-
Integrating Smoking Cessation Treatment Into Web-Based Usual Psychological Care for People With Common Mental Illness: Feasibility Randomized Controlled Trial (ESCAPE Digital). JMIR Ment Health. 2025 Dec 05; 12:e78424. Taylor G, Jacobsen P, Blackwell A, Daryan S, Roy D, Duffy D, Hisler G, Sawyer K, Ainsworth B, Hiscock D, Papadakis S, Brown J, Brown J, Brown J, Munafò M, Aveyard P. PMID: 41348446; PMCID: PMC12717507.
-
WhatsApp-Based Intervention for Diabetes Prevention and Care in Argentina: Implementation and Process Evaluation. JMIR Form Res. 2025 Dec 01; 9:e81098. Nejamis A, Gutierrez L, López MV, Ciganda Cha AD, Mendoza Quispe O, Irazola V, Beratarrechea A. PMID: 41325602; PMCID: PMC12706442.
-
Social Media Use Among Parents and Caregivers of Children With Rare Genetic Diseases: Scoping Review. J Med Internet Res. 2025 Nov 28; 27:e77087. Davis C, Bogaert L, Powell J, Low K. PMID: 41313807; PMCID: PMC12701349.
-
A 6-Month Evaluation of the Peer-Ceived Momentary Assessment Method in a Small Sample of Liver Transplant Patients and Their Support Persons: Longitudinal Observational Study. JMIR Form Res. 2025 Nov 27; 9:e55907. Berrocal A, Concepcion W, Wac K. PMID: 41309085; PMCID: PMC12699256.
-
AI-Powered Thermography for Diabetic Foot Risk Stratification: Multicenter Cross-Sectional Study. JMIR Form Res. 2025 Nov 27; 9:e81289. Alwashmi MF, Alghali M, Abu-Ashour W, Arabe AM, Al Soheimi A, Alharbi NA, Badahdah HM. PMID: 41308190; PMCID: PMC12699249.
-
Registry-Based Assessment of Shunt Operation Methods and Outcomes in Idiopathic Normal Pressure Hydrocephalus (RASHOMON Study): Protocol for a Multicenter Prospective Observational Cohort Study. JMIR Res Protoc. 2025 Nov 21; 14:e80678. Okumura E, Takeuchi K, Momota H, Nagatani T, Taoka T, Aimi Y, Hashizume A, Okazaki M, Saito R. PMID: 41268971; PMCID: PMC12680931.
-
Considerations for Patient Privacy of Large Language Models in Health Care: Scoping Review. J Med Internet Res. 2025 Nov 21; 27:e76571. Zhong X, Li S, Li S, Chen Z, Ge L, Yu D, Wang S, You L, Shang H. PMID: 41269747; PMCID: PMC12680930.
-
Three Body-Worn Accelerometers in the French NutriNet-Santé Cohort: Feasibility and Acceptability Study. JMIR Form Res. 2025 Nov 20; 9:e76167. Soumaré A, Fezeu LK, Bouchan J, Delestre F, Bellicha A, Cardon G, Donnelly A, Hebestreit A, Touvier M, Oppert JM, Vanhelst J. PMID: 41264348; PMCID: PMC12679073.
-
Implementation of the German Clinical Practice Guideline for Multimorbidity Using a Digital Tool in Primary Care: Pilot Cluster Randomized Clinical Trial. JMIR Aging. 2025 Nov 20; 8:e79767. Nothacker J, Paucke V, Lezius S, Zapf A, Lühmann D, Scherer M, Schäfer I. PMID: 41263476; PMCID: PMC12679070.
-
Optimizing Workplace Digital Mental Health Interventions: Systematic Review and Meta-Analysis. J Med Internet Res. 2025 Nov 17; 27:e71253. Stratton E, Morris RW, Milton A, Deady M, Choi I, Glozier N. PMID: 41247788; PMCID: PMC12670063.
-
Development of a Virtual Home-Based Cycling Intervention for Individuals With Chronic Obstructive Pulmonary Disease: Qualitative Study. JMIR Form Res. 2025 Nov 14; 9:e71234. Christensen KK, Bøggild H, Weinreich UM, Stoustrup AL. PMID: 41237402; PMCID: PMC12663703.
