N,
Rosenthal P
. PMID: 36179890.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Reconstructing the SARS-CoV-2 epidemic in eastern Uganda through longitudinal serosurveillance in a malaria cohort. medRxiv. 2022 Sep 21.
Briggs J
, Takahashi S, Nayebare P, Cuu G, Rek J, Zedi M, Kizza T, Arinaitwe E, Nankabirwa JI, Kamya M, Jagannathan P, Jacobson K,
Rosenthal PJ
, Dorsey G,
Greenhouse B
, Ssewanyana I, Rodríguez-Barraquer I. PMID: 36172117; PMCID:
PMC9516854
View in:
PubMed
Mentions:
Susceptibilities of Ugandan Plasmodium falciparum Isolates to Proteasome Inhibitors. Antimicrob Agents Chemother. 2022 10 18; 66(10):e0081722.
Garg S,
Kreutzfeld O
, Chelebieva S, Tumwebaze PK, Byaruhanga O, Okitwi M, Orena S, Katairo T, Nsobya SL, Conrad MD, Aydemir O, Legac J, Gould AE, Bayles BR, Bailey JA, Duffey M, Lin G, Kirkman LA, Cooper RA,
Rosenthal PJ
. PMID: 36094216; PMCID:
PMC9578402
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Piperaquine-Induced QTc Prolongation Decreases With Repeated Monthly Dihydroartemisinin-Piperaquine Dosing in Pregnant Ugandan Women. Clin Infect Dis. 2022 08 31; 75(3):406-415.
Hughes E, Wallender E, Kajubi R, Jagannathan P, Ochieng T, Kakuru A, Kamya MR,
Clark TD
Rosenthal PJ
Dorsey G
Aweeka F
Savic RM
. PMID: 34864925; PMCID:
PMC9427153
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
The Multistage Antimalarial Compound Calxinin Perturbates P. falciparum Ca2+ Homeostasis by Targeting a Unique Ion Channel. Pharmaceutics. 2022 Jun 28; 14(7).
Gupta Y, Sharma N, Singh S, Romero JG, Rajendran V, Mogire RM, Kashif M, Beach J, Jeske W, Ogutu BR, Kanzok SM, Akala HM, Legac J,
Rosenthal PJ
, Rademacher DJ, Durvasula R, Singh AP, Rathi B, Kempaiah P. PMID: 35890267; PMCID:
PMC9319510
View in:
PubMed
Mentions:
STARTER checklist for antimalarial therapeutic efficacy reporting. Malar J. 2022 06 13; 21(1):187.
Plucinski MM, Ashley EA, Bassat Q, Venkatesan M,
Rosenthal PJ
, Halsey ES. PMID: 35698123; PMCID:
PMC9195280
View in:
PubMed
Mentions:
Fields:
STARTER Checklist for Antimalarial Therapeutic Efficacy Reporting. Am J Trop Med Hyg. 2022 06 13; 107(1):1-3.
Plucinski M, Ashley EA, Bassat Q, Venkatesan M,
Rosenthal PJ
, Halsey E. PMID: 35880678; PMCID:
PMC9294688
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Impact of long-term administration of maralixibat on children with cholestasis secondary to Alagille syndrome. Hepatol Commun. 2022 08; 6(8):1922-1933.
Shneider BL, Spino CA, Kamath BM, Magee JC, Ignacio RV, Huang S, Horslen SP, Molleston JP, Miethke AG,
Kohli R
, Leung DH, Jensen MK, Loomes KM, Karpen SJ, Mack C,
Rosenthal P
, Squires RH, Baker A, Rajwal S, Kelly D, Sokol RJ, Thompson RJ, for ChiLDReN and UK IMAGO/IMAGINE Investigators. PMID: 35672955; PMCID:
PMC9315125
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Use of funded multicenter prospective longitudinal databases to inform clinical trials in rare diseases-Examination of cholestatic liver disease in Alagille syndrome. Hepatol Commun. 2022 08; 6(8):1910-1921.
Shneider BL, Kamath BM, Magee JC, Goodrich NP, Loomes KM, Ye W, Spino C, Alonso EM, Molleston JP, Bezerra JA, Wang KS, Karpen SJ, Horslen SP, Guthery SL,
Rosenthal P
, Squires RH, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 35506349; PMCID:
PMC9315119
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183. Nat Commun. 2022 04 20; 13(1):2158.
de Vries LE, Jansen PAM, Barcelo C, Munro J, Verhoef JMJ, Pasaje CFA, Rubiano K, Striepen J, Abla N, Berning L, Bolscher JM, Demarta-Gatsi C, Henderson RWM, Huijs T, Koolen KMJ, Tumwebaze PK, Yeo T, Aguiar ACC, Angulo-Barturen I, Churchyard A, Baum J, Fernández BC, Fuchs A, Gamo FJ, Guido RVC, Jiménez-Diaz MB, Pereira DB, Rochford R, Roesch C, Sanz LM, Trevitt G, Witkowski B, Wittlin S, Cooper RA,
Rosenthal PJ
, Sauerwein RW, Schalkwijk J, Hermkens PHH, Bonnert RV, Campo B, Fidock DA, Llinás M, Niles JC, Kooij TWA, Dechering KJ. PMID: 35444200; PMCID:
PMC9021288
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Risk of variceal hemorrhage and pretransplant mortality in children with biliary atresia. Hepatology. 2022 09; 76(3):712-726.
Bass LM, Ye W, Hawthorne K, Leung DH, Murray KF, Molleston JP, Romero R, Karpen S,
Rosenthal P
, Loomes KM, Wang KS, Squires RH, Miethke A, Ng VL, Horslen S, Kyle Jensen M, Sokol RJ, Magee JC, Shneider BL, ChiLDReN. PMID: 35271743; PMCID:
PMC9378352
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Malaria in 2022: Challenges and Progress. Am J Trop Med Hyg. 2022 Apr 12.
Rosenthal PJ
. PMID: 35413687; PMCID:
PMC9209912
View in:
PubMed
Mentions:
22
Fields:
Cooperation in Countering Artemisinin Resistance in Africa: Learning from COVID-19. Am J Trop Med Hyg. 2022 Apr 12.
Rosenthal PJ
, Björkman A, Dhorda M, Djimde A, Dondorp AM, Gaye O, Guerin PJ, Juma E, Kwiatkowski DP, Merson L, Ntoumi F, Price RN, Raman J, Roos DS, Ter Kuile F, Tinto H, Tomko SS, White NJ, Barnes KI. PMID: 35413688; PMCID:
PMC9209939
View in:
PubMed
Mentions:
Fields:
Field evaluation of the diagnostic performance of EasyScan GO: a digital malaria microscopy device based on machine-learning. Malar J. 2022 Apr 12; 21(1):122.
Das D, Vongpromek R, Assawariyathipat T, Srinamon K, Kennon K, Stepniewska K, Ghose A, Sayeed AA, Faiz MA, Netto RLA, Siqueira A, Yerbanga SR, Ouédraogo JB, Callery JJ, Peto TJ, Tripura R, Koukouikila-Koussounda F, Ntoumi F, Ong'echa JM, Ogutu B, Ghimire P, Marfurt J, Ley B, Seck A, Ndiaye M, Moodley B, Sun LM, Archasuksan L, Proux S, Nsobya SL,
Rosenthal PJ
, Horning MP, McGuire SK, Mehanian C, Burkot S, Delahunt CB, Bachman C, Price RN, Dondorp AM, Chappuis F, Guérin PJ, Dhorda M. PMID: 35413904; PMCID:
PMC9004086
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Animals
Reply to Li, Henry, and Nguyen. Am J Gastroenterol. 2022 04 01; 117(4):688.
Khalili M
, Kleiner DE, King WC, Sterling RK, Ghany MG, Chung RT, Bhan AK,
Rosenthal P
, Lisker-Melman M,
Ramachandran R
, Lok AS. PMID: 35158369; PMCID:
PMC8976722
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Discovery of spirooxadiazoline oxindoles with dual-stage antimalarial activity. Eur J Med Chem. 2022 Jun 05; 236:114324.
Lopes EA, Mestre R, Fontinha D, Legac J, Pei JV, Sanches-Vaz M, Mori M, Lehane AM,
Rosenthal PJ
, Prudêncio M, Santos MMM. PMID: 35390711.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Determination of unbound piperaquine in human plasma by ultra-high performance liquid chromatography tandem mass spectrometry. J Chromatogr Open. 2022 Nov; 2.
Huang L
, Sok V, Aslam-Mir U, Marzan F, Whalen M,
Rosenthal PJ
Aweeka F
. PMID: 35531322; PMCID:
PMC9068709
View in:
PubMed
Mentions:
Changes in serum hepatitis B surface and e antigen, interferon-inducible protein 10, and aminotransferase levels during combination therapy of immune-tolerant chronic hepatitis B. Hepatology. 2022 09; 76(3):775-787.
Perrillo R, Lin HS,
Schwarz KB
Rosenthal P
, Lisker-Melman M, Chung RT, Prokunina-Olsson L, Cloherty G, Feld J, Hepatitis B Research Network (HBRN). PMID: 35188674.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Impact of Short-Term Storage on Ex Vivo Antimalarial Susceptibilities of Fresh Ugandan Plasmodium falciparum Isolates. Antimicrob Agents Chemother. 2022 04 19; 66(4):e0143721.
Okitwi M, Orena S, Thomas K, Tumwebaze PK, Byaruhanga O, Nsobya SL, Conrad MD, Bayles BR,
Rosenthal PJ
, Cooper RA. PMID: 35266828; PMCID:
PMC9017344
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Identification, Characterization, and Synthesis of Natural Parasitic Cysteine Protease Inhibitors: Pentacitidins Are More Potent Falcitidin Analogues. ACS Chem Biol. 2022 03 18; 17(3):576-589.
Brinkmann S, Semmler S, Kersten C, Patras MA, Kurz M, Fuchs N, Hammerschmidt SJ, Legac J, Hammann PE, Vilcinskas A,
Rosenthal PJ
, Schirmeister T, Bauer A, Schäberle TF. PMID: 35262340.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Discovery and Preclinical Pharmacology of INE963, a Potent and Fast-Acting Blood-Stage Antimalarial with a High Barrier to Resistance and Potential for Single-Dose Cures in Uncomplicated Malaria. J Med Chem. 2022 03 10; 65(5):3798-3813.
Taft BR, Yokokawa F, Kirrane T, Mata AC, Huang R, Blaquiere N, Waldron G, Zou B, Simon O, Vankadara S, Chan WL, Ding M, Sim S, Straimer J, Guiguemde A, Lakshminarayana SB, Jain JP, Bodenreider C, Thompson C, Lanshoeft C, Shu W, Fang E, Qumber J, Chan K, Pei L, Chen YL, Schulz H, Lim J, Abas SN, Ang X, Liu Y, Angulo-Barturen I, Jiménez-Díaz MB, Gamo FJ, Crespo-Fernandez B,
Rosenthal PJ
, Cooper RA, Tumwebaze P, Aguiar ACC, Campo B, Campbell S, Wagner J, Diagana TT, Sarko C. PMID: 35229610; PMCID:
PMC9278664
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Assessment of Clinical Outcomes Among Children and Adolescents Hospitalized With COVID-19 in 6 Sub-Saharan African Countries. JAMA Pediatr. 2022 Mar 01; 176(3):e216436.
Nachega JB, Sam-Agudu NA, Machekano RN, Rabie H, van der Zalm MM, Redfern A, Dramowski A, O'Connell N, Pipo MT, Tshilanda MB, Byamungu LN, Masekela R, Jeena PM, Pillay A, Gachuno OW, Kinuthia J, Ishoso DK, Amoako E, Agyare E, Agbeno EK, Martyn-Dickens C, Sylverken J, Enimil A, Jibril AM, Abdullahi AM, Amadi O, Umar UM, Sigwadhi LN, Hermans MP, Otokoye JO, Mbala-Kingebeni P, Muyembe-Tamfum JJ, Zumla A, Sewankambo NK, Aanyu HT, Musoke P, Suleman F, Adejumo P, Noormahomed EV, Deckelbaum RJ, Fowler MG, Tshilolo L, Smith G, Mills EJ, Umar LW, Siedner MJ, Kruger M,
Rosenthal PJ
, Mellors JW, Mofenson LM, African Forum for Research and Education in Health (AFREhealth) COVID-19 Research Collaboration on C. PMID: 35044430; PMCID:
PMC8771438
View in:
PubMed
Mentions:
45
Fields:
Translation:
Humans
Cells
PH
Public Health
Decreased Susceptibility to Dihydrofolate Reductase Inhibitors Associated With Genetic Polymorphisms in Ugandan Plasmodium falciparum Isolates. J Infect Dis. 2022 02 15; 225(4):696-704.
Kreutzfeld O
, Tumwebaze PK, Byaruhanga O, Katairo T, Okitwi M, Orena S, Rasmussen SA, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Duffey M, Cooper RA,
Rosenthal PJ
. PMID: 34460932; PMCID:
PMC8844592
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Organ-Specific Comorbidities Are Associated With Distinct Complications After Liver Transplantation for Biliary Atresia. Liver Transpl. 2022 05; 28(5):855-866.
Taylor SA, Venkat V, Arnon R, Gopalareddy VV,
Rosenthal P
, Anderson SG, Anand R, Daniel JF, Society of Pediatric Liver Transplantation. PMID: 34821466.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Artemisinin resistance in Africa: How urgent is the threat? Med. 2021 12 10; 2(12):1287-1288.
Fidock DA,
Rosenthal PJ
. PMID: 35005674; PMCID:
PMC8729812
View in:
PubMed
Mentions:
14
Fields:
Translation:
Humans
Animals
PH
Public Health
Identifying an optimal dihydroartemisinin-piperaquine dosing regimen for malaria prevention in young Ugandan children. Nat Commun. 2021 11 18; 12(1):6714.
Wallender E, Ali AM, Hughes E, Kakuru A, Jagannathan P, Muhindo MK, Opira B, Whalen M,
Huang L
, Duvalsaint M, Legac J, Kamya MR,
Dorsey G
Aweeka F
Rosenthal PJ
Savic RM
. PMID: 34795281; PMCID:
PMC8602248
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing. Antimicrob Agents Chemother. 2022 01 18; 66(1):e0116321.
Kanai M, Yeo T, Asua V,
Rosenthal PJ
, Fidock DA, Mok S. PMID: 34694871; PMCID:
PMC8765236
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Presentation and Outcomes of Infants With Idiopathic Cholestasis: A Multicenter Prospective Study. J Pediatr Gastroenterol Nutr. 2021 10 01; 73(4):478-484.
Hertel PM, Hawthorne K, Kim S, Finegold MJ, Shneider BL, Squires JE, Gupta NA,
Bull LN
, Murray KF, Kerkar N, Ng VL, Molleston JP, Bezerra JA, Loomes KM, Taylor SA,
Schwarz KB
, Turmelle YP,
Rosenthal P
, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 34310436; PMCID:
PMC8448404
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Are Artemisinin-Based Combination Therapies For Malaria Beginning To Fail in Africa? Am J Trop Med Hyg. 2021 09 07; 105(4):857-858.
Rosenthal PJ
. PMID: 34491214; PMCID:
PMC8592154
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Associations between Varied Susceptibilities to PfATP4 Inhibitors and Genotypes in Ugandan Plasmodium falciparum Isolates. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0077121.
Kreutzfeld O
, Rasmussen SA, Ramanathan AA, Tumwebaze PK, Byaruhanga O, Katairo T, Asua V, Okitwi M, Orena S, Legac J, Conrad MD, Nsobya SL, Aydemir O, Bailey J, Duffey M, Bayles BR, Vaidya AB, Cooper RA,
Rosenthal PJ
. PMID: 34339273; PMCID:
PMC8448140
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance. Sci Transl Med. 2021 07 21; 13(603).
Murithi JM, Pascal C, Bath J, Boulenc X, Gnädig NF, Pasaje CFA, Rubiano K, Yeo T, Mok S, Klieber S, Desert P, Jiménez-Díaz MB, Marfurt J, Rouillier M, Cherkaoui-Rbati MH, Gobeau N, Wittlin S, Uhlemann AC, Price RN, Wirjanata G, Noviyanti R, Tumwebaze P, Cooper RA,
Rosenthal PJ
, Sanz LM, Gamo FJ, Joseph J, Singh S, Bashyam S, Augereau JM, Giraud E, Bozec T, Vermat T, Tuffal G, Guillon JM, Menegotto J, Sallé L, Louit G, Cabanis MJ, Nicolas MF, Doubovetzky M, Merino R, Bessila N, Angulo-Barturen I, Baud D, Bebrevska L, Escudié F, Niles JC, Blasco B, Campbell S, Courtemanche G, Fraisse L, Pellet A, Fidock DA, Leroy D. PMID: 34290058; PMCID:
PMC8530196
View in:
PubMed
Mentions:
24
Fields:
Translation:
Animals
Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness. Elife. 2021 07 19; 10.
Stokes BH, Dhingra SK, Rubiano K, Mok S, Straimer J, Gnädig NF, Deni I, Schindler KA, Bath JR, Ward KE, Striepen J, Yeo T, Ross LS, Legrand E, Ariey F, Cunningham CH, Souleymane IM, Gansané A, Nzoumbou-Boko R, Ndayikunda C, Kabanywanyi AM, Uwimana A, Smith SJ, Kolley O, Ndounga M, Warsame M, Leang R, Nosten F, Anderson TJ,
Rosenthal PJ
, Ménard D, Fidock DA. PMID: 34279219; PMCID:
PMC8321553
View in:
PubMed
Mentions:
100
Fields:
Translation:
Humans
Animals
Balanced impacts of fitness and drug pressure on the evolution of PfMDR1 polymorphisms in Plasmodium falciparum. Malar J. 2021 Jun 30; 20(1):292.
Duvalsaint M, Conrad MD, Tukwasibwe S, Tumwebaze PK, Legac J, Cooper RA,
Rosenthal PJ
. PMID: 34193148; PMCID:
PMC8247092
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Challenges and opportunities for use of long-lasting insecticidal nets to prevent malaria during overnight travel in Uganda: a qualitative study. Malar J. 2021 Jun 26; 20(1):283.
Ekusai-Sebatta D, Arinaitwe E, Mpimbaza A, Nankabirwa JI, Drakeley C,
Rosenthal PJ
, Staedke SG, Muyinda H. PMID: 34174892; PMCID:
PMC8235645
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Drug susceptibility of Plasmodium falciparum in eastern Uganda: a longitudinal phenotypic and genotypic study. Lancet Microbe. 2021 09; 2(9):e441-e449.
Tumwebaze PK, Katairo T, Okitwi M, Byaruhanga O, Orena S, Asua V, Duvalsaint M, Legac J, Chelebieva S, Ceja FG, Rasmussen SA, Conrad MD, Nsobya SL, Aydemir O, Bailey JA, Bayles BR,
Rosenthal PJ
, Cooper RA. PMID: 34553183; PMCID:
PMC8454895
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Animals
Sources of persistent malaria transmission in a setting with effective malaria control in eastern Uganda: a longitudinal, observational cohort study. Lancet Infect Dis. 2021 11; 21(11):1568-1578.
Andolina C, Rek JC, Briggs J, Okoth J, Musiime A, Ramjith J, Teyssier N, Conrad M, Nankabirwa JI, Lanke K,
Rodriguez-Barraquer I
, Meerstein-Kessel L, Arinaitwe E, Olwoch P,
Rosenthal PJ
, Kamya MR,
Dorsey G
Greenhouse B
, Drakeley C, Staedke SG, Bousema T. PMID: 34146476; PMCID:
PMC8554388
View in:
PubMed
Mentions:
104
Fields:
Translation:
Humans
Animals
Design, synthesis, crystal structure and anti-plasmodial evaluation of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives. RSC Med Chem. 2021 Jun 23; 12(6):970-981.
Pal K, Raza MK, Legac J, Ataur Rahman M, Manzoor S,
Rosenthal PJ
, Hoda N. PMID: 34223162; PMCID:
PMC8221264
View in:
PubMed
Mentions:
Use of a Comprehensive 66-Gene Cholestasis Sequencing Panel in 2171 Cholestatic Infants, Children, and Young Adults. J Pediatr Gastroenterol Nutr. 2021 05 01; 72(5):654-660.
Karpen SJ, Kamath BM, Alexander JJ, Ichetovkin I,
Rosenthal P
, Sokol RJ, Dunn S, Thompson RJ, Heubi JE. PMID: 33720099.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. J Med Chem. 2021 05 13; 64(9):6085-6136.
Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, Deni I, Lawong A, Huang A, Chen G, Wang W, Jayaseelan J, Katneni K, Patil R, Saunders J, Shahi SP, Chittimalla R, Angulo-Barturen I, Jiménez-Díaz MB, Wittlin S, Tumwebaze PK,
Rosenthal PJ
, Cooper RA, Aguiar ACC, Guido RVC, Pereira DB, Mittal N,
Winzeler EA
, Tomchick DR, Laleu B, Burrows JN, Rathod PK, Fidock DA, Charman SA, Phillips MA. PMID: 33876936; PMCID:
PMC8171248
View in:
PubMed
Mentions:
18
Fields:
Translation:
Animals
A trio of quinoline-isoniazid-phthalimide with promising antiplasmodial potential: Synthesis, in-vitro evaluation and heme-polymerization inhibition studies. Bioorg Med Chem. 2021 06 01; 39:116159.
Rani A, Sharma A, Legac J,
Rosenthal PJ
, Singh P, Kumar V. PMID: 33895706.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Has artemisinin resistance emerged in Africa? Lancet Infect Dis. 2021 08; 21(8):1056-1057.
Rosenthal PJ
. PMID: 33864802.
View in:
PubMed
Mentions:
19
Fields:
Translation:
Humans
Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda. J Infect Dis. 2021 03 29; 223(6):985-994.
Asua V, Conrad MD, Aydemir O, Duvalsaint M, Legac J, Duarte E, Tumwebaze P, Chin DM, Cooper RA, Yeka A, Kamya MR,
Dorsey G
, Nsobya SL, Bailey J,
Rosenthal PJ
. PMID: 33146722; PMCID:
PMC8006419
View in:
PubMed
Mentions:
118
Fields:
Translation:
Humans
Animals
Development of a Highly Selective Plasmodium falciparum Proteasome Inhibitor with Anti-malaria Activity in Humanized Mice. Angew Chem Int Ed Engl. 2021 04 19; 60(17):9279-9283.
Zhan W, Zhang H, Ginn J, Leung A, Liu YJ, Michino M, Toita A, Okamoto R, Wong TT, Imaeda T, Hara R, Yukawa T, Chelebieva S, Tumwebaze PK, Lafuente-Monasterio MJ, Martinez-Martinez MS, Vendome J, Beuming T, Sato K, Aso K,
Rosenthal PJ
, Cooper RA, Meinke PT, Nathan CF, Kirkman LA, Lin G. PMID: 33433953; PMCID:
PMC8087158
View in:
PubMed
Mentions:
26
Fields:
Translation:
Animals
Cells
Diversity of KIR genes and their HLA-C ligands in Ugandan populations with historically varied malaria transmission intensity. Malar J. 2021 Feb 25; 20(1):111.
Tukwasibwe S, Traherne JA, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jiang W, Nankabirwa JI, Rek J, Arinaitwe E, Nsobya SL, Atuheirwe M, Frank M, Godwin A, Jagannathan P, Cose S, Kamya MR,
Dorsey G
Rosenthal PJ
, Colucci F, Nakimuli A. PMID: 33632228; PMCID:
PMC7908804
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Within-household clustering of genetically related Plasmodium falciparum infections in a moderate transmission area of Uganda. Malar J. 2021 Feb 02; 20(1):68.
Briggs J
, Kuchta A, Murphy M, Tessema S, Arinaitwe E, Rek J, Chen A, Nankabirwa JI, Drakeley C, Smith D, Bousema T, Kamya M,
Rodriguez-Barraquer I
, Staedke S,
Dorsey G
Rosenthal PJ
Greenhouse B
. PMID: 33531029; PMCID:
PMC8042884
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Impact of a Rapid Decline in Malaria Transmission on Antimalarial IgG Subclasses and Avidity. Front Immunol. 2020; 11:576663.
Ssewanyana I, Rek J, Rodriguez I, Wu L, Arinaitwe E, Nankabirwa JI, Beeson JG, Mayanja-Kizza H,
Rosenthal PJ
Dorsey G
, Kamya MR, Drakeley C,
Greenhouse B
, Tetteh KKA. PMID: 33584643; PMCID:
PMC7873448
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Animals
PH
Public Health
Prevalence of Malaria Parasite Infections among U.S.-Bound Congolese Refugees with and without Splenomegaly. Am J Trop Med Hyg. 2021 01 18; 104(3):996-999.
Mwesigwa M, Webster JL, Nsobya SL, Rowan A, Basnet MS, Phares CR, Weinberg M, Klosovsky A, Naoum M,
Rosenthal PJ
, Stauffer WM. PMID: 33534754; PMCID:
PMC7941850
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Deletions of pfhrp2 and pfhrp3 genes were uncommon in rapid diagnostic test-negative Plasmodium falciparum isolates from Uganda. Malar J. 2021 Jan 02; 20(1):4.
Nsobya SL, Walakira A, Namirembe E, Kiggundu M, Nankabirwa JI, Ruhamyankaka E, Arinaitwe E, Conrad MD, Kamya MR,
Dorsey G
Rosenthal PJ
. PMID: 33386076; PMCID:
PMC7777526
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Year 100 of the American Journal of Tropical Medicine and Hygiene: A Remarkable Year. Am J Trop Med Hyg. 2021 01; 104(1):1-3.
Rosenthal PJ
. PMID: 33432913; PMCID:
PMC7790076
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Non-adherence to long-lasting insecticide treated bednet use following successful malaria control in Tororo, Uganda. PLoS One. 2020; 15(12):e0243303.
Rek J, Musiime A, Zedi M, Otto G, Kyagamba P, Asiimwe Rwatooro J, Arinaitwe E, Nankabirwa J, Staedke SG, Drakeley C,
Rosenthal PJ
, Kamya M,
Dorsey G
Krezanoski PJ
. PMID: 33270743; PMCID:
PMC7714220
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
PH
Public Health
Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women. Antimicrob Agents Chemother. 2020 11 17; 64(12).
