Abstract To reduce the morbidity and mortality from colorectal cancer, current clinical practice focuses on screening for early detection and polypectomy as a form of secondary prevention, complemented with surgical interventions when appropriate. No pharmaceutical agent is curre…
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Interactions Between Dietary Metabolites and Regulatory Risk Variants for Human Colon Cancer - PMC
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439979
INTRODUCTION Colorectal cancer ( CRC ) is the second leading cause of cancer death globally 1 . Diet is an important environmental risk factor for CRC, contributing to 30–50% of cases 2 , 3 . Major dietary risks include a high fat intake, processed red meats, low fiber intake, an…
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Abstract Simple Summary Exosomes are small (40–160 nanometer) extracellular vesicles with significant roles in cancer development and progression. Exosomes are abundantly produced by cancer cells, carry tumor-specific content, such as DNA, RNA, and proteins, and have the potentia…
Tumor characterization and resection Current intervention for CRC includes diagnosis, staging, resection, adjuvant chemotherapy, treatment of recurrent disease and ongoing surveillance. Diagnostic determination depends in part on histological assessment of the resected polyp. All…
Abstract Accurately modeling tumor biology and testing novel therapies on patient-derived cells is critically important to developing therapeutic regimens personalized to a patient’s specific disease. The vascularized microtumor (VMT), or “tumor-on-a-chip,” is a physiologic precl…
Abstract Steatotic liver enhances liver metastasis of colorectal cancer (CRC), but this process is not fully understood. Steatotic liver induced by a high-fat diet increases cancer-associated fibroblast (CAF) infiltration and collagen and hyaluronic acid (HA) production. We inves…
Abstract Introduction Although African Americans have the highest incidence and mortality from colorectal cancer (CRC), they are less likely than other racial groups to undergo CRC screening. Previous research has identified barriers to CRC screening among African Americans. Howe…
Early Childhood Research Quarterly 64 (2023) 381–393 Contents lists available at ScienceDirect Early Childhood Research Quarterly journal homepage: www.elsevier.com/locate/ecresq Centering teacher and parent voice to realize culturally relevant computational thinking in early chi…
Abstract In addition to genetic changes, the occurrence of epigenetic alterations is associated with accumulation of both genetic and epigenetic events that promote the development and progression of human cancer. Previously, we reported a set of candidate genes that comprise par…
Baseline Study for a Comprehensive Child Law in Ethiopia Center for Human Rights Studies College of Law and Governance Studies Addis Ababa University September 2013 Special thanks to the Save the Children-Norway in Addis Ababa, Ethiopia Published in 2013 by Address Selection and …
Abstract Colorectal cancer (CRC) is the second leading cause of cancer-related deaths in the US. For the vast majority of patients with advanced CRC (ie, for those in whom metastatic tumors are unresectable), treatment is palliative and typically involves chemotherapy, biologic t…