-
Embracing the Future of Medical Education With Large Language Model-Based Virtual Patients: Scoping Review. J Med Internet Res. 2025 Nov 13; 27:e79091. Zeng J, Qi W, Shen S, Liu X, Liu X, Li S, Li S, Wang B, Dong C, Zhu X, Shi Y, Lou X, Wang B, Yao J, Jiang G, Zhang Q, Cao S. PMID: 41232097; PMCID: PMC12661241.
-
Automated Personalized Goal Setting for Individual Exercise Behavior: Protocol for a Web-Based Adaptive Intervention Trial. JMIR Res Protoc. 2025 Nov 12; 14:e73766. Caro JC, Nguyen PH, Lipman S. PMID: 41222972; PMCID: PMC12658392.
-
Efficacy of Preventive Pressurized Intraperitoneal Aerosol Chemotherapy in Patients With Locally Advanced Gastric Cancer: Protocol for a Prospective Controlled Trial. JMIR Res Protoc. 2025 Nov 11; 14:e78053. Kerimkulov A, Uskenbayev T, Sarina T, Mamlin M, Shalekenov S, Yessenbayeva G, Kainazarov T, Burkitbayev Z, Ussipbekov B, Kovalchuk D, Rakhmankulov A, Rakhmankulova A, Gaipov A. PMID: 41218205; PMCID: PMC12648122.
-
Expectant Mothers' Reflections on Childhood and Parenting: Cross-Sectional Study. JMIR Form Res. 2025 Nov 07; 9:e80060. Mjølstad BP, Vie GÅ, Getz LO, Hansen MH, Mørkved HS, Austad B. PMID: 41202304; PMCID: PMC12639342.
-
Diabetes knowledge, risk and severity perceptions, lifestyle behaviours and management barriers among Sub-Saharan African immigrants living in the UK: an ethnographic study. BMC Public Health. 2025 Aug 22; 25(1):2883. Onuorah L, Santy-Tomlinson J, Draper P. PMID: 40846934; PMCID: PMC12372270.
-
Multi-omic analysis of meningeal cerebral amyloid angiopathy reveals enrichment of unsubstituted glucosamine and extracellular proteins. J Neuropathol Exp Neurol. 2025 May 01; 84(5):398-411. Mayfield JE, Rajic AJ, Aguilar-Calvo P, Soldau K, Flores S, Lawrence R, Choudhury B, Ghassemian M, Pizzo DP, Wagner SL, Danque GA, Sumowski P, Hansen LA, Goodwill V, Esko JD, Sigurdson CJ. PMID: 40156913; PMCID: PMC12012350.
-
Graduate Students' Perspectives on Obtaining a Master's of Science in Respiratory Care. Respir Care. 2025 04; 70(4):384-392. Koster MS, McHenry KL, Caldwell-Chadwick BG, Null MM. PMID: 40193534.
-
Integrative multiomics reveals common endotypes across PSEN1, PSEN2, and APP mutations in familial Alzheimer's disease. Alzheimers Res Ther. 2025 Jan 04; 17(1):5. Valdes P, Caldwell AB, Liu Q, Fitzgerald MQ, Ramachandran S, Karch CM, Dominantly Inherited Alzheimer Network (DIAN), Galasko DR, Yuan SH, Wagner SL, Subramaniam S. PMID: 39754192; PMCID: PMC11699654.
-
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease. Acta Neuropathol Commun. 2024 10 21; 12(1):166. Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O. PMID: 39434170; PMCID: PMC11492509.
-
Association of Lower Rostral Anterior Cingulate GABA+ and Dysregulated Cortisol Stress Response With Altered Functional Connectivity in Young Adults With Lifetime Depression: A Multimodal Imaging Investigation of Trait and State Effects. Am J Psychiatry. 2024 Jul 01; 181(7):639-650. Ironside M, Duda JM, Moser AD, Holsen LM, Zuo CS, Du F, Perlo S, Richards CE, Chen X, Chen X, Nickerson LD, Null KE, Esfand SM, Alexander MM, Crowley DJ, Lauze M, Misra M, Goldstein JM, Pizzagalli DA. PMID: 38685857; PMCID: PMC11216878.
-
[Determination of trace anions in battery-grade lithium carbonate by double-inhibition on-line matrix-removal ion chromatography]. Se Pu. 2024 Mar 08; 42(3):291-295. Wu G, Wu G, Wu GQ. PMID: 38503706; PMCID: PMC10951807.