Nayebare P, Asua V, Conrad MD, Kajubi R, Kakuru A, Nankabirwa JI, Muhanguzi D,
Dorsey G
, Kamya MR, Nsobya S,
Rosenthal PJ
. PMID: 33020152; PMCID:
PMC7674052
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Piperaquine Exposure Is Altered by Pregnancy, HIV, and Nutritional Status in Ugandan Women. Antimicrob Agents Chemother. 2020 11 17; 64(12).
Hughes E, Imperial M, Wallender E, Kajubi R,
Huang L
, Jagannathan P, Zhang N, Kakuru A, Natureeba P, Mwima MW, Muhindo M, Mwebaza N,
Clark TD
, Opira B, Nakalembe M,
Havlir D
, Kamya M,
Rosenthal PJ
Dorsey G
Aweeka F
Savic RM
. PMID: 33020153; PMCID:
PMC7674024
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Association between recent overnight travel and use of long-lasting insecticidal nets in rural Uganda: a prospective cohort study in Tororo. Malar J. 2020 Nov 11; 19(1):405.
Arinaitwe E, Nankabirwa JI,
Krezanoski P
, Rek J, Kamya V,
Epstein A
Rosenthal PJ
, Drakeley C, Kamya MR,
Dorsey G
, Staedke SG. PMID: 33176793; PMCID:
PMC7661187
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Resistance to Some But Not Other Dimeric Lindenane Sesquiterpenoid Esters Is Mediated by Mutations in a Plasmodium falciparum Esterase. ACS Infect Dis. 2020 11 13; 6(11):2994-3003.
Butler JH, Baptista RP, Valenciano AL, Zhou B, Kissinger JC, Tumwebaze PK,
Rosenthal PJ
, Cooper RA, Yue JM, Cassera MB. PMID: 32970404; PMCID:
PMC11075783
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Modeling Outcomes in Children With Biliary Atresia With Native Liver After 2 Years of Age. Hepatol Commun. 2020 Dec; 4(12):1824-1834.
Venkat V, Ng VL, Magee JC, Ye W, Hawthorne K, Harpavat S, Molleston JP, Murray KF, Wang KS,
Soufi N
, Bass LM, Alonso EM, Bezerra JA, Jensen MK, Kamath BM, Loomes KM, Mack CL,
Rosenthal P
, Shneider BL, Squires RH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network. PMID: 33305153; PMCID:
PMC7706301
View in:
PubMed
Mentions:
13
Fields:
Malaria Diagnosed in an Urban Setting Strongly Associated with Recent Overnight Travel: A Case-Control Study from Kampala, Uganda. Am J Trop Med Hyg. 2020 10; 103(4):1517-1524.
Arinaitwe E, Mpimbaza A, Nankabirwa JI, Kamya V, Asiimwe A, Kuule JK, Kamya MR, Drakeley C,
Dorsey G
Rosenthal PJ
, Staedke SG. PMID: 32840203; PMCID:
PMC7543847
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Associations between Aminoquinoline Resistance Genotypes and Clinical Presentations of Plasmodium falciparum Infection in Uganda. Antimicrob Agents Chemother. 2020 09 21; 64(10).
Cuu G, Asua V, Tukwasibwe S, Nsobya SL, Nanteza A, Kimuda MP, Mpimbaza A,
Rosenthal PJ
. PMID: 32660999; PMCID:
PMC7508615
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Keep Politics out of Funding Decisions for Medical Research and Public Health. Am J Trop Med Hyg. 2020 09; 103(3):931-932.
Rosenthal PJ
, Bausch DG, Goraleski KA, Hill DR, Jacobson JA, John CC, Breman JG. PMID: 32700678; PMCID:
PMC7470536
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
PH
Public Health
Nonfasted Liver Stiffness Correlates with Liver Disease Parameters and Portal Hypertension in Pediatric Cholestatic Liver Disease. Hepatol Commun. 2020 Nov; 4(11):1694-1707.
Shneider BL, Goodrich NP, Ye W, Sawyers C, Molleston JP, Merion RM, Leung DH, Karpen SJ, Kamath BM, Cavallo L, Wang K, Teckman JH, Squires JE, Sundaram SS,
Rosenthal P
, Romero R, Murray KF, Loomes KM, Jensen MK, Bezerra JA, Bass LM, Sokol RJ, Magee JC, Childhood Liver Disease Research Network (ChiLDReN). PMID: 33163838; PMCID:
PMC7603532
View in:
PubMed
Mentions:
Fields:
Amalgamating Isatin/Indole/Nitroimidazole with 7-chloroquinolines via azide-alkyne cycloaddition: Synthesis, anti-plasmodial, and cytotoxic evaluation. Chem Biol Drug Des. 2020 12; 96(6):1355-1361.
Kumar S, Saini A, Legac J,
Rosenthal PJ
, Raj R, Kumar V. PMID: 32515142.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Variations in killer-cell immunoglobulin-like receptor and human leukocyte antigen genes and immunity to malaria. Cell Mol Immunol. 2020 08; 17(8):799-806.
Tukwasibwe S, Nakimuli A, Traherne J, Chazara O, Jayaraman J, Trowsdale J, Moffett A, Jagannathan P,
Rosenthal PJ
, Cose S, Colucci F. PMID: 32541835; PMCID:
PMC7294524
View in:
PubMed
Mentions:
20
Fields:
Translation:
Humans
Animals
Perspectives on Battling COVID-19 in Countries of Latin America and the Caribbean. Am J Trop Med Hyg. 2020 08; 103(2):593-596.
Andrus JK, Evans-Gilbert T, Santos JI, Guzman MG,
Rosenthal PJ
, Toscano C, Valenzuela MT, Siqueira M, Etienne C, Breman JG. PMID: 32524963; PMCID:
PMC7410452
View in:
PubMed
Mentions:
20
Fields:
Translation:
Humans
Cells
PH
Public Health
COVID-19: Shining the Light on Africa. Am J Trop Med Hyg. 2020 06; 102(6):1145-1148.
Rosenthal PJ
, Breman JG, Djimde AA, John CC, Kamya MR, Leke RGF, Moeti MR, Nkengasong J, Bausch DG. PMID: 32372749; PMCID:
PMC7253089
View in:
PubMed
Mentions:
49
Fields:
Translation:
Humans
Cells
PH
Public Health
Determination of piperaquine concentration in human plasma and the correlation of capillary versus venous plasma concentrations. PLoS One. 2020; 15(5):e0233893.
Mwebaza N, Cheah V, Forsman C, Kajubi R, Marzan F, Wallender E,
Dorsey G
Rosenthal PJ
Aweeka F
Huang L
. PMID: 32470030; PMCID:
PMC7259774
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Lead Optimization of Second-Generation Acridones as Broad-Spectrum Antimalarials. J Med Chem. 2020 06 11; 63(11):6179-6202.
Kancharla P, Dodean RA, Li Y, Pou S, Pybus B, Melendez V, Read L, Bane CE, Vesely B, Kreishman-Deitrick M, Black C, Li Q, Sciotti RJ, Olmeda R, Luong TL, Gaona H, Potter B, Sousa J, Marcsisin S, Caridha D, Xie L, Vuong C, Zeng Q, Zhang J, Zhang P, Lin H, Butler K, Roncal N, Gaynor-Ohnstad L, Leed SE, Nolan C, Ceja FG, Rasmussen SA, Tumwebaze PK,
Rosenthal PJ
, Mu J, Bayles BR, Cooper RA, Reynolds KA, Smilkstein MJ, Riscoe MK, Kelly JX. PMID: 32390431; PMCID:
PMC7354843
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
Unraveling the Relationship Between Itching, Scratch Scales, and Biomarkers in Children With Alagille Syndrome. Hepatol Commun. 2020 Jul; 4(7):1012-1018.
Kamath BM, Spino C, McLain R, Magee JC, Fredericks EM, Setchell KD, Miethke A, Molleston JP, Mack CL, Squires RH, Alonso EM, Murray KF, Loomes KM, Kyle Jensen M, Karpen SJ,
Rosenthal P
, Thomas D, Sokol RJ, Shneider BL, Childhood Liver Disease Research Network (ChiLDReN). PMID: 32626833; PMCID:
PMC7327199
View in:
PubMed
Mentions:
Fields:
Antimalarial Trioxolanes with Superior Drug-Like Properties and In Vivo Efficacy. ACS Infect Dis. 2020 07 10; 6(7):1827-1835.
Blank BR, Gonciarz RL, Talukder P, Gut J, Legac J,
Rosenthal PJ
Renslo AR
. PMID: 32369341; PMCID:
PMC7363035
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
The Impact of Control Interventions on Malaria Burden in Young Children in a Historically High-Transmission District of Uganda: A Pooled Analysis of Cohort Studies from 2007 to 2018. Am J Trop Med Hyg. 2020 08; 103(2):785-792.
Kamya MR, Kakuru A, Muhindo M, Arinaitwe E, Nankabirwa JI, Rek J, Bigira V, Kapisi J, Wanzira H, Achan J, Natureeba P, Gasasira A,
Havlir D
, Jagannathan P,
Rosenthal PJ
Rodriguez-Barraquer I
Dorsey G
. PMID: 32431280; PMCID:
PMC7410449
View in:
PubMed
Mentions:
19
Fields:
Translation:
Humans
PH
Public Health
The Importance of Diagnostic Testing during a Viral Pandemic: Early Lessons from Novel Coronavirus Disease (COVID-19). Am J Trop Med Hyg. 2020 05; 102(5):915-916.
Rosenthal PJ
. PMID: 32238224; PMCID:
PMC7204570
View in:
PubMed
Mentions:
20
Fields:
Translation:
Humans
Cells
PH
Public Health
The impact of antimalarial resistance on the genetic structure of Plasmodium falciparum in the DRC. Nat Commun. 2020 04 30; 11(1):2107.
Verity R, Aydemir O, Brazeau NF, Watson OJ,
Hathaway NJ
, Mwandagalirwa MK, Marsh PW, Thwai K, Fulton T, Denton M, Morgan AP, Parr JB, Tumwebaze PK, Conrad M,
Rosenthal PJ
, Ishengoma DS, Ngondi J, Gutman J, Mulenga M, Norris DE, Moss WJ, Mensah BA, Myers-Hansen JL, Ghansah A, Tshefu AK, Ghani AC, Meshnick SR, Bailey JA, Juliano JJ. PMID: 32355199; PMCID:
PMC7192906
View in:
PubMed
Mentions:
70
Fields:
Translation:
Humans
Animals
Are three drugs for malaria better than two? Lancet. 2020 04 25; 395(10233):1316-1317.
Rosenthal PJ
. PMID: 32171077.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Plasmodium falciparum Resistance to a Lead Benzoxaborole Due to Blocked Compound Activation and Altered Ubiquitination or Sumoylation. mBio. 2020 01 28; 11(1).
Sindhe KMV,
Wu W
, Legac J, Zhang YK, Easom EE, Cooper RA, Plattner JJ, Freund YR,
DeRisi JL
Rosenthal PJ
. PMID: 31992618; PMCID:
PMC6989105
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
Animals
Cells
Outcomes of Childhood Cholestasis in Alagille Syndrome: Results of a Multicenter Observational Study. Hepatol Commun. 2020 Mar; 4(3):387-398.
Kamath BM, Ye W, Goodrich NP, Loomes KM, Romero R, Heubi JE, Leung DH, Spinner NB, Piccoli DA, Alonso EM, Guthery SL, Karpen SJ, Mack CL, Molleston JP, Murray KF,
Rosenthal P
, Squires JE, Teckman J, Wang KS, Thompson R, Magee JC, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 33313463; PMCID:
PMC7049675
View in:
PubMed
Mentions:
29
Fields:
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study. Malar J. 2020 Jan 15; 19(1):21.
Kakande E,
Greenhouse B
, Bajunirwe F, Drakeley C, Nankabirwa JI, Walakira A, Nsobya SL, Katureebe A, Rek J, Arinaitwe E,
Rosenthal PJ
, Kamya MR,
Dorsey G
Rodriguez-Barraquer I
. PMID: 31941490; PMCID:
PMC6964006
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Falcipain cysteine proteases of malaria parasites: An update. Biochim Biophys Acta Proteins Proteom. 2020 03; 1868(3):140362.
Rosenthal PJ
. PMID: 31927030.
View in:
PubMed
Mentions:
26
Fields:
Translation:
Animals
Functionalized Naphthalimide-4-aminoquinoline Conjugates as Promising Antiplasmodials, with Mechanistic Insights. ACS Med Chem Lett. 2020 Feb 13; 11(2):154-161.
Legac J, Adeniyi AA, Kisten P,
Rosenthal PJ
, Singh P, Kumar V. PMID: 32071682; PMCID:
PMC7025377
View in:
PubMed
Mentions:
Coupling the Antimalarial Cell Penetrating Peptide TP10 to Classical Antimalarial Drugs Primaquine and Chloroquine Produces Strongly Hemolytic Conjugates. Molecules. 2019 Dec 12; 24(24).
Aguiar L, Biosca A, Lantero E, Gut J, Vale N,
Rosenthal PJ
, Nogueira F, Andreu D, Fernàndez-Busquets X, Gomes P. PMID: 31842498; PMCID:
PMC6943437
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Design, synthesis, heme binding and density functional theory studies of isoindoline-dione-4-aminoquinolines as potential antiplasmodials. Future Med Chem. 2020 02; 12(3):193-205.
Rani A, Kumar S, Legac J, Adeniyi AA, Awolade P, Singh P,
Rosenthal PJ
, Kumar V. PMID: 31802710; PMCID:
PMC7099627
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Biannual versus annual mass azithromycin distribution and malaria seroepidemiology among preschool children in Niger: a sub-study of a cluster randomized trial. Malar J. 2019 Dec 03; 18(1):389.
Oldenburg CE
, Amza A, Cooley G, Kadri B, Nassirou B,
Arnold BF
Rosenthal PJ
O'Brien KS
, West SK, Bailey RL,
Porco TC
Keenan JD
Lietman TM
, Martin DL. PMID: 31796025; PMCID:
PMC6889587
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Malaria parasites fine-tune mutations to resist drugs. Nature. 2019 12; 576(7786):217-219.
Tilley L,
Rosenthal PJ
. PMID: 31822828.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Distinct Biomarker Profiles Distinguish Malawian Children with Malarial and Non-malarial Sepsis. Am J Trop Med Hyg. 2019 12; 101(6):1424-1433.
Kortz TB
, Nyirenda J, Tembo D, Elfving K,
Baltzell K
, Bandawe G,
Rosenthal PJ
Macfarlane SB
, Mandala W, Nyirenda TS. PMID: 31595873; PMCID:
PMC6896879
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Synthesis, anti-plasmodial and cytotoxic evaluation of 1H-1,2,3-triazole/acyl hydrazide integrated tetrahydro-β-carboline-4-aminoquinoline conjugates. Bioorg Med Chem Lett. 2020 01 15; 30(2):126810.
Sharma B, Kaur S, Legac J,
Rosenthal PJ
, Kumar V. PMID: 31740250.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Be Careful What You Eat! Am J Trop Med Hyg. 2019 11; 101(5):955-956.
Rosenthal PJ
. PMID: 31549613; PMCID:
PMC6838582
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
PH
Public Health
Phenotypes of Chronic Hepatitis B in Children From a Large North American Cohort. J Pediatr Gastroenterol Nutr. 2019 11; 69(5):588-594.
Schwarz KB
, Lombardero M, Di Bisceglie AM, Murray KF,
Rosenthal P
, Ling SC, Cloonan YK, Rodriguez-Baez N, Schwarzenberg SJ, Hoofnagle JH, Teckman J, Hepatitis B Research Network (HBRN). PMID: 31436702; PMCID:
PMC6814562
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
[(7-chloroquinolin-4-yl)amino]acetophenones and their copper(II) derivatives: Synthesis, characterization, computational studies and antimalarial activity. EXCLI J. 2019; 18:962-987.
de J Parra Y, Andueza L FD, Ferrer M RE, Bruno Colmenarez J, Acosta ME, Charris J,
Rosenthal PJ
, Gut J. PMID: 31762723; PMCID:
PMC6868921
View in:
PubMed
Mentions:
The Diversity of the Plasmodium falciparum K13 Propeller Domain Did Not Increase after Implementation of Artemisinin-Based Combination Therapy in Uganda. Antimicrob Agents Chemother. 2019 10; 63(10).
Conrad MD, Nsobya SL,
Rosenthal PJ
. PMID: 31358588; PMCID:
PMC6761569
View in:
PubMed
Mentions:
13
Fields:
Translation:
Humans
Animals
Artemisinin Resistance in Eastern India. Clin Infect Dis. 2019 09 13; 69(7):1153-1155.
Rosenthal PJ
. PMID: 30541018.
View in:
PubMed
Mentions:
Fields:
Has Rotavirus Vaccination Decreased the Prevalence of Biliary Atresia? J Clin Gastroenterol. 2019 09; 53(8):e348-e351.
Danial E, Fleck-Derderian S,
Rosenthal P
. PMID: 30222646.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
PH
Public Health
A Prospective Trial of Withdrawal and Reinstitution of Ursodeoxycholic Acid in Pediatric Primary Sclerosing Cholangitis. Hepatol Commun. 2019 Nov; 3(11):1482-1495.
Black DD, Mack C, Kerkar N, Miloh T, Sundaram SS, Anand R, Gupta A, Alonso E, Arnon R, Bulut P, Karpen S, Lin CH,
Rosenthal P
, Ryan M, Squires RH, Valentino P, Elsea SH, Shneider BL. PMID: 31701072; PMCID:
PMC6824074
View in:
PubMed
Mentions:
Fields:
Antimalarial drug resistance in Africa: the calm before the storm? Lancet Infect Dis. 2019 10; 19(10):e338-e351.
Conrad MD,
Rosenthal PJ
. PMID: 31375467.
View in:
PubMed
Mentions:
141
Fields:
Translation:
Humans
Animals
Reduced Exposure to Piperaquine, Compared to Adults, in Young Children Receiving Dihydroartemisinin-Piperaquine as Malaria Chemoprevention. Clin Pharmacol Ther. 2019 12; 106(6):1310-1318.
Whalen ME, Kajubi R, Chamankhah N,
Huang L
, Orukan F, Wallender E, Kamya MR,
Dorsey G
, Jagannathan P,
Rosenthal PJ
, Mwebaza N,
Aweeka FT
. PMID: 31173649; PMCID:
PMC6851416
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
A shorter course for anti-relapse therapy against vivax malaria. Lancet. 2019 09 14; 394(10202):898-900.
Rosenthal PJ
. PMID: 31327565.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Mass Drug Administration to Control and Eliminate Malaria in Africa: How Do We Best Utilize the Tools at Hand? Clin Infect Dis. 2019 07 02; 69(2):287-289.
Guler JL,
Rosenthal PJ
. PMID: 30304408.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Identification of a potent benzoxaborole drug candidate for treating cryptosporidiosis. Nat Commun. 2019 06 27; 10(1):2816.
Lunde CS, Stebbins EE, Jumani RS, Hasan MM, Miller P, Barlow J, Freund YR, Berry P, Stefanakis R, Gut J,
Rosenthal PJ
, Love MS, McNamara CW, Easom E, Plattner JJ, Jacobs RT, Huston CD. PMID: 31249291; PMCID:
PMC6597546
View in:
PubMed
Mentions:
26
Fields:
Translation:
Humans
Animals
Biannual mass azithromycin distributions and malaria parasitemia in pre-school children in Niger: A cluster-randomized, placebo-controlled trial. PLoS Med. 2019 06; 16(6):e1002835.
Arzika AM, Maliki R, Boubacar N, Kane S, Cotter SY, Lebas E, Cook C, Bailey RL, West SK,
Rosenthal PJ
Porco TC
Lietman TM
Keenan JD
, MORDOR Study Group. PMID: 31237871; PMCID:
PMC6592520
View in:
PubMed
Mentions:
28
Fields:
Translation:
Humans
PH
Public Health
Improvement of Asparagine Ethylenediamines as Anti-malarial Plasmodium-Selective Proteasome Inhibitors. J Med Chem. 2019 07 11; 62(13):6137-6145.
Zhan W, Visone J, Ouellette T, Harris JC, Wang R, Zhang H, Singh PK, Ginn J, Sukenick G, Wong TT, Okoro JI, Scales RM, Tumwebaze PK,
Rosenthal PJ
, Kafsack BFC, Cooper RA, Meinke PT, Kirkman LA, Lin G. PMID: 31177777; PMCID:
PMC7104388
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Animals
Metagenomic next-generation sequencing of samples from pediatric febrile illness in Tororo, Uganda. PLoS One. 2019; 14(6):e0218318.
Ramesh A, Nakielny S, Hsu J, Kyohere M, Byaruhanga O, de Bourcy C, Egger R, Dimitrov B, Juan YF, Sheu J, Wang J, Kalantar K,
Langelier C
Ruel T
, Mpimbaza A,
Wilson MR
Rosenthal PJ
DeRisi JL
. PMID: 31220115; PMCID:
PMC6586300
View in:
PubMed
Mentions:
60
Fields:
Translation:
Humans
Animals
Cells
Understanding the context of delays in seeking appropriate care for children with symptoms of severe malaria in Uganda. PLoS One. 2019; 14(6):e0217262.
Mpimbaza A, Nayiga S, Ndeezi G,
Rosenthal PJ
, Karamagi C, Katahoire A. PMID: 31166968; PMCID:
PMC6550380
View in:
PubMed
Mentions:
18
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Expanded Availability of Intravenous Artesunate for the Treatment of Severe Malaria in the United States. Am J Trop Med Hyg. 2019 06; 100(6):1295-1296.
Rosenthal PJ
, Tan KR. PMID: 30927931; PMCID:
PMC6553912
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials. J Med Chem. 2019 06 13; 62(11):5562-5578.
Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA,
Rosenthal PJ
, Grau GER, Hunt NH, Payne RJ. PMID: 31062592.
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Substituted 1,3-dioxoisoindoline-4-aminoquinolines coupled via amide linkers: Synthesis, antiplasmodial and cytotoxic evaluation. Bioorg Chem. 2019 07; 88:102912.
Rani A, Legac J,
Rosenthal PJ
, Kumar V. PMID: 30991190.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Identification of Polycystic Kidney Disease 1 Like 1 Gene Variants in Children With Biliary Atresia Splenic Malformation Syndrome. Hepatology. 2019 09; 70(3):899-910.
Berauer JP, Mezina AI, Okou DT, Sabo A, Muzny DM, Gibbs RA, Hegde MR, Chopra P, Cutler DJ, Perlmutter DH,
Bull LN
, Thompson RJ, Loomes KM, Spinner NB, Rajagopalan R, Guthery SL, Moore B, Yandell M, Harpavat S, Magee JC, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Alonso EM,
Rosenthal P
, Squires RH, Wang KS, Finegold MJ, Russo P, Sherker AH, Sokol RJ, Karpen SJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 30664273; PMCID:
PMC6642859
View in:
PubMed
Mentions:
42
Fields:
Translation:
Humans
Persistent Parasitemia Despite Dramatic Reduction in Malaria Incidence After 3 Rounds of Indoor Residual Spraying in Tororo, Uganda. J Infect Dis. 2019 03 15; 219(7):1104-1111.
Nankabirwa JI, Briggs J, Rek J, Arinaitwe E, Nayebare P,
Katrak S
, Staedke SG,
Rosenthal PJ
Rodriguez-Barraquer I
, Kamya MR,
Dorsey G
Greenhouse B
. PMID: 30383230; PMCID:
PMC6420168
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
PH
Public Health
Comparative Efficacy of Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine for the Treatment of Uncomplicated Malaria in Ugandan Children. J Infect Dis. 2019 03 15; 219(7):1112-1120.
Yeka A, Wallender E, Mulebeke R, Kibuuka A, Kigozi R, Bosco A, Kyambadde P, Opigo J, Kalyesubula S, Senzoga J,
Vinden J
, Conrad M,
Rosenthal PJ
. PMID: 30418593; PMCID:
PMC7868963
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Animals
Changing Molecular Markers of Antimalarial Drug Sensitivity across Uganda. Antimicrob Agents Chemother. 2019 03; 63(3).
Asua V,
Vinden J
, Conrad MD, Legac J, Kigozi SP, Kamya MR,
Dorsey G
, Nsobya SL,
Rosenthal PJ
. PMID: 30559133; PMCID:
PMC6395896
View in:
PubMed
Mentions:
49
Fields:
Translation:
Humans
Animals
Malaria: How Are We Doing and How Can We Do Better? Am J Trop Med Hyg. 2019 02; 100(2):239-241.
Rosenthal PJ
, John CC, Rabinovich NR. PMID: 30628572; PMCID:
PMC6367613
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
PH
Public Health
Optimal dosing of dihydroartemisinin-piperaquine for seasonal malaria chemoprevention in young children. Nat Commun. 2019 01 29; 10(1):480.
Chotsiri P, Zongo I, Milligan P, Compaore YD, Somé AF, Chandramohan D, Hanpithakpong W, Nosten F, Greenwood B,
Rosenthal PJ
, White NJ, Ouédraogo JB, Tarning J. PMID: 30696903; PMCID:
PMC6351525
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Modeling Prevention of Malaria and Selection of Drug Resistance with Different Dosing Schedules of Dihydroartemisinin-Piperaquine Preventive Therapy during Pregnancy in Uganda. Antimicrob Agents Chemother. 2019 02; 63(2).
Wallender E, Zhang N, Conrad M, Kakuru A, Muhindo M, Tumwebaze P, Kajubi R, Mota D, Legac J, Jagannathan P,
Havlir D
, Kamya M,
Dorsey G
Aweeka F
Rosenthal PJ
Savic RM
. PMID: 30530597; PMCID:
PMC6355581
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Center variation in screening for and management of metabolic syndrome in pediatric liver transplant recipients: A survey of SPLIT centers. Pediatr Transplant. 2019 05; 23(3):e13347.
Hilk K,
Zerofsky M
, Rhee S,
Rosenthal P
Perito ER
. PMID: 30664821; PMCID:
PMC6642860
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Association Between Recent Overnight Travel and Risk of Malaria: A Prospective Cohort Study at 3 Sites in Uganda. Clin Infect Dis. 2019 01 07; 68(2):313-320.
