Introduction Brain metastases (BrM) are CNS tumors commonly arising in patients with lung, melanoma, and breast cancer ( 1 ). The emergence of BrM usually marks the most advanced stage of a metastatic disease and is generally associated with poor survival. Therapeutic options for…

JCI - USP22 drives tumor immune evasion and checkpoint blockade resistance through EZH2-mediated epigenetic silencing of MHC-I Go to JCI Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by email Advertising Job board Contact The Journal o…

Results Tumor-infiltrating T cells are clonally-expanded To generate proof-of-concept data that immunotherapies are likely to augment anti-tumor immune responses in pediatric brain tumors, we examined naturally-induced T cell responses in the TME for features that are associated …

Abstract Background Adjuvant immune checkpoint blockade (ICB) following chemoradiotherapy and adding ICB to chemotherapy have been key advances for stages III-IV non-small cell lung cancer (NSCLC) treatment. However, known biomarkers like PD-L1 are not consistently indicative of …

Abstract Background Immune checkpoint blockade (ICB) has transformed cancer therapy, with long-term responses and a favorable safety profile; however, only a minority of patients respond. Response to ICB is influenced by immune-related genetic factors such as HLA haplotype, poten…

Single-cell spatial transcriptomic mapping of HGSC To spatially map HGSC in the setting of metastatic disease, we applied in situ imaging with high-plex RNA detection at single-cell resolution to 130 HGSC tumors from a total of 94 patients to generate 202 tissue profiles, yieldin…

Date: July 1, 2025 To: ICB Stakeholders and the General Public From: Dr. Joseph Troiani, PhD, CADC, President, Illinois Certification Board Subject: Updates to the CADC Credential Effective July 1, 2025 The Illinois Certification Board (ICB) remains committed to aligning its cred…

Institute for Collaborative Biotechnologies (ICB) | UC Santa Barbara | Institute for Collaborative Biotechnology (ICB) | UCSB, MIT and Caltech. Biologically-Enabled Materials Cognitive Neuroscience Systems and Synthetic Biology Advanced Scientific Research Institute for Collabora…

Background: Immune checkpoint blockade (ICB) has improved outcomes for patients with microsatellite instability high (MSI-H)/deficient mismatch repair (dMMR) tumors. However, not all MSI-H/dMMR patients will exhibit the same ICB efficacy. Previous studies suggest that concomitant…

EPUB Content Documents 3.0.1 EPUB Content Documents 3.0.1 Recommended Specification 26 June 2014 This version Latest version Previous version diff of changes from the previous version is also available. Please refer to the errata for this document, which may include some normativ…

ARID1A Deficiency Regulates Anti-Tumor Immune Response in Esophageal Adenocarcinoma - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS A lock ( ) or https:// mean…

RESEARCH ARTICLE Species delimitation in asexual insects of economic importance: The case of black scale (Parasaissetia nigra), a cosmopolitan parthenogenetic pest scale insect Yen-Po Lin1,2,3*, Robert D. Edwards4, Takumasa Kondo5, Thomas L. Semple3, Lyn G. Cook2 1 College of Lif…

Martin University - UNCF ICB Martin University Est. 1977 Indianapolis, IN UNCF Member Institution Transformation Partner since 2020 Website: martin.edu "This additional relationship will enhance what we’re already doing together toward student success and also encourage and devel…

Strategy Development - UNCF ICB The strategy team champions the mission and vision of the Institute for Capacity Building by engaging mission-aligned partners, funders, advisors, subject matter experts and thought leaders to accelerate ICB’s work and broaden its impact. Works wit…

Home - UNCF ICB For more than 80 years, UNCF has served as a beacon for those ready to invest in—and act on—the belief that no mind should be wasted nor any dream deferred. UNCF’s Institute for Capacity Building partners with HBCUs, their supporters and champions to advance the i…