-
PS1/gamma-secretase acts as rogue chaperone of glutamate transporter EAAT2/GLT-1 in Alzheimer's disease. Res Sq. 2023 Nov 07. Perrin F, Anderson LC, Mitchell SPC, Sinha P, Turchyna Y, Maesako M, Houser MCQ, Zhang C, Wagner SL, Tanzi RE, Berezovska O. PMID: 37986905; PMCID: PMC10659539.
-
Safety and efficacy of tafasitamab with or without lenalidomide added to first-line R-CHOP for DLBCL: the phase 1b First-MIND study. Blood. 2023 10 19; 142(16):1348-1358. Belada D, Kopeckova K, Bergua Burgues JM, Stevens D, André M, Persona EP, Pichler P, Staber PB, Trneny M, Duell J, Waldron-Lynch M, Wagner S, Mukhopadhyay A, Dirnberger-Hertweck M, Burke JM, Nowakowski GS. PMID: 37369099; PMCID: PMC10651865.
-
Three-tiered fetal heart rate interpretation system and adverse neonatal and maternal outcomes: a systematic review and meta-analysis. Am J Obstet Gynecol. 2023 10; 229(4):377-387. Zullo F, Di Mascio D, Raghuraman N, Wagner S, Brunelli R, Giancotti A, Mendez-Figueroa H, Cahill AG, Gupta M, Berghella V, Blackwell SC, Chauhan SP. PMID: 37044237.
-
Porcine reproductive and respiratory syndrome virus degrades DDX10 via SQSTM1/p62-dependent selective autophagy to antagonize its antiviral activity. Autophagy. 2023 08; 19(8):2257-2274. Li J, Li J, Zhou Y, Zhao W, Zhao W, Liu J, Liu J, Ullah R, Fang P, Fang L, Xiao S. PMID: 36779599; PMCID: PMC10351467.
-
[Determination of organophosphate diesters in facility vegetable soils using ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2023 Jan; 41(1):58-65. Liu M, Wang M, Zhao A, Zhao A, Zhu L, Wang C, Wei C, Liu W, Liu W, Xu J. PMID: 36633077; PMCID: PMC9837671.
-
DBI/ACBP is a targetable autophagy checkpoint involved in aging and cardiovascular disease. Autophagy. 2023 07; 19(7):2166-2169. Montégut L, Joseph A, Chen H, Chen H, Abdellatif M, Ruckenstuhl C, Martins I, Madeo F, Kroemer G. PMID: 36579946; PMCID: PMC10283417.
-
Transcriptomic profiling of sporadic Alzheimer's disease patients. Mol Brain. 2022 10 12; 15(1):83. Caldwell AB, Anantharaman BG, Ramachandran S, Nguyen P, Liu Q, Trinh I, Galasko DR, Desplats PA, Wagner SL, Subramaniam S. PMID: 36224601; PMCID: PMC9559068.
-
Author Correction: Polycomb CBX7 has a unifying role in cellular lifespan. Nat Cell Biol. 2022 Sep; 24(9):1445. Gil J, Bernard D, Martínez D, Beach D. PMID: 35941232.
-
A Resolving Hematoma Causing Cortical Hand Syndrome Mistaken as a Hemorrhagic Tumor in a Patient Presenting for Sacroiliac Joint Injection: Case Report. Pain Med Case Rep. 2022 Sep; 6(5):195-197. Lu L, Hussey P, Burke MD. PMID: 41299934.
-
Acute Vision Loss Sequela of Complex Regional Pain Syndrome Type 1 Successfully Treated with Stellate Ganglion Block: Case Report. Pain Med Case Rep. 2022 Sep; 6(5):155-158. Lu L, Hillegass MG. PMID: 41299926.
-
[Plasma metabolomics in a deep vein thrombosis rat model based on ultra-high performance liquid chromatography-electrostatic field orbitrap high resolution mass spectrometry]. Se Pu. 2022 Aug; 40(8):736-745. Gu Y, Zang P, Li J, Li J, Yan Y, Wang J. PMID: 35903841; PMCID: PMC9404070.
-
Age-Dependent Behavioral and Metabolic Assessment of AppNL-G-F/NL-G-F Knock-in (KI) Mice. Front Mol Neurosci. 2022; 15:909989. Wang S, Ichinomiya T, Savchenko P, Devulapalli S, Wang D, Beltz G, Saito T, Saido TC, Wagner SL, Patel HH, Head BP. PMID: 35966019; PMCID: PMC9373872.