Arinaitwe E,
Dorsey G
, Nankabirwa JI, Kigozi SP, Katureebe A, Kakande E, Rek J,
Rosenthal PJ
, Drakeley C, Kamya MR, Staedke SG. PMID: 29868722; PMCID:
PMC6321857
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Volume 100 of the American Journal of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2019 01; 100(1):3-4.
Rosenthal PJ
, Vinetz JM, Siegel C, Kazura JW. PMID: 30652665; PMCID:
PMC6335895
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Bone Density in Children With Chronic Liver Disease Correlates With Growth and Cholestasis. Hepatology. 2019 01; 69(1):245-257.
Loomes KM, Spino C, Goodrich NP, Hangartner TN, Marker AE, Heubi JE, Kamath BM, Shneider BL,
Rosenthal P
, Hertel PM, Karpen SJ, Molleston JP, Murray KF,
Schwarz KB
, Squires RH, Teckman J, Turmelle YP, Alonso EM, Sherker AH, Magee JC, Sokol RJ, Childhood Liver Disease Research Network. PMID: 30063078; PMCID:
PMC6324969
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Caregiver responses and association with delayed care-seeking in children with uncomplicated and severe malaria. Malar J. 2018 Dec 18; 17(1):476.
Mpimbaza A, Katahoire A,
Rosenthal PJ
, Karamagi C, Ndeezi G. PMID: 30563514; PMCID:
PMC6299589
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Artemisinin Resistance Outside of Southeast Asia. Am J Trop Med Hyg. 2018 12; 99(6):1357-1359.
Rosenthal PJ
. PMID: 30426924; PMCID:
PMC6283499
View in:
PubMed
Mentions:
13
Fields:
Translation:
Humans
Animals
Ombitasvir/Paritaprevir/Ritonavir With or Without Dasabuvir and With or Without Ribavirin for Adolescents With HCV Genotype 1 or 4. Hepatol Commun. 2018 Nov; 2(11):1311-1319.
Leung DH, Wirth S, Yao BB, Viani RM, Gonzalez-Peralta RP, Jonas MM, Lobritto SJ, Narkewicz MR, Sokal E, Fortuny C, Hsu EK, Del Valle-Segarra A, Zha J, Larsen L, Liu L, Shuster DL, Cohen DE,
Rosenthal P
. PMID: 30411078; PMCID:
PMC6211326
View in:
PubMed
Mentions:
Fields:
Molecular assays for antimalarial drug resistance surveillance: A target product profile. PLoS One. 2018; 13(9):e0204347.
Nsanzabana C, Ariey F, Beck HP, Ding XC, Kamau E, Krishna S, Legrand E, Lucchi N, Miotto O, Nag S, Noedl H, Roper C,
Rosenthal PJ
, Schallig HDFH, Taylor SM, Volkman SK, Gonzalez IJ. PMID: 30235327; PMCID:
PMC6147503
View in:
PubMed
Mentions:
24
Fields:
Associations between erythrocyte polymorphisms and risks of uncomplicated and severe malaria in Ugandan children: A case control study. PLoS One. 2018; 13(9):e0203229.
Mpimbaza A, Walakira A, Ndeezi G, Katahoire A, Karamagi C, Nsobya SL, Tukwasibwe S, Asua V,
Rosenthal PJ
. PMID: 30222732; PMCID:
PMC6141089
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Intermittent Preventive Treatment for Malaria in Pregnancy: Optimization of Target Concentrations of Dihydroartemisinin-Piperaquine. Clin Infect Dis. 2018 09 14; 67(7):1079-1088.
Savic RM
, Jagannathan P, Kajubi R,
Huang L
, Zhang N, Were M, Kakuru A, Muhindo MK, Mwebaza N, Wallender E,
Clark TD
, Opira B, Kamya M,
Havlir DV
Rosenthal PJ
Dorsey G
Aweeka FT
. PMID: 29547881; PMCID:
PMC6137112
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Cysteine proteases in protozoan parasites. PLoS Negl Trop Dis. 2018 08; 12(8):e0006512.
Siqueira-Neto JL,
Debnath A
, McCall LI, Bernatchez JA, Ndao M,
Reed SL
Rosenthal PJ
. PMID: 30138453; PMCID:
PMC6107107
View in:
PubMed
Mentions:
64
Fields:
Translation:
Humans
Animals
Plasmodium falciparum Falcipain-2a Polymorphisms in Southeast Asia and Their Association With Artemisinin Resistance. J Infect Dis. 2018 07 02; 218(3):434-442.
Siddiqui FA, Cabrera M, Wang M, Brashear A, Kemirembe K, Wang Z, Miao J, Chookajorn T, Yang Z, Cao Y, Dong G,
Rosenthal PJ
, Cui L. PMID: 29659945; PMCID:
PMC6048984
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Antimalarial proteasome inhibitor reveals collateral sensitivity from intersubunit interactions and fitness cost of resistance. Proc Natl Acad Sci U S A. 2018 07 17; 115(29):E6863-E6870.
Kirkman LA, Zhan W, Visone J, Dziedziech A, Singh PK, Fan H, Tong X, Bruzual I, Hara R, Kawasaki M, Imaeda T, Okamoto R, Sato K, Michino M, Alvaro EF, Guiang LF, Sanz L, Mota DJ, Govindasamy K, Wang R, Ling Y, Tumwebaze PK, Sukenick G, Shi L, Vendome J, Bhanot P,
Rosenthal PJ
, Aso K, Foley MA, Cooper RA, Kafsack B, Doggett JS, Nathan CF, Lin G. PMID: 29967165; PMCID:
PMC6055138
View in:
PubMed
Mentions:
55
Fields:
Translation:
Humans
Animals
Predicting Optimal Dihydroartemisinin-Piperaquine Regimens to Prevent Malaria During Pregnancy for Human Immunodeficiency Virus-Infected Women Receiving Efavirenz. J Infect Dis. 2018 03 05; 217(6):964-972.
Wallender E, Vucicevic K, Jagannathan P,
Huang L
, Natureeba P, Kakuru A, Muhindo M, Nakalembe M,
Havlir D
, Kamya M,
Aweeka F
Dorsey G
Rosenthal PJ
Savic RM
. PMID: 29272443; PMCID:
PMC5853566
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Endoperoxide-8-aminoquinoline hybrids as dual-stage antimalarial agents with enhanced metabolic stability. Eur J Med Chem. 2018 Apr 10; 149:69-78.
Capela R, Magalhães J, Miranda D, Machado M, Sanches-Vaz M, Albuquerque IS, Sharma M, Gut J,
Rosenthal PJ
, Frade R, Perry MJ, Moreira R, Prudêncio M, Lopes F. PMID: 29499488.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Clinical consequences of submicroscopic malaria parasitaemia in Uganda. Malar J. 2018 Feb 05; 17(1):67.
Katrak S
, Nayebare P, Rek J, Arinaitwe E, Nankabirwa JI, Kamya M,
Dorsey G
Rosenthal PJ
Greenhouse B
. PMID: 29402282; PMCID:
PMC5800031
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
"The Way We Were" Ken Warren's Legacy and Modern Investments in Global Health. Am J Trop Med Hyg. 2017 12; 97(6):1955-1957.
Dunavan CP,
Rosenthal PJ
. PMID: 29187275; PMCID:
PMC5805082
View in:
PubMed
Mentions:
Fields:
Changing Antimalarial Drug Sensitivities in Uganda. Antimicrob Agents Chemother. 2017 12; 61(12).
Rasmussen SA, Ceja FG, Conrad MD, Tumwebaze PK, Byaruhanga O, Katairo T, Nsobya SL,
Rosenthal PJ
, Cooper RA. PMID: 28923866; PMCID:
PMC5700361
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Microwave-promoted facile access to 4-aminoquinoline-phthalimides: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2018 Jan 01; 143:150-156.
Rani A, Singh A, Gut J,
Rosenthal PJ
, Kumar V. PMID: 29174811.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Impact of Intermittent Preventive Treatment During Pregnancy on Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Uganda. J Infect Dis. 2017 11 15; 216(8):1008-1017.
Conrad MD, Mota D, Foster M, Tukwasibwe S, Legac J, Tumwebaze P, Whalen M, Kakuru A, Nayebare P, Wallender E,
Havlir DV
, Jagannathan P,
Huang L
Aweeka F
, Kamya MR,
Dorsey G
Rosenthal PJ
. PMID: 28968782; PMCID:
PMC5853776
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
Animals
Demographic, Socioeconomic, and Geographic Factors Leading to Severe Malaria and Delayed Care Seeking in Ugandan Children: A Case-Control Study. Am J Trop Med Hyg. 2017 Nov; 97(5):1513-1523.
Mpimbaza A, Ndeezi G, Katahoire A,
Rosenthal PJ
, Karamagi C. PMID: 29016322; PMCID:
PMC5817743
View in:
PubMed
Mentions:
37
Fields:
Translation:
Humans
Comparative Prevalence of Plasmodium falciparum Resistance-Associated Genetic Polymorphisms in Parasites Infecting Humans and Mosquitoes in Uganda. Am J Trop Med Hyg. 2017 Nov; 97(5):1576-1580.
Conrad MD, Mota D, Musiime A, Kilama M, Rek J, Kamya M,
Dorsey G
Rosenthal PJ
. PMID: 29016309; PMCID:
PMC5817777
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Performance of Loop-Mediated Isothermal Amplification for the Identification of Submicroscopic Plasmodium falciparum Infection in Uganda. Am J Trop Med Hyg. 2017 12; 97(6):1777-1781.
Katrak S
Murphy M
, Nayebare P, Rek J, Smith M, Arinaitwe E, Nankabirwa JI, Kamya M,
Dorsey G
Rosenthal PJ
Greenhouse B
. PMID: 29016335; PMCID:
PMC5805042
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda. Infect Genet Evol. 2017 11; 55:281-287.
Walakira A, Tukwasibwe S, Kiggundu M, Verra F, Kakeeto P, Ruhamyankaka E, Drakeley C,
Dorsey G
, Kamya MR, Nsobya SL,
Rosenthal PJ
. PMID: 28939159; PMCID:
PMC5685907
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Let's Eliminate Diseases, Not Institutes: The Case for the Fogarty International Center. Am J Trop Med Hyg. 2017 09; 97(3):629-630.
Rosenthal PJ
, Goraleski KA, Rabinovich NR, Walker PF. PMID: 28990909; PMCID:
PMC5590616
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
Plasmodium Species Infecting Children Presenting with Malaria in Uganda. Am J Trop Med Hyg. 2017 Sep; 97(3):753-757.
Asua V, Tukwasibwe S, Conrad M, Walakira A, Nankabirwa JI, Mugenyi L, Kamya MR, Nsobya SL,
Rosenthal PJ
. PMID: 28990911; PMCID:
PMC5590612
View in:
PubMed
Mentions:
28
Fields:
Translation:
Humans
Animals
Sofosbuvir and ribavirin in adolescents 12-17 years old with hepatitis C virus genotype 2 or 3 infection. Hepatology. 2017 10; 66(4):1102-1110.
Wirth S,
Rosenthal P
, Gonzalez-Peralta RP, Jonas MM, Balistreri WF, Lin CH, Hardikar W, Kersey K, Massetto B, Kanwar B, Brainard DM, Shao J, Svarovskaia E, Kirby B, Arnon R, Murray KF,
Schwarz KB
. PMID: 28543053.
View in:
PubMed
Mentions:
25
Fields:
Translation:
Humans
Cells
CT
Clinical Trials
Development of Novel Peptide-Based Michael Acceptors Targeting Rhodesain and Falcipain-2 for the Treatment of Neglected Tropical Diseases (NTDs). J Med Chem. 2017 08 24; 60(16):6911-6923.
Previti S, Ettari R, Cosconati S, Amendola G, Chouchene K, Wagner A, Hellmich UA, Ulrich K, Krauth-Siegel RL, Wich PR, Schmid I, Schirmeister T, Gut J,
Rosenthal PJ
, Grasso S, Zappalà M. PMID: 28763614.
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Animals
Cells
The Relative Effects of Artemether-lumefantrine and Non-artemisinin Antimalarials on Gametocyte Carriage and Transmission of Plasmodium falciparum: A Systematic Review and Meta-analysis. Clin Infect Dis. 2017 Aug 01; 65(3):486-494.
Ippolito MM, Johnson J, Mullin C, Mallow C, Morgan N, Wallender E, Li T,
Rosenthal PJ
. PMID: 28402391; PMCID:
PMC5850314
View in:
PubMed
Mentions:
14
Fields:
Translation:
Humans
Animals
4-Aminoquinoline-chalcone/-N-acetylpyrazoline conjugates: Synthesis and antiplasmodial evaluation. Eur J Med Chem. 2017 Sep 29; 138:993-1001.
Kumar S, Saini A, Gut J,
Rosenthal PJ
, Raj R, Kumar V. PMID: 28756265.
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Cells
Mass Azithromycin and Malaria Parasitemia in Niger: Results from a Community-Randomized Trial. Am J Trop Med Hyg. 2017 Sep; 97(3):696-701.
O'Brien KS
, Cotter SY, Amza A, Kadri B, Nassirou B, Stoller NE, Zhou Z, Cotter C, West SK, Bailey RL,
Rosenthal PJ
, Gaynor BD,
Porco TC
Lietman TM
. PMID: 28722569; PMCID:
PMC5590561
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Association Between Cytokines and Liver Histology in Children with Nonalcoholic Fatty Liver Disease. Hepatol Commun. 2017 Sep; 1(7):609-622.
Perito ER
Ajmera V
, Bass NM,
Rosenthal P
, Lavine JE,
Schwimmer JB
, Yates KP, Diehl AM, Molleston JP, Murray KF, Scheimann A,
Gill R
Glidden D
, Aouizerat B. PMID: 29130075; PMCID:
PMC5679472
View in:
PubMed
Mentions:
19
Fields:
Enantioselective Synthesis and in Vivo Evaluation of Regioisomeric Analogues of the Antimalarial Arterolane. J Med Chem. 2017 07 27; 60(14):6400-6407.
Blank BR, Gut J,
Rosenthal PJ
Renslo AR
. PMID: 28692297; PMCID:
PMC5535261
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Benzoxaborole Antimalarial Agents. Part 5. Lead Optimization of Novel Amide Pyrazinyloxy Benzoxaboroles and Identification of a Preclinical Candidate. J Med Chem. 2017 07 13; 60(13):5889-5908.
Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Freund YR, Berry P, Ciaravino V, Erve JCL,
Rosenthal PJ
, Campo B, Gamo FJ, Sanz LM, Cao J. PMID: 28635296.
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Animals
Initial assessment of the infant with neonatal cholestasis-Is this biliary atresia? PLoS One. 2017; 12(5):e0176275.
Shneider BL, Moore J, Kerkar N, Magee JC, Ye W, Karpen SJ, Kamath BM, Molleston JP, Bezerra JA, Murray KF, Loomes KM, Whitington PF,
Rosenthal P
, Squires RH, Guthery SL, Arnon R,
Schwarz KB
, Turmelle YP, Sherker AH, Sokol RJ, Childhood Liver Disease Research Network. PMID: 28493866; PMCID:
PMC5426590
View in:
PubMed
Mentions:
13
Fields:
Translation:
Humans
CT
Clinical Trials
Piperazine-linked 4-aminoquinoline-chalcone/ferrocenyl-chalcone conjugates: Synthesis and antiplasmodial evaluation. Chem Biol Drug Des. 2017 Oct; 90(4):590-595.
Singh A, Rani A, Gut J,
Rosenthal PJ
, Kumar V. PMID: 28332319.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Drug resistance mediating Plasmodium falciparum polymorphisms and clinical presentations of parasitaemic children in Uganda. Malar J. 2017 03 21; 16(1):125.
Tukwasibwe S, Tumwebaze P, Conrad M, Arinaitwe E, Kamya MR,
Dorsey G
, Nsobya SL,
Greenhouse B
Rosenthal PJ
. PMID: 28327148; PMCID:
PMC5361791
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat Commun. 2017 03 06; 8:14574.
Sonoiki E, Ng CL, Lee MC, Guo D, Zhang YK, Zhou Y, Alley MR, Ahyong V, Sanz LM, Lafuente-Monasterio MJ, Dong C, Schupp PG, Gut J, Legac J, Cooper RA, Gamo FJ,
DeRisi J
, Freund YR, Fidock DA,
Rosenthal PJ
. PMID: 28262680; PMCID:
PMC5343452
View in:
PubMed
Mentions:
66
Fields:
Translation:
Humans
Animals
Cells
Targeting Toxoplasma gondii CPSF3 as a new approach to control toxoplasmosis. EMBO Mol Med. 2017 03; 9(3):385-394.
Palencia A, Bougdour A, Brenier-Pinchart MP, Touquet B, Bertini RL, Sensi C, Gay G, Vollaire J, Josserand V, Easom E, Freund YR, Pelloux H,
Rosenthal PJ
, Cusack S, Hakimi MA. PMID: 28148555; PMCID:
PMC5331205
View in:
PubMed
Mentions:
42
Fields:
Translation:
Animals
Changing Antimalarial Drug Resistance Patterns Identified by Surveillance at Three Sites in Uganda. J Infect Dis. 2017 02 15; 215(4):631-635.
Tumwebaze P, Tukwasibwe S, Taylor A, Conrad M, Ruhamyankaka E, Asua V, Walakira A, Nankabirwa J, Yeka A, Staedke SG,
Greenhouse B
, Nsobya SL, Kamya MR,
Dorsey G
Rosenthal PJ
. PMID: 28039354; PMCID:
PMC5853976
View in:
PubMed
Mentions:
47
Fields:
Translation:
Humans
Animals
Avidity of anti-malarial antibodies inversely related to transmission intensity at three sites in Uganda. Malar J. 2017 02 10; 16(1):67.
Ssewanyana I, Arinaitwe E, Nankabirwa JI, Yeka A, Sullivan R, Kamya MR,
Rosenthal PJ
Dorsey G
, Mayanja-Kizza H, Drakeley C,
Greenhouse B
, Tetteh KK. PMID: 28183299; PMCID:
PMC5301436
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Animals
Cells
Evidence-Based Policies on Migration and Global Health are Essential to Maintain the Health of Those Inside and Outside the United States. Am J Trop Med Hyg. 2017 Jan 11; 96(1):5-6.
Rosenthal PJ
, Bausch DG, Higgs S, Rabinovich NR, Hill DR, Plowe CV, Goraleski KA, Walker PF. PMID: 28077738; PMCID:
PMC5239708
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Altered Plasmodium falciparum Sensitivity to the Antiretroviral Protease Inhibitor Lopinavir Associated with Polymorphisms in pfmdr1. Antimicrob Agents Chemother. 2017 01; 61(1).
Sonoiki E, Nsanzabana C, Legac J, Sindhe KM,
DeRisi J
Rosenthal PJ
. PMID: 27821443; PMCID:
PMC5192118
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Measures of Malaria Burden after Long-Lasting Insecticidal Net Distribution and Indoor Residual Spraying at Three Sites in Uganda: A Prospective Observational Study. PLoS Med. 2016 Nov; 13(11):e1002167.
Katureebe A, Zinszer K, Arinaitwe E, Rek J, Kakande E, Charland K, Kigozi R, Kilama M, Nankabirwa J, Yeka A, Mawejje H, Mpimbaza A, Katamba H, Donnelly MJ,
Rosenthal PJ
, Drakeley C, Lindsay SW, Staedke SG, Smith DL,
Greenhouse B
, Kamya MR,
Dorsey G
. PMID: 27824885; PMCID:
PMC5100985
View in:
PubMed
Mentions:
107
Fields:
Translation:
Humans
PH
Public Health
The (International) American Society of Tropical Medicine and Hygiene. Am J Trop Med Hyg. 2016 Nov 02; 95(5):980-982.
Rosenthal PJ
, Hill DR, Bausch DG, Goraleski KA, Higgs S, Walker PF, Plowe CV. PMID: 27807294; PMCID:
PMC5094245
View in:
PubMed
Mentions:
Fields:
Translation:
PH
Public Health
Artemether-Lumefantrine and Dihydroartemisinin-Piperaquine Exert Inverse Selective Pressure on Plasmodium Falciparum Drug Sensitivity-Associated Haplotypes in Uganda. Open Forum Infect Dis. 2017; 4(1):ofw229.
Taylor AR, Flegg JA, Holmes CC, Guérin PJ, Sibley CH, Conrad MD,
Dorsey G
Rosenthal PJ
. PMID: 28480232; PMCID:
PMC5413987
View in:
PubMed
Mentions:
23
Communicable Diseases: A Global Perspective. Am J Trop Med Hyg. 2016 Oct 05; 95(4):974-975.
Rosenthal PJ
. PMID: 27708202.
View in:
PubMed
Mentions:
Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity. Antimicrob Agents Chemother. 2016 10; 60(10):5649-54.
Nankabirwa JI, Conrad MD, Legac J, Tukwasibwe S, Tumwebaze P, Wandera B, Brooker SJ, Staedke SG, Kamya MR, Nsobya SL,
Dorsey G
Rosenthal PJ
. PMID: 27401569; PMCID:
PMC5038325
View in:
PubMed
Mentions:
19
Fields:
Translation:
Humans
Animals
PH
Public Health
Cryptosporidium and Toxoplasma Parasites Are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 10; 60(10):5817-27.
Palencia A, Liu RJ, Lukarska M, Gut J, Bougdour A, Touquet B, Wang ED, Li X, Alley MR, Freund YR,
Rosenthal PJ
, Hakimi MA, Cusack S. PMID: 27431220; PMCID:
PMC5038320
View in:
PubMed
Mentions:
35
Fields:
Translation:
Humans
Animals
Cells
4-Aminoquinoline-ferrocenyl-chalcone conjugates: Synthesis and anti-plasmodial evaluation. Eur J Med Chem. 2017 Jan 05; 125:269-277.
Singh A, Gut J,
Rosenthal PJ
, Kumar V. PMID: 27688182.
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
Characterizing microscopic and submicroscopic malaria parasitaemia at three sites with varied transmission intensity in Uganda. Malar J. 2016 09 15; 15:470.
Rek J,
Katrak S
, Obasi H, Nayebare P, Katureebe A, Kakande E, Arinaitwe E, Nankabirwa JI, Jagannathan P, Drakeley C, Staedke SG, Smith DL, Bousema T, Kamya M,
Rosenthal PJ
Dorsey G
Greenhouse B
. PMID: 27628178; PMCID:
PMC5024471
View in:
PubMed
Mentions:
35
Fields:
Translation:
Humans
PH
Public Health
Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites. ChemMedChem. 2016 10 06; 11(19):2194-2204.
Carrasco MP, Machado M, Gonçalves L, Sharma M, Gut J, Lukens AK, Wirth DF, André V, Duarte MT, Guedes RC, Dos Santos DJ,
Rosenthal PJ
, Mazitschek R, Prudêncio M, Moreira R. PMID: 27538856.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Chronic Hepatitis C Infection in Children. Adv Pediatr. 2016 08; 63(1):173-94.
Pham YH,
Rosenthal P
. PMID: 27426900.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Antimalarial Benzoxaboroles Target Plasmodium falciparum Leucyl-tRNA Synthetase. Antimicrob Agents Chemother. 2016 08; 60(8):4886-95.
Sonoiki E, Palencia A, Guo D, Ahyong V, Dong C, Li X, Hernandez VS, Zhang YK, Choi W, Gut J, Legac J, Cooper R, Alley MR, Freund YR,
DeRisi J
, Cusack S,
Rosenthal PJ
. PMID: 27270277; PMCID:
PMC4958189
View in:
PubMed
Mentions:
33
Fields:
Translation:
Animals
Azithromycin for Malaria? Am J Trop Med Hyg. 2016 07 06; 95(1):2-4.
Rosenthal PJ
. PMID: 27215296; PMCID:
PMC4944689
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Novel squaramides with in vitro liver stage antiplasmodial activity. Bioorg Med Chem. 2016 Apr 15; 24(8):1786-92.
Ribeiro CJ, Espadinha M, Machado M, Gut J, Gonçalves LM,
Rosenthal PJ
, Prudêncio M, Moreira R, Santos MM. PMID: 26968650.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Estimating malaria parasite prevalence from community surveys in Uganda: a comparison of microscopy, rapid diagnostic tests and polymerase chain reaction. Malar J. 2015 Dec 30; 14:528.
Nankabirwa JI, Yeka A, Arinaitwe E, Kigozi R, Drakeley C, Kamya MR,
Greenhouse B
Rosenthal PJ
Dorsey G
, Staedke SG. PMID: 26714465; PMCID:
PMC4696244
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Animals
Total Serum Bilirubin within 3 Months of Hepatoportoenterostomy Predicts Short-Term Outcomes in Biliary Atresia. J Pediatr. 2016 Mar; 170:211-7.e1-2.
Shneider BL, Magee JC, Karpen SJ, Rand EB, Narkewicz MR, Bass LM,
Schwarz K
, Whitington PF, Bezerra JA, Kerkar N, Haber B,
Rosenthal P
, Turmelle YP, Molleston JP, Murray KF, Ng VL, Wang KS, Romero R, Squires RH, Arnon R, Sherker AH, Moore J, Ye W, Sokol RJ, Childhood Liver Disease Research Network (ChiLDReN). PMID: 26725209; PMCID:
PMC4826612
View in:
PubMed
Mentions:
61
Fields:
Translation:
Humans
Artesunate/Amodiaquine Versus Artemether/Lumefantrine for the Treatment of Uncomplicated Malaria in Uganda: A Randomized Trial. J Infect Dis. 2016 Apr 01; 213(7):1134-42.
Yeka A, Kigozi R, Conrad MD, Lugemwa M, Okui P, Katureebe C, Belay K, Kapella BK, Chang MA, Kamya MR, Staedke SG,
Dorsey G
Rosenthal PJ
. PMID: 26597254; PMCID:
PMC4836737
View in:
PubMed
Mentions:
54
Fields:
Translation:
Humans
Enantiopure Indolizinoindolones with in vitro Activity against Blood- and Liver-Stage Malaria Parasites. ChemMedChem. 2015 Dec; 10(12):2080-9.
