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Anhedonia underlies the association between childhood unpredictability and adult PTSD symptoms: Evidence from three independent longitudinal cohorts. Psychol Med. 2026 Mar 05; 56:e68. Hunt C, Glynn LM, Davis EP, Baram TZ, Nievergelt CM, Castillo G, Cortes C, Chang CY, Baker D, Risbrough VB. PMID: 41782389.
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Hippocampal estrogen levels, receptor types, and epigenetics contribute to sex-specific memory vulnerabilities to concurrent acute stresses. Neuron. 2026 Feb 03. Hokenson RE, Rodríguez-Acevedo KL, Chen Y, Short AK, Samrari SA, Devireddy B, Jensen BJ, Winter JJ, Gall CM, Soma KK, Heller EA, Baram TZ. PMID: 41638202.
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Sex and Stress Govern the Function and Innervation of a Basolateral Amygdala to Nucleus Accumbens Corticotropin-Releasing Hormone/GABA-Expressing Projection. J Neurosci. 2026 01 14; 46(2). Taniguchi L, Goodpaster CM, Chen Y, de Carvalho GB, Birnie MT, Paul A, Chiang A, Chen LY, Baram TZ, DeNardo LA. PMID: 41271439; PMCID: PMC12809659.
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Early life stress induces social behavioral deficits and peripheral biomarker alterations in adolescence that perpetuate intergenerationally. bioRxiv. 2025 Dec 01. McGowan JC, Katzenstein JL, Chace NS, Wagner-Sanchez C, Okotore T, Ogunfowora T, Baram TZ, Folorunso OO, Carlezon WA. PMID: 41383766; PMCID: PMC12694602.
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A Combined Neuroanatomy, Ex Vivo Imaging, and Immunohistochemistry Defined MRI Mask for the Human Paraventricular Nucleus of the Thalamus. Hum Brain Mapp. 2025 Oct 01; 46(14):e70366. Tetzlaff MR, Leonard BT, Yassa MA, Baram TZ, Rasmussen JM. PMID: 40996431; PMCID: PMC12462541.
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Probing the roles of developmentally active neurons, in early-life adversity induced disruptions of adult behaviors. Front Neurosci. 2025; 19:1671495. Weber R, Mortazavi A, Baram TZ, Floriou-Servou A. PMID: 41064232; PMCID: PMC12500684.
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Sex-Specific Effects of Early-Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents. Biol Psychiatry Glob Open Sci. 2025 Nov; 5(6):100561. Davis EP, Leonard BT, Jirsaraie RJ, Keator DB, Small SL, Sandman CA, Risbrough VB, Stern HS, Glynn LM, Yassa MA, Baram TZ, Rasmussen JM. PMID: 41346393; PMCID: PMC12673399.
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A combined neuroanatomy, ex vivo imaging and immunohistochemistry defined MRI mask for the human paraventricular nucleus of the thalamus. bioRxiv. 2025 May 04. Tetzlaff MR, Leonard BT, Yassa MA, Baram TZ, Rasmussen JM. PMID: 40654773; PMCID: PMC12247677.
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Unexpected mechanisms of sex-specific memory vulnerabilities to acute traumatic stress. bioRxiv. 2025 Mar 26. Hokenson RE, Rodríguez-Acevedo KL, Chen Y, Short AK, Samrari SA, Devireddy B, Jensen BJ, Winter JJ, Gall CM, Soma KK, Heller EA, Baram TZ. PMID: 40196630; PMCID: PMC11974907.
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The evolving neurobiology of early-life stress. Neuron. 2025 May 21; 113(10):1474-1490. Birnie MT, Baram TZ. PMID: 40101719; PMCID: PMC12097948.
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Contribution of an under-recognized adversity to child health risk: large-scale, population-based ACEs screening. medRxiv. 2025 Feb 05. Glynn LM, Liu SR, Golden C, Weiss M, Lucas CT, Cooper DM, Ehwerhemuepha L, Stern HS, Baram TZ. PMID: 39974059; PMCID: PMC11838625.
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Targeting corticotropin-releasing hormone receptor type 1 (Crhr1) neurons: validating the specificity of a novel transgenic Crhr1-FlpO mouse. Brain Struct Funct. 2024 Dec 18; 230(1):12. Hardy M, Chen Y, Baram TZ, Justice NJ. PMID: 39692887; PMCID: PMC11655595.
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Sex-and Stress-Dependent Plasticity of a Corticotropin Releasing Hormone / GABA Projection from the Basolateral Amygdala to Nucleus Accumbens that Mediates Reward Behaviors. bioRxiv. 2024 Dec 01. Taniguchi L, Goodpaster CM, de Carvalho GB, Birnie MT, Chen Y, Chen LY, Baram TZ, DeNardo LA. PMID: 39651305; PMCID: PMC11623690.
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PTEN deletion in the adult dentate gyrus induces epilepsy. Neurobiol Dis. 2024 12; 203:106736. Yonan JM, Chen KD, Baram TZ, Steward O. PMID: 39547478; PMCID: PMC11756830.
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Targeting Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Neurons: Validating the Specificity of a Novel Transgenic Crhr1-FlpO Mouse. bioRxiv. 2024 Nov 09. Hardy M, Chen Y, Baram TZ, Justice NJ. PMID: 39574624; PMCID: PMC11580988.
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Sex-Specific Effects of Early Life Unpredictability on Hippocampal and Amygdala Responses to Novelty in Adolescents. bioRxiv. 2024 Sep 21. Davis EP, Leonard BT, Jirsaraie RJ, Keator DB, Small SL, Sandman CA, Risbrough VB, Stern HS, Glynn LM, Yassa MA, Baram TZ, Rasmussen JM. PMID: 39345394; PMCID: PMC11429980.
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Opioid drug seeking after early-life adversity: a role for delta opioid receptors. Addict Neurosci. 2024 Dec; 13. Levis SC, Birnie MT, Xie Y, Kamei N, Kulkarni PV, Montesinos JS, Perrone CR, Cahill CM, Baram TZ, Mahler SV. PMID: 40995017; PMCID: PMC12456463.
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Enduring memory consequences of early-life stress / adversity: Structural, synaptic, molecular and epigenetic mechanisms. Neurobiol Stress. 2024 Nov; 33:100669. Baram TZ, Birnie MT. PMID: 39309367; PMCID: PMC11415888.
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PTEN DELETION IN THE ADULT DENTATE GYRUS INDUCES EPILEPSY. bioRxiv. 2024 Aug 09. Yonan JM, Chen KD, Baram TZ, Steward O. PMID: 39149280; PMCID: PMC11326251.
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Computational Modeling Differentiates Learning Rate From Reward Sensitivity Deficits Produced by Early-Life Adversity in a Rodent Touchscreen Probabilistic Reward Task. Biol Psychiatry Glob Open Sci. 2024 Nov; 4(6):100362. Kangas BD, Ang YS, Short AK, Baram TZ, Pizzagalli DA. PMID: 39262818; PMCID: PMC11387686.
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Individual longitudinal changes in DNA-methylome identify signatures of early-life adversity and correlate with later outcome. Neurobiol Stress. 2024 Jul; 31:100652. Short AK, Weber R, Kamei N, Wilcox Thai C, Arora H, Mortazavi A, Stern HS, Glynn L, Baram TZ. PMID: 38962694; PMCID: PMC11219970.