-
Autophagy and its mediated mitochondrial quality control maintain pollen tube growth and male fertility in Arabidopsis. Autophagy. 2023 03; 19(3):768-783. Yan H, Zhuang M, Xu X, Li S, Li S, Yang M, Li N, Du X, Hu K, Peng X, Huang W, Huang W, Wu H, Wu H, Tse YC, Zhao L, Wang H. PMID: 35786359; PMCID: PMC9980518.
-
Endotype reversal as a novel strategy for screening drugs targeting familial Alzheimer's disease. Alzheimers Dement. 2022 11; 18(11):2117-2130. Caldwell AB, Liu Q, Zhang C, Schroth GP, Galasko DR, Rynearson KD, Tanzi RE, Yuan SH, Wagner SL, Subramaniam S. PMID: 35084109; PMCID: PMC9787711.
-
Preclinical validation of a potent γ-secretase modulator for Alzheimer's disease prevention. J Exp Med. 2021 04 05; 218(4). Rynearson KD, Ponnusamy M, Prikhodko O, Xie Y, Zhang C, Nguyen P, Hug B, Sawa M, Becker A, Spencer B, Florio J, Mante M, Salehi B, Arias C, Galasko D, Head BP, Johnson G, Lin JH, Duddy SK, Rissman RA, Mobley WC, Thinakaran G, Tanzi RE, Wagner SL. PMID: 33651103; PMCID: PMC7931646.
-
Synapsin-caveolin-1 gene therapy preserves neuronal and synaptic morphology and prevents neurodegeneration in a mouse model of AD. Mol Ther Methods Clin Dev. 2021 Jun 11; 21:434-450. Wang S, Leem JS, Podvin S, Hook V, Kleschevnikov N, Savchenko P, Dhanani M, Zhou K, Kelly IC, Zhang T, Miyanohara A, Nguyen P, Kleschevnikov A, Wagner SL, Trojanowski JQ, Roth DM, Patel HH, Patel PM, Head BP. PMID: 33981778; PMCID: PMC8065227.
-
Uniform criteria for total hip replacement surgery in patients with hip osteoarthritis: a decision tool to guide treatment decisions. Int J Qual Health Care. 2021 Mar 04; 33(1). Atsma F, Molenkamp O, Bouma H, Bolder SB, Groenewoud AS, Westert GP. PMID: 33616656; PMCID: PMC7941208.
-
Molecular imaging of Alzheimer's disease-related gamma-secretase in mice and nonhuman primates. J Exp Med. 2020 12 07; 217(12). Xu Y, Wang C, Wey HY, Liang Y, Chen Z, Choi SH, Ran C, Rynearson KD, Bernales DR, Koegel RE, Fiedler SA, Striar R, Wagner SL, Tanzi RE, Zhang C. PMID: 32936886; PMCID: PMC7553790.
-
Dedifferentiation and neuronal repression define familial Alzheimer's disease. Sci Adv. 2020 11; 6(46). Caldwell AB, Liu Q, Schroth GP, Galasko DR, Yuan SH, Wagner SL, Subramaniam S. PMID: 33188013; PMCID: PMC7673760.
-
Injury, Illness, and Mental Health Risks in United States Domestic Mariners. J Occup Environ Med. 2020 10; 62(10):839-841. Lefkowitz RY, Null DB, Slade MD, Redlich CA. PMID: 32769797.
-
Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators. Bioorg Med Chem. 2020 11 15; 28(22):115734. Rynearson KD, Buckle RN, Herr RJ, Mayhew NJ, Chen X, Paquette WD, Sakwa SA, Yang J, Barnes KD, Nguyen P, Mobley WC, Johnson G, Lin JH, Tanzi RE, Wagner SL. PMID: 33007551; PMCID: PMC7917164.
-
γ-Secretase Partitioning into Lipid Bilayers Remodels Membrane Microdomains after Direct Insertion. Langmuir. 2020 06 16; 36(23):6569-6579. Barros M, Houlihan WJ, Paresi CJ, Brendel M, Rynearson KD, Lee CW, Prikhodko O, Cregger C, Chang G, Wagner SL, Gilchrist ML, Li YM. PMID: 32432881; PMCID: PMC7887708.