Pereira NA, Monteiro Â, Machado M, Gut J, Molins E, Perry MJ, Dourado J, Moreira R,
Rosenthal PJ
, Prudêncio M, Santos MM. PMID: 26525306.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
Artefenomel: a promising new antimalarial drug. Lancet Infect Dis. 2016 Jan; 16(1):6-8.
Rosenthal PJ
. PMID: 26448142.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Trioxolane-Mediated Delivery of Mefloquine Limits Brain Exposure in a Mouse Model of Malaria. ACS Med Chem Lett. 2015 Nov 12; 6(11):1145-9.
Lauterwasser EM, Fontaine SD, Li H, Gut J, Katneni K, Charman SA,
Rosenthal PJ
, Bogyo M,
Renslo AR
. PMID: 26617969; PMCID:
PMC4645246
View in:
PubMed
Mentions:
The RTS,S/AS01 vaccine continues to show modest protection against malaria in African infants and children. Evid Based Med. 2015 Oct; 20(5):179.
Rosenthal PJ
. PMID: 26316645.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Antimalarial Drug Resistance: Literature Review and Activities and Findings of the ICEMR Network. Am J Trop Med Hyg. 2015 Sep; 93(3 Suppl):57-68.
Cui L, Mharakurwa S, Ndiaye D, Rathod PK,
Rosenthal PJ
. PMID: 26259943; PMCID:
PMC4574275
View in:
PubMed
Mentions:
127
Fields:
Translation:
Humans
Animals
Novel serologic biomarkers provide accurate estimates of recent Plasmodium falciparum exposure for individuals and communities. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4438-47.
Helb DA, Tetteh KK,
Felgner PL
, Skinner J, Hubbard A, Arinaitwe E, Mayanja-Kizza H, Ssewanyana I, Kamya MR, Beeson JG, Tappero J, Smith DL, Crompton PD,
Rosenthal PJ
Dorsey G
, Drakeley CJ,
Greenhouse B
. PMID: 26216993; PMCID:
PMC4538641
View in:
PubMed
Mentions:
153
Fields:
Translation:
Humans
Animals
Benzoxaborole antimalarial agents. Part 4. Discovery of potent 6-(2-(alkoxycarbonyl)pyrazinyl-5-oxy)-1,3-dihydro-1-hydroxy-2,1-benzoxaboroles. J Med Chem. 2015 Jul 09; 58(13):5344-54.
Zhang YK, Plattner JJ, Easom EE, Jacobs RT, Guo D, Sanders V, Freund YR, Campo B,
Rosenthal PJ
, Bu W, Gamo FJ, Sanz LM, Ge M, Li L, Ding J, Yang Y. PMID: 26067904; PMCID:
PMC4500456
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Bacteremia Among Febrile Ugandan Children Treated with Antimalarials Despite a Negative Malaria Test. Am J Trop Med Hyg. 2015 Aug; 93(2):276-280.
Kibuuka A, Byakika-Kibwika P, Achan J, Yeka A, Nalyazi JN, Mpimbaza A,
Rosenthal PJ
, Kamya MR. PMID: 26055736; PMCID:
PMC4530747
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Cells
Lack of Artemisinin Resistance in Plasmodium falciparum in Uganda Based on Parasitological and Molecular Assays. Antimicrob Agents Chemother. 2015 Aug; 59(8):5061-4.
Cooper RA, Conrad MD, Watson QD, Huezo SJ, Ninsiima H, Tumwebaze P, Nsobya SL,
Rosenthal PJ
. PMID: 26033725; PMCID:
PMC4505276
View in:
PubMed
Mentions:
49
Fields:
Translation:
Humans
Animals
Randomized Noninferiority Trial of Dihydroartemisinin-Piperaquine Compared with Sulfadoxine-Pyrimethamine plus Amodiaquine for Seasonal Malaria Chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2015 Aug; 59(8):4387-96.
Zongo I, Milligan P, Compaore YD, Some AF, Greenwood B, Tarning J,
Rosenthal PJ
, Sutherland C, Nosten F, Ouedraogo JB. PMID: 25918149; PMCID:
PMC4505196
View in:
PubMed
Mentions:
50
Fields:
Translation:
Humans
The effect of dosing strategies on the therapeutic efficacy of artesunate-amodiaquine for uncomplicated malaria: a meta-analysis of individual patient data. BMC Med. 2015 Mar 31; 13:66.
WorldWide Antimalarial Resistance Network (WWARN) AS-AQ Study Group, Adjuik MA, Allan R, Anvikar AR, Ashley EA, Ba MS, Barennes H, Barnes KI, Bassat Q, Baudin E, Björkman A, Bompart F, Bonnet M, Borrmann S, Brasseur P, Bukirwa H, Checchi F, Cot M, Dahal P, D'Alessandro U, Deloron P, Desai M, Diap G, Djimde AA,
Dorsey G
, Doumbo OK, Espié E, Etard JF, Fanello CI, Faucher JF, Faye B, Flegg JA, Gaye O, Gething PW, González R, Grandesso F, Guerin PJ, Guthmann JP, Hamour S, Hasugian AR, Hay SI, Humphreys GS, Jullien V, Juma E, Kamya MR, Karema C, Kiechel JR, Kremsner PG, Krishna S, Lameyre V, Ibrahim LM, Lee SJ, Lell B, Mårtensson A, Massougbodji A, Menan H, Ménard D, Menéndez C, Meremikwu M, Moreira C, Nabasumba C, Nambozi M, Ndiaye JL, Nikiema F, Nsanzabana C, Ntoumi F, Ogutu BR, Olliaro P, Osorio L, Ouédraogo JB, Penali LK, Pene M, Pinoges L, Piola P, Price RN, Roper C,
Rosenthal PJ
, Rwagacondo CE, Same-Ekobo A, Schramm B, Seck A, Sharma B, Sibley CH, Sinou V, Sirima SB, Smith JJ, Smithuis F, Somé FA, Sow D, Staedke SG, Stepniewska K, Swarthout TD, Sylla K, Talisuna AO, Tarning J, Taylor WR, Temu EA, Thwing JI, Tjitra E, Tine RC, Tinto H, Vaillant MT, Valecha N, Van den Broek I, White NJ, Yeka A, Zongo I. PMID: 25888957; PMCID:
PMC4411752
View in:
PubMed
Mentions:
29
Fields:
Translation:
Humans
Synthesis and in vitro antiplasmodial evaluation of 7-chloroquinoline-chalcone and 7-chloroquinoline-ferrocenylchalcone conjugates. Eur J Med Chem. 2015 May 05; 95:230-9.
Raj R, Saini A, Gut J,
Rosenthal PJ
, Kumar V. PMID: 25817773.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Targeting the erythrocytic and liver stages of malaria parasites with s-triazine-based hybrids. ChemMedChem. 2015 May; 10(5):883-90.
Rodrigues CA, Frade RF, Albuquerque IS, Perry MJ, Gut J, Machado M,
Rosenthal PJ
, Prudêncio M, Afonso CA, Moreira R. PMID: 25784585.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Allosteric regulation of the Plasmodium falciparum cysteine protease falcipain-2 by heme. Arch Biochem Biophys. 2015 May 01; 573:92-9.
Marques AF, Gomes PS, Oliveira PL,
Rosenthal PJ
, Pascutti PG, Lima LM. PMID: 25791019.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Malaria transmission, infection, and disease at three sites with varied transmission intensity in Uganda: implications for malaria control. Am J Trop Med Hyg. 2015 May; 92(5):903-12.
Kamya MR, Arinaitwe E, Wanzira H, Katureebe A, Barusya C, Kigozi SP, Kilama M, Tatem AJ,
Rosenthal PJ
, Drakeley C, Lindsay SW, Staedke SG, Smith DL,
Greenhouse B
Dorsey G
. PMID: 25778501; PMCID:
PMC4426576
View in:
PubMed
Mentions:
148
Fields:
Translation:
Humans
Animals
PH
Public Health
The Effect of Storage and Extraction Methods on Amplification of Plasmodium falciparum DNA from Dried Blood Spots. Am J Trop Med Hyg. 2015 May; 92(5):922-5.
Schwartz A, Baidjoe A,
Rosenthal PJ
Dorsey G
, Bousema T,
Greenhouse B
. PMID: 25758652; PMCID:
PMC4426578
View in:
PubMed
Mentions:
36
Fields:
Translation:
Animals
Cells
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children. Antimicrob Agents Chemother. 2015; 59(6):3018-30.
Tumwebaze P, Conrad MD, Walakira A, LeClair N, Byaruhanga O, Nakazibwe C, Kozak B,
Bloome J
, Okiring J, Kakuru A, Bigira V, Kapisi J, Legac J, Gut J, Cooper RA, Kamya MR,
Havlir DV
Dorsey G
Greenhouse B
, Nsobya SL,
Rosenthal PJ
. PMID: 25753626; PMCID:
PMC4432194
View in:
PubMed
Mentions:
50
Fields:
Translation:
Humans
Animals
N10,N11-di-alkylamine indolo[3,2-b]quinolines as hemozoin inhibitors: design, synthesis and antiplasmodial activity. Bioorg Med Chem. 2015 Apr 01; 23(7):1530-9.
Figueiras M, Coelho L, Wicht KJ, Santos SA, Lavrado J, Gut J,
Rosenthal PJ
, Nogueira F, Egan TJ, Moreira R, Paulo A. PMID: 25725608.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Perspectives on Ebola. Am J Trop Med Hyg. 2015 Feb; 92(2):219-220.
Rosenthal PJ
, Bausch DG. PMID: 25582689; PMCID:
PMC4347313
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
PH
Public Health
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials. J Med Chem. 2014 Dec 26; 57(24):10557-63.
Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S,
Rosenthal PJ
, Hunt NH, Payne RJ. PMID: 25412465.
View in:
PubMed
Mentions:
19
Fields:
Translation:
Humans
Animals
Cells
Synthesis and structure-activity-relationship studies of thiazolidinediones as antiplasmodial inhibitors of the Plasmodium falciparum cysteine protease falcipain-2. Eur J Med Chem. 2015 Jan 27; 90:507-18.
Sharma RK, Younis Y, Mugumbate G, Njoroge M, Gut J,
Rosenthal PJ
, Chibale K. PMID: 25486422.
View in:
PubMed
Mentions:
14
Fields:
Translation:
Animals
Cells
Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS. 2014 Nov 28; 28(18):2701-9.
Kamya MR, Kapisi J, Bigira V,
Clark TD
, Kinara S, Mwangwa F, Muhindo MK, Kakuru A,
Aweeka FT
Huang L
, Jagannathan P, Achan J,
Havlir DV
Rosenthal PJ
Dorsey G
. PMID: 25493596; PMCID:
PMC4487368
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
Drug delivery to the malaria parasite using an arterolane-like scaffold. ChemMedChem. 2015 Jan; 10(1):47-51.
Fontaine SD, Spangler B, Gut J, Lauterwasser EM,
Rosenthal PJ
Renslo AR
. PMID: 25314098; PMCID:
PMC4420023
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Cells
Long-term growth outcomes in children treated for chronic hepatitis C. J Pediatr. 2014 Dec; 165(6):1252-4.
Jonas MM,
Schwarz KB
, Gonzalez-Peralta R, Lobritto S, Molleston JP, Murray KF,
Rosenthal P
, Wen J, Wat C, Pavlovic V, Warne C. PMID: 25241178.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis. 2015 Mar 01; 211(5):680-8.
Taylor SM, Parobek CM, DeConti DK, Kayentao K, Coulibaly SO, Greenwood BM, Tagbor H, Williams J, Bojang K, Njie F, Desai M, Kariuki S, Gutman J, Mathanga DP, Mårtensson A, Ngasala B, Conrad MD,
Rosenthal PJ
, Tshefu AK, Moormann AM, Vulule JM, Doumbo OK, Ter Kuile FO, Meshnick SR, Bailey JA, Juliano JJ. PMID: 25180240; PMCID:
PMC4402372
View in:
PubMed
Mentions:
193
Fields:
Translation:
Humans
Animals
Polymorphisms in K13 and falcipain-2 associated with artemisinin resistance are not prevalent in Plasmodium falciparum isolated from Ugandan children. PLoS One. 2014; 9(8):e105690.
Conrad MD, Bigira V, Kapisi J, Muhindo M, Kamya MR,
Havlir DV
Dorsey G
Rosenthal PJ
. PMID: 25144768; PMCID:
PMC4140830
View in:
PubMed
Mentions:
86
Fields:
Translation:
Humans
Animals
Cells
CT
Clinical Trials
Efficacy and day 7 plasma piperaquine concentrations in African children treated for uncomplicated malaria with dihydroartemisinin-piperaquine. PLoS One. 2014; 9(8):e103200.
Zongo I, Somé FA, Somda SA, Parikh S, Rouamba N,
Rosenthal PJ
, Tarning J, Lindegardh N, Nosten F, Ouédraogo JB. PMID: 25133389; PMCID:
PMC4136730
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
CT
Clinical Trials
Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial. PLoS Med. 2014 Aug; 11(8):e1001689.
Bigira V, Kapisi J,
Clark TD
, Kinara S, Mwangwa F, Muhindo MK, Osterbauer B,
Aweeka FT
Huang L
, Achan J,
Havlir DV
Rosenthal PJ
, Kamya MR,
Dorsey G
. PMID: 25093754; PMCID:
PMC4122345
View in:
PubMed
Mentions:
76
Fields:
Translation:
Humans
β-amino-alcohol tethered 4-aminoquinoline-isatin conjugates: synthesis and antimalarial evaluation. Eur J Med Chem. 2014 Sep 12; 84:566-73.
Gut J,
Rosenthal PJ
, Kumar V. PMID: 25062007; PMCID:
PMC7115587
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am J Trop Med Hyg. 2014 Oct; 91(4):833-843.
Venkatesan M, Gadalla NB, Stepniewska K, Dahal P, Nsanzabana C, Moriera C, Price RN, Mårtensson A,
Rosenthal PJ
Dorsey G
, Sutherland CJ, Guérin P, Davis TME, Ménard D, Adam I, Ademowo G, Arze C, Baliraine FN, Berens-Riha N, Björkman A, Borrmann S, Checchi F, Desai M, Dhorda M, Djimdé AA, El-Sayed BB, Eshetu T, Eyase F, Falade C, Faucher JF, Fröberg G, Grivoyannis A, Hamour S, Houzé S, Johnson J, Kamugisha E, Kariuki S, Kiechel JR, Kironde F, Kofoed PE, LeBras J, Malmberg M, Mwai L, Ngasala B, Nosten F, Nsobya SL, Nzila A, Oguike M, Otienoburu SD, Ogutu B, Ouédraogo JB, Piola P, Rombo L, Schramm B, Somé AF, Thwing J, Ursing J, Wong RPM, Zeynudin A, Zongo I, Plowe CV, Sibley CH. PMID: 25048375; PMCID:
PMC4183414
View in:
PubMed
Mentions:
188
Fields:
Translation:
Humans
Animals
Discovery of highly selective 7-chloroquinoline-thiohydantoins with potent antimalarial activity. Eur J Med Chem. 2014 Sep 12; 84:425-32.
Raj R, Mehra V, Gut J,
Rosenthal PJ
, Wicht KJ, Egan TJ, Hopper M, Wrischnik LA, Land KM, Kumar V. PMID: 25038484.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Medical status of 219 children with biliary atresia surviving long-term with their native livers: results from a North American multicenter consortium. J Pediatr. 2014 Sep; 165(3):539-546.e2.
Ng VL, Haber BH, Magee JC, Miethke A, Murray KF, Michail S, Karpen SJ, Kerkar N, Molleston JP, Romero R,
Rosenthal P
Schwarz KB
, Shneider BL, Turmelle YP, Alonso EM, Sherker AH, Sokol RJ, Childhood Liver Disease Research and Education Network (CHiLDREN). PMID: 25015575; PMCID:
PMC4144331
View in:
PubMed
Mentions:
29
Fields:
Translation:
Humans
Synthetic compounds from an in house library as inhibitors of falcipain-2 from Plasmodium falciparum. J Enzyme Inhib Med Chem. 2015 Apr; 30(2):299-307.
Bertoldo JB, Chiaradia-Delatorre LD, Mascarello A, Leal PC, Cordeiro MN, Nunes RJ, Sarduy ES,
Rosenthal PJ
, Terenzi H. PMID: 24964346.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Tetraoxane-pyrimidine nitrile hybrids as dual stage antimalarials. J Med Chem. 2014 Jun 12; 57(11):4916-23.
Oliveira R, Guedes RC, Meireles P, Albuquerque IS, Gonçalves LM, Pires E, Bronze MR, Gut J,
Rosenthal PJ
, Prudêncio M, Moreira R, O'Neill PM, Lopes F. PMID: 24824551.
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
Cells
Longitudinal outcomes in a cohort of Ugandan children randomized to artemether-lumefantrine versus dihydroartemisinin-piperaquine for the treatment of malaria. Clin Infect Dis. 2014 Aug 15; 59(4):509-16.
Wanzira H, Kakuru A, Arinaitwe E, Bigira V, Muhindo MK, Conrad M,
Rosenthal PJ
, Kamya MR, Tappero JW,
Dorsey G
. PMID: 24825870.
View in:
PubMed
Mentions:
32
Fields:
Translation:
Humans
Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda. Am J Trop Med Hyg. 2014 Jul; 91(1):54-61.
Mbogo GW, Nankoberanyi S, Tukwasibwe S, Baliraine FN, Nsobya SL, Conrad MD, Arinaitwe E, Kamya M, Tappero J, Staedke SG,
Dorsey G
Greenhouse B
Rosenthal PJ
. PMID: 24799371; PMCID:
PMC4080569
View in:
PubMed
Mentions:
52
Fields:
Translation:
Humans
Animals
Point of care testing for malaria using LAMP, loop mediated isothermal amplification. J Infect Dis. 2014 Oct 15; 210(8):1167-9.
Hsiang MS
Greenhouse B
Rosenthal PJ
. PMID: 24795471.
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
Probing the aurone scaffold against Plasmodium falciparum: design, synthesis and antimalarial activity. Eur J Med Chem. 2014 Jun 10; 80:523-34.
Carrasco MP, Newton AS, Gonçalves L, Góis A, Machado M, Gut J, Nogueira F, Hänscheid T, Guedes RC, dos Santos DJ,
Rosenthal PJ
, Moreira R. PMID: 24813880.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Artemisinin-based combination therapies are efficacious and safe for treatment of uncomplicated malaria in HIV-infected Ugandan children. Clin Infect Dis. 2014 Aug 01; 59(3):446-53.
Kakuru A, Achan J, Muhindo MK, Ikilezi G, Arinaitwe E, Mwangwa F,
Ruel T
Clark TD
Charlebois E
Rosenthal PJ
Havlir D
, Kamya MR, Tappero JW,
Dorsey G
. PMID: 24759826; PMCID:
PMC4155440
View in:
PubMed
Mentions:
13
Fields:
Translation:
Humans
Virologic and immunologic outcomes of HIV-infected Ugandan children randomized to lopinavir/ritonavir or nonnucleoside reverse transcriptase inhibitor therapy. J Acquir Immune Defic Syndr. 2014 Apr 15; 65(5):535-41.
Ruel TD
, Kakuru A, Ikilezi G, Mwangwa F,
Dorsey G
Rosenthal PJ
Charlebois E
Havlir D
, Kamya M, Achan J. PMID: 24326597; PMCID:
PMC3999287
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Bis-alkylamine Indolo[3,2-b]quinolines as hemozoin ligands: implications for antimalarial cytostatic and cytocidal activities. J Med Chem. 2014 Apr 24; 57(8):3295-313.
Paulo A, Figueiras M, Machado M, Charneira C, Lavrado J, Santos SA, Lopes D, Gut J,
Rosenthal PJ
, Nogueira F, Moreira R. PMID: 24673163.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Selection of drug resistance-mediating Plasmodium falciparum genetic polymorphisms by seasonal malaria chemoprevention in Burkina Faso. Antimicrob Agents Chemother. 2014 Jul; 58(7):3660-5.
Somé AF, Zongo I, Compaoré YD, Sakandé S, Nosten F, Ouédraogo JB,
Rosenthal PJ
. PMID: 24733476; PMCID:
PMC4068591
View in:
PubMed
Mentions:
38
Fields:
Translation:
Humans
Animals
Cross-talk between malarial cysteine proteases and falstatin: the BC loop as a hot-spot target. PLoS One. 2014; 9(4):e93008.
Sundararaj S, Saxena AK, Sharma R, Vashisht K, Sharma S, Anvikar A, Dixit R,
Rosenthal PJ
, Pandey KC. PMID: 24699522; PMCID:
PMC3974720
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Estimation of malaria haplotype and genotype frequencies: a statistical approach to overcome the challenge associated with multiclonal infections. Malar J. 2014 Mar 17; 13:102.
Taylor AR, Flegg JA, Nsobya SL, Yeka A, Kamya MR,
Rosenthal PJ
Dorsey G
, Sibley CH, Guerin PJ, Holmes CC. PMID: 24636676; PMCID:
PMC4004158
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Animals
Validation of the ligase detection reaction fluorescent microsphere assay for the detection of Plasmodium falciparum resistance mediating polymorphisms in Uganda. Malar J. 2014 Mar 14; 13:95.
Nankoberanyi S, Mbogo GW, LeClair NP, Conrad MD, Tumwebaze P, Tukwasibwe S, Kamya MR, Tappero J, Nsobya SL,
Rosenthal PJ
. PMID: 24629020; PMCID:
PMC4004386
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Animals
7-chloroquinoline-isatin conjugates: antimalarial, antitubercular, and cytotoxic evaluation. Chem Biol Drug Des. 2014 May; 83(5):622-9.
Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J,
Rosenthal PJ
, Forge D, Kumar V. PMID: 24341638.
View in:
PubMed
Mentions:
18
Fields:
Translation:
Animals
Cells
Impact of intermittent preventive treatment with dihydroartemisinin-piperaquine on malaria in Ugandan schoolchildren: a randomized, placebo-controlled trial. Clin Infect Dis. 2014 May; 58(10):1404-12.
Nankabirwa JI, Wandera B, Amuge P, Kiwanuka N,
Dorsey G
Rosenthal PJ
, Brooker SJ, Staedke SG, Kamya MR. PMID: 24621953; PMCID:
PMC4001293
View in:
PubMed
Mentions:
74
Fields:
Translation:
Humans
Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial. Am J Trop Med Hyg. 2014 May; 90(5):846-51.
Gaynor BD, Amza A, Kadri B, Nassirou B, Lawan O, Maman L, Stoller NE, Yu SN, Chin SA, West SK, Bailey RL,
Rosenthal PJ
Keenan JD
Porco TC
Lietman TM
. PMID: 24615132; PMCID:
PMC4015576
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J Infect Dis. 2014 Aug 01; 210(3):344-53.
Conrad MD, LeClair N, Arinaitwe E, Wanzira H, Kakuru A, Bigira V, Muhindo M, Kamya MR, Tappero JW,
Greenhouse B
Dorsey G
Rosenthal PJ
. PMID: 24610872; PMCID:
PMC4110461
View in:
PubMed
Mentions:
76
Fields:
Translation:
Humans
Animals
Synthesis, biological evaluation, hydration site thermodynamics, and chemical reactivity analysis of α-keto substituted peptidomimetics for the inhibition of Plasmodium falciparum. Bioorg Med Chem Lett. 2014 Mar 01; 24(5):1274-9.
Weldon DJ, Shah F, Chittiboyina AG, Sheri A, Chada RR, Gut J,
Rosenthal PJ
, Shivakumar D, Sherman W, Desai P, Jung JC, Avery MA. PMID: 24507921.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda. J Infect Dis. 2014 Jul 01; 210(1):154-7.
Tukwasibwe S, Mugenyi L, Mbogo GW, Nankoberanyi S, Maiteki-Sebuguzi C, Joloba ML, Nsobya SL, Staedke SG,
Rosenthal PJ
. PMID: 24446524; PMCID:
PMC4162000
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Animals
1H-1,2,3-Triazole-tethered isatin-7-chloroquinoline and 3-hydroxy-indole-7-chloroquinoline conjugates: synthesis and antimalarial evaluation. Bioorg Med Chem Lett. 2014 Feb 01; 24(3):756-9.
Raj R, Gut J,
Rosenthal PJ
, Kumar V. PMID: 24424135.
View in:
PubMed
Mentions:
16
Fields:
Translation:
Animals
Changes at our journal. Am J Trop Med Hyg. 2014 Jan; 90(1):1-2.
Rosenthal PJ
. PMID: 24402700; PMCID:
PMC3886403
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Determination of the antimalarial drug piperaquine in small volume pediatric plasma samples by LC-MS/MS. Bioanalysis. 2014; 6(23):3081-9.
Kjellin LL,
Dorsey G
Rosenthal PJ
Aweeka F
Huang L
. PMID: 25529877; PMCID:
PMC4321809
View in:
PubMed
Mentions:
20
Fields:
Translation:
Humans
Novel endoperoxide-based transmission-blocking antimalarials with liver- and blood-schizontocidal activities. ACS Med Chem Lett. 2014 Feb 13; 5(2):108-12.
Miranda D, Capela R, Albuquerque IS, Meireles P, Paiva I, Nogueira F, Amewu R, Gut J,
Rosenthal PJ
, Oliveira R, Mota MM, Moreira R, Marti F, Prudêncio M, O'Neill PM, Lopes F. PMID: 24900781; PMCID:
PMC4027774
View in:
PubMed
Mentions:
15
Urea/oxalamide tethered β-lactam-7-chloroquinoline conjugates: synthesis and in vitro antimalarial evaluation. Eur J Med Chem. 2014 Jan; 71:128-34.
Singh P, Raj R, Singh P, Gut J,
Rosenthal PJ
, Kumar V. PMID: 24287561.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
4-Aminoquinoline-β-lactam conjugates: synthesis, antimalarial, and antitubercular evaluation. Chem Biol Drug Des. 2014 Feb; 83(2):191-7.
Raj R, Biot C, Carrère-Kremer S, Kremer L, Guérardel Y, Gut J,
Rosenthal PJ
, Kumar V. PMID: 24034147.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Novel anti-plasmodial hits identified by virtual screening of the ZINC database. J Comput Aided Mol Des. 2013 Oct; 27(10):859-71.
