Frontiers | TCR Signaling Emerges from the Sum of Many Parts REVIEW article Front. Immunol. , 25 June 2012 Sec. T Cell Biology Volume 3 - 2012 | https://doi.org/10.3389/fimmu.2012.00159 TCR Signaling Emerges from the Sum of Many Parts M S Michael S. Kuhns 1,2 * M M Mark M. Davis …

Single-cell analysis can reveal important functional insights that are masked in bulk analysis of cell populations 1 – 3 . Recent technological advances have improved our ability to query expression of multiple genes in single cells simultaneously, thereby helping to resolve the …

Abstract Quantitative metrics for vaccine-induced T-cell responses are an important need for developing correlates of protection and their use in vaccine-based medical management and population health. Molecular TCR analysis is an appealing strategy but currently requires a targe…

Abstract CD4 + T cells play a critical role in antitumor immunity via recognition of peptide antigens presented on MHC class II (MHC-II). Although some solid cancers can be induced to express MHC-II, the extent to which this enables direct recognition by tumor-specific CD4 + T ce…

Pre-existing tumor-resident T cells with cytotoxic potential associate with response to neoadjuvant anti-PD-1 in head and neck cancer - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS …

Enhancing and inhibitory motifs regulate CD4 activity | eLife Version of Record July 28, 2022 Accepted Manuscript July 21, 2022 Cite Share Comment Open annotations (there are currently annotations on this page). 1,702 views 343 downloads citations Altmetric provides a collated sc…

INTRODUCTION CD4+ T cells display immunologic memory of past infections( 1 ), although there is a lack of studies following CD4+ T cell clones through multiple repeated infections in humans to assess their long-term stability, plasticity, and the fidelity of their recall response…

The CD4 transmembrane GGXXG and juxtamembrane (C/F)CV+C motifs mediate pMHCII-specific signaling independently of CD4-LCK interactions | eLife Version of Record April 19, 2024 Read the peer reviews Reviewed Preprint v2 March 14, 2024 Reviewed Preprint v1 September 28, 2023 Cite S…

‘Immunological circuits’ as sources of emergent behaviors The idea that circuits of immune cell-cell interactions are primary determinants of the systemic properties of immunity is not new, although our ability to realize it has been limited until recent advances in computation a…

INTRODUCTION Glioblastoma is the most common primary malignant adult brain tumor with a dismal prognosis for patients despite maximal standard of care therapy ( 1 , 2 ). Glioblastoma displays extraordinary cellular heterogeneity, but it remains unclear which populations drive the…

Introduction Gulf War illness (GWI), affecting over 25% of the 700,000 military personnel deployed to the 1991 Persian Gulf War 1 , features a variety of symptoms including fatigue, pain, memory/concentration problems, balance disturbances, post-exertion malaise, chronic diarrhea…

Revue archéologique de l’Est tome 64 | 2015 n° 187 Le site de Mittelhausen « Liesbuehl/Gimbretter Weg» (Bas-Rhin, Alsace) : économie et environnement d’une aire d’ensilage de La Tène ancienne dans le Kochersberg Christophe Croutsch, Michaël Landolt, Emeline Broc, Felix Fleischer,…

Exploring the Relations in Relational Engagement: Addressing Barriers to Transformative Consumer Research Abstract Marketing academics are increasingly seeking societal impact from their work yet still encounter problems in creating and sustaining meaningful relationships with th…

The Simplicity of Divine Ideas Michelle Panchuk According to Theistic Conceptual Realism (TCR), divine concepts, conceived of as eternal aspects of the divine mind, do the metaphysical lifting for which abstract universals are posited on platonic realist accounts of abstract obje…

Teaching Curriculum Resources: A Guiding Light for Effective Instruction In the dynamic world of education, teachers play a pivotal role in shaping the minds of future generations. To effectively fulfill this responsibility, they rely on a comprehensive toolkit of resources, incl…