-
Amyloid-β42/40 ratio drives tau pathology in 3D human neural cell culture models of Alzheimer's disease. Nat Commun. 2020 03 13; 11(1):1377. Kwak SS, Washicosky KJ, Brand E, von Maydell D, Aronson J, Kim S, Capen DE, Cetinbas M, Sadreyev R, Ning S, Bylykbashi E, Xia W, Wagner SL, Choi SH, Tanzi RE, Kim DY. PMID: 32170138; PMCID: PMC7070004.
-
The GSM BPN-15606 as a Potential Candidate for Preventative Therapy in Alzheimer's Disease. J Alzheimers Dis. 2020; 73(4):1541-1554. Prikhodko O, Rynearson KD, Sekhon T, Mante MM, Nguyen PD, Rissman RA, Tanzi RE, Wagner SL. PMID: 31958080.
-
APP-Mediated Signaling Prevents Memory Decline in Alzheimer's Disease Mouse Model. Cell Rep. 2019 04 30; 27(5):1345-1355.e6. Deyts C, Clutter M, Pierce N, Chakrabarty P, Ladd TB, Goddi A, Rosario AM, Cruz P, Vetrivel K, Wagner SL, Thinakaran G, Golde TE, Parent AT. PMID: 31042463; PMCID: PMC6508668.
-
Reduction of the expression of the late-onset Alzheimer's disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model. J Biol Chem. 2019 03 22; 294(12):4477-4487. Andrew RJ, De Rossi P, Nguyen P, Kowalski HR, Recupero AJ, Guerbette T, Krause SV, Rice RC, Laury-Kleintop L, Wagner SL, Thinakaran G. PMID: 30692199; PMCID: PMC6433054.
-
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons. Cell Stem Cell. 2019 03 07; 24(3):363-375.e9. van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB. PMID: 30686764; PMCID: PMC6414424.
-
Screening drug effects in patient-derived cancer cells links organoid responses to genome alterations. Mol Syst Biol. 2017 11 27; 13(11):955. Jabs J, Zickgraf FM, Park J, Wagner S, Jiang X, Jechow K, Kleinheinz K, Toprak UH, Schneider MA, Meister M, Spaich S, Sütterlin M, Schlesner M, Trumpp A, Sprick M, Eils R, Conrad C. PMID: 29180611; PMCID: PMC5731348.
-
Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 11 07; 114(45):E9665-E9674. Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, Thinakaran G. PMID: 29078331; PMCID: PMC5692556.
-
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1. EBioMedicine. 2017 Oct; 24:93-101. Raven F, Ward JF, Zoltowska KM, Wan Y, Bylykbashi E, Miller SJ, Shen X, Choi SH, Rynearson KD, Berezovska O, Wagner SL, Tanzi RE, Zhang C. PMID: 28919280; PMCID: PMC5652037.
-
Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.
-
Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme. Bioorg Med Chem Lett. 2016 08 15; 26(16):3928-37. Rynearson KD, Buckle RN, Barnes KD, Herr RJ, Mayhew NJ, Paquette WD, Sakwa SA, Nguyen PD, Johnson G, Tanzi RE, Wagner SL. PMID: 27426299.
-
Visualizing APP and BACE-1 approximation in neurons yields insight into the amyloidogenic pathway. Nat Neurosci. 2016 Jan; 19(1):55-64. Das U, Wang L, Ganguly A, Saikia JM, Wagner SL, Koo EH, Roy S. PMID: 26642089; PMCID: PMC4782935.
-
Combined Pan-RAF and MEK Inhibition Overcomes Multiple Resistance Mechanisms to Selective RAF Inhibitors. Mol Cancer Ther. 2015 Dec; 14(12):2700-11. Whittaker SR, Cowley GS, Wagner S, Luo F, Root DE, Garraway LA. PMID: 26351322; PMCID: PMC4674359.
-
γ-Secretase modulators reduce endogenous amyloid β42 levels in human neural progenitor cells without altering neuronal differentiation. FASEB J. 2015 Aug; 29(8):3335-41. D'Avanzo C, Sliwinski C, Wagner SL, Tanzi RE, Kim DY, Kovacs DM. PMID: 25903103; PMCID: PMC4511200.