Mugumbate G, Newton AS,
Rosenthal PJ
, Gut J, Moreira R, Chibale K, Guedes RC. PMID: 24158745.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Synthesis and in vitro and in vivo pharmacological evaluation of new 4-aminoquinoline-based compounds. ACS Med Chem Lett. 2013 Dec 12; 4(12):1198-202.
Tukulula M, Njoroge M, Abay ET, Mugumbate GC, Wiesner L, Taylor D, Gibhard L, Norman J, Swart KJ, Gut J,
Rosenthal PJ
, Barteau S, Streckfuss J, Kameni-Tcheudji J, Chibale K. PMID: 24900630; PMCID:
PMC4027225
View in:
PubMed
Mentions:
Structural optimization of quinolon-4(1H)-imines as dual-stage antimalarials: toward increased potency and metabolic stability. J Med Chem. 2013 Oct 10; 56(19):7679-90.
Ressurreição AS, Gonçalves D, Sitoe AR, Albuquerque IS, Gut J, Góis A, Gonçalves LM, Bronze MR, Hanscheid T, Biagini GA,
Rosenthal PJ
, Prudêncio M, O'Neill P, Mota MM, Lopes F, Moreira R. PMID: 24020770.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Flavones as isosteres of 4(1H)-quinolones: discovery of ligand efficient and dual stage antimalarial lead compounds. Eur J Med Chem. 2013 Nov; 69:872-80.
Rodrigues T, Ressurreição AS, da Cruz FP, Albuquerque IS, Gut J, Carrasco MP, Gonçalves D, Guedes RC, dos Santos DJ, Mota MM,
Rosenthal PJ
, Moreira R, Prudêncio M, Lopes F. PMID: 24125849.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Squaric acid/4-aminoquinoline conjugates: novel potent antiplasmodial agents. Eur J Med Chem. 2013 Nov; 69:365-72.
Ribeiro CJ, Kumar SP, Gut J, Gonçalves LM,
Rosenthal PJ
, Moreira R, Santos MM. PMID: 24077527.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Biochemical and immunological mechanisms by which sickle cell trait protects against malaria. Malar J. 2013 Sep 11; 12:317.
Gong L, Parikh S,
Rosenthal PJ
Greenhouse B
. PMID: 24025776; PMCID:
PMC3847285
View in:
PubMed
Mentions:
39
Fields:
Translation:
Humans
Blocking Plasmodium falciparum development via dual inhibition of hemoglobin degradation and the ubiquitin proteasome system by MG132. PLoS One. 2013; 8(9):e73530.
Prasad R, Kolla VK, Legac J, Singhal N, Navale R,
Rosenthal PJ
, Sijwali PS. PMID: 24023882; PMCID:
PMC3759421
View in:
PubMed
Mentions:
35
Fields:
Translation:
Humans
Animals
Cells
The interplay between drug resistance and fitness in malaria parasites. Mol Microbiol. 2013 Sep; 89(6):1025-38.
Rosenthal PJ
. PMID: 23899091; PMCID:
PMC3792794
View in:
PubMed
Mentions:
92
Fields:
Translation:
Humans
Animals
Antiplasmodial sesquiterpenes from the seeds of Salacia longipes var. camerunensis. Phytochemistry. 2013 Dec; 96:347-52.
Mba'ning BM, Lenta BN, Noungoué DT, Antheaume C, Fongang YF, Ngouela SA, Boyom FF,
Rosenthal PJ
, Tsamo E, Sewald N, Laatsch H. PMID: 23863332.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
An endoperoxide-based hybrid approach to deliver falcipain inhibitors inside malaria parasites. ChemMedChem. 2013 Sep; 8(9):1528-36.
Oliveira R, Newton AS, Guedes RC, Miranda D, Amewu RK, Srivastava A, Gut J,
Rosenthal PJ
, O'Neill PM, Ward SA, Lopes F, Moreira R. PMID: 23853126.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Tetrazole-based deoxyamodiaquines: synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents. Bioorg Med Chem. 2013 Sep 01; 21(17):4904-13.
Tukulula M, Njoroge M, Mugumbate GC, Gut J,
Rosenthal PJ
, Barteau S, Streckfuss J, Heudi O, Kameni-Tcheudji J, Chibale K. PMID: 23896611.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Biological evaluation of hydroxynaphthoquinones as anti-malarials. Malar J. 2013 Jul 10; 12:234.
Schuck DC, Ferreira SB, Cruz LN, da Rocha DR, Moraes MS, Nakabashi M,
Rosenthal PJ
, Ferreira VF, Garcia CR. PMID: 23841934; PMCID:
PMC3726445
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Animals
Cells
An artesunate-containing antimalarial treatment regimen did not suppress cytomegalovirus viremia. J Clin Virol. 2013 Sep; 58(1):276-8.
Gantt S, Huang ML, Magaret A, Bunts L, Selke S, Wald A,
Rosenthal PJ
Dorsey G
, Casper C. PMID: 23827788; PMCID:
PMC4036801
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites. Antimicrob Agents Chemother. 2013 Sep; 57(9):4245-4251.
Ochong E, Tumwebaze PK, Byaruhanga O,
Greenhouse B
Rosenthal PJ
. PMID: 23796921; PMCID:
PMC3754360
View in:
PubMed
Mentions:
14
Fields:
Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits. Mol Inform. 2013 Jul; 32(7):659-70.
Carrasco MP, Gut J, Rodrigues T, Ribeiro MH, Lopes F,
Rosenthal PJ
, Moreira R, Dos Santos DJ. PMID: 27481771.
View in:
PubMed
Mentions:
Fields:
Optimization of a ligase detection reaction-fluorescent microsphere assay for characterization of resistance-mediating polymorphisms in African samples of Plasmodium falciparum. J Clin Microbiol. 2013 Aug; 51(8):2564-70.
LeClair NP, Conrad MD, Baliraine FN, Nsanzabana C, Nsobya SL,
Rosenthal PJ
. PMID: 23720790; PMCID:
PMC3719660
View in:
PubMed
Mentions:
31
Fields:
Translation:
Humans
Animals
Quinolin-4(1H)-imines are potent antiplasmodial drugs targeting the liver stage of malaria. J Med Chem. 2013 Jun 13; 56(11):4811-5.
Rodrigues T, da Cruz FP, Lafuente-Monasterio MJ, Gonçalves D, Ressurreição AS, Sitoe AR, Bronze MR, Gut J, Schneider G, Mota MM,
Rosenthal PJ
, Prudêncio M, Gamo FJ, Lopes F, Moreira R. PMID: 23701465.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Design, Synthesis, and Antiplasmodial Activity of Hybrid Compounds Based on (2R,3S)-N-Benzoyl-3-phenylisoserine. ACS Med Chem Lett. 2013 Jul 11; 4(7):637-41.
Njogu PM, Gut J,
Rosenthal PJ
, Chibale K. PMID: 24900723; PMCID:
PMC4027494
View in:
PubMed
Mentions:
10
Synthesis, Antiplasmodial Activity, and β-Hematin Inhibition of Hydroxypyridone-Chloroquine Hybrids. ACS Med Chem Lett. 2013 Jul 11; 4(7):642-6.
Andayi WA, Egan TJ, Gut J,
Rosenthal PJ
, Chibale K. PMID: 24900724; PMCID:
PMC4027233
View in:
PubMed
Mentions:
In vitro and in vivo antimalarial efficacies of optimized tetracyclines. Antimicrob Agents Chemother. 2013 Jul; 57(7):3131-6.
Draper MP, Bhatia B, Assefa H, Honeyman L, Garrity-Ryan LK, Verma AK, Gut J, Larson K, Donatelli J, Macone A, Klausner K, Leahy RG, Odinecs A, Ohemeng K,
Rosenthal PJ
, Nelson ML. PMID: 23629719; PMCID:
PMC3697387
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Falcipain-2 inhibition by suramin and suramin analogues. Bioorg Med Chem. 2013 Jul 01; 21(13):3667-73.
Marques AF, Esser D,
Rosenthal PJ
, Kassack MU, Lima LM. PMID: 23680445.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Azide-alkyne cycloaddition en route to 1H-1,2,3-triazole-tethered 7-chloroquinoline-isatin chimeras: synthesis and antimalarial evaluation. Eur J Med Chem. 2013 Apr; 62:590-6.
Raj R, Singh P, Singh P, Gut J,
Rosenthal PJ
, Kumar V. PMID: 23434528.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Cells
Prevalence of asymptomatic parasitemia and gametocytemia among HIV-infected Ugandan children randomized to receive different antiretroviral therapies. Am J Trop Med Hyg. 2013 Apr; 88(4):744-6.
Ikilezi G, Achan J, Kakuru A,
Ruel T
Charlebois E
Clark TD
Rosenthal PJ
Havlir D
, Kamya MR,
Dorsey G
. PMID: 23358639; PMCID:
PMC3617863
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
Substrate specificity studies of the cysteine peptidases falcipain-2 and falcipain-3 from Plasmodium falciparum and demonstration of their kininogenase activity. Mol Biochem Parasitol. 2013 Feb; 187(2):111-6.
Cotrin SS, Gouvêa IE, Melo PM, Bagnaresi P, Assis DM, Araújo MS, Juliano MA, Gazarini ML,
Rosenthal PJ
, Juliano L, Carmona AK. PMID: 23354130.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
N-cinnamoylated chloroquine analogues as dual-stage antimalarial leads. J Med Chem. 2013 Jan 24; 56(2):556-67.
Pérez BC, Teixeira C, Albuquerque IS, Gut J,
Rosenthal PJ
, Gomes JR, Prudêncio M, Gomes P. PMID: 23273038.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
Animals
Increasing incidence of malaria in children despite insecticide-treated bed nets and prompt anti-malarial therapy in Tororo, Uganda. Malar J. 2012 Dec 28; 11:435.
Jagannathan P, Muhindo MK, Kakuru A, Arinaitwe E,
Greenhouse B
, Tappero J,
Rosenthal PJ
, Kaharuza F, Kamya MR,
Dorsey G
. PMID: 23273022; PMCID:
PMC3551700
View in:
PubMed
Mentions:
61
Fields:
Translation:
Humans
PH
Public Health
In vitro efficiency of 9-(N-cinnamoylbutyl)aminoacridines against blood- and liver-stage malaria parasites. Bioorg Med Chem Lett. 2013 Feb 01; 23(3):610-3.
Pérez B, Teixeira C, Gomes AS, Albuquerque IS, Gut J,
Rosenthal PJ
, Prudêncio M, Gomes P. PMID: 23290049.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Associations between antibodies to a panel of Plasmodium falciparum specific antigens and response to sub-optimal antimalarial therapy in Kampala, Uganda. PLoS One. 2012; 7(12):e52571.
Keh CE
, Jha AR, Nzarubara B, Lanar DE, Dutta S, Theisen M,
Rosenthal PJ
Dorsey G
, Nixon DF,
Greenhouse B
. PMID: 23285095; PMCID:
PMC3526588
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Prevalence of PCR detectable malaria infection among febrile patients with a negative Plasmodium falciparum specific rapid diagnostic test in Zanzibar. Am J Trop Med Hyg. 2013 Feb; 88(2):289-91.
Baltzell KA
, Shakely D,
Hsiang M
, Kemere J, Ali AS, Björkman A, Mårtensson A, Omar R, Elfving K, Msellem M, Aydin-Schmidt B,
Rosenthal PJ
Greenhouse B
. PMID: 23249688; PMCID:
PMC3583319
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Ferrous iron-dependent delivery of therapeutic agents to the malaria parasite. Future Med Chem. 2012 Dec; 4(18):2241-9.
Mahajan SS, Gut J,
Rosenthal PJ
Renslo AR
. PMID: 23234548; PMCID:
PMC3574796
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Antiretroviral agents and prevention of malaria in HIV-infected Ugandan children. N Engl J Med. 2012 Nov 29; 367(22):2110-8.
Achan J, Kakuru A, Ikilezi G,
Ruel T
Clark TD
, Nsanzabana C,
Charlebois E
Aweeka F
Dorsey G
Rosenthal PJ
Havlir D
, Kamya MR. PMID: 23190222; PMCID:
PMC3664297
View in:
PubMed
Mentions:
60
Fields:
Translation:
Humans
PH
Public Health
Compounds from Sorindeia juglandifolia (Anacardiaceae) exhibit potent anti-plasmodial activities in vitro and in vivo. Malar J. 2012 Nov 21; 11:382.
Kamkumo RG, Ngoutane AM, Tchokouaha LR, Fokou PV, Madiesse EA, Legac J, Kezetas JJ, Lenta BN, Boyom FF, Dimo T, Mbacham WF, Gut J,
Rosenthal PJ
. PMID: 23171238; PMCID:
PMC3519527
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Concomitant efavirenz reduces pharmacokinetic exposure to the antimalarial drug artemether-lumefantrine in healthy volunteers. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):310-6.
Huang L
, Parikh S,
Rosenthal PJ
, Lizak P, Marzan F,
Dorsey G
Havlir D
Aweeka FT
. PMID: 22918158; PMCID:
PMC3511816
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
CT
Clinical Trials
1,4-naphthoquinone cations as antiplasmodial agents: hydroxy-, acyloxy-, and alkoxy-substituted analogues. ACS Med Chem Lett. 2012 Dec 13; 3(12):1029-33.
Lu X, Altharawi A, Gut J,
Rosenthal PJ
, Long TE. PMID: 24936235; PMCID:
PMC4056940
View in:
PubMed
Mentions:
Cinnamic acid/chloroquinoline conjugates as potent agents against chloroquine-resistant Plasmodium falciparum. ChemMedChem. 2012 Sep; 7(9):1537-40.
Pérez B, Teixeira C, Gut J,
Rosenthal PJ
, Gomes JR, Gomes P. PMID: 22753234.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Benzoheterocyclic amodiaquine analogues with potent antiplasmodial activity: synthesis and pharmacological evaluation. Bioorg Med Chem Lett. 2012 Aug 01; 22(15):5046-50.
Ongarora DS, Gut J,
Rosenthal PJ
, Masimirembwa CM, Chibale K. PMID: 22749280.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: towards the development of potential dual action antimalarials. Eur J Med Chem. 2012 Aug; 54:887-99.
Pérez BC, Teixeira C, Figueiras M, Gut J,
Rosenthal PJ
, Gomes JR, Gomes P. PMID: 22683112.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Cells
Intracellular proteolysis of kininogen by malaria parasites promotes release of active kinins. Malar J. 2012 May 07; 11:156.
Bagnaresi P, Barros NM, Assis DM, Melo PM, Fonseca RG, Juliano MA, Pesquero JB, Juliano L,
Rosenthal PJ
, Carmona AK, Gazarini ML. PMID: 22564457; PMCID:
PMC3407703
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
Computer-aided drug design of falcipain inhibitors: virtual screening, structure-activity relationships, hydration site thermodynamics, and reactivity analysis. J Chem Inf Model. 2012 Mar 26; 52(3):696-710.
Shah F, Gut J, Legac J, Shivakumar D, Sherman W,
Rosenthal PJ
, Avery MA. PMID: 22332946.
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Cells
Phosphonium lipocations as antiparasitic agents. Bioorg Med Chem Lett. 2012 Apr 15; 22(8):2976-9.
Long TE, Lu X, Galizzi M, Docampo R, Gut J,
Rosenthal PJ
. PMID: 22414614; PMCID:
PMC3321104
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Evidence for both innate and acquired mechanisms of protection from Plasmodium falciparum in children with sickle cell trait. Blood. 2012 Apr 19; 119(16):3808-14.
Gong L, Maiteki-Sebuguzi C,
Rosenthal PJ
, Hubbard AE, Drakeley CJ,
Dorsey G
Greenhouse B
. PMID: 22327223; PMCID:
PMC3335384
View in:
PubMed
Mentions:
47
Fields:
Translation:
Humans
Animals
Neurocognitive and motor deficits in HIV-infected Ugandan children with high CD4 cell counts. Clin Infect Dis. 2012 Apr; 54(7):1001-9.
Ruel TD
, Boivin MJ, Boal HE, Bangirana P,
Charlebois E
Havlir DV
Rosenthal PJ
Dorsey G
, Achan J, Akello C, Kamya MR,
Wong JK
. PMID: 22308272; PMCID:
PMC3297647
View in:
PubMed
Mentions:
88
Fields:
Translation:
Humans
How do we best diagnose malaria in Africa? Am J Trop Med Hyg. 2012 Feb; 86(2):192-193.
Rosenthal PJ
. PMID: 22302846; PMCID:
PMC3269265
View in:
PubMed
Mentions:
16
Fields:
Translation:
Humans
Animals
The effect of HIV on malaria in the context of the current standard of care for HIV-infected populations in Africa. Future Virol. 2012; 7(7):699-708.
Kamya MR, Byakika-Kibwika P, Gasasira AF,
Havlir D
Rosenthal PJ
Dorsey G
, Achan J. PMID: 23293660; PMCID:
PMC3535690
View in:
PubMed
Mentions:
Novel potent metallocenes against liver stage malaria. Antimicrob Agents Chemother. 2012 Mar; 56(3):1564-70.
Matos J, da Cruz FP, Cabrita É, Gut J, Nogueira F, do Rosário VE, Moreira R,
Rosenthal PJ
, Prudêncio M, Gomes P. PMID: 22155838; PMCID:
PMC3294896
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Synthesis, docking and in vitro antimalarial evaluation of bifunctional hybrids derived from β-lactams and 7-chloroquinoline using click chemistry. Bioorg Med Chem Lett. 2012 Jan 01; 22(1):57-61.
Singh P, Singh P, Kumar M, Gut J,
Rosenthal PJ
, Kumar K, Kumar V, Mahajan MP, Bisetty K. PMID: 22172698.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Efficacy and safety of artemether-lumefantrine in the treatment of acute, uncomplicated Plasmodium falciparum malaria: a pooled analysis. Am J Trop Med Hyg. 2011 Nov; 85(5):793-804.
Makanga M, Bassat Q, Falade CO, Premji ZG, Krudsood S, Hunt P, Walter V, Beck HP, Marrast AC, Cousin M,
Rosenthal PJ
. PMID: 22049029; PMCID:
PMC3205621
View in:
PubMed
Mentions:
33
Fields:
Translation:
Humans
The seroprevalence of Helicobacter pylori and its relationship to malaria in Ugandan children. Trans R Soc Trop Med Hyg. 2012 Jan; 106(1):35-42.
Gupta V, Perez-Perez GI,
Dorsey G
Rosenthal PJ
, Blaser MJ. PMID: 22018600.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Aza vinyl sulfones: synthesis and evaluation as antiplasmodial agents. Bioorg Med Chem. 2011 Dec 15; 19(24):7635-42.
Glória PM, Gut J, Gonçalves LM,
Rosenthal PJ
, Moreira R, Santos MM. PMID: 22071522.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda. J Infect Dis. 2011 Oct 01; 204(7):1120-4.
Baliraine FN,
Rosenthal PJ
. PMID: 21881128; PMCID:
PMC3164433
View in:
PubMed
Mentions:
56
Fields:
Translation:
Humans
Animals
Identification of new antimalarial leads by use of virtual screening against cytochrome bc₁. Bioorg Med Chem. 2011 Nov 01; 19(21):6302-8.
Rodrigues T, Moreira R, Gut J,
Rosenthal PJ
, O Neill PM, Biagini GA, Lopes F, dos Santos DJ, Guedes RC. PMID: 21958736.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
In vitro activity of antiretroviral drugs against Plasmodium falciparum. Antimicrob Agents Chemother. 2011 Nov; 55(11):5073-7.
Nsanzabana C,
Rosenthal PJ
. PMID: 21876053; PMCID:
PMC3194998
View in:
PubMed
Mentions:
31
Fields:
Translation:
Animals
Molecular markers of antifolate resistance in Plasmodium falciparum isolates from Luanda, Angola. Malar J. 2011 Aug 24; 10:248.
Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F,
Rosenthal PJ
, do Rosário VE, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 21864379; PMCID:
PMC3176256
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Design and evaluation of primaquine-artemisinin hybrids as a multistage antimalarial strategy. Antimicrob Agents Chemother. 2011 Oct; 55(10):4698-706.
Capela R, Cabal GG,
Rosenthal PJ
, Gut J, Mota MM, Moreira R, Lopes F, Prudêncio M. PMID: 21807973; PMCID:
PMC3186991
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Animals
Cells
In vitro sensitivity of Plasmodium falciparum field isolates to extracts from Cameroonian Annonaceae plants. Parasitol Res. 2012 Jan; 110(1):109-17.
Kemgne EA, Mbacham WF, Boyom FF, Zollo PH, Tsamo E,
Rosenthal PJ
. PMID: 21739316.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Malaria in Uganda: challenges to control on the long road to elimination. II. The path forward. Acta Trop. 2012 Mar; 121(3):196-201.
Talisuna A, Adibaku S,
Dorsey G
, Kamya MR,
Rosenthal PJ
. PMID: 21756863; PMCID:
PMC3439212
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
PH
Public Health
Antibodies to Plasmodium falciparum antigens predict a higher risk of malaria but protection from symptoms once parasitemic. J Infect Dis. 2011 Jul 01; 204(1):19-26.
Greenhouse B
, Ho B, Hubbard A, Njama-Meya D, Narum DL, Lanar DE, Dutta S,
Rosenthal PJ
Dorsey G
, John CC. PMID: 21628654; PMCID:
PMC3105040
View in:
PubMed
Mentions:
70
Fields:
Translation:
Humans
Animals
Lessons from sickle cell disease in the treatment and control of malaria. N Engl J Med. 2011 Jun 30; 364(26):2549-51.
Rosenthal PJ
. PMID: 21714653.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc Natl Acad Sci U S A. 2011 Jul 12; 108(28):11405-10.
Klonis N, Crespo-Ortiz MP, Bottova I, Abu-Bakar N, Kenny S,
Rosenthal PJ
, Tilley L. PMID: 21709259; PMCID:
PMC3136263
View in:
PubMed
Mentions:
178
Fields:
Translation:
Humans
Animals
Cells
Development of antitrypanosomal and antiplasmodial nonpeptidic cysteine protease inhibitors based on N-protected-guanidino-furan and -pyrrole building blocks. ChemMedChem. 2011 Sep 05; 6(9):1581-6.
Langolf S, Machon U, Ehlers M, Sicking W, Schirmeister T, Büchhold C, Gelhaus C,
Rosenthal PJ
, Schmuck C. PMID: 21678556.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Quinine, an old anti-malarial drug in a modern world: role in the treatment of malaria. Malar J. 2011 May 24; 10:144.
Achan J, Talisuna AO, Erhart A, Yeka A, Tibenderana JK, Baliraine FN,
Rosenthal PJ
, D'Alessandro U. PMID: 21609473; PMCID:
PMC3121651
View in:
PubMed
Mentions:
285
Fields:
Enone- and chalcone-chloroquinoline hybrid analogues: in silico guided design, synthesis, antiplasmodial activity, in vitro metabolism, and mechanistic studies. J Med Chem. 2011 May 26; 54(10):3637-49.
Guantai EM, Ncokazi K, Egan TJ, Gut J,
Rosenthal PJ
, Bhampidipati R, Kopinathan A, Smith PJ, Chibale K. PMID: 21500839; PMCID:
PMC3104272
View in:
PubMed
Mentions:
15
Fields:
Translation:
Humans
Animals
Cells
Mining a cathepsin inhibitor library for new antiparasitic drug leads. PLoS Negl Trop Dis. 2011 May 03; 5(5):e1023.
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM,
Debnath A
, Engel JC,
Rosenthal PJ
McKerrow JH
Arkin MR
Renslo AR
. PMID: 21572521; PMCID:
PMC3086806
View in:
PubMed
Mentions:
25
Fields:
Translation:
Animals
Identification of novel malarial cysteine protease inhibitors using structure-based virtual screening of a focused cysteine protease inhibitor library. J Chem Inf Model. 2011 Apr 25; 51(4):852-64.
Shah F, Mukherjee P, Gut J, Legac J,
Rosenthal PJ
, Tekwani BL, Avery MA. PMID: 21428453.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Malaria in Uganda: challenges to control on the long road to elimination: I. Epidemiology and current control efforts. Acta Trop. 2012 Mar; 121(3):184-95.
Yeka A, Gasasira A, Mpimbaza A, Achan J, Nankabirwa J, Nsobya S, Staedke SG, Donnelly MJ, Wabwire-Mangen F, Talisuna A,
Dorsey G
, Kamya MR,
Rosenthal PJ
. PMID: 21420377; PMCID:
PMC3156969
View in:
PubMed
Mentions:
138
Fields:
Translation:
Humans
Animals
PH
Public Health
Novel thiolactone-isatin hybrids as potential antimalarial and antitubercular agents. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2055-8.
Hans RH, Wiid IJ, van Helden PD, Wan B, Franzblau SG, Gut J,
Rosenthal PJ
, Chibale K. PMID: 21376591.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
An image-based assay for high throughput screening of Giardia lamblia. J Microbiol Methods. 2011 Mar; 84(3):398-405.
Gut J, Ang KK, Legac J,
Arkin MR
Rosenthal PJ
McKerrow JH
. PMID: 21262276.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Animals
Potent antiplasmodial extracts from Cameroonian Annonaceae. J Ethnopharmacol. 2011 Apr 12; 134(3):717-24.
Boyom FF, Fokou PV, Yamthe LR, Mfopa AN, Kemgne EM, Mbacham WF, Tsamo E, Zollo PH, Gut J,
Rosenthal PJ
. PMID: 21256952.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Design, synthesis and evaluation of 3-methylene-substituted indolinones as antimalarials. Eur J Med Chem. 2011 Mar; 46(3):927-33.
Praveen Kumar S, Gut J, Guedes RC,
Rosenthal PJ
, Santos MM, Moreira R. PMID: 21295887.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Incorporation of basic side chains into cryptolepine scaffold: structure-antimalarial activity relationships and mechanistic studies. J Med Chem. 2011 Feb 10; 54(3):734-50.
Lavrado J, Cabal GG, Prudêncio M, Mota MM, Gut J,
Rosenthal PJ
, Díaz C, Guedes RC, dos Santos DJ, Bichenkova E, Douglas KT, Moreira R, Paulo A. PMID: 21207937.
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
Animals
Cells
New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors. ChemMedChem. 2011 Jan 03; 6(1):141-52.