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Inhibition of Neuron-Restrictive Silencing Factor (REST/NRSF) Chromatin Binding Attenuates Epileptogenesis. eNeuro. 2024 May; 11(5). Hall AM, Kamei N, Shao M, Mun HS, Chen K, Chen Y, Baram TZ. PMID: 38641413; PMCID: PMC11103648.
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Paraventricular Thalamus Neuronal Ensembles Encode Early-life Adversity and Mediate the Consequent Sex-dependent Disruptions of Adult Reward Behaviors. bioRxiv. 2024 Apr 29. Kooiker CL, Birnie MT, Floriou-Servou A, Ding Q, Thiagarajan N, Hardy M, Baram TZ. PMID: 38746198; PMCID: PMC11092514.
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Infant hedonic/anhedonic processing index (HAPI-Infant): Assessing infant anhedonia and its prospective association with adolescent depressive symptoms. J Affect Disord. 2024 05 01; 352:281-287. Irwin JL, Davis EP, Sandman CA, Baram TZ, Stern HS, Glynn LM. PMID: 38307131; PMCID: PMC11874644.
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Childhood unpredictability is associated with increased risk for long- and short-term depression and anhedonia symptoms following combat deployment. J Mood Anxiety Disord. 2024 Jun; 6. Hunt C, Vinograd M, Glynn LM, Davis EP, Baram TZ, Stern H, Nievergelt C, Cuccurazzu B, Napan C, Delmar D, Baker DG, Risborough VB. PMID: 38911511; PMCID: PMC11192232.
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Within-subject changes in methylome profile identify individual signatures of early-life adversity, with a potential to predict neuropsychiatric outcome. bioRxiv. 2023 Dec 19. Short AK, Weber R, Kamei N, Thai CW, Arora H, Mortazavi A, Stern HS, Glynn L, Baram TZ. PMID: 38187766; PMCID: PMC10769190.
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Across ages and places: Unpredictability of maternal sensory signals and child internalizing behaviors. J Affect Disord. 2024 02 15; 347:557-567. Aran Ö, Swales DA, Bailey NA, Korja R, Holmberg E, Eskola E, Nolvi S, Perasto L, Nordenswan E, Karlsson H, Karlsson L, Sandman CA, Stern HS, Baram TZ, Glynn LM, Davis EP. PMID: 38007106; PMCID: PMC10843791.
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Prenatal Exposure to Maternal Mood Entropy Is Associated With a Weakened and Inflexible Salience Network in Adolescence. Biol Psychiatry Cogn Neurosci Neuroimaging. 2024 02; 9(2):207-216. Jirsaraie RJ, Palma AM, Small SL, Sandman CA, Davis EP, Baram TZ, Stern H, Glynn LM, Yassa MA. PMID: 37611745; PMCID: PMC10881896.
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Spatial learning impairments and discoordination of entorhinal-hippocampal circuit coding following prolonged febrile seizures. Hippocampus. 2023 08; 33(8):970-992. Kloc ML, Chen Y, Daglian JM, Holmes GL, Baram TZ, Barry JM. PMID: 37096324; PMCID: PMC10529121.
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Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice. Nat Commun. 2023 02 25; 14(1):1088. Birnie MT, Short AK, de Carvalho GB, Taniguchi L, Gunn BG, Pham AL, Itoga CA, Xu X, Chen LY, Mahler SV, Chen Y, Baram TZ. PMID: 36841826; PMCID: PMC9968307.
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Seeking the Amygdala: Novel Use of Diffusion Tensor Imaging to Delineate the Basolateral Amygdala. Biomedicines. 2023 Feb 13; 11(2). Obenaus A, Kinney-Lang E, Jullienne A, Haddad E, Wendel KM, Shereen AD, Solodkin A, Dunn JF, Baram TZ. PMID: 36831071; PMCID: PMC9953214.
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Genetic Tagging Uncovers a Robust, Selective Activation of the Thalamic Paraventricular Nucleus by Adverse Experiences Early in Life. Biol Psychiatry Glob Open Sci. 2023 Oct; 3(4):746-755. Kooiker CL, Chen Y, Birnie MT, Baram TZ. PMID: 37881549; PMCID: PMC10593902.
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Influence of early-life adversity on responses to acute and chronic ethanol in female mice. Alcohol Clin Exp Res (Hoboken). 2023 02; 47(2):336-347. Okhuarobo A, Angelo M, Bolton JL, Lopez C, Igbe I, Baram TZ, Contet C. PMID: 36462937; PMCID: PMC9992294.
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Exposure to unpredictability and mental health: Validation of the brief version of the Questionnaire of Unpredictability in Childhood (QUIC-5) in English and Spanish. Front Psychol. 2022; 13:971350. Lindert NG, Maxwell MY, Liu SR, Stern HS, Baram TZ, Poggi Davis E, Risbrough VB, Baker DG, Nievergelt CM, Glynn LM. PMID: 36438371; PMCID: PMC9682115.
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Early life exposure to unpredictable parental sensory signals shapes cognitive development across three species. Front Behav Neurosci. 2022; 16:960262. Davis EP, McCormack K, Arora H, Sharpe D, Short AK, Bachevalier J, Glynn LM, Sandman CA, Stern HS, Sanchez M, Baram TZ. PMID: 36338881; PMCID: PMC9630745.
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Sex-dependent effects of multiple acute concurrent stresses on memory: a role for hippocampal estrogens. Front Behav Neurosci. 2022; 16:984494. Hokenson RE, Alam YH, Short AK, Jung S, Jang C, Baram TZ. PMID: 36160685; PMCID: PMC9492881.
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Resource scarcity but not maternal separation provokes unpredictable maternal care sequences in mice and both upregulate Crh-associated gene expression in the amygdala. Neurobiol Stress. 2022 Sep; 20:100484. Demaestri C, Gallo M, Mazenod E, Hong AT, Arora H, Short AK, Stern H, Baram TZ, Bath KG. PMID: 36120094; PMCID: PMC9475315.
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Why do mothers never stop grieving for their deceased children? Enduring alterations of brain connectivity and function. Front Hum Neurosci. 2022; 16:925242. Kark SM, Adams JG, Sathishkumar M, Granger SJ, McMillan L, Baram TZ, Yassa MA. PMID: 36118972; PMCID: PMC9478601.
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Vascular topology and blood flow are acutely impacted by experimental febrile status epilepticus. J Cereb Blood Flow Metab. 2023 01; 43(1):84-98. Salehi A, Salari S, Jullienne A, Daglian J, Chen K, Baram TZ, Obenaus A. PMID: 35912523; PMCID: PMC9875348.
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Enduring disruption of reward and stress circuit activities by early-life adversity in male rats. Transl Psychiatry. 2022 06 16; 12(1):251. Levis SC, Birnie MT, Bolton JL, Perrone CR, Montesinos JS, Baram TZ, Mahler SV. PMID: 35705547; PMCID: PMC9200783.
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Principles of emotional brain circuit maturation. Science. 2022 06 03; 376(6597):1055-1056. Birnie MT, Baram TZ. PMID: 35653483; PMCID: PMC9840462.
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Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses. Cell Rep. 2022 03 29; 38(13):110600. Bolton JL, Short AK, Othy S, Kooiker CL, Shao M, Gunn BG, Beck J, Bai X, Law SM, Savage JC, Lambert JJ, Belelli D, Tremblay MÈ, Cahalan MD, Baram TZ. PMID: 35354026; PMCID: PMC9014810.