-
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015; 10(2):e0118379. Weissmiller AM, Natera-Naranjo O, Reyna SM, Pearn ML, Zhao X, Nguyen P, Cheng S, Goldstein LS, Tanzi RE, Wagner SL, Mobley WC, Wu C. PMID: 25710492; PMCID: PMC4339551.
-
Effect of potent γ-secretase modulator in human neurons derived from multiple presenilin 1-induced pluripotent stem cell mutant carriers. JAMA Neurol. 2014 Dec; 71(12):1481-9. Liu Q, Waltz S, Woodruff G, Ouyang J, Israel MA, Herrera C, Sarsoza F, Tanzi RE, Koo EH, Ringman JM, Goldstein LS, Wagner SL, Yuan SH. PMID: 25285942; PMCID: PMC4374637.
-
A synthetic antibody fragment targeting nicastrin affects assembly and trafficking of γ-secretase. J Biol Chem. 2014 Dec 12; 289(50):34851-61. Zhang X, Hoey R, Koide A, Dolios G, Paduch M, Nguyen P, Wu X, Li Y, Wagner SL, Wang R, Koide S, Sisodia SS. PMID: 25352592; PMCID: PMC4263884.
-
A three-dimensional human neural cell culture model of Alzheimer's disease. Nature. 2014 Nov 13; 515(7526):274-8. Choi SH, Kim YH, Hebisch M, Sliwinski C, Lee S, D'Avanzo C, Chen H, Hooli B, Asselin C, Muffat J, Klee JB, Zhang C, Wainger BJ, Peitz M, Kovacs DM, Woolf CJ, Wagner SL, Tanzi RE, Kim DY. PMID: 25307057; PMCID: PMC4366007.
-
Soluble γ-secretase modulators selectively inhibit the production of the 42-amino acid amyloid β peptide variant and augment the production of multiple carboxy-truncated amyloid β species. Biochemistry. 2014 Feb 04; 53(4):702-13. Wagner SL, Zhang C, Cheng S, Nguyen P, Zhang X, Rynearson KD, Wang R, Li Y, Sisodia SS, Mobley WC, Tanzi RE. PMID: 24401146; PMCID: PMC3929337.
-
Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer disease β-amyloid peptide secretion. J Biol Chem. 2013 Sep 13; 288(37):26955-66. Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PD, Wagner SL, Villereal ML, Thinakaran G. PMID: 23902769; PMCID: PMC3772244.
-
Potential use of γ-secretase modulators in the treatment of Alzheimer disease. Arch Neurol. 2012 Oct; 69(10):1255-8. Wagner SL, Tanzi RE, Mobley WC, Galasko D. PMID: 22801784; PMCID: PMC3747667.
-
Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein. J Biol Chem. 2011 Jul 22; 286(29):26166-77. Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G. PMID: 21642424; PMCID: PMC3138254.
-
And four equals one: presenilin takes the gamma-secretase role by itself. Proc Natl Acad Sci U S A. 2010 Dec 14; 107(50):21236-7. Lessard CB, Wagner SL, Koo EH. PMID: 21135249; PMCID: PMC3003118.
-
Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of gamma-secretase activity toward amyloid precursor protein and other substrates. J Biol Chem. 2010 Dec 03; 285(49):38042-52. Gong P, Vetrivel KS, Nguyen PD, Meckler X, Cheng H, Kounnas MZ, Wagner SL, Parent AT, Thinakaran G. PMID: 20921220; PMCID: PMC2992238.
-
Modulation of gamma-secretase reduces beta-amyloid deposition in a transgenic mouse model of Alzheimer's disease. Neuron. 2010 Sep 09; 67(5):769-80. Kounnas MZ, Danks AM, Cheng S, Tyree C, Ackerman E, Zhang X, Ahn K, Nguyen P, Comer D, Mao L, Yu C, Pleynet D, Digregorio PJ, Velicelebi G, Stauderman KA, Comer WT, Mobley WC, Li YM, Sisodia SS, Tanzi RE, Wagner SL. PMID: 20826309; PMCID: PMC2947312.
-
NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. J Clin Invest. 2009 Dec; 119(12):3692-702. Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. PMID: 19907078; PMCID: PMC2786797.
-
Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity. Hum Mol Genet. 2009 Oct 15; 18(20):3987-96. Kim M, Suh J, Romano D, Truong MH, Mullin K, Hooli B, Norton D, Tesco G, Elliott K, Wagner SL, Moir RD, Becker KD, Tanzi RE. PMID: 19608551; PMCID: PMC2748890.