Büchold C, Hemberger Y, Heindl C, Welker A, Degel B, Pfeuffer T, Staib P, Schneider S,
Rosenthal PJ
, Gut J, Morschhäuser J, Bringmann G, Schirmeister T. PMID: 21082722.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Early virologic failure and the development of antiretroviral drug resistance mutations in HIV-infected Ugandan children. J Acquir Immune Defic Syndr. 2011 Jan 01; 56(1):44-50.
Ruel TD
, Kamya MR, Li P, Pasutti W,
Charlebois ED
, Liegler T,
Dorsey G
Rosenthal PJ
Havlir DV
Wong JK
, Achan J. PMID: 21099693; PMCID:
PMC3078046
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Cells
Falcipains and other cysteine proteases of malaria parasites. Adv Exp Med Biol. 2011; 712:30-48.
Rosenthal PJ
. PMID: 21660657.
View in:
PubMed
Mentions:
64
Fields:
Translation:
Animals
FRET peptides reveal differential proteolytic activation in intraerythrocytic stages of the malaria parasites Plasmodium berghei and Plasmodium yoelii. Int J Parasitol. 2011 Mar; 41(3-4):363-72.
Cruz LN, Alves E, Leal MT, Juliano MA,
Rosenthal PJ
, Juliano L, Garcia CR. PMID: 21168413.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Synthesis and structure-activity relationships of novel benzoxaboroles as a new class of antimalarial agents. Bioorg Med Chem Lett. 2011 Jan 15; 21(2):644-51.
Zhang YK, Plattner JJ, Freund YR, Easom EE, Zhou Y, Gut J,
Rosenthal PJ
, Waterson D, Gamo FJ, Angulo-Barturen I, Ge M, Li Z, Li L, Jian Y, Cui H, Wang H, Yang J. PMID: 21195617.
View in:
PubMed
Mentions:
18
Fields:
Translation:
Humans
Animals
Cells
Brazilian Plasmodium falciparum isolates: investigation of candidate polymorphisms for artemisinin resistance before introduction of artemisinin-based combination therapy. Malar J. 2010 Dec 08; 9:355.
Gama BE, de Oliveira NK, de Souza JM, Santos F, de Carvalho LJ, Melo YF,
Rosenthal PJ
, Daniel-Ribeiro CT, Ferreira-da-Cruz Mde F. PMID: 21143867; PMCID:
PMC3017535
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Antiplasmodial volatile extracts from Cleistopholis patens Engler & Diels and Uvariastrum pierreanum Engl. (Engl. & Diels) (Annonaceae) growing in Cameroon. Parasitol Res. 2011 May; 108(5):1211-7.
Boyom FF, Ngouana V, Kemgne EA, Zollo PH, Menut C, Bessiere JM, Gut J,
Rosenthal PJ
. PMID: 21107862; PMCID:
PMC3077741
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda. Antimicrob Agents Chemother. 2011 Feb; 55(2):615-22.
Baliraine FN, Nsobya SL, Achan J, Tibenderana JK, Talisuna AO,
Greenhouse B
Rosenthal PJ
. PMID: 21078941; PMCID:
PMC3028814
View in:
PubMed
Mentions:
19
Fields:
Translation:
Humans
Animals
Cells
CT
Clinical Trials
Design, synthesis, and development of novel guaianolide-endoperoxides as potential antimalarial agents. J Med Chem. 2010 Nov 11; 53(21):7864-8.
Sun L, Shah F, Helal MA, Wu Y, Pedduri Y, Chittiboyina AG, Gut J,
Rosenthal PJ
, Avery MA. PMID: 20945914.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Short-term risk of HIV disease progression and death in Ugandan children not eligible for antiretroviral therapy. J Acquir Immune Defic Syndr. 2010 Nov; 55(3):330-5.
Charlebois ED
Ruel TD
, Gasasira AF, Achan J, Kateera F, Akello C, Cao H,
Dorsey G
Rosenthal PJ
, Ssewanyana I, Kamya MR,
Havlir DV
. PMID: 20592617; PMCID:
PMC3025136
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Design, synthesis and in vitro antimalarial evaluation of triazole-linked chalcone and dienone hybrid compounds. Bioorg Med Chem. 2010 Dec 01; 18(23):8243-56.
Guantai EM, Ncokazi K, Egan TJ, Gut J,
Rosenthal PJ
, Smith PJ, Chibale K. PMID: 21044845.
View in:
PubMed
Mentions:
31
Fields:
Translation:
Animals
Cells
Endoperoxide carbonyl falcipain 2/3 inhibitor hybrids: toward combination chemotherapy of malaria through a single chemical entity. J Med Chem. 2010 Nov 25; 53(22):8202-6.
Gibbons P, Verissimo E, Araujo NC, Barton V, Nixon GL, Amewu RK, Chadwick J, Stocks PA, Biagini GA, Srivastava A,
Rosenthal PJ
, Gut J, Guedes RC, Moreira R, Sharma R, Berry N, Cristiano ML, Shone AE, Ward SA, O'Neill PM. PMID: 20979352.
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Cells
Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren. PLoS One. 2010 Oct 19; 5(10):e13438.
Nankabirwa J, Cundill B, Clarke S, Kabatereine N,
Rosenthal PJ
Dorsey G
, Brooker S, Staedke SG. PMID: 20976051; PMCID:
PMC2957410
View in:
PubMed
Mentions:
44
Fields:
Translation:
Humans
Biochemical properties of a novel cysteine protease of Plasmodium vivax, vivapain-4. PLoS Negl Trop Dis. 2010 Oct 12; 4(10):e849.
Na BK, Bae YA, Zo YG, Choe Y, Kim SH, Desai PV, Avery MA,
Craik CS
, Kim TS,
Rosenthal PJ
, Kong Y. PMID: 20967286; PMCID:
PMC2953480
View in:
PubMed
Mentions:
16
Fields:
Translation:
Animals
Cells
Novel application of Locked Nucleic Acid chemistry for a Taqman assay for measuring diverse human immunodeficiency virus type 1 subtypes. J Virol Methods. 2010 Dec; 170(1-2):115-20.
Li P,
Ruel T
, Fujimoto K,
Hatano H
Yukl S
, Eller LA, Liegler T, Kamya M, Gassasira A,
Dorsey G
Rosenthal PJ
Havlir DV
Wong JK
. PMID: 20863855; PMCID:
PMC3280821
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Cells
Falcipain inhibitors: optimization studies of the 2-pyrimidinecarbonitrile lead series. J Med Chem. 2010 Aug 26; 53(16):6129-52.
Coterón JM, Catterick D, Castro J, Chaparro MJ, Díaz B, Fernández E, Ferrer S, Gamo FJ, Gordo M, Gut J, de las Heras L, Legac J, Marco M, Miguel J, Muñoz V, Porras E, de la Rosa JC, Ruiz JR, Sandoval E, Ventosa P,
Rosenthal PJ
, Fiandor JM. PMID: 20672841.
View in:
PubMed
Mentions:
27
Fields:
Translation:
Animals
Bis-alkylamine quindolone derivatives as new antimalarial leads. Bioorg Med Chem Lett. 2010 Oct 01; 20(19):5634-7.
Lavrado J, Gani K, Nobre PA, Santos SA, Figueiredo P, Lopes D, Rosário Vd, Gut J,
Rosenthal PJ
, Moreira R, Paulo A. PMID: 20801652.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS. 2010 Jul 31; 24(12):1945-52.
Bebell LM,
Pilcher CD
Dorsey G
Havlir D
, Kamya MR,
Busch MP
, Dunn Williams J, Nugent CT, Bentsen C,
Rosenthal PJ
Charlebois ED
. PMID: 20543656; PMCID:
PMC2909782
View in:
PubMed
Mentions:
25
Fields:
Translation:
Humans
Cells
Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children. PLoS One. 2010 Jul 30; 5(7):e11759.
Clark TD
, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C,
Greenhouse B
, Staedke SG, Kamya MR,
Dorsey G
Rosenthal PJ
. PMID: 20689585; PMCID:
PMC2912768
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity. J Inorg Biochem. 2010 Oct; 104(10):1079-83.
Khanye SD, Smith GS, Lategan C, Smith PJ, Gut J,
Rosenthal PJ
, Chibale K. PMID: 20621360.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Effect of trimethoprim-sulphamethoxazole on the risk of malaria in HIV-infected Ugandan children living in an area of widespread antifolate resistance. Malar J. 2010 Jun 23; 9:177.
Gasasira AF, Kamya MR, Ochong EO, Vora N, Achan J,
Charlebois E
Ruel T
, Kateera F, Meya DN,
Havlir D
Rosenthal PJ
Dorsey G
. PMID: 20573194; PMCID:
PMC2903607
View in:
PubMed
Mentions:
37
Fields:
Translation:
Humans
Animals
Plasmodium falciparum isolates from Angola show the StctVMNT haplotype in the pfcrt gene. Malar J. 2010 Jun 18; 9:174.
Gama BE, Pereira-Carvalho GA, Lutucuta Kosi FJ, Almeida de Oliveira NK, Fortes F,
Rosenthal PJ
, Daniel-Ribeiro CT, de Fátima Ferreira-da-Cruz M. PMID: 20565881; PMCID:
PMC2898790
View in:
PubMed
Mentions:
37
Fields:
Translation:
Humans
Animals
Chemical genetics of Plasmodium falciparum. Nature. 2010 May 20; 465(7296):311-5.
Guiguemde WA, Shelat AA, Bouck D, Duffy S, Crowther GJ, Davis PH, Smithson DC, Connelly M, Clark J, Zhu F, Jiménez-Díaz MB, Martinez MS, Wilson EB, Tripathi AK, Gut J, Sharlow ER, Bathurst I, El Mazouni F, Fowble JW, Forquer I, McGinley PL, Castro S, Angulo-Barturen I, Ferrer S,
Rosenthal PJ
Derisi JL
, Sullivan DJ, Lazo JS, Roos DS, Riscoe MK, Phillips MA, Rathod PK, Van Voorhis WC, Avery VM, Guy RK. PMID: 20485428; PMCID:
PMC2874979
View in:
PubMed
Mentions:
286
Fields:
Translation:
Humans
Animals
Cells
Functional evaluation of Plasmodium export signals in Plasmodium berghei suggests multiple modes of protein export. PLoS One. 2010 Apr 19; 5(4):e10227.
Sijwali PS,
Rosenthal PJ
. PMID: 20419102; PMCID:
PMC2856681
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso. Antimicrob Agents Chemother. 2010 May; 54(5):1949-54.
Somé AF, Séré YY, Dokomajilar C, Zongo I, Rouamba N,
Greenhouse B
, Ouédraogo JB,
Rosenthal PJ
. PMID: 20231394; PMCID:
PMC2863637
View in:
PubMed
Mentions:
71
Fields:
Translation:
Humans
Animals
Michael acceptor based antiplasmodial and antitrypanosomal cysteine protease inhibitors with unusual amino acids. J Med Chem. 2010 Mar 11; 53(5):1951-63.
Breuning A, Degel B, Schulz F, Büchold C, Stempka M, Machon U, Heppner S, Gelhaus C, Leippe M, Leyh M, Kisker C, Rath J, Stich A, Gut J,
Rosenthal PJ
, Schmuck C, Schirmeister T. PMID: 20131843.
View in:
PubMed
Mentions:
16
Fields:
Translation:
Animals
Comparison of the antiplasmodial and falcipain-2 inhibitory activity of beta-amino alcohol thiolactone-chalcone and isatin-chalcone hybrids. Bioorg Med Chem Lett. 2010 Apr 01; 20(7):2234-7.
Hans RH, Gut J,
Rosenthal PJ
, Chibale K. PMID: 20206517.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda. Malar J. 2010 Jan 15; 9:19.
Gupta V,
Dorsey G
, Hubbard AE,
Rosenthal PJ
Greenhouse B
. PMID: 20074380; PMCID:
PMC2817701
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Animals
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda. Antimicrob Agents Chemother. 2010 Mar; 54(3):1200-6.
Nsobya SL, Kiggundu M, Nanyunja S, Joloba M,
Greenhouse B
Rosenthal PJ
. PMID: 20065051; PMCID:
PMC2825959
View in:
PubMed
Mentions:
60
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Synthesis, antimalarial and antitubercular activity of acetylenic chalcones. Bioorg Med Chem Lett. 2010 Feb 01; 20(3):942-4.
Hans RH, Guantai EM, Lategan C, Smith PJ, Wan B, Franzblau SG, Gut J,
Rosenthal PJ
, Chibale K. PMID: 20045640.
View in:
PubMed
Mentions:
29
Fields:
Translation:
Animals
Cells
Imidazoquines as antimalarial and antipneumocystis agents. J Med Chem. 2009 Dec 10; 52(23):7800-7.
Vale N, Prudêncio M, Marques CA, Collins MS, Gut J, Nogueira F, Matos J,
Rosenthal PJ
, Cushion MT, do Rosário VE, Mota MM, Moreira R, Gomes P. PMID: 19799426; PMCID:
PMC2788672
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
Cells
PH
Public Health
Selection of parasites with diminished drug susceptibility by amodiaquine-containing antimalarial regimens in Uganda. J Infect Dis. 2009 Dec 01; 200(11):1650-7.
Nawaz F, Nsobya SL, Kiggundu M, Joloba M,
Rosenthal PJ
. PMID: 19905933; PMCID:
PMC2782860
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Cells
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children. Clin Infect Dis. 2009 Dec 01; 49(11):1629-37.
Arinaitwe E, Sandison TG, Wanzira H, Kakuru A, Homsy J, Kalamya J, Kamya MR, Vora N,
Greenhouse B
Rosenthal PJ
, Tappero J,
Dorsey G
. PMID: 19877969.
View in:
PubMed
Mentions:
83
Fields:
Translation:
Humans
Placental malaria among HIV-infected and uninfected women receiving anti-folates in a high transmission area of Uganda. Malar J. 2009 Nov 14; 8:254.
Newman PM
, Wanzira H, Tumwine G, Arinaitwe E, Waldman S, Achan J,
Havlir D
Rosenthal PJ
Dorsey G
Clark TD
Cohan D
. PMID: 19912657; PMCID:
PMC2781026
View in:
PubMed
Mentions:
23
Fields:
Translation:
Humans
Cells
PH
Public Health
Antimalarial activity of azadipeptide nitriles. Bioorg Med Chem Lett. 2010 Jan 01; 20(1):252-5.
Löser R, Gut J,
Rosenthal PJ
, Frizler M, Gütschow M, Andrews KT. PMID: 19913414; PMCID:
PMC2818362
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda. Antimicrob Agents Chemother. 2010 Jan; 54(1):52-9.
Mwesigwa J, Parikh S, McGee B, German P, Drysdale T, Kalyango JN,
Clark TD
Dorsey G
, Lindegardh N, Annerberg A,
Rosenthal PJ
, Kamya MR,
Aweeka F
. PMID: 19841149; PMCID:
PMC2798532
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Impact of the method of G6PD deficiency assessment on genetic association studies of malaria susceptibility. PLoS One. 2009 Sep 30; 4(9):e7246.
Johnson MK,
Clark TD
, Njama-Meya D,
Rosenthal PJ
, Parikh S. PMID: 19789650; PMCID:
PMC2748715
View in:
PubMed
Mentions:
38
Fields:
Translation:
Humans
On-bead screening of a combinatorial fumaric acid derived peptide library yields antiplasmodial cysteine protease inhibitors with unusual peptide sequences. J Med Chem. 2009 Sep 24; 52(18):5662-72.
Machon U, Büchold C, Stempka M, Schirmeister T, Gelhaus C, Leippe M, Gut J,
Rosenthal PJ
, Kisker C, Leyh M, Schmuck C. PMID: 19715342.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Treatment of nonalcoholic fatty liver disease in children: TONIC trial design. Contemp Clin Trials. 2010 Jan; 31(1):62-70.
Lavine JE,
Schwimmer JB
, Molleston JP, Scheimann AO, Murray KF, Abrams SH,
Rosenthal P
, Sanyal AJ, Robuck PR, Brunt EM, Unalp A, Tonascia J, Nonalcoholic Steatohepatitis Clinical Research Network Research Group. PMID: 19761871; PMCID:
PMC2936451
View in:
PubMed
Mentions:
41
Fields:
Translation:
Humans
Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan children. Malar J. 2009 Sep 15; 8:213.
Jensen TP
, Bukirwa H, Njama-Meya D, Francis D, Kamya MR,
Rosenthal PJ
Dorsey G
. PMID: 19754955; PMCID:
PMC2749863
View in:
PubMed
Mentions:
34
Fields:
Translation:
Humans
Kaposi sarcoma-associated herpesvirus (KSHV) seroprevalence in population-based samples of African children: evidence for at least 2 patterns of KSHV transmission. J Infect Dis. 2009 Aug 01; 200(3):430-8.
Butler LM,
Dorsey G
, Hladik W,
Rosenthal PJ
, Brander C,
Neilands TB
, Mbisa G, Whitby D, Kiepiela P, Mosam A, Mzolo S, Dollard SC,
Martin JN
. PMID: 19534596; PMCID:
PMC3975590
View in:
PubMed
Mentions:
49
Fields:
Translation:
Humans
Cells
Lopinavir/ritonavir affects pharmacokinetic exposure of artemether/lumefantrine in HIV-uninfected healthy volunteers. J Acquir Immune Defic Syndr. 2009 Aug 01; 51(4):424-9.
German P, Parikh S, Lawrence J,
Dorsey G
Rosenthal PJ
Havlir D
Charlebois E
, Hanpithakpong W, Lindegardh N,
Aweeka FT
. PMID: 19506482.
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial. BMJ. 2009 Jul 21; 339:b2763.
Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR,
Dorsey G
, D'Alessandro U,
Rosenthal PJ
, Talisuna AO. PMID: 19622553; PMCID:
PMC2714631
View in:
PubMed
Mentions:
53
Fields:
Translation:
Humans
Vinyl sulfones as antiparasitic agents and a structural basis for drug design. J Biol Chem. 2009 Sep 18; 284(38):25697-703.
Kerr ID, Lee JH, Farady CJ, Marion R, Rickert M, Sajid M, Pandey KC,
Caffrey CR
, Legac J, Hansell E,
McKerrow JH
Craik CS
Rosenthal PJ
, Brinen LS. PMID: 19620707; PMCID:
PMC2757971
View in:
PubMed
Mentions:
88
Fields:
Translation:
Animals
Cells
Antiparasitic activities of novel, orally available fumagillin analogs. Bioorg Med Chem Lett. 2009 Sep 01; 19(17):5128-31.
Arico-Muendel C, Centrella PA, Contonio BD, Morgan BA, O'Donovan G, Paradise CL, Skinner SR, Sluboski B, Svendsen JL, White KF,
Debnath A
, Gut J, Wilson N,
McKerrow JH
DeRisi JL
Rosenthal PJ
, Chiang PK. PMID: 19648008; PMCID:
PMC2745105
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Predictors of anti-convulsant treatment failure in children presenting with malaria and prolonged seizures in Kampala, Uganda. Malar J. 2009 Jun 29; 8:145.
Mpimbaza A, Staedke SG, Ndeezi G, Byarugaba J,
Rosenthal PJ
. PMID: 19563665; PMCID:
PMC2707379
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Regulatory elements within the prodomain of Falcipain-2, a cysteine protease of the malaria parasite Plasmodium falciparum. PLoS One. 2009 May 27; 4(5):e5694.
Pandey KC, Barkan DT,
Sali A
Rosenthal PJ
. PMID: 19479029; PMCID:
PMC2682653
View in:
PubMed
Mentions:
21
Fields:
Translation:
Animals
Cells
Design, synthesis and structure-activity relationships of (1H-pyridin-4-ylidene)amines as potential antimalarials. Bioorg Med Chem Lett. 2009 Jul 01; 19(13):3476-80.
Rodrigues T, Guedes RC, dos Santos DJ, Carrasco M, Gut J,
Rosenthal PJ
, Moreira R, Lopes F. PMID: 19467600.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Artemisinin-dipeptidyl vinyl sulfone hybrid molecules: design, synthesis and preliminary SAR for antiplasmodial activity and falcipain-2 inhibition. Bioorg Med Chem Lett. 2009 Jun 15; 19(12):3229-32.
Capela R, Oliveira R, Gonçalves LM, Domingos A, Gut J,
Rosenthal PJ
, Lopes F, Moreira R. PMID: 19435664; PMCID:
PMC2742655
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Home management of malaria with artemether-lumefantrine compared with standard care in urban Ugandan children: a randomised controlled trial. Lancet. 2009 May 09; 373(9675):1623-31.
Staedke SG, Mwebaza N, Kamya MR,
Clark TD
Dorsey G
Rosenthal PJ
, Whitty CJ. PMID: 19362361.
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Hemoglobin cleavage site-specificity of the Plasmodium falciparum cysteine proteases falcipain-2 and falcipain-3. PLoS One. 2009; 4(4):e5156.
Subramanian S, Hardt M, Choe Y, Niles RK, Johansen EB, Legac J, Gut J, Kerr ID,
Craik CS
Rosenthal PJ
. PMID: 19357776; PMCID:
PMC2663817
View in:
PubMed
Mentions:
30
Fields:
Translation:
Humans
Animals
Cells
Resistance-mediating polymorphisms in Plasmodium falciparum infections in Kinshasa, Democratic Republic of the Congo. Am J Trop Med Hyg. 2009 Apr; 80(4):555-8.
Mobula L, Lilley B, Tshefu AK,
Rosenthal PJ
. PMID: 19346374.
View in:
PubMed
Mentions:
18
Fields:
Translation:
Humans
Animals
Antiplasmodial activity of extracts from seven medicinal plants used in malaria treatment in Cameroon. J Ethnopharmacol. 2009 Jun 25; 123(3):483-8.
Boyom FF, Kemgne EM, Tepongning R, Ngouana V, Mbacham WF, Tsamo E, Zollo PH, Gut J,
Rosenthal PJ
. PMID: 19442463.
View in:
PubMed
Mentions:
19
Fields:
Translation:
Animals
Cells
Antimalarial compounds from the stem bark of Vismia laurentii. Z Naturforsch C J Biosci. 2009 Mar-Apr; 64(3-4):210-4.
Noungoue DT, Chaabi M, Ngouela S, Antheaume C, Boyom FF, Gut J,
Rosenthal PJ
, Lobstein A, Tsamo E. PMID: 19526714.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Decreasing efficacy of antimalarial combination therapy in Uganda is explained by decreasing host immunity rather than increasing drug resistance. J Infect Dis. 2009 Mar 01; 199(5):758-65.
Greenhouse B
, Slater M, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C,
Clark TD
, Staedke SG, Kamya MR, Hubbard A,
Rosenthal PJ
Dorsey G
. PMID: 19199542; PMCID:
PMC2733854
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Animals
Structures of falcipain-2 and falcipain-3 bound to small molecule inhibitors: implications for substrate specificity. J Med Chem. 2009 Feb 12; 52(3):852-7.
Kerr ID, Lee JH, Pandey KC, Harrison A, Sajid M,
Rosenthal PJ
, Brinen LS. PMID: 19128015; PMCID:
PMC2651692
View in:
PubMed
Mentions:
51
Fields:
Translation:
Animals
Cells
The Distribution and Immune Profile of T Cell Subsets in HIV-Infected Children from Uganda. AIDS Res Hum Retroviruses. 2009 Jan; 25(1):65-71.
Ssewanyana I, Baker CA,
Ruel T
, Bousheri S, Kamya M,
Dorsey G
Rosenthal PJ
Charlebois E
Havlir D
, Cao H. PMID: 19182922; PMCID:
PMC2858297
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Cells
Synthesis and evaluation of non-peptidic cysteine protease inhibitors of P. falciparum derived from etacrynic acid. Molecules. 2008 Dec 23; 14(1):19-35.
Dude MA, Kaeppler U, Herb M, Schiller M, Schulz F, Vedder B, Heppner S, Pradel G, Gut J,
Rosenthal PJ
, Schirmeister T, Leippe M, Gelhaus C. PMID: 19104483; PMCID:
PMC6253875
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Development of protease inhibitors for protozoan infections. Curr Opin Infect Dis. 2008 Dec; 21(6):668-72.
McKerrow JH
Rosenthal PJ
, Swenerton R, Doyle P. PMID: 18978536; PMCID:
PMC2732359
View in:
PubMed
Mentions:
46
Fields:
Translation:
Humans
Animals
Complexity of Plasmodium falciparum clinical samples from Uganda during short-term culture. J Infect Dis. 2008 Nov 15; 198(10):1554-7.
Nsobya SL, Kiggundu M, Joloba M,
Dorsey G
Rosenthal PJ
. PMID: 18808336.
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
Animals
Human genetics and malaria: relevance for the design of clinical trials. J Infect Dis. 2008 Nov 01; 198(9):1255-7.
Parikh S,
Rosenthal PJ
. PMID: 18752442.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Synthesis of chlorovinyl sulfones as structural analogs of chalcones and their antiplasmodial activities. Eur J Med Chem. 2009 Apr; 44(4):1457-62.
Dominguez JN, Leon C, Rodrigues J, Gamboa de Dominguez N, Gut J,
Rosenthal PJ
. PMID: 19036479.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Experimental malaria infection triggers early expansion of natural killer cells. Infect Immun. 2008 Dec; 76(12):5873-82.
Kim CC, Parikh S, Sun JC, Myrick A,
Lanier LL
Rosenthal PJ
DeRisi JL
. PMID: 18824529; PMCID:
PMC2583561
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Cells
Factors determining the heterogeneity of malaria incidence in children in Kampala, Uganda. J Infect Dis. 2008 Aug 01; 198(3):393-400.
Clark TD
Greenhouse B
, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Staedke SG, Seto E, Kamya MR,
Rosenthal PJ
Dorsey G
. PMID: 18522503.
View in:
PubMed
Mentions:
102
Fields:
Translation:
Humans
Animals
Safety and tolerability of combination antimalarial therapies for uncomplicated falciparum malaria in Ugandan children. Malar J. 2008 Jun 11; 7:106.
Maiteki-Sebuguzi C, Jagannathan P, Yau VM,
Clark TD
, Njama-Meya D, Nzarubara B, Talisuna AO, Kamya MR,
Rosenthal PJ
Dorsey G
, Staedke SG. PMID: 18547415; PMCID:
PMC2441629
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda. PLoS One. 2008 Jun 11; 3(6):e2390.
