This is the released version of VarCon; for the devel version, see VarCon . VarCon: an R package for retrieving neighboring nucleotides of an SNV Bioconductor version: Release (3.22) VarCon is an R package which converts the positional information from the annotation of an single…
Abstract Rationale: Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disorder characterized by progressive loss of pulmonary microvessels. Although mutations in the bone morphogenetic receptor 2 (BMPR2) are found in 80% of heritable and ∼15% of patients wit…
Abstract Background The standard of care treatment for muscle-invasive bladder cancer (MIBC) is radical cystectomy, which is typically preceded by neoadjuvant chemotherapy. However, the inability to assess minimal residual disease (MRD) noninvasively limits our ability to offer b…
Background: Hantaviruses - dichotomized into New World (i.e. Andes virus, ANDV; Sin Nombre virus, SNV) and Old-World viruses (i.e. Hantaan virus, HTNV) - are zoonotic viruses transmitted from rodents to humans. Currently, no FDA-approved vaccines against hantaviruses exist. Given…
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Abstract Background Autism spectrum disorders (ASDs) are more prevalent in males, suggesting a multiple threshold liability model in which females are, on average, protected by sex-differential mechanisms. Under this model, autistic females are predicted to carry a more penetrant…
Abstract MicroRNAs (miRNAs) regulate diverse cancer hallmarks through sequence-specific regulation of gene expression, so genetic variability in their seed sequences or target sites could be responsible for cancer initiation or progression. While several efforts have been made to…
Antiquités africaines 55 | 2019 L’Afrique du Nord de la protohistoire à la conquête arabe 55 2019 Antiquités Africaines CNRS EDITIONS ANTIQUITÉS AFRICAINES L’AFRIQUE DU NORD DE LA PROTOHISTOIRE À LA CONQUÊTE ARABE Les Antiquités africaines publient des études historiques et arché…
DEVELOPMENT BULLETIN No. 81 November 2019 Editor: Pamela Thomas 81 LEADERSHIP FOR INCLUSIVE DEVELOPMENT THEMES • Dimensions of leadership • A review of womens’ leadership roles • Leadership in feminist organisations • Leadership for inclusion v inclusive leadership • Individuals …
Phylogenetic analysis of M . tuberculosis in Chiangrai 1170 successfully sequenced M . tuberculosis isolates were classified by phylogeny into Lineage 1–4 (L1-4) based on phylogenetic analysis of SNVs (single nucleotide variants) identified across their entire genomes. The result…
Subject enrollment In total, 273 subjects were recruited as part of the iPSCORE study, of which 215 subjects have been included in previous studies 39 , 40 , 41 . Data for additional 204 subjects were obtained from the HipSci Collection 42 , 43 . We have complied with all relevan…
Laboratoire et analyses | Institut de cardiologie de Montréal 70 ans au coeur de vos vies! Patient ou visiteur Professionnel de la santé Centre de recherche Étudiant Carrières Se rendre à l’ICM Accéder au dossier médical Prendre et préparer un rendez-vous Intervention d’un jour V…
Urine tumor DNA detection of minimal residual disease in muscle-invasive bladder cancer treated with curative-intent radical cystectomy: A cohort study | PLOS Medicine Article Authors Metrics Comments Media Coverage Reader Comments Figures Correction 14 Dec 2021: Chauhan PS, Chen…
Abstract Hanoi is the capital of Vietnam, one of the 30 countries with a high tuberculosis (TB) burden. Fundamental data on the molecular epidemiology of the disease is required for future TB management. To identify lineages and genotypes of Mycobacterium tuberculosis (Mtb), conv…
We performed whole-genome sequencing (WGS) of 208 genomes from 53 families affected by simplex autism. For the majority of these families, no copy-number variant (CNV) or candidate de novo gene-disruptive single-nucleotide variant (SNV) had been detected by microarray or whole-ex…