Main Identifying individuals at high risk of developing disease is a priority for preventative medicine. Most traditional risk assessment tools rely on clinical parameters such as age, sex and family history, and a reduced set of basic biomarkers tailored to the disease under stu…

PCSK9 genetic variants, carotid atherosclerosis and vascular remodelling - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely connected to the .gov website. …

Plasma proteomic profiles identify biomarkers predicting Crohn’s disease up to 16 years before onset | Nature Communications Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more…

Identifying genes associated with brain volumetric differences through tissue specific transcriptomic inference from GWAS summary data - PMC Skip to main content Official websites use .gov A .gov website belongs to an official government organization in the United States. Secure …

Study design The UKB study is a population-based cohort of around half a million participants from the UK aged between 40 and 59 years who were recruited between 2006 and 2010 (baseline assessment). Deep phenotype and genetic data are available for participants, including blood a…

Plasma protein-derived organ age estimates in the UKB To derive estimates of organ-specific biological age from the plasma proteome, we (1) identified plasma proteins likely derived from a specific organ (Supplementary Tables 1 and 2 , Methods and Supplementary Fig. 1 ); (2) trai…

United Keetoowah Band | Home | Tahlequah, OK top of page "Siyo!" is how we say "hello!" Welcome to the official website for the United Keetoowah Band of Cherokee Indians in Oklahoma! We are a sovereign nation headquartered in Tahlequah, Oklahoma and one of only three federally re…

United Keetoowah Band | Home | Tahlequah, OK top of page "Siyo!" is how we say "hello!" Welcome to the official website for the United Keetoowah Band of Cherokee Indians in Oklahoma! We are a sovereign nation headquartered in Tahlequah, Oklahoma and one of only three federally re…

Summary Large biobank samples provide an opportunity to integrate broad phenotyping, familial records, and molecular genetics data to study complex traits and diseases. We introduce Pearson-Aitken Family Genetic Risk Scores (PA-FGRS), a method for estimating disease liability fro…

İklim Sözlüğü: İklim değişikliği için günlük rehber | United Nations Development Programme Ana içeriğe atla İklim Sözlüğü: İklim değişikliği için günlük rehber 2 Şubat 2023 İklim değişikliği, içinde bulunduğumuz çağın belirleyici krizi. Her geçen gün daha fazla insan iklim eylemi…

Purpose: Idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS) are rare reproductive disorders with known genetic heterogeneity. Using exome sequencing, our group previously reported the prevalence of pathogenic and likely pathogenic (P/LP) variants in genes c…

Purpose: Idiopathic hypogonadotropic hypogonadism (IHH) and Kallmann syndrome (KS) are rare reproductive disorders with known genetic heterogeneity. Using exome sequencing, our group previously reported the prevalence of pathogenic and likely pathogenic (P/LP) variants in genes c…

Background: Observational studies suggest associations between extremes of sleep duration and myocardial infarction (MI), but the causal contribution of sleep to MI and its potential to mitigate genetic predisposition to coronary disease is unclear. Objectives: This study sought …

Papers by Alberto Vidal-Diez Simulation model for atypical scrapie and input data supporting EFSA's mandate EFSA-Q-2020-00662 Simulation model if the within-flock transmission of atypical scrapie assuming the disease is con... more Simulation model if the within-flock transmissio…

Assessing the influence of plasma metabolites on chronic skin ulcer risk: a two-sample Mendelian randomization study | Scientific Reports Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend y…