Yeka A,
Dorsey G
, Kamya MR, Talisuna A, Lugemwa M, Rwakimari JB, Staedke SG,
Rosenthal PJ
, Wabwire-Mangen F, Bukirwa H. PMID: 18545692; PMCID:
PMC2405936
View in:
PubMed
Mentions:
95
Fields:
Translation:
Humans
Monitoring antimalarial safety and tolerability in clinical trials: a case study from Uganda. Malar J. 2008 Jun 11; 7:107.
Staedke SG, Jagannathan P, Yeka A, Bukirwa H, Banek K, Maiteki-Sebuguzi C,
Clark TD
, Nzarubara B, Njama-Meya D, Mpimbaza A,
Rosenthal PJ
, Kamya MR, Wabwire-Mangen F,
Dorsey G
, Talisuna AO. PMID: 18547416; PMCID:
PMC2464601
View in:
PubMed
Mentions:
11
Fields:
Translation:
Humans
HIV RNA suppression among HIV-infected Ugandan children with measles. J Acquir Immune Defic Syndr. 2008 Jun 01; 48(2):225-7.
Ruel TD
, Achan J, Gasasira AF,
Charlebois ED
, Mehbratu T,
Rosenthal PJ
Dorsey G
, Kamya MR, Kekitiinwa A,
Wong J
Havlir DV
. PMID: 18520684; PMCID:
PMC3040680
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Imidazolidin-4-one peptidomimetic derivatives of primaquine: synthesis and antimalarial activity. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4150-3.
Vale N, Matos J, Gut J, Nogueira F, do Rosário V,
Rosenthal PJ
, Moreira R, Gomes P. PMID: 18539459.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS One. 2008 May 21; 3(5):e2252.
Angulo-Barturen I, Jiménez-Díaz MB, Mulet T, Rullas J, Herreros E, Ferrer S, Jiménez E, Mendoza A, Regadera J,
Rosenthal PJ
, Bathurst I, Pompliano DL, Gómez de las Heras F, Gargallo-Viola D. PMID: 18493601; PMCID:
PMC2375113
View in:
PubMed
Mentions:
93
Fields:
Translation:
Humans
Animals
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors. Bioorg Med Chem Lett. 2008 Jul 15; 18(14):4210-4.
Verissimo E, Berry N, Gibbons P, Cristiano ML,
Rosenthal PJ
, Gut J, Ward SA, O'Neill PM. PMID: 18554905.
View in:
PubMed
Mentions:
12
Fields:
Translation:
Humans
Animals
Cells
Apicoplast translation, transcription and genome replication: targets for antimalarial antibiotics. Trends Parasitol. 2008 Jun; 24(6):279-84.
Dahl EL,
Rosenthal PJ
. PMID: 18450512.
View in:
PubMed
Mentions:
68
Fields:
Translation:
Humans
Animals
Cells
Artesunate for the treatment of severe falciparum malaria. N Engl J Med. 2008 Apr 24; 358(17):1829-36.
Rosenthal PJ
. PMID: 18434652.
View in:
PubMed
Mentions:
54
Fields:
Translation:
Humans
Animals
Discordant patterns of genetic variation at two chloroquine resistance loci in worldwide populations of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2008 Jun; 52(6):2212-22.
Mehlotra RK, Mattera G, Bockarie MJ, Maguire JD, Baird JK, Sharma YD, Alifrangis M,
Dorsey G
Rosenthal PJ
, Fryauff DJ, Kazura JW, Stoneking M, Zimmerman PA. PMID: 18411325; PMCID:
PMC2415780
View in:
PubMed
Mentions:
43
Fields:
Translation:
Humans
Animals
High risk of neutropenia in HIV-infected children following treatment with artesunate plus amodiaquine for uncomplicated malaria in Uganda. Clin Infect Dis. 2008 Apr 01; 46(7):985-91.
Gasasira AF, Kamya MR, Achan J, Mebrahtu T, Kalyango JN,
Ruel T
Charlebois E
, Staedke SG, Kekitiinwa A,
Rosenthal PJ
Havlir D
Dorsey G
. PMID: 18444813.
View in:
PubMed
Mentions:
37
Fields:
Translation:
Humans
Endodesmiadiol, a friedelane triterpenoid, and other antiplasmodial compounds from Endodesmia calophylloides. Chem Pharm Bull (Tokyo). 2008 Mar; 56(3):374-7.
Ngouamegne ET, Fongang RS, Ngouela S, Boyom FF, Rohmer M, Tsamo E, Gut J,
Rosenthal PJ
. PMID: 18310952.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
Plasmodium food vacuole plasmepsins are activated by falcipains. J Biol Chem. 2008 May 09; 283(19):12870-6.
Drew ME, Banerjee R, Uffman EW, Gilbertson S,
Rosenthal PJ
, Goldberg DE. PMID: 18308731; PMCID:
PMC2442342
View in:
PubMed
Mentions:
52
Fields:
Translation:
Animals
Cells
Rapid diagnostic tests for malaria at sites of varying transmission intensity in Uganda. J Infect Dis. 2008 Feb 15; 197(4):510-8.
Hopkins H, Bebell L, Kambale W, Dokomajilar C,
Rosenthal PJ
Dorsey G
. PMID: 18240951.
View in:
PubMed
Mentions:
106
Fields:
Translation:
Humans
Animals
PH
Public Health
Anti-plasmodial and cholinesterase inhibiting activities of some constituents of Psorospermum glaberrimum. Chem Pharm Bull (Tokyo). 2008 Feb; 56(2):222-6.
Ndjakou Lenta B, Devkota KP, Ngouela S, Fekam Boyom F, Naz Q, Choudhary MI, Tsamo E,
Rosenthal PJ
, Sewald N. PMID: 18239315.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Humans
Animals
Cells
Cryptolepine analogues containing basic aminoalkyl side-chains at C-11: synthesis, antiplasmodial activity, and cytotoxicity. Bioorg Med Chem Lett. 2008 Feb 15; 18(4):1378-81.
Lavrado J, Paulo A, Gut J,
Rosenthal PJ
, Moreira R. PMID: 18207399.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Comparison of buccal midazolam with rectal diazepam in the treatment of prolonged seizures in Ugandan children: a randomized clinical trial. Pediatrics. 2008 Jan; 121(1):e58-64.
Mpimbaza A, Ndeezi G, Staedke S,
Rosenthal PJ
, Byarugaba J. PMID: 18166545.
View in:
PubMed
Mentions:
44
Fields:
Translation:
Humans
HIV-1 infection in patients referred for malaria blood smears at government health clinics in Uganda. J Acquir Immune Defic Syndr. 2007 Dec 15; 46(5):624-30.
Bebell LM, Gasasira A, Kiggundu M, Dokomajilar C, Kamya MR,
Charlebois ED
Havlir D
Rosenthal PJ
Dorsey G
. PMID: 18043317.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Anti-Pneumocystis carinii and antiplasmodial activities of primaquine-derived imidazolidin-4-ones. Bioorg Med Chem Lett. 2008 Jan 15; 18(2):485-8.
Vale N, Collins MS, Gut J, Ferraz R,
Rosenthal PJ
, Cushion MT, Moreira R, Gomes P. PMID: 18077165.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Animals
Pattern of malaria-specific T-cell responses in a cohort of Ugandan children. J Trop Pediatr. 2008 Feb; 54(1):6-13.
Ssewanyana I, Pietras C, Baker CA, Nghania F, Jones NG,
Rosenthal PJ
Dorsey G
, Cao H. PMID: 17984125.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Cells
Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso. Clin Infect Dis. 2007 Dec 01; 45(11):1453-61.
Zongo I,
Dorsey G
, Rouamba N, Dokomajilar C, Séré Y,
Rosenthal PJ
, Ouédraogo JB. PMID: 17990228.
View in:
PubMed
Mentions:
76
Fields:
Translation:
Humans
Animals
Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues. Bioorg Med Chem Lett. 2007 Dec 01; 17(23):6434-8.
Biot C, Pradines B, Sergeant MH, Gut J,
Rosenthal PJ
, Chibale K. PMID: 17949976.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Effects of trimethoprim-sulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS. 2007 Oct 01; 21(15):2059-66.
Kamya MR, Gasasira AF, Achan J, Mebrahtu T,
Ruel T
, Kekitiinwa A,
Charlebois ED
Rosenthal PJ
Havlir D
Dorsey G
. PMID: 17885296.
View in:
PubMed
Mentions:
54
Fields:
Translation:
Humans
World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria. Malar J. 2007 Sep 06; 6:121.
Plowe CV, Roper C, Barnwell JW, Happi CT, Joshi HH, Mbacham W, Meshnick SR, Mugittu K, Naidoo I, Price RN, Shafer RW, Sibley CH, Sutherland CJ, Zimmerman PA,
Rosenthal PJ
. PMID: 17822535; PMCID:
PMC2008207
View in:
PubMed
Mentions:
70
Fields:
Translation:
Humans
PH
Public Health
Multiple antibiotics exert delayed effects against the Plasmodium falciparum apicoplast. Antimicrob Agents Chemother. 2007 Oct; 51(10):3485-90.
Dahl EL,
Rosenthal PJ
. PMID: 17698630; PMCID:
PMC2043295
View in:
PubMed
Mentions:
170
Fields:
Translation:
Animals
Screening of protease inhibitors as antiplasmodial agents. Part I: Aziridines and epoxides. ChemMedChem. 2007 Aug; 2(8):1214-24.
Schulz F, Gelhaus C, Degel B, Vicik R, Heppner S, Breuning A, Leippe M, Gut J,
Rosenthal PJ
, Schirmeister T. PMID: 17562535.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials. Antimicrob Agents Chemother. 2007 Sep; 51(9):3096-103.
Greenhouse B
, Dokomajilar C, Hubbard A,
Rosenthal PJ
Dorsey G
. PMID: 17591848; PMCID:
PMC2043236
View in:
PubMed
Mentions:
47
Fields:
Translation:
Humans
Animals
Cells
Falcipain cysteine proteases require bipartite motifs for trafficking to the Plasmodium falciparum food vacuole. J Biol Chem. 2007 Aug 24; 282(34):24961-9.
Subramanian S, Sijwali PS,
Rosenthal PJ
. PMID: 17565983.
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Animals
Cells
Resistance-mediating Plasmodium falciparum pfcrt and pfmdr1 alleles after treatment with artesunate-amodiaquine in Uganda. Antimicrob Agents Chemother. 2007 Aug; 51(8):3023-5.
Nsobya SL, Dokomajilar C, Joloba M,
Dorsey G
Rosenthal PJ
. PMID: 17562798; PMCID:
PMC1932488
View in:
PubMed
Mentions:
54
Fields:
Translation:
Humans
Animals
Comparison of HRP2- and pLDH-based rapid diagnostic tests for malaria with longitudinal follow-up in Kampala, Uganda. Am J Trop Med Hyg. 2007 Jun; 76(6):1092-7.
Hopkins H, Kambale W, Kamya MR, Staedke SG,
Dorsey G
Rosenthal PJ
. PMID: 17556616.
View in:
PubMed
Mentions:
58
Fields:
Translation:
Humans
Animals
Combination therapy for uncomplicated falciparum malaria in Ugandan children: a randomized trial. JAMA. 2007 May 23; 297(20):2210-9.
Dorsey G
, Staedke S,
Clark TD
, Njama-Meya D, Nzarubara B, Maiteki-Sebuguzi C, Dokomajilar C, Kamya MR,
Rosenthal PJ
. PMID: 17519410.
View in:
PubMed
Mentions:
107
Fields:
Translation:
Humans
Animals
Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial. PLoS Clin Trials. 2007 May 18; 2(5):e20.
Kamya MR, Yeka A, Bukirwa H, Lugemwa M, Rwakimari JB, Staedke SG, Talisuna AO,
Greenhouse B
, Nosten F,
Rosenthal PJ
, Wabwire-Mangen F,
Dorsey G
. PMID: 17525792; PMCID:
PMC1876597
View in:
PubMed
Mentions:
96
The structure of chagasin in complex with a cysteine protease clarifies the binding mode and evolution of an inhibitor family. Structure. 2007 May; 15(5):535-43.
Wang SX, Pandey KC, Scharfstein J, Whisstock J, Huang RK, Jacobelli J,
Fletterick RJ
Rosenthal PJ
, Abrahamson M, Brinen LS, Rossi A,
Sali A
McKerrow JH
. PMID: 17502099.
View in:
PubMed
Mentions:
28
Fields:
Translation:
Animals
Cells
A chimeric cysteine protease of Plasmodium berghei engineered to resemble the Plasmodium falciparum protease falcipain-2. Protein Eng Des Sel. 2007 Apr; 20(4):171-7.
Singh A, Walker KJ, Sijwali PS, Lau AL,
Rosenthal PJ
. PMID: 17430972.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Hepatotoxicity due to a drug interaction between amodiaquine plus artesunate and efavirenz. Clin Infect Dis. 2007 Mar 15; 44(6):889-91.
German P,
Greenhouse B
, Coates C,
Dorsey G
Rosenthal PJ
Charlebois E
, Lindegardh N,
Havlir D
Aweeka FT
. PMID: 17304470.
View in:
PubMed
Mentions:
27
Fields:
Translation:
Humans
Amodiaquine metabolism is impaired by common polymorphisms in CYP2C8: implications for malaria treatment in Africa. Clin Pharmacol Ther. 2007 Aug; 82(2):197-203.
Parikh S, Ouedraogo JB, Goldstein JA,
Rosenthal PJ
Kroetz DL
. PMID: 17361129.
View in:
PubMed
Mentions:
60
Fields:
Translation:
Humans
Anti-plasmodial activity of some constituents of the root bark of Harungana madagascariensis LAM. (Hypericaceae). Chem Pharm Bull (Tokyo). 2007 Mar; 55(3):464-7.
Ndjakou Lenta B, Ngouela S, Fekam Boyom F, Tantangmo F, Feuya Tchouya GR, Tsamo E, Gut J,
Rosenthal PJ
, Donald Connolly J. PMID: 17329893.
View in:
PubMed
Mentions:
14
Fields:
Translation:
Animals
Cells
Artemether-lumefantrine versus amodiaquine plus sulfadoxine-pyrimethamine for uncomplicated falciparum malaria in Burkina Faso: a randomised non-inferiority trial. Lancet. 2007 Feb 10; 369(9560):491-8.
Zongo I,
Dorsey G
, Rouamba N, Tinto H, Dokomajilar C, Guiguemde RT,
Rosenthal PJ
, Ouedraogo JB. PMID: 17292769.
View in:
PubMed
Mentions:
72
Fields:
Translation:
Humans
Synthesis and evaluation of sulfonylurea derivatives as novel antimalarials. Eur J Med Chem. 2007 Jun; 42(6):735-42.
León C, Rodrigues J, Gamboa de Domínguez N, Charris J, Gut J,
Rosenthal PJ
, Domínguez JN. PMID: 17321641.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005. Malar J. 2006 Dec 14; 5:122.
Collins WJ,
Greenhouse B
Rosenthal PJ
Dorsey G
. PMID: 17169157; PMCID:
PMC1716173
View in:
PubMed
Mentions:
26
Fields:
Translation:
Humans
Animals
Falstatin, a cysteine protease inhibitor of Plasmodium falciparum, facilitates erythrocyte invasion. PLoS Pathog. 2006 Nov; 2(11):e117.
Pandey KC, Singh N, Arastu-Kapur S, Bogyo M,
Rosenthal PJ
. PMID: 17083274; PMCID:
PMC1630708
View in:
PubMed
Mentions:
39
Fields:
Translation:
Humans
Animals
Cells
Validation of microsatellite markers for use in genotyping polyclonal Plasmodium falciparum infections. Am J Trop Med Hyg. 2006 Nov; 75(5):836-42.
Greenhouse B
, Myrick A, Dokomajilar C, Woo JM, Carlson EJ,
Rosenthal PJ
Dorsey G
. PMID: 17123974; PMCID:
PMC1697796
View in:
PubMed
Mentions:
66
Fields:
Translation:
Humans
Animals
Cells
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum. Bioorg Med Chem. 2007 Jan 01; 15(1):273-82.
Chipeleme A, Gut J,
Rosenthal PJ
, Chibale K. PMID: 17052908.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Cells
Tetracyclines specifically target the apicoplast of the malaria parasite Plasmodium falciparum. Antimicrob Agents Chemother. 2006 Sep; 50(9):3124-31.
Dahl EL, Shock JL, Shenai BR, Gut J,
DeRisi JL
Rosenthal PJ
. PMID: 16940111; PMCID:
PMC1563505
View in:
PubMed
Mentions:
110
Fields:
Translation:
Humans
Animals
Cells
Effect of cotrimoxazole prophylaxis taken by human immunodeficiency virus (HIV)-infected persons on the selection of sulfadoxine-pyrimethamine-resistant malaria parasites among HIV-uninfected household members. Am J Trop Med Hyg. 2006 Sep; 75(3):375-80.
Malamba SS, Mermin J, Reingold A, Lule JR, Downing R, Ransom R, Kigozi A, Hunt BM, Hubbard A,
Rosenthal PJ
Dorsey G
. PMID: 16968909.
View in:
PubMed
Mentions:
21
Fields:
Translation:
Humans
Animals
False-positive results of enzyme immunoassays for human immunodeficiency virus in patients with uncomplicated malaria. J Clin Microbiol. 2006 Aug; 44(8):3021-4.
Gasasira AF,
Dorsey G
, Kamya MR,
Havlir D
, Kiggundu M,
Rosenthal PJ
Charlebois ED
. PMID: 16891532; PMCID:
PMC1594619
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
Structural basis for unique mechanisms of folding and hemoglobin binding by a malarial protease. Proc Natl Acad Sci U S A. 2006 Aug 01; 103(31):11503-8.
Wang SX, Pandey KC, Somoza JR, Sijwali PS,
Kortemme T
, Brinen LS,
Fletterick RJ
Rosenthal PJ
McKerrow JH
. PMID: 16864794; PMCID:
PMC1544199
View in:
PubMed
Mentions:
30
Fields:
Translation:
Humans
Animals
Cells
Gene disruptions demonstrate independent roles for the four falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2006 Nov; 150(1):96-106.
Sijwali PS, Koo J, Singh N,
Rosenthal PJ
. PMID: 16890302.
View in:
PubMed
Mentions:
58
Fields:
Translation:
Humans
Animals
Cells
Roles of specific Plasmodium falciparum mutations in resistance to amodiaquine and sulfadoxine-pyrimethamine in Burkina Faso. Am J Trop Med Hyg. 2006 Jul; 75(1):162-5.
Dokomajilar C, Lankoande ZM,
Dorsey G
, Zongo I, Ouedraogo JB,
Rosenthal PJ
. PMID: 16837725.
View in:
PubMed
Mentions:
41
Fields:
Translation:
Humans
Animals
Antimalarial effects of human immunodeficiency virus type 1 protease inhibitors differ from those of the aspartic protease inhibitor pepstatin. Antimicrob Agents Chemother. 2006 Jun; 50(6):2207-9.
Parikh S, Liu J, Sijwali P, Gut J, Goldberg DE,
Rosenthal PJ
. PMID: 16723585; PMCID:
PMC1479139
View in:
PubMed
Mentions:
14
Fields:
Translation:
Animals
Chloroquine or amodiaquine combined with sulfadoxine-pyrimethamine for uncomplicated malaria: a systematic review. Trop Med Int Health. 2006 Jun; 11(6):789-99.
Hwang J, Bitarakwate E, Pai M, Reingold A,
Rosenthal PJ
Dorsey G
. PMID: 16771999.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Artemisinin combination therapies for treatment of uncomplicated malaria in Uganda. PLoS Clin Trials. 2006 May; 1(1):e7.
Bukirwa H, Yeka A, Kamya MR, Talisuna A, Banek K, Bakyaita N, Rwakimari JB,
Rosenthal PJ
, Wabwire-Mangen F,
Dorsey G
, Staedke SG. PMID: 16871329; PMCID:
PMC1488893
View in:
PubMed
Mentions:
79
Dipeptide vinyl sultams: synthesis via the Wittig-Horner reaction and activity against papain, falcipain-2 and Plasmodium falciparum. Bioorg Med Chem Lett. 2006 Aug 01; 16(15):4115-9.
Valente C, Guedes RC, Moreira R, Iley J, Gut J,
Rosenthal PJ
. PMID: 16697641.
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Application of multicomponent reactions to antimalarial drug discovery. Part 2: New antiplasmodial and antitrypanosomal 4-aminoquinoline gamma- and delta-lactams via a 'catch and release' protocol. Bioorg Med Chem. 2006 Aug 15; 14(16):5605-15.
Musonda CC, Gut J,
Rosenthal PJ
, Yardley V, Carvalho de Souza RC, Chibale K. PMID: 16690319.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Cells
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic. Antimicrob Agents Chemother. 2006 May; 50(5):1893-5.
Dokomajilar C, Nsobya SL,
Greenhouse B
Rosenthal PJ
Dorsey G
. PMID: 16641472; PMCID:
PMC1472234
View in:
PubMed
Mentions:
103
Fields:
Translation:
Humans
Animals
PH
Public Health
Short report: Dynamics of Plasmodium falciparum malaria after sub-optimal therapy in Uganda. Am J Trop Med Hyg. 2006 May; 74(5):758-61.
Myrick A, Leemann E, Dokomajilar C, Hopkins H,
Dorsey G
, Kamya MR,
Rosenthal PJ
. PMID: 16687676.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Complexity of Plasmodium falciparum infections and antimalarial drug efficacy at 7 sites in Uganda. J Infect Dis. 2006 Apr 15; 193(8):1160-3.
Lee SA
, Yeka A, Nsobya SL, Dokomajilar C,
Rosenthal PJ
, Talisuna A,
Dorsey G
. PMID: 16544257.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Identification of novel parasitic cysteine protease inhibitors by use of virtual screening. 2. The available chemical directory. J Med Chem. 2006 Mar 09; 49(5):1576-84.
Desai PV, Patny A, Gut J,
Rosenthal PJ
, Tekwani B, Srivastava A, Avery M. PMID: 16509575.
View in:
PubMed
Mentions:
21
Fields:
Translation:
Animals
Cells
Geographic differences in antimalarial drug efficacy in Uganda are explained by differences in endemicity and not by known molecular markers of drug resistance. J Infect Dis. 2006 Apr 01; 193(7):978-86.
Francis D, Nsobya SL, Talisuna A, Yeka A, Kamya MR, Machekano R, Dokomajilar C,
Rosenthal PJ
Dorsey G
. PMID: 16518760.
View in:
PubMed
Mentions:
55
Fields:
Translation:
Humans
PH
Public Health
CD4 T cell activation as a predictor for treatment failure in Ugandans with Plasmodium falciparum malaria. Am J Trop Med Hyg. 2006 Jan; 74(1):41-3.
Eggena MP, Hopkins H, Barugahare B, Okello M, Ssali F, Mugyenyi P,
Rosenthal PJ
, Cao H,
Dorsey G
. PMID: 16407344.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Anti-plasmodial and antioxidant activities of constituents of the seed shells of Symphonia globulifera Linn f. Phytochemistry. 2006 Feb; 67(3):302-6.
Ngouela S, Lenta BN, Noungoue DT, Ngoupayo J, Boyom FF, Tsamo E, Gut J,
Rosenthal PJ
, Connolly JD. PMID: 16368120.
View in:
PubMed
Mentions:
14
Fields:
Translation:
Animals
Plasmodium falciparum: biochemical characterization of the cysteine protease falcipain-2'. Exp Parasitol. 2006 Mar; 112(3):187-92.
Singh N, Sijwali PS, Pandey KC,
Rosenthal PJ
. PMID: 16337629.
View in:
PubMed
Mentions:
22
Fields:
Translation:
Animals
Cells
Effect of HIV-1 infection on antimalarial treatment outcomes in Uganda: a population-based study. J Infect Dis. 2006 Jan 01; 193(1):9-15.
Kamya MR, Gasasira AF, Yeka A, Bakyaita N, Nsobya SL, Francis D,
Rosenthal PJ
Dorsey G
Havlir D
. PMID: 16323126.
View in:
PubMed
Mentions:
61
Fields:
Translation:
Humans
Cells
Amodiaquine, sulfadoxine-pyrimethamine, and combination therapy for uncomplicated falciparum malaria: a randomized controlled trial from Burkina Faso. Am J Trop Med Hyg. 2005 Nov; 73(5):826-32.
Zongo I,
Dorsey G
, Rouamba N, Dokomajilar C, Lankoande M, Ouedraogo JB,
Rosenthal PJ
. PMID: 16282288.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Distinguishing recrudescences from new infections in antimalarial clinical trials: major impact of interpretation of genotyping results on estimates of drug efficacy. Am J Trop Med Hyg. 2005 Aug; 73(2):256-62.
Slater M, Kiggundu M, Dokomajilar C, Kamya MR, Bakyaita N, Talisuna A,
Rosenthal PJ
Dorsey G
. PMID: 16103584.
View in:
PubMed
Mentions:
28
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Artemisinin versus nonartemisinin combination therapy for uncomplicated malaria: randomized clinical trials from four sites in Uganda. PLoS Med. 2005 Jul; 2(7):e190.
Yeka A, Banek K, Bakyaita N, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya SL, Kilian A, Slater M, Reingold A,
Rosenthal PJ
, Wabwire-Mangen F,
Dorsey G
. PMID: 16033307; PMCID:
PMC1181876
View in:
PubMed
Mentions:
58
Fields:
Translation:
Humans
Antimalarial activity of human immunodeficiency virus type 1 protease inhibitors. Antimicrob Agents Chemother. 2005 Jul; 49(7):2983-5.
Parikh S, Gut J, Istvan E, Goldberg DE,
Havlir DV
Rosenthal PJ
. PMID: 15980379; PMCID:
PMC1168637
View in:
PubMed
Mentions:
64
Fields:
Translation:
Humans
Animals
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif. Proc Natl Acad Sci U S A. 2005 Jun 28; 102(26):9138-43.
Pandey KC, Wang SX, Sijwali PS, Lau AL,
McKerrow JH
Rosenthal PJ
. PMID: 15964982; PMCID:
PMC1166610
View in:
PubMed
Mentions:
36
Fields:
Translation:
Humans
Animals
Cells
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivatives. J Med Chem. 2005 May 19; 48(10):3654-8.
Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J,
Rosenthal PJ
. PMID: 15887974.
View in:
PubMed
Mentions:
37
Fields:
Translation:
Animals
Cells
Design, synthesis and anti-plasmodial evaluation in vitro of new 4-aminoquinoline isatin derivatives. Bioorg Med Chem. 2005 May 02; 13(9):3249-61.
Chiyanzu I, Clarkson C, Smith PJ, Lehman J, Gut J,
Rosenthal PJ
, Chibale K. PMID: 15809160.
View in:
PubMed
Mentions:
30
Fields:
Translation:
Animals
Cells
Sulfadoxine-pyrimethamine plus chloroquine or amodiaquine for uncomplicated falciparum malaria: a randomized, multisite trial to guide national policy in Uganda. Am J Trop Med Hyg. 2005 May; 72(5):573-80.
Bakyaita N,
Dorsey G
, Yeka A, Banek K, Staedke SG, Kamya MR, Talisuna A, Kironde F, Nsobya S, Kilian A, Reingold A,
Rosenthal PJ
, Wabwire-Mangen F. PMID: 15891132.
View in:
PubMed
Mentions:
22
Fields:
Translation:
Humans
CT
Clinical Trials
Synthesis and antimalarial activity of sulfonamide chalcone derivatives. Farmaco. 2005 Apr; 60(4):307-11.
Domínguez JN, León C, Rodrigues J, Gamboa de Domínguez N, Gut J,
Rosenthal PJ
. PMID: 15848205.
View in:
PubMed
Mentions:
25
Fields:
Translation:
Animals
Biosynthesis, localization, and processing of falcipain cysteine proteases of Plasmodium falciparum. Mol Biochem Parasitol. 2005 Feb; 139(2):205-12.
Dahl EL,
Rosenthal PJ
. PMID: 15664655.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Humans
Animals
Cells
Discovery of potent thiosemicarbazone inhibitors of rhodesain and cruzain. Bioorg Med Chem Lett. 2005 Jan 03; 15(1):121-3.
Fujii N, Mallari JP, Hansell EJ, Mackey Z, Doyle P, Zhou YM, Gut J,
Rosenthal PJ
McKerrow JH
, Guy RK. PMID: 15582423.
View in:
PubMed
Mentions:
26
Fields:
Principal role of dihydropteroate synthase mutations in mediating resistance to sulfadoxine-pyrimethamine in single-drug and combination therapy of uncomplicated malaria in Uganda. Am J Trop Med Hyg. 2004 Dec; 71(6):758-63.
Dorsey G
, Dokomajilar C, Kiggundu M, Staedke SG, Kamya MR,
Rosenthal PJ
. PMID: 15642967.
View in:
PubMed
Mentions:
29
Fields:
Translation:
Humans
Animals
Cysteine proteases of malaria parasites. Int J Parasitol. 2004 Dec; 34(13-14):1489-99.
Rosenthal PJ
. PMID: 15582526.
View in:
PubMed
Mentions:
125
Fields:
Translation:
Animals
Cells
Host polymorphisms and the incidence of malaria in Ugandan children. Am J Trop Med Hyg. 2004 Dec; 71(6):750-3.
Parikh S,
Dorsey G
Rosenthal PJ
. PMID: 15642965.
View in:
PubMed
Mentions:
26
Fields:
Translation:
Humans
Cells
Combination treatments for uncomplicated falciparum malaria in Kampala, Uganda: randomised clinical trial. Lancet. 2004 Nov 27-Dec 3; 364(9449):1950-7.
Staedke SG, Mpimbaza A, Kamya MR, Nzarubara BK,
Dorsey G
Rosenthal PJ
. PMID: 15567011.
View in:
PubMed
Mentions:
39
Fields:
Translation:
Humans
CT
Clinical Trials
Evaluation of cysteine proteases of Plasmodium vivax as antimalarial drug targets: sequence analysis and sensitivity to cysteine protease inhibitors. Parasitol Res. 2004 Oct; 94(4):312-7.
Na BK, Kim TS,
Rosenthal PJ
, Lee JK, Kong Y. PMID: 15372231.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Antiplasmodial chalcones inhibit sorbitol-induced hemolysis of Plasmodium falciparum-infected erythrocytes. Antimicrob Agents Chemother. 2004 Sep; 48(9):3241-5.
Go ML, Liu M, Wilairat P,
Rosenthal PJ
, Saliba KJ, Kirk K. PMID: 15328079; PMCID:
PMC514760
View in:
PubMed
Mentions:
14
Fields:
Translation:
Humans
Animals
Cells
Application of multi-component reactions to antimalarial drug discovery. Part 1: Parallel synthesis and antiplasmodial activity of new 4-aminoquinoline Ugi adducts. Bioorg Med Chem Lett. 2004 Aug 02; 14(15):3901-5.
Musonda CC, Taylor D, Lehman J, Gut J,
Rosenthal PJ
, Chibale K. PMID: 15225694.
View in:
PubMed
Mentions:
15
Fields:
Translation:
Animals
Cells
Selection of cysteine protease inhibitor-resistant malaria parasites is accompanied by amplification of falcipain genes and alteration in inhibitor transport. J Biol Chem. 2004 Aug 20; 279(34):35236-41.
Singh A,
Rosenthal PJ
. PMID: 15192087.
View in:
PubMed
Mentions:
13
Fields:
Translation:
Animals
Synthesis and structure-activity relationships of parasiticidal thiosemicarbazone cysteine protease inhibitors against Plasmodium falciparum, Trypanosoma brucei, and Trypanosoma cruzi. J Med Chem. 2004 Jun 03; 47(12):3212-9.
Greenbaum DC, Mackey Z, Hansell E, Doyle P, Gut J,
Caffrey CR
, Lehrman J,
Rosenthal PJ
McKerrow JH
, Chibale K. PMID: 15163200.
View in:
PubMed
Mentions:
57
Fields:
Translation:
Animals
Antimalarial drug discovery: efficacy models for compound screening. Nat Rev Drug Discov. 2004 Jun; 3(6):509-20.
Fidock DA,
Rosenthal PJ
, Croft SL, Brun R, Nwaka S. PMID: 15173840.
View in:
PubMed
Mentions:
278
Fields:
Translation:
Humans
Animals
Plasmodium falciparum cysteine protease falcipain-1 is not essential in erythrocytic stage malaria parasites. Proc Natl Acad Sci U S A. 2004 Jun 08; 101(23):8721-6.
Sijwali PS, Kato K, Seydel KB, Gut J, Lehman J, Klemba M, Goldberg DE, Miller LH,
Rosenthal PJ
. PMID: 15166288; PMCID:
PMC423262
View in:
PubMed
Mentions:
35
Fields:
Translation:
Humans
Animals
Cells
Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis. 2004 Jun 15; 189(12):2220-6.
Nsobya SL, Parikh S, Kironde F, Lubega G, Kamya MR,
Rosenthal PJ
Dorsey G
. PMID: 15181569.
View in:
PubMed
Mentions:
35
Fields:
Translation:
Humans
Animals
Relationship between age, molecular markers, and response to sulphadoxine-pyrimethamine treatment in Kampala, Uganda. Trop Med Int Health. 2004 May; 9(5):624-9.
Staedke SG, Sendagire H, Lamola S, Kamya MR,
Dorsey G
Rosenthal PJ
. PMID: 15117308.
View in:
PubMed
Mentions:
58
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Gene disruption confirms a critical role for the cysteine protease falcipain-2 in hemoglobin hydrolysis by Plasmodium falciparum. Proc Natl Acad Sci U S A. 2004 Mar 30; 101(13):4384-9.
Sijwali PS,
Rosenthal PJ
. PMID: 15070727; PMCID:
PMC384756
View in:
PubMed
Mentions:
107
Fields:
Translation:
Animals
Cells
Identification and biochemical characterization of vivapains, cysteine proteases of the malaria parasite Plasmodium vivax. Biochem J. 2004 Mar 01; 378(Pt 2):529-38.
Na BK, Shenai BR, Sijwali PS, Choe Y, Pandey KC, Singh A,
Craik CS
Rosenthal PJ
. PMID: 14629194; PMCID:
PMC1223978
View in:
PubMed
Mentions:
30
Fields:
Translation:
Animals
Cells
Antimalarial activities of novel synthetic cysteine protease inhibitors. Antimicrob Agents Chemother. 2003 Dec; 47(12):3810-4.
Lee BJ, Singh A, Chiang P, Kemp SJ, Goldman EA, Weinhouse MI, Vlasuk GP,
Rosenthal PJ
. PMID: 14638488; PMCID:
PMC296233
View in:
PubMed
Mentions:
21
Fields:
Translation:
Animals
Composition and anti-plasmodial activities of essential oils from some Cameroonian medicinal plants. Phytochemistry. 2003 Dec; 64(7):1269-75.
Boyom FF, Ngouana V, Zollo PH, Menut C, Bessiere JM, Gut J,
Rosenthal PJ
. PMID: 14599525.
View in:
PubMed
Mentions:
16
Fields:
Translation:
Animals
5HT1A serotonin receptor agonists inhibit Plasmodium falciparum by blocking a membrane channel. Antimicrob Agents Chemother. 2003 Dec; 47(12):3806-9.
Locher CP, Ruben PC, Gut J,
Rosenthal PJ
. PMID: 14638487; PMCID:
PMC296210
View in:
PubMed
Mentions:
10
Fields:
Translation:
Humans
Animals
Cells
Independent intramolecular mediators of folding, activity, and inhibition for the Plasmodium falciparum cysteine protease falcipain-2. J Biol Chem. 2004 Jan 30; 279(5):3484-91.
Pandey KC, Sijwali PS, Singh A, Na BK,
Rosenthal PJ
. PMID: 14625277.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Animals
Cells
Antimalarial drug discovery: old and new approaches. J Exp Biol. 2003 Nov; 206(Pt 21):3735-44.
Rosenthal PJ
. PMID: 14506208.
View in:
PubMed
Mentions:
46
Fields:
Translation:
Animals
Cells
Synthesis and evaluation of isatins and thiosemicarbazone derivatives against cruzain, falcipain-2 and rhodesain. Bioorg Med Chem Lett. 2003 Oct 20; 13(20):3527-30.
Chiyanzu I, Hansell E, Gut J,
Rosenthal PJ
McKerrow JH
, Chibale K. PMID: 14505663.
View in:
PubMed
Mentions:
28
Fields:
Prevention of increasing rates of treatment failure by combining sulfadoxine-pyrimethamine with artesunate or amodiaquine for the sequential treatment of malaria. J Infect Dis. 2003 Oct 15; 188(8):1231-8.
Dorsey G
, Vlahos J, Kamya MR, Staedke SG,
Rosenthal PJ
. PMID: 14551894.
View in:
PubMed
Mentions:
13
Fields:
Translation:
Humans
Animals
Validation of a simplified method for using molecular markers to predict sulfadoxine-pyrimethamine treatment failure in African children with falciparum malaria. Am J Trop Med Hyg. 2003 Sep; 69(3):247-52.
Kyabayinze D,
Cattamanchi A
, Kamya MR,
Rosenthal PJ
Dorsey G
. PMID: 14628939.
Short report: proximity to mosquito breeding sites as a risk factor for clinical malaria episodes in an urban cohort of Ugandan children. Am J Trop Med Hyg. 2003 Sep; 69(3):244-6.
Staedke SG, Nottingham EW, Cox J, Kamya MR,
Rosenthal PJ
Dorsey G
. PMID: 14628938.
View in:
PubMed
Mentions:
63
Fields:
Translation:
Humans
Animals
PH
Public Health
Structure-based approach to falcipain-2 inhibitors: synthesis and biological evaluation of 1,6,7-trisubstituted dihydroisoquinolines and isoquinolines. Bioorg Med Chem. 2003 May 15; 11(10):2293-9.
Batra S, Sabnis YA,
Rosenthal PJ
, Avery MA. PMID: 12713840.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Animals
Cells
Probing the structure of falcipain-3, a cysteine protease from Plasmodium falciparum: comparative protein modeling and docking studies. Protein Sci. 2003 Mar; 12(3):501-9.
Sabnis YA, Desai PV,
Rosenthal PJ
, Avery MA. PMID: 12592020; PMCID:
PMC2312452
View in:
PubMed
Mentions:
10
Fields:
Translation:
Animals
Cells
Comparative efficacy of aminoquinoline-antifolate combinations for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2003 Feb; 68(2):127-32.
Gasasira AF,
Dorsey G
, Nzarubara B, Staedke SG, Nassali A,
Rosenthal PJ
, Kamya MR. PMID: 12641399.
View in:
PubMed
Mentions:
14
Fields:
Translation:
Humans
CT
Clinical Trials
Distinguishing recrudescence from reinfection in a longitudinal antimalarial drug efficacy study: comparison of results based on genotyping of msp-1, msp-2, and glurp. Am J Trop Med Hyg. 2003 Feb; 68(2):133-9.
Cattamanchi A
, Kyabayinze D, Hubbard A,
Rosenthal PJ
Dorsey G
. PMID: 12641400.
View in:
PubMed
Mentions:
89
Fields:
Translation:
Humans
Animals
Structure-activity relationships for inhibition of cysteine protease activity and development of Plasmodium falciparum by peptidyl vinyl sulfones. Antimicrob Agents Chemother. 2003 Jan; 47(1):154-60.
Shenai BR, Lee BJ, Alvarez-Hernandez A, Chong PY, Emal CD,
Neitz RJ
, Roush WR,
Rosenthal PJ
. PMID: 12499184; PMCID:
PMC149004
View in:
PubMed
Mentions:
38
Fields:
Translation:
Animals
Sulfadoxine/pyrimethamine alone or with amodiaquine or artesunate for treatment of uncomplicated malaria: a longitudinal randomised trial. Lancet. 2002 Dec 21-28; 360(9350):2031-8.
Dorsey G
, Njama D, Kamya MR,
Cattamanchi A
, Kyabayinze D, Staedke SG, Gasasira A,
Rosenthal PJ
. PMID: 12504399.
View in:
PubMed
Mentions:
43
Fields:
Translation:
Humans
Animals
CT
Clinical Trials
Critical role of amino acid 23 in mediating activity and specificity of vinckepain-2, a papain-family cysteine protease of rodent malaria parasites. Biochem J. 2002 Nov 15; 368(Pt 1):273-81.
Singh A, Shenai BR, Choe Y, Gut J, Sijwali PS,
Craik CS
Rosenthal PJ
. PMID: 12169096; PMCID:
PMC1222974
View in:
PubMed
Mentions:
17
Fields:
Translation:
Animals
Cells
Reducing requirements for hemoglobin hydrolysis by Plasmodium falciparum cysteine proteases. Mol Biochem Parasitol. 2002 Jun; 122(1):99-104.
Shenai BR,
Rosenthal PJ
. PMID: 12076775.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Synthesis and evaluation of new antimalarial analogues of quinoline alkaloids derived from Cinchona ledgeriana Moens ex Trimen. Bioorg Med Chem Lett. 2002 May 20; 12(10):1351-5.
Park BS, Kim DY,
Rosenthal PJ
, Huh SC, Lee BJ, Park E-, Kim SM, Kim JE, Kim MH, Huh TL, Choi YJ, Suh KH, Choi WS, Lee SE. PMID: 11992775.
View in:
PubMed
Mentions:
Fields:
Translation:
Humans
Animals
Cells
Stage-specific antimalarial activity of cysteine protease inhibitors. Biol Chem. 2002 May; 383(5):843-7.
Shenai BR, Semenov AV,
Rosenthal PJ
. PMID: 12108550.
View in:
PubMed
Mentions:
10
Fields:
Translation:
Animals
Cells
Homology modeling of falcipain-2: validation, de novo ligand design and synthesis of novel inhibitors. J Biomol Struct Dyn. 2002 Apr; 19(5):765-74.
Sabnis Y,
Rosenthal PJ
, Desai P, Avery MA. PMID: 11922834.
View in:
PubMed
Mentions:
Fields:
Translation:
Animals
Cells
Hydrolysis of erythrocyte proteins by proteases of malaria parasites. Curr Opin Hematol. 2002 Mar; 9(2):140-5.
Rosenthal PJ
. PMID: 11844998.
View in:
PubMed
Mentions:
32
Fields:
Translation:
Humans
Animals
Cells
Folding of the Plasmodium falciparum cysteine protease falcipain-2 is mediated by a chaperone-like peptide and not the prodomain. J Biol Chem. 2002 Apr 26; 277(17):14910-5.
Sijwali PS, Shenai BR,
Rosenthal PJ
. PMID: 11827964.
View in:
PubMed
Mentions:
24
Fields:
Translation:
Animals
Cells
Cysteine proteases of malaria parasites: targets for chemotherapy. Curr Pharm Des. 2002; 8(18):1659-72.
Rosenthal PJ
, Sijwali PS, Singh A, Shenai BR. PMID: 12132997.
View in:
PubMed
Mentions:
48
Fields:
Translation:
Humans
Animals
Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem J. 2001 Dec 01; 360(Pt 2):481-9.
Sijwali PS, Shenai BR, Gut J, Singh A,
Rosenthal PJ
. PMID: 11716777; PMCID:
PMC1222249
View in:
PubMed
Mentions:
75
Fields:
Translation:
Humans
Animals
Cells
The impact of whole genome sequence data on drug discovery--a malaria case study. Mol Med. 2001 Oct; 7(10):698-710.
Joachimiak MP, Chang C,
Rosenthal PJ
, Cohen FE. PMID: 11713369; PMCID:
PMC1949995
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Humans
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Amodiaquine, sulfadoxine/pyrimethamine, and combination therapy for treatment of uncomplicated falciparum malaria in Kampala, Uganda: a randomised trial. Lancet. 2001 Aug 04; 358(9279):368-74.
Staedke SG, Kamya MR,
Dorsey G
, Gasasira A, Ndeezi G,
Charlebois ED
Rosenthal PJ
. PMID: 11502317.
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Mentions:
30
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Humans
CT
Clinical Trials
Systematic optimization of expression and refolding of the Plasmodium falciparum cysteine protease falcipain-2. Protein Expr Purif. 2001 Jun; 22(1):128-34.
Sijwali PS, Brinen LS,
Rosenthal PJ
. PMID: 11388810.
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Mentions:
34
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Animals
Cells
Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda. J Infect Dis. 2001 May 01; 183(9):1417-20.
Dorsey G
, Kamya MR, Singh A,
Rosenthal PJ
. PMID: 11294677.
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Mentions:
60
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Humans
Animals
Comparison of efficacies of cysteine protease inhibitors against five strains of Plasmodium falciparum. Antimicrob Agents Chemother. 2001 Mar; 45(3):949-51.
Singh A,
Rosenthal PJ
. PMID: 11181388; PMCID:
PMC90401
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Mentions:
22
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Animals
The comparative efficacy of chloroquine and sulfadoxine-pyrimethamine for the treatment of uncomplicated falciparum malaria in Kampala, Uganda. Trans R Soc Trop Med Hyg. 2001 Jan-Feb; 95(1):50-5.
Kamya MR,
Dorsey G
, Gasasira A, Ndeezi G, Babirye JN, Staedke SG,
Rosenthal PJ
. PMID: 11280066.
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Humans
Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase of Plasmodium falciparum. J Biol Chem. 2000 Sep 15; 275(37):29000-10.
Shenai BR, Sijwali PS, Singh A,
Rosenthal PJ
. PMID: 10887194.
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Mentions:
95
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Animals
Cells
Difficulties in the prevention, diagnosis, and treatment of imported malaria. Arch Intern Med. 2000 Sep 11; 160(16):2505-10.
Dorsey G
, Gandhi M, Oyugi JH,
Rosenthal PJ
. PMID: 10979063.
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Mentions:
16
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Humans
Predictors of chloroquine treatment failure in children and adults with falciparum malaria in Kampala, Uganda. Am J Trop Med Hyg. 2000 Jun; 62(6):686-92.
Dorsey G
, Kamya MR, Ndeezi G, Babirye JN, Phares CR, Olson JE, Katabira ET,
Rosenthal PJ
. PMID: 11304055.
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Mentions:
20
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Humans
Animals
CT
Clinical Trials
Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. Bioorg Med Chem. 1999 Apr; 7(4):633-8.
Olson JE, Lee GK, Semenov A,
Rosenthal PJ
. PMID: 10353642.
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Mentions:
35
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Humans
Animals
Cells
Proteases of protozoan parasites. Adv Parasitol. 1999; 43:105-59.
Rosenthal PJ
. PMID: 10214691.
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Mentions:
25
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Humans
Animals
Plasminogen activators are not required in the erythrocytic life cycle of malaria parasites. Mol Biochem Parasitol. 1998 Nov 30; 97(1-2):253-7.
Rosenthal PJ
, Semenov A, Ploplis VA, Plow EF. PMID: 9879906.
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Humans
Animals
Cells
Plasmodial serine repeat antigen homologues with properties of schizont cysteine proteases. Mol Biochem Parasitol. 1998 Sep 01; 95(1):153-8.
Gor DO, Li AC, Wiser MF,
Rosenthal PJ
. PMID: 9763298.
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Antimalarial synergy of cysteine and aspartic protease inhibitors. Antimicrob Agents Chemother. 1998 Sep; 42(9):2254-8.
Semenov A, Olson JE,
Rosenthal PJ
. PMID: 9736544; PMCID:
PMC105801
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Mentions:
30
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Animals
Humoral immune responses of Africans to cysteine protease-related antigens of Plasmodium falciparum. J Infect Dis. 1998 Jul; 178(1):285-8.
Gor DO,
Rosenthal PJ
. PMID: 9652457.
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Humans
Animals
Protective immune responses against protease-like antigens of the murine malaria parasite Plasmodium vinckei. Vaccine. 1998 Jul; 16(11-12):1193-202.
Gor DO, Li AC,
Rosenthal PJ
. PMID: 9682379.
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Animals
Cells
Proteases of malaria parasites: new targets for chemotherapy. Emerg Infect Dis. 1998 Jan-Mar; 4(1):49-57.
Rosenthal PJ
. PMID: 9452398; PMCID:
PMC2627653
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Mentions:
28
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Humans
Animals
Cells
Hemoglobin catabolism and iron utilization by malaria parasites. Mol Biochem Parasitol. 1996 Dec 20; 83(2):131-9.
Rosenthal PJ
, Meshnick SR. PMID: 9027746.
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Mentions:
39
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Animals
Antimalarial effects of vinyl sulfone cysteine proteinase inhibitors. Antimicrob Agents Chemother. 1996 Jul; 40(7):1600-3.
Rosenthal PJ
, Olson JE, Lee GK, Palmer JT, Klaus JL, Rasnick D. PMID: 8807047; PMCID:
PMC163380
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Mentions:
41
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Humans
Animals
Cells
Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites. Blood. 1996 May 15; 87(10):4448-54.
Gamboa de Domínguez ND,
Rosenthal PJ
. PMID: 8639807.
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Mentions:
11
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Animals
Cells
Conservation of key amino acids among the cysteine proteinases of multiple malarial species. Mol Biochem Parasitol. 1996 Jan; 75(2):255-60.
Rosenthal PJ
. PMID: 8992323.
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Animals
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Functional expression of falcipain, a Plasmodium falciparum cysteine proteinase, supports its role as a malarial hemoglobinase. Infect Immun. 1995 Jun; 63(6):2120-5.
Salas F, Fichmann J, Lee GK, Scott MD,
Rosenthal PJ
. PMID: 7768590; PMCID:
PMC173275
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Mentions:
24
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Animals
Cells
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites. Exp Parasitol. 1995 Mar; 80(2):272-81.
Rosenthal PJ
. PMID: 7895837.
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Mentions:
30
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Humans
Animals
Cells
Anti-malarial drug development using models of enzyme structure. Chem Biol. 1994 Sep; 1(1):31-7.
Li Z, Chen X, Davidson E, Zwang O, Mendis C, Ring CS, Roush WR, Fegley G, Li R,
Rosenthal PJ
, et al. PMID: 9383368.
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Characterization of a Plasmodium vivax cysteine proteinase gene identifies uniquely conserved amino acids that may mediate the substrate specificity of malarial hemoglobinases. J Mol Biol. 1994 Aug 12; 241(2):312-6.
Rosenthal PJ
, Ring CS, Chen X, Cohen FE. PMID: 8057374.
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Humans
Animals
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A Plasmodium vinckei cysteine proteinase shares unique features with its Plasmodium falciparum analogue. Biochim Biophys Acta. 1993 Apr 29; 1173(1):91-3.
Rosenthal PJ
. PMID: 8485161.
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Animals
Cells
Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J Clin Invest. 1993 Mar; 91(3):1052-6.
Rosenthal PJ
, Lee GK, Smith RE. PMID: 8450035; PMCID:
PMC288059
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Mentions:
37
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Animals
Isolation and characterization of a cysteine proteinase gene of Plasmodium falciparum. Mol Biochem Parasitol. 1992 Mar; 51(1):143-52.
Rosenthal PJ
, Nelson RG. PMID: 1565129.
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Mentions:
26
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Animals
Cells
Antimalarial effects of peptide inhibitors of a Plasmodium falciparum cysteine proteinase. J Clin Invest. 1991 Nov; 88(5):1467-72.
Rosenthal PJ
, Wollish WS, Palmer JT, Rasnick D. PMID: 1939639; PMCID:
PMC295650
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Mentions:
45
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Humans
Animals
Cells
Plasmodium falciparum: inhibitors of lysosomal cysteine proteinases inhibit a trophozoite proteinase and block parasite development. Mol Biochem Parasitol. 1989 Jun 15; 35(2):177-83.
Rosenthal PJ
McKerrow JH
, Rasnick D, Leech JH. PMID: 2671722.
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Mentions:
20
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Animals
Cells
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum. J Clin Invest. 1988 Nov; 82(5):1560-6.
Rosenthal PJ
McKerrow JH
, Aikawa M, Nagasawa H, Leech JH. PMID: 3053784; PMCID:
PMC442723
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Mentions:
88
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Animals
Rectal leishmaniasis in a patient with acquired immunodeficiency syndrome. Am J Med. 1988 Feb; 84(2):307-9.
Rosenthal PJ
, Chaisson RE, Hadley WK, Leech JH. PMID: 3407656.
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Humans