Abstract Understanding the nature of renal erythropoietin-producing cells (REPs) remains a central challenge for elucidating the mechanisms involved in hypoxia and/or anemia-induced erythropoietin (Epo) production in adult mammals. Previous studies have shown that REPs are renal …

Epo transgene rescues Epo-null mice from embryonic lethality To attain liver-specific Epo expression, we constructed a 3.3 K-Epo3 ′ transgene based on the mouse Epo gene, which consisted of an 8.0-kilobase (kb) Epo gene fragment with a 0.3-kb sequence deletion in the 3′-untransla…

The indispensable roles of Epo in primitive erythropoiesis To elucidate the contribution of Epo to primitive erythropoiesis, we analysed an Epo-knockout (Epo-KO or Epo −/− ) mouse line ( Supplementary Fig. S1 ) 20 , 21 . No apparent abnormality was observed in Epo-KO embryos at E…

Frontiers | Renal erythropoietin-producing cells in health and disease REVIEW article Front. Physiol. , 03 June 2015 Sec. Renal Physiology and Pathophysiology Volume 6 - 2015 | https://doi.org/10.3389/fphys.2015.00167 Renal erythropoietin-producing cells in health and disease T S…

Abstract Background Erythropoietin (EPO) has been reported as a novel determinant of fibroblast growth factor 23 (FGF23) production; however, it is unknown whether FGF23 is stimulated by chronic exposure to EPO or by EPO administration in nonpolycystic chronic kidney disease (CKD…

Research Article Nephrology Free access | 10.1172/JCI57301 Dysfunction of fibroblasts of extrarenal origin underlies renal fibrosis and renal anemia in mice 1 Career-Path Promotion Unit for Young Life Scientists, Graduate School of Medicine, Kyoto University, Yoshida-konoe-cho, S…

Published by : International Journal of Engineering Research & Technology (IJERT) http://www.ijert.org ISSN: 2278-0181 Vol. 6 Issue 07, July - 2017 The Influence of Erythropoietin (EPO) on Cancer Cells and its Role in the Cancer Treatment Almedina Kozić, Lejla Gurbeta, Enisa Oman…

Abstract Background The iron regulatory hormones erythroferrone (ERFE), erythropoietin (EPO), and hepcidin, and the cargo receptor nuclear receptor coactivator 4 (NCOA4) are expressed in the placenta. However, determinants of placental expression of these proteins and their assoc…

ABSTRACT Background Maintaining adequate iron status during pregnancy is important for the mother and her developing fetus. Iron homeostasis is influenced by 3 regulatory hormones: erythropoietin (EPO), hepcidin, and erythroferrone (ERFE). To date, normative data on ERFE across p…

Introduction Testosterone is an important regulator of erythropoiesis in men and women ( Bhasin et al. , 2010 ; Mirand EA, 1965 ). Circulating testosterone levels have been associated with hemoglobin levels in community-dwelling middle-aged and older men ( Ferrucci L, 2006 ; Yeap…

Abstract Introduction Erythropoietin (Epo) is a putative neuroprotective therapy that did not improve overall outcomes in a phase 3 randomized controlled trial for neonates with moderate or severe hypoxic-ischemic encephalopathy (HIE). However, HIE is a heterogeneous disorder, an…

Abstract Hypoxia-inducible factor prolyl hydroxylase inhibitors stabilize levels of hypoxia-inducible factor that upregulate transcription of multiple genes associated with the response to hypoxia, including production of erythropoietin. We conducted two phase 2a studies to explo…

Frontiers | Developing a visual model to represent the implementation of an ambitious mathematics program CONCEPTUAL ANALYSIS article Front. Educ. , 21 May 2025 Sec. STEM Education Volume 10 - 2025 | https://doi.org/10.3389/feduc.2025.1579921 Developing a visual model to represen…

Nephrology Dialysis Transplantation 29 (Supplement 3): iii90–iii101, 2014 doi:10.1093/ndt/gfu143 SP068 EFFECTS OF CILASTATIN ON GENTAMICIN-INDUCED RENAL EXPERIMENTAL ACUTE KIDNEY INJURY DAMAGE. IN VITRO AND IN VIVO EVIDENCE Juan C. Jado1, Blanca Humanes1, Virginia Lopez-Parra1, S…

… and Ex Vivo Evaluation of Ivermectin Within Different NanoDrug Delivery Vehicles for Transdermal Drug Delivery Eunice Maureen Steenekamp, Wilna Liebenberg, Hendrik J. R. Lemmer and Minja Gerber Special Issue Transdermal Delivery: Challenges and Opportunities Edited by Dr. Nina D…