-
Molecular phylogeny and genetic identification of populations of two species of Feirana frogs (Amphibia: Anura, Ranidae, Dicroglossinae, Paini) endemic to China. Zoolog Sci. 2009 Jul; 26(7):500-9. Wang B, Jiang J, Xie F, Chen X, Dubois A, Liang G, Wagner S. PMID: 19663646.
-
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE. Am J Hum Genet. 2008 Nov; 83(5):623-32. Bertram L, Lange C, Mullin K, Parkinson M, Hsiao M, Hogan MF, Schjeide BM, Hooli B, Divito J, Ionita I, Jiang H, Laird N, Moscarillo T, Ohlsen KL, Elliott K, Wang X, Hu-Lince D, Ryder M, Murphy A, Wagner SL, Blacker D, Becker KD, Tanzi RE. PMID: 18976728; PMCID: PMC2668052.
-
Is alpha-T catenin (VR22) an Alzheimer's disease risk gene? J Med Genet. 2007 Jan; 44(1):e63. Bertram L, Mullin K, Parkinson M, Hsiao M, Moscarillo TJ, Wagner SL, Becker KD, Velicelebi G, Blacker D, Tanzi RE. PMID: 17209133; PMCID: PMC2597918.
-
Ubiquilin 1 modulates amyloid precursor protein trafficking and Abeta secretion. J Biol Chem. 2006 Oct 27; 281(43):32240-53. Hiltunen M, Lu A, Thomas AV, Romano DM, Kim M, Jones PB, Xie Z, Kounnas MZ, Wagner SL, Berezovska O, Hyman BT, Tesco G, Bertram L, Tanzi RE. PMID: 16945923.
-
STIM1, an essential and conserved component of store-operated Ca2+ channel function. J Cell Biol. 2005 May 09; 169(3):435-45. Roos J, DiGregorio PJ, Yeromin AV, Ohlsen K, Lioudyno M, Zhang S, Safrina O, Kozak JA, Wagner SL, Cahalan MD, Veliçelebi G, Stauderman KA. PMID: 15866891; PMCID: PMC2171946.
-
Family-based association between Alzheimer's disease and variants in UBQLN1. N Engl J Med. 2005 Mar 03; 352(9):884-94. Bertram L, Hiltunen M, Parkinson M, Ingelsson M, Lange C, Ramasamy K, Mullin K, Menon R, Sampson AJ, Hsiao MY, Elliott KJ, Velicelebi G, Moscarillo T, Hyman BT, Wagner SL, Becker KD, Blacker D, Tanzi RE. PMID: 15745979.
-
Reductions in beta-amyloid concentrations in vivo by the gamma-secretase inhibitors BMS-289948 and BMS-299897. Biochem Pharmacol. 2005 Feb 15; 69(4):689-98. Anderson JJ, Holtz G, Baskin PP, Turner M, Rowe B, Wang B, Kounnas MZ, Lamb BT, Barten D, Felsenstein K, McDonald I, Srinivasan K, Munoz B, Wagner SL. PMID: 15670587.
-
ATP effects on insulin-degrading enzyme are mediated primarily through its triphosphate moiety. J Biol Chem. 2004 Dec 24; 279(52):54216-20. Song ES, Juliano MA, Juliano L, Fried MG, Wagner SL, Hersh LB. PMID: 15494400.
-
Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase. Hum Mol Genet. 2004 Jan 15; 13(2):159-70. Jankowsky JL, Fadale DJ, Anderson J, Xu GM, Gonzales V, Jenkins NA, Copeland NG, Lee MK, Younkin LH, Wagner SL, Younkin SG, Borchelt DR. PMID: 14645205.
-
Genetic association of Alzheimer's disease with multiple polymorphisms in alpha-2-macroglobulin. Hum Mol Genet. 2003 Nov 01; 12(21):2765-76. Saunders AJ, Bertram L, Mullin K, Sampson AJ, Latifzai K, Basu S, Jones J, Kinney D, MacKenzie-Ingano L, Yu S, Albert MS, Moscarillo TJ, Go RC, Bassett SS, Daly MJ, Laird NM, Wang X, Velicelebi G, Wagner SL, Becker DK, Tanzi RE, Blacker D. PMID: 12966032.
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