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Developmental Trajectories of Anhedonia in Preclinical Models. Curr Top Behav Neurosci. 2022; 58:23-41. Birnie MT, Levis SC, Mahler SV, Baram TZ. PMID: 35156184; PMCID: PMC10226722.
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Single-Cell Transcriptional Changes in Hypothalamic Corticotropin-Releasing Factor-Expressing Neurons After Early-Life Adversity Inform Enduring Alterations in Vulnerabilities to Stress. Biol Psychiatry Glob Open Sci. 2023 Jan; 3(1):99-109. Short AK, Thai CW, Chen Y, Kamei N, Pham AL, Birnie MT, Bolton JL, Mortazavi A, Baram TZ. PMID: 36712559; PMCID: PMC9874075.
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A cross-species assay demonstrates that reward responsiveness is enduringly impacted by adverse, unpredictable early-life experiences. Neuropsychopharmacology. 2022 02; 47(3):767-775. Kangas BD, Short AK, Luc OT, Stern HS, Baram TZ, Pizzagalli DA. PMID: 34921225; PMCID: PMC8682039.
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Early life adversity in male mice sculpts reward circuits. Neurobiol Stress. 2021 Nov; 15:100409. Wendel KM, Short AK, Noarbe BP, Haddad E, Palma AM, Yassa MA, Baram TZ, Obenaus A. PMID: 34746338; PMCID: PMC8554344.
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Recurrent febrile seizures alter intrahippocampal temporal coordination but do not cause spatial learning impairments. Epilepsia. 2021 12; 62(12):3117-3130. Kloc ML, Daglian JM, Holmes GL, Baram TZ, Barry JM. PMID: 34562024; PMCID: PMC8900210.
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Corrigendum: Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI. Front Integr Neurosci. 2021; 15:724071. Kark SM, Birnie MT, Baram TZ, Yassa MA. PMID: 34381338; PMCID: PMC8351810.
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The Paraventricular Thalamus: A Potential Sensor and Integrator of Emotionally Salient Early-Life Experiences. Front Behav Neurosci. 2021; 15:673162. Kooiker CL, Birnie MT, Baram TZ. PMID: 34079442; PMCID: PMC8166219.
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Neurodevelopmental origins of substance use disorders: Evidence from animal models of early-life adversity and addiction. Eur J Neurosci. 2022 05; 55(9-10):2170-2195. Levis SC, Baram TZ, Mahler SV. PMID: 33825217; PMCID: PMC8494863.
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Functional Connectivity of the Human Paraventricular Thalamic Nucleus: Insights From High Field Functional MRI. Front Integr Neurosci. 2021; 15:662293. Kark SM, Birnie MT, Baram TZ, Yassa MA. PMID: 33967711; PMCID: PMC8096909.
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Multiple Disruptions of Glial-Neuronal Networks in Epileptogenesis That Follows Prolonged Febrile Seizures. Front Neurol. 2021; 12:615802. Brennan GP, Garcia-Curran MM, Patterson KP, Luo R, Baram TZ. PMID: 33679583; PMCID: PMC7930821.
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The Developmental Origins of Opioid Use Disorder and Its Comorbidities. Front Hum Neurosci. 2021; 15:601905. Levis SC, Mahler SV, Baram TZ. PMID: 33643011; PMCID: PMC7904686.
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Augmented seizure susceptibility and hippocampal epileptogenesis in a translational mouse model of febrile status epilepticus. Epilepsia. 2021 03; 62(3):647-658. Chen KD, Hall AM, Garcia-Curran MM, Sanchez GA, Daglian J, Luo R, Baram TZ. PMID: 33475157; PMCID: PMC8817061.
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A predictable home environment may protect child mental health during the COVID-19 pandemic. Neurobiol Stress. 2021 May; 14:100291. Glynn LM, Davis EP, Luby JL, Baram TZ, Sandman CA. PMID: 33532520; PMCID: PMC7823041.
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Aberrant Maturation of the Uncinate Fasciculus Follows Exposure to Unpredictable Patterns of Maternal Signals. J Neurosci. 2021 02 10; 41(6):1242-1250. Granger SJ, Glynn LM, Sandman CA, Small SL, Obenaus A, Keator DB, Baram TZ, Stern H, Yassa MA, Davis EP. PMID: 33328295; PMCID: PMC7888232.
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Unexpected Transcriptional Programs Contribute to Hippocampal Memory Deficits and Neuronal Stunting after Early-Life Adversity. Cell Rep. 2020 12 15; 33(11):108511. Bolton JL, Schulmann A, Garcia-Curran MM, Regev L, Chen Y, Kamei N, Shao M, Singh-Taylor A, Jiang S, Noam Y, Molet J, Mortazavi A, Baram TZ. PMID: 33326786; PMCID: PMC7817243.
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Unexpected Role of Physiological Estrogen in Acute Stress-Induced Memory Deficits. J Neurosci. 2021 01 27; 41(4):648-662. Hokenson RE, Short AK, Chen Y, Pham AL, Adams ET, Bolton JL, Swarup V, Gall CM, Baram TZ. PMID: 33262247; PMCID: PMC7842761.
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A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity. Neurobiol Stress. 2020 Nov; 13:100269. Okhuarobo A, Bolton JL, Igbe I, Zorrilla EP, Baram TZ, Contet C. PMID: 33344722; PMCID: PMC7739069.
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Neurodevelopmental Optimization after Early-Life Adversity: Cross-Species Studies to Elucidate Sensitive Periods and Brain Mechanisms to Inform Early Intervention. Trends Neurosci. 2020 10; 43(10):744-751. Luby JL, Baram TZ, Rogers CE, Barch DM. PMID: 32863044; PMCID: PMC7530018.
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Multiple Simultaneous Acute Stresses in Mice: Single or Repeated Induction. Bio Protoc. 2020 Aug 05; 10(15):e3699. Hokenson RE, Oijala M, Short AK, Bolton JL, Chen Y, Molet J, Maras PM, Baram TZ, Lur G. PMID: 33659365; PMCID: PMC7842319.
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Prenatal maternal mood entropy is associated with child neurodevelopment. Emotion. 2021 Apr; 21(3):489-498. Howland MA, Sandman CA, Davis EP, Stern HS, Phelan M, Baram TZ, Glynn LM. PMID: 32202848; PMCID: PMC10491461.
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Unpredictable maternal behavior is associated with a blunted infant cortisol response. Dev Psychobiol. 2020 09; 62(6):882-888. Noroña-Zhou AN, Morgan A, Glynn LM, Sandman CA, Baram TZ, Stern HS, Davis EP. PMID: 32115696; PMCID: PMC7822564.
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Intra-individual changes in methylome profiles: an epigenetic 'scar' of early-life adversity? Neuropsychopharmacology. 2020 01; 45(1):218. Mortazavi A, Baram TZ. PMID: 31471558; PMCID: PMC6879488.
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Plasticity of the Reward Circuitry After Early-Life Adversity: Mechanisms and Significance. Biol Psychiatry. 2020 05 15; 87(10):875-884. Birnie MT, Kooiker CL, Short AK, Bolton JL, Chen Y, Baram TZ. PMID: 32081365; PMCID: PMC7211119.
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On the early life origins of vulnerability to opioid addiction. Mol Psychiatry. 2021 08; 26(8):4409-4416. Levis SC, Bentzley BS, Molet J, Bolton JL, Perrone CR, Baram TZ, Mahler SV. PMID: 31822817; PMCID: PMC7282971.
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Dexamethasone Attenuates Hyperexcitability Provoked by Experimental Febrile Status Epilepticus. eNeuro. 2019 Nov/Dec; 6(6). Garcia-Curran MM, Hall AM, Patterson KP, Shao M, Eltom N, Chen K, Dubé CM, Baram TZ. PMID: 31685676; PMCID: PMC6860985.
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Blocking CRH receptors in adults mitigates age-related memory impairments provoked by early-life adversity. Neuropsychopharmacology. 2020 02; 45(3):515-523. Short AK, Maras PM, Pham AL, Ivy AS, Baram TZ. PMID: 31698409; PMCID: PMC6969076.
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Early-life adversity and neurological disease: age-old questions and novel answers. Nat Rev Neurol. 2019 11; 15(11):657-669. Short AK, Baram TZ. PMID: 31530940; PMCID: PMC7261498.
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Across continents and demographics, unpredictable maternal signals are associated with children's cognitive function. EBioMedicine. 2019 Aug; 46:256-263. Davis EP, Korja R, Karlsson L, Glynn LM, Sandman CA, Vegetabile B, Kataja EL, Nolvi S, Sinervä E, Pelto J, Karlsson H, Stern HS, Baram TZ. PMID: 31362905; PMCID: PMC6710909.
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Construction and disruption of spatial memory networks during development. Learn Mem. 2019 07; 26(7):206-218. Baram TZ, Donato F, Holmes GL. PMID: 31209115; PMCID: PMC6581006.
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Intra-individual methylomics detects the impact of early-life adversity. Life Sci Alliance. 2019 04; 2(2). Jiang S, Kamei N, Bolton JL, Ma X, Stern HS, Baram TZ, Mortazavi A. PMID: 30936186; PMCID: PMC6445397.
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New viral-genetic mapping uncovers an enrichment of corticotropin-releasing hormone-expressing neuronal inputs to the nucleus accumbens from stress-related brain regions. J Comp Neurol. 2019 10 15; 527(15):2474-2487. Itoga CA, Chen Y, Fateri C, Echeverry PA, Lai JM, Delgado J, Badhon S, Short A, Baram TZ, Xu X. PMID: 30861133; PMCID: PMC6688927.
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Programming of Stress-Sensitive Neurons and Circuits by Early-Life Experiences. Front Behav Neurosci. 2019; 13:30. Bolton JL, Short AK, Simeone KA, Daglian J, Baram TZ. PMID: 30833892; PMCID: PMC6387907.
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The influence of unpredictable, fragmented parental signals on the developing brain. Front Neuroendocrinol. 2019 04; 53:100736. Glynn LM, Baram TZ. PMID: 30711600; PMCID: PMC6776465.
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Measuring novel antecedents of mental illness: the Questionnaire of Unpredictability in Childhood. Neuropsychopharmacology. 2019 04; 44(5):876-882. Glynn LM, Stern HS, Howland MA, Risbrough VB, Baker DG, Nievergelt CM, Baram TZ, Davis EP. PMID: 30470840; PMCID: PMC6461958.
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Hyper-diversity of CRH interneurons in mouse hippocampus. Brain Struct Funct. 2019 Mar; 224(2):583-598. Gunn BG, Sanchez GA, Lynch G, Baram TZ, Chen Y. PMID: 30456559; PMCID: PMC6420853.
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Epilepsy-predictive magnetic resonance imaging changes following experimental febrile status epilepticus: Are they translatable to the clinic? Epilepsia. 2018 11; 59(11):2005-2018. Curran MM, Haddad E, Patterson KP, Choy M, Dubé CM, Baram TZ, Obenaus A. PMID: 30256385; PMCID: PMC6217797.
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Parental smartphone use and children's mental outcomes: a neuroscience perspective. Neuropsychopharmacology. 2019 01; 44(2):239-240. Baram TZ, Bolton JL. PMID: 30181594; PMCID: PMC6300543.
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Experience-dependent neuroplasticity of the developing hypothalamus: integrative epigenomic approaches. Epigenetics. 2018; 13(3):318-330. Vogel Ciernia A, Laufer BI, Dunaway KW, Mordaunt CE, Coulson RL, Totah TS, Stolzenberg DS, Frahm JC, Singh-Taylor A, Baram TZ, LaSalle JM, Yasui DH. PMID: 29613827; PMCID: PMC5997166.
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Network specialization during adolescence: Hippocampal effective connectivity in boys and girls. Neuroimage. 2018 07 15; 175:402-412. Riley JD, Chen EE, Winsell J, Davis EP, Glynn LM, Baram TZ, Sandman CA, Small SL, Solodkin A. PMID: 29649560; PMCID: PMC5978413.
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Cortical Thinning and Neuropsychiatric Outcomes in Children Exposed to Prenatal Adversity: A Role for Placental CRH? Am J Psychiatry. 2018 05 01; 175(5):471-479. Sandman CA, Curran MM, Davis EP, Glynn LM, Head K, Baram TZ. PMID: 29495899; PMCID: PMC5930042.
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Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. Neurobiol Stress. 2018 Feb; 8:57-67. Bolton JL, Ruiz CM, Rismanchi N, Sanchez GA, Castillo E, Huang J, Cross C, Baram TZ, Mahler SV. PMID: 29888304; PMCID: PMC5991313.
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Prenatal maternal mood patterns predict child temperament and adolescent mental health. J Affect Disord. 2018 03 01; 228:83-90. Glynn LM, Howland MA, Sandman CA, Davis EP, Phelan M, Baram TZ, Stern HS. PMID: 29241049; PMCID: PMC10387303.
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Stress and Seizures: Space, Time and Hippocampal Circuits. Trends Neurosci. 2017 11; 40(11):667-679. Gunn BG, Baram TZ. PMID: 28916130; PMCID: PMC5660662.
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Exposure to unpredictable maternal sensory signals influences cognitive development across species. Proc Natl Acad Sci U S A. 2017 09 26; 114(39):10390-10395. Davis EP, Stout SA, Molet J, Vegetabile B, Glynn LM, Sandman CA, Heins K, Stern H, Baram TZ. PMID: 28893979; PMCID: PMC5625898.
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Anhedonia Following Early-Life Adversity Involves Aberrant Interaction of Reward and Anxiety Circuits and Is Reversed by Partial Silencing of Amygdala Corticotropin-Releasing Hormone Gene. Biol Psychiatry. 2018 Jan 15; 83(2):137-147. Bolton JL, Molet J, Regev L, Chen Y, Rismanchi N, Haddad E, Yang DZ, Obenaus A, Baram TZ. PMID: 29033027; PMCID: PMC5723546.
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The Endogenous Stress Hormone CRH Modulates Excitatory Transmission and Network Physiology in Hippocampus. Cereb Cortex. 2017 08 01; 27(8):4182-4198. Gunn BG, Cox CD, Chen Y, Frotscher M, Gall CM, Baram TZ, Lynch G. PMID: 28460009; PMCID: PMC6248689.
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Chronic early life stress induced by limited bedding and nesting (LBN) material in rodents: critical considerations of methodology, outcomes and translational potential. Stress. 2017 09; 20(5):421-448. Walker CD, Bath KG, Joels M, Korosi A, Larauche M, Lucassen PJ, Morris MJ, Raineki C, Roth TL, Sullivan RM, Taché Y, Baram TZ. PMID: 28617197; PMCID: PMC5705407.
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Neuroinflammation imaging markers for epileptogenesis. Epilepsia. 2017 07; 58 Suppl 3:11-19. Koepp MJ, Årstad E, Bankstahl JP, Dedeurwaerdere S, Friedman A, Potschka H, Ravizza T, Theodore WH, Baram TZ. PMID: 28675560.
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Abnormal dendritic maturation of developing cortical neurons exposed to corticotropin releasing hormone (CRH): Insights into effects of prenatal adversity? PLoS One. 2017; 12(6):e0180311. Curran MM, Sandman CA, Poggi Davis E, Glynn LM, Baram TZ. PMID: 28658297; PMCID: PMC5489219.
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New insights into early-life stress and behavioral outcomes. Curr Opin Behav Sci. 2017 Apr; 14:133-139. Bolton JL, Molet J, Ivy A, Baram TZ. PMID: 28413813; PMCID: PMC5389892.
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Enduring Memory Impairments Provoked by Developmental Febrile Seizures Are Mediated by Functional and Structural Effects of Neuronal Restrictive Silencing Factor. J Neurosci. 2017 04 05; 37(14):3799-3812. Patterson KP, Barry JM, Curran MM, Singh-Taylor A, Brennan G, Rismanchi N, Page M, Noam Y, Holmes GL, Baram TZ. PMID: 28275159; PMCID: PMC5394897.
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The Role of Sirt1 in Epileptogenesis. eNeuro. 2017 Jan-Feb; 4(1). Hall AM, Brennan GP, Nguyen TM, Singh-Taylor A, Mun HS, Sargious MJ, Baram TZ. PMID: 28197553; PMCID: PMC5301079.
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NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience. Mol Psychiatry. 2018 03; 23(3):648-657. Singh-Taylor A, Molet J, Jiang S, Korosi A, Bolton JL, Noam Y, Simeone K, Cope J, Chen Y, Mortazavi A, Baram TZ. PMID: 28070121; PMCID: PMC5503824.
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Converging, Synergistic Actions of Multiple Stress Hormones Mediate Enduring Memory Impairments after Acute Simultaneous Stresses. J Neurosci. 2016 11 02; 36(44):11295-11307. Chen Y, Molet J, Lauterborn JC, Trieu BH, Bolton JL, Patterson KP, Gall CM, Lynch G, Baram TZ. PMID: 27807170; PMCID: PMC5148245.
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MRI uncovers disrupted hippocampal microstructure that underlies memory impairments after early-life adversity. Hippocampus. 2016 12; 26(12):1618-1632. Molet J, Maras PM, Kinney-Lang E, Harris NG, Rashid F, Ivy AS, Solodkin A, Obenaus A, Baram TZ. PMID: 27657911; PMCID: PMC5452614.
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Temporal Coordination of Hippocampal Neurons Reflects Cognitive Outcome Post-febrile Status Epilepticus. EBioMedicine. 2016 May; 7:175-90. Barry JM, Sakkaki S, Barriere SJ, Patterson KP, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. PMID: 27322471; PMCID: PMC4909381.
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Dual and Opposing Roles of MicroRNA-124 in Epilepsy Are Mediated through Inflammatory and NRSF-Dependent Gene Networks. Cell Rep. 2016 Mar 15; 14(10):2402-12. Brennan GP, Dey D, Chen Y, Patterson KP, Magnetta EJ, Hall AM, Dube CM, Mei YT, Baram TZ. PMID: 26947066; PMCID: PMC4794429.
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Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels in Epilepsy. Cold Spring Harb Perspect Med. 2016 Mar 01; 6(3):a022384. Brennan GP, Baram TZ, Poolos NP. PMID: 26931806; PMCID: PMC4772079.
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Fragmentation and high entropy of neonatal experience predict adolescent emotional outcome. Transl Psychiatry. 2016 Jan 05; 6:e702. Molet J, Heins K, Zhuo X, Mei YT, Regev L, Baram TZ, Stern H. PMID: 26731439; PMCID: PMC5068874.
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Rapid, Coordinate Inflammatory Responses after Experimental Febrile Status Epilepticus: Implications for Epileptogenesis. eNeuro. 2015 Sep-Oct; 2(5). Patterson KP, Brennan GP, Curran M, Kinney-Lang E, Dubé C, Rashid F, Ly C, Obenaus A, Baram TZ. PMID: 26730400; PMCID: PMC4699830.
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Diversity of Reporter Expression Patterns in Transgenic Mouse Lines Targeting Corticotropin-Releasing Hormone-Expressing Neurons. Endocrinology. 2015 Dec; 156(12):4769-80. Chen Y, Molet J, Gunn BG, Ressler K, Baram TZ. PMID: 26402844; PMCID: PMC4655217.
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Short-term modern life-like stress exacerbates Aβ-pathology and synapse loss in 3xTg-AD mice. J Neurochem. 2015 Sep; 134(5):915-26. Baglietto-Vargas D, Chen Y, Suh D, Ager RR, Rodriguez-Ortiz CJ, Medeiros R, Myczek K, Green KN, Baram TZ, LaFerla FM. PMID: 26077803; PMCID: PMC4792118.
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Toward Understanding How Early-Life Stress Reprograms Cognitive and Emotional Brain Networks. Neuropsychopharmacology. 2016 Jan; 41(1):197-206. Chen Y, Baram TZ. PMID: 26105143; PMCID: PMC4677123.
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T2 relaxation time post febrile status epilepticus predicts cognitive outcome. Exp Neurol. 2015 Jul; 269:242-52. Barry JM, Choy M, Dube C, Robbins A, Obenaus A, Lenck-Santini PP, Scott RC, Baram TZ, Holmes GL. PMID: 25939697; PMCID: PMC4446141.
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Synaptic rewiring of stress-sensitive neurons by early-life experience: a mechanism for resilience? Neurobiol Stress. 2015 Jan 01; 1:109-115. Singh-Taylor A, Korosi A, Molet J, Gunn BG, Baram TZ. PMID: 25530985; PMCID: PMC4267062.
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Hyper-excitability and epilepsy generated by chronic early-life stress. Neurobiol Stress. 2015; 2:10-19. Dubé CM, Molet J, Singh-Taylor A, Ivy A, Maras PM, Baram TZ. PMID: 25884016; PMCID: PMC4395864.
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The transcription factor NRSF contributes to epileptogenesis by selective repression of a subset of target genes. Elife. 2014 Aug 12; 3:e01267. McClelland S, Brennan GP, Dubé C, Rajpara S, Iyer S, Richichi C, Bernard C, Baram TZ. PMID: 25117540; PMCID: PMC4129437.
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Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multi-modal stress. Mol Psychiatry. 2014 Jul; 19(7):745. Maras PM, Molet J, Chen Y, Rice C, Ji SG, Solodkin A, Baram TZ. PMID: 24969262.
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A novel, noninvasive, predictive epilepsy biomarker with clinical potential. J Neurosci. 2014 Jun 25; 34(26):8672-84. Choy M, Dubé CM, Patterson K, Barnes SR, Maras P, Blood AB, Hasso AN, Obenaus A, Baram TZ. PMID: 24966369; PMCID: PMC4069350.
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Naturalistic rodent models of chronic early-life stress. Dev Psychobiol. 2014 Dec; 56(8):1675-88. Molet J, Maras PM, Avishai-Eliner S, Baram TZ. PMID: 24910169; PMCID: PMC4777289.
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Origins of temporal lobe epilepsy: febrile seizures and febrile status epilepticus. Neurotherapeutics. 2014 Apr; 11(2):242-50. Patterson KP, Baram TZ, Shinnar S. PMID: 24604424; PMCID: PMC3996115.
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Preferential loss of dorsal-hippocampus synapses underlies memory impairments provoked by short, multimodal stress. Mol Psychiatry. 2014 Jul; 19(7):811-22. Maras PM, Molet J, Chen Y, Rice C, Ji SG, Solodkin A, Baram TZ. PMID: 24589888; PMCID: PMC4074447.
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Filamin A promotes dynamin-dependent internalization of hyperpolarization-activated cyclic nucleotide-gated type 1 (HCN1) channels and restricts Ih in hippocampal neurons. J Biol Chem. 2014 Feb 28; 289(9):5889-903. Noam Y, Ehrengruber MU, Koh A, Feyen P, Manders EM, Abbott GW, Wadman WJ, Baram TZ. PMID: 24403084; PMCID: PMC3937658.
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Inflammatory processes, febrile seizures, and subsequent epileptogenesis. Epilepsy Curr. 2014 Jan; 14(1 Suppl):15-22. Choy M, Dubé CM, Ehrengruber M, Baram TZ. PMID: 24955071; PMCID: PMC3966647.
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Novel HCN2 mutation contributes to febrile seizures by shifting the channel's kinetics in a temperature-dependent manner. PLoS One. 2013; 8(12):e80376. Nakamura Y, Shi X, Numata T, Mori Y, Inoue R, Lossin C, Baram TZ, Hirose S. PMID: 24324597; PMCID: PMC3851455.
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NMDA receptor activation and calpain contribute to disruption of dendritic spines by the stress neuropeptide CRH. J Neurosci. 2013 Oct 23; 33(43):16945-60. Andres AL, Regev L, Phi L, Seese RR, Chen Y, Gall CM, Baram TZ. PMID: 24155300; PMCID: PMC3807024.
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Corticotropin releasing factor in neuroplasticity. Front Neuroendocrinol. 2014 Apr; 35(2):171-9. Regev L, Baram TZ. PMID: 24145148; PMCID: PMC3965598.
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How Does a Neuron "know" to Modulate Its Epigenetic Machinery in Response to Early-Life Environment/Experience? Front Psychiatry. 2013; 4:89. Karsten CA, Baram TZ. PMID: 23966959; PMCID: PMC3744051.
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Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus. Stress. 2014 Jan; 17(1):39-50. Cope JL, Regev L, Chen Y, Korosi A, Rice CJ, Ji S, Rogge GA, Wood MA, Baram TZ. PMID: 23768074; PMCID: PMC3869921.
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The neuron-specific chromatin regulatory subunit BAF53b is necessary for synaptic plasticity and memory. Nat Neurosci. 2013 May; 16(5):552-61. Vogel-Ciernia A, Matheos DP, Barrett RM, Kramár EA, Azzawi S, Chen Y, Magnan CN, Zeller M, Sylvain A, Haettig J, Jia Y, Tran A, Dang R, Post RJ, Chabrier M, Babayan AH, Wu JI, Crabtree GR, Baldi P, Baram TZ, Lynch G, Wood MA. PMID: 23525042; PMCID: PMC3777648.
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Fragmentation and unpredictability of early-life experience in mental disorders. Am J Psychiatry. 2012 Sep; 169(9):907-15. Baram TZ, Davis EP, Obenaus A, Sandman CA, Small SL, Solodkin A, Stern H. PMID: 22885631; PMCID: PMC3483144.
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Distinct regional and subcellular localization of the actin-binding protein filamin A in the mature rat brain. J Comp Neurol. 2012 Sep 01; 520(13):3013-34. Noam Y, Phan L, McClelland S, Manders EM, Ehrengruber MU, Wadman WJ, Baram TZ, Chen Y. PMID: 22434607; PMCID: PMC3393847.
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The brain, seizures and epilepsy throughout life: understanding a moving target. Epilepsy Curr. 2012 Jul; 12(Suppl 3):7-12. Baram TZ. PMID: 23476117; PMCID: PMC3588148.
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Finding a better drug for epilepsy: antiinflammatory targets. Epilepsia. 2012 Jul; 53(7):1113-8. Dedeurwaerdere S, Friedman A, Fabene PF, Mazarati A, Murashima YL, Vezzani A, Baram TZ. PMID: 22691043; PMCID: PMC3389561.
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Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites. J Biol Chem. 2012 May 18; 287(21):17656-17661. Marcelin B, Lugo JN, Brewster AL, Liu Z, Lewis AS, McClelland S, Chetkovich DM, Baram TZ, Anderson AE, Becker A, Esclapez M, Bernard C. PMID: 22511771; PMCID: PMC3366832.
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Tuning synaptic transmission in the hippocampus by stress: the CRH system. Front Cell Neurosci. 2012; 6:13. Chen Y, Andres AL, Frotscher M, Baram TZ. PMID: 22514519; PMCID: PMC3322336.
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Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells. J Neurosci. 2012 Mar 14; 32(11):3736-47. Marcelin B, Liu Z, Chen Y, Lewis AS, Becker A, McClelland S, Chetkovich DM, Migliore M, Baram TZ, Esclapez M, Bernard C. PMID: 22423094; PMCID: PMC3321843.
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Impairment of synaptic plasticity by the stress mediator CRH involves selective destruction of thin dendritic spines via RhoA signaling. Mol Psychiatry. 2013 Apr; 18(4):485-96. Chen Y, Kramár EA, Chen LY, Babayan AH, Andres AL, Gall CM, Lynch G, Baram TZ. PMID: 22411227; PMCID: PMC3440527.
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Hyperpolarization-activated cation current Ih of dentate gyrus granule cells is upregulated in human and rat temporal lobe epilepsy. Biochem Biophys Res Commun. 2012 Mar 30; 420(1):156-60. Surges R, Kukley M, Brewster A, Rüschenschmidt C, Schramm J, Baram TZ, Beck H, Dietrich D. PMID: 22405820; PMCID: PMC3383809.
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Sculpting the hippocampus from within: stress, spines, and CRH. Trends Neurosci. 2012 May; 35(5):315-24. Maras PM, Baram TZ. PMID: 22386641; PMCID: PMC3423222.
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Forebrain CRF₁ modulates early-life stress-programmed cognitive deficits. J Neurosci. 2011 Sep 21; 31(38):13625-34. Wang XD, Rammes G, Kraev I, Wolf M, Liebl C, Scharf SH, Rice CJ, Wurst W, Holsboer F, Deussing JM, Baram TZ, Stewart MG, Müller MB, Schmidt MV. PMID: 21940453; PMCID: PMC3380621.
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Neuron-restrictive silencer factor-mediated hyperpolarization-activated cyclic nucleotide gated channelopathy in experimental temporal lobe epilepsy. Ann Neurol. 2011 Sep; 70(3):454-64. McClelland S, Flynn C, Dubé C, Richichi C, Zha Q, Ghestem A, Esclapez M, Bernard C, Baram TZ. PMID: 21905079; PMCID: PMC3177145.
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Towards an integrated view of HCN channel role in epilepsy. Curr Opin Neurobiol. 2011 Dec; 21(6):873-9. Noam Y, Bernard C, Baram TZ. PMID: 21782415; PMCID: PMC3235400.
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Treatment of infantile spasms: emerging insights from clinical and basic science perspectives. J Child Neurol. 2011 Nov; 26(11):1411-21. Stafstrom CE, Arnason BG, Baram TZ, Catania A, Cortez MA, Glauser TA, Pranzatelli MR, Riikonen R, Rogawski MA, Shinnar S, Swann JW. PMID: 21719797.
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Trafficking and gating of hyperpolarization-activated cyclic nucleotide-gated channels are regulated by interaction with tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) and cyclic AMP at distinct sites. J Biol Chem. 2011 Jun 10; 286(23):20823-34. Han Y, Noam Y, Lewis AS, Gallagher JJ, Wadman WJ, Baram TZ, Chetkovich DM. PMID: 21504900; PMCID: PMC3121500.
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Epileptogenesis after prolonged febrile seizures: mechanisms, biomarkers and therapeutic opportunities. Neurosci Lett. 2011 Jun 27; 497(3):155-62. McClelland S, Dubé CM, Yang J, Baram TZ. PMID: 21356275; PMCID: PMC3109205.
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Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory. Neurobiol Learn Mem. 2011 Jul; 96(1):79-88. McClelland S, Korosi A, Cope J, Ivy A, Baram TZ. PMID: 21338703; PMCID: PMC3111759.
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Forebrain CRHR1 deficiency attenuates chronic stress-induced cognitive deficits and dendritic remodeling. Neurobiol Dis. 2011 Jun; 42(3):300-10. Wang XD, Chen Y, Wolf M, Wagner KV, Liebl C, Scharf SH, Harbich D, Mayer B, Wurst W, Holsboer F, Deussing JM, Baram TZ, Müller MB, Schmidt MV. PMID: 21296667; PMCID: PMC3200197.
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Does acquired epileptogenesis in the immature brain require neuronal death. Epilepsy Curr. 2011 Jan; 11(1):21-6. Baram TZ, Jensen FE, Brooks-Kayal A. PMID: 21461261; PMCID: PMC3063568.
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Temperature elevation increases GABA(A) -mediated cortical inhibition in a mouse model of genetic epilepsy. Epilepsia. 2011 Jan; 52(1):179-84. Hill EL, Hosie S, Mulligan RS, Richards KL, Davies PJ, Dubé CM, Baram TZ, Reid CA, Jones MV, Petrou S. PMID: 21219304; PMCID: PMC3354703.
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The role of inflammation in epilepsy. Nat Rev Neurol. 2011 Jan; 7(1):31-40. Vezzani A, French J, Bartfai T, Baram TZ. PMID: 21135885; PMCID: PMC3378051.
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Plasticity of the stress response early in life: mechanisms and significance. Dev Psychobiol. 2010 Nov; 52(7):661-70. Korosi A, Baram TZ. PMID: 20862706; PMCID: PMC3203734.
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Infantile spasms: a U.S. consensus report. Epilepsia. 2010 Oct; 51(10):2175-89. Pellock JM, Hrachovy R, Shinnar S, Baram TZ, Bettis D, Dlugos DJ, Gaillard WD, Gibson PA, Holmes GL, Nordl DR, O'Dell C, Shields WD, Trevathan E, Wheless JW. PMID: 20608959.
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Hippocampal dysfunction and cognitive impairments provoked by chronic early-life stress involve excessive activation of CRH receptors. J Neurosci. 2010 Sep 29; 30(39):13005-15. Ivy AS, Rex CS, Chen Y, Dubé C, Maras PM, Grigoriadis DE, Gall CM, Lynch G, Baram TZ. PMID: 20881118; PMCID: PMC2991143.
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Early life programming and neurodevelopmental disorders. Biol Psychiatry. 2010 Aug 15; 68(4):314-9. Bale TL, Baram TZ, Brown AS, Goldstein JM, Insel TR, McCarthy MM, Nemeroff CB, Reyes TM, Simerly RB, Susser ES, Nestler EJ. PMID: 20674602; PMCID: PMC3168778.
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Correlated memory defects and hippocampal dendritic spine loss after acute stress involve corticotropin-releasing hormone signaling. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13123-8. Chen Y, Rex CS, Rice CJ, Dubé CM, Gall CM, Lynch G, Baram TZ. PMID: 20615973; PMCID: PMC2919915.
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Epileptogenesis provoked by prolonged experimental febrile seizures: mechanisms and biomarkers. J Neurosci. 2010 Jun 02; 30(22):7484-94. Dubé CM, Ravizza T, Hamamura M, Zha Q, Keebaugh A, Fok K, Andres AL, Nalcioglu O, Obenaus A, Vezzani A, Baram TZ. PMID: 20519523; PMCID: PMC2906240.
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Augmented currents of an HCN2 variant in patients with febrile seizure syndromes. Ann Neurol. 2010 Apr; 67(4):542-6. Dibbens LM, Reid CA, Hodgson B, Thomas EA, Phillips AM, Gazina E, Cromer BA, Clarke AL, Baram TZ, Scheffer IE, Berkovic SF, Petrou S. PMID: 20437590; PMCID: PMC3383007.
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Trafficking and surface expression of hyperpolarization-activated cyclic nucleotide-gated channels in hippocampal neurons. J Biol Chem. 2010 May 07; 285(19):14724-36. Noam Y, Zha Q, Phan L, Wu RL, Chetkovich DM, Wadman WJ, Baram TZ. PMID: 20215108; PMCID: PMC2863223.
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Altered function of the SCN1A voltage-gated sodium channel leads to gamma-aminobutyric acid-ergic (GABAergic) interneuron abnormalities. J Biol Chem. 2010 Mar 26; 285(13):9823-9834. Martin MS, Dutt K, Papale LA, Dubé CM, Dutton SB, de Haan G, Shankar A, Tufik S, Meisler MH, Baram TZ, Goldin AL, Escayg A. PMID: 20100831; PMCID: PMC2843231.
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Early-life experience reduces excitation to stress-responsive hypothalamic neurons and reprograms the expression of corticotropin-releasing hormone. J Neurosci. 2010 Jan 13; 30(2):703-13. Korosi A, Shanabrough M, McClelland S, Liu ZW, Borok E, Gao XB, Horvath TL, Baram TZ. PMID: 20071535; PMCID: PMC2822406.
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Hyperpolarized views on the roles of the hyperpolarization-activated channels in neuronal excitability. Epilepsy Curr. 2010 Jan; 10(1):28-30. Noam Y, Baram TZ. PMID: 20126337; PMCID: PMC2812721.
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The pathways from mother's love to baby's future. Front Behav Neurosci. 2009; 3:27. Korosi A, Baram TZ. PMID: 19826614; PMCID: PMC2759360.
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Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations. J Neurosci. 2009 Jul 08; 29(27):8847-57. Kanyshkova T, Pawlowski M, Meuth P, Dubé C, Bender RA, Brewster AL, Baumann A, Baram TZ, Pape HC, Budde T. PMID: 19587292; PMCID: PMC2768285.
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The neuro-symphony of stress. Nat Rev Neurosci. 2009 06; 10(6):459-66. Joëls M, Baram TZ. PMID: 19339973; PMCID: PMC2844123.
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Alternatively spliced isoforms of TRIP8b differentially control h channel trafficking and function. J Neurosci. 2009 May 13; 29(19):6250-65. Lewis AS, Schwartz E, Chan CS, Noam Y, Shin M, Wadman WJ, Surmeier DJ, Baram TZ, Macdonald RL, Chetkovich DM. PMID: 19439603; PMCID: PMC2730639.
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Mice lacking doublecortin and doublecortin-like kinase 2 display altered hippocampal neuronal maturation and spontaneous seizures. Proc Natl Acad Sci U S A. 2009 Apr 21; 106(16):6766-71. Kerjan G, Koizumi H, Han EB, Dubé CM, Djakovic SN, Patrick GN, Baram TZ, Heinemann SF, Gleeson JG. PMID: 19342486; PMCID: PMC2672532.
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Febrile seizures: mechanisms and relationship to epilepsy. Brain Dev. 2009 May; 31(5):366-71. Dubé CM, Brewster AL, Baram TZ. PMID: 19232478; PMCID: PMC2698702.
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Cognitive dysfunction after experimental febrile seizures. Exp Neurol. 2009 Jan; 215(1):167-77. Dubé CM, Zhou JL, Hamamura M, Zhao Q, Ring A, Abrahams J, McIntyre K, Nalcioglu O, Shatskih T, Baram TZ, Holmes GL. PMID: 19000675; PMCID: PMC2649663.
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Hyperpolarization activated cyclic-nucleotide gated (HCN) channels in developing neuronal networks. Prog Neurobiol. 2008 Nov; 86(3):129-40. Bender RA, Baram TZ. PMID: 18834920; PMCID: PMC2606691.
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A novel mouse model for acute and long-lasting consequences of early life stress. Endocrinology. 2008 Oct; 149(10):4892-900. Rice CJ, Sandman CA, Lenjavi MR, Baram TZ. PMID: 18566122; PMCID: PMC2582918.
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Dysfunctional nurturing behavior in rat dams with limited access to nesting material: a clinically relevant model for early-life stress. Neuroscience. 2008 Jun 26; 154(3):1132-42. Ivy AS, Brunson KL, Sandman C, Baram TZ. PMID: 18501521; PMCID: PMC2517119.
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Rapid loss of dendritic spines after stress involves derangement of spine dynamics by corticotropin-releasing hormone. J Neurosci. 2008 Mar 12; 28(11):2903-11. Chen Y, Dubé CM, Rice CJ, Baram TZ. PMID: 18337421; PMCID: PMC2409370.
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The central corticotropin releasing factor system during development and adulthood. Eur J Pharmacol. 2008 Apr 07; 583(2-3):204-14. Korosi A, Baram TZ. PMID: 18275957; PMCID: PMC2329668.
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Activity-dependent heteromerization of the hyperpolarization-activated, cyclic-nucleotide gated (HCN) channels: role of N-linked glycosylation. J Neurochem. 2008 Apr; 105(1):68-77. Zha Q, Brewster AL, Richichi C, Bender RA, Baram TZ. PMID: 17988239; PMCID: PMC2747799.
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Go "West," young man...The quest for animal models of infantile spasms (West syndrome). Epilepsy Curr. 2007 Nov-Dec; 7(6):165-7. Baram TZ. PMID: 18049727; PMCID: PMC2096721.
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Fever, febrile seizures and epilepsy. Trends Neurosci. 2007 Oct; 30(10):490-6. Dubé CM, Brewster AL, Richichi C, Zha Q, Baram TZ. PMID: 17897728; PMCID: PMC2766556.
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Mechanisms of seizure-induced 'transcriptional channelopathy' of hyperpolarization-activated cyclic nucleotide gated (HCN) channels. Neurobiol Dis. 2008 Feb; 29(2):297-305. Richichi C, Brewster AL, Bender RA, Simeone TA, Zha Q, Yin HZ, Weiss JH, Baram TZ. PMID: 17964174; PMCID: PMC2292123.
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Ps in the (channel) pod are not alike... Epilepsy Curr. 2007 Sep-Oct; 7(5):136-7. Noam Y, Baram TZ. PMID: 17998975; PMCID: PMC2043134.
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Localization of HCN1 channels to presynaptic compartments: novel plasticity that may contribute to hippocampal maturation. J Neurosci. 2007 Apr 25; 27(17):4697-706. Bender RA, Kirschstein T, Kretz O, Brewster AL, Richichi C, Rüschenschmidt C, Shigemoto R, Beck H, Frotscher M, Baram TZ. PMID: 17460082; PMCID: PMC3086816.
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New roles for interleukin-1 Beta in the mechanisms of epilepsy. Epilepsy Curr. 2007 Mar-Apr; 7(2):45-50. Vezzani A, Baram TZ. PMID: 17505552; PMCID: PMC1867084.
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Models for infantile spasms: an arduous journey to the Holy Grail... Ann Neurol. 2007 Feb; 61(2):89-91. Baram TZ. PMID: 17315207; PMCID: PMC2917175.
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Epileptogenesis in the developing brain: what can we learn from animal models? Epilepsia. 2007; 48 Suppl 5:2-6. Bender RA, Baram TZ. PMID: 17910574; PMCID: PMC2735872.
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Regulated expression of HCN channels and cAMP levels shape the properties of the h current in developing rat hippocampus. Eur J Neurosci. 2006 Jul; 24(1):94-104. Surges R, Brewster AL, Bender RA, Beck H, Feuerstein TJ, Baram TZ. PMID: 16882011; PMCID: PMC2919221.
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Cellular and molecular mechanisms of hippocampal activation by acute stress are age-dependent. Mol Psychiatry. 2006 Nov; 11(11):992-1002. Chen Y, Fenoglio KA, Dubé CM, Grigoriadis DE, Baram TZ. PMID: 16801951; PMCID: PMC2927976.
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Functional stabilization of weakened thalamic pacemaker channel regulation in rat absence epilepsy. J Physiol. 2006 Aug 15; 575(Pt 1):83-100. Kuisle M, Wanaverbecq N, Brewster AL, Frère SG, Pinault D, Baram TZ, Lüthi A. PMID: 16728450; PMCID: PMC1819420.
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Quantitative analysis and subcellular distribution of mRNA and protein expression of the hyperpolarization-activated cyclic nucleotide-gated channels throughout development in rat hippocampus. Cereb Cortex. 2007 Mar; 17(3):702-12. Brewster AL, Chen Y, Bender RA, Yeh A, Shigemoto R, Baram TZ. PMID: 16648453; PMCID: PMC3100721.
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Hippocampal neuroplasticity induced by early-life stress: functional and molecular aspects. Front Neuroendocrinol. 2006 Jul; 27(2):180-92. Fenoglio KA, Brunson KL, Baram TZ. PMID: 16603235; PMCID: PMC2937188.
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Neuroplasticity of the hypothalamic-pituitary-adrenal axis early in life requires recurrent recruitment of stress-regulating brain regions. J Neurosci. 2006 Mar 01; 26(9):2434-42. Fenoglio KA, Chen Y, Baram TZ. PMID: 16510721; PMCID: PMC2408688.
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Temporal lobe epilepsy after experimental prolonged febrile seizures: prospective analysis. Brain. 2006 Apr; 129(Pt 4):911-22. Dubé C, Richichi C, Bender RA, Chung G, Litt B, Baram TZ. PMID: 16446281; PMCID: PMC3100674.
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Synchronized network activity in developing rat hippocampus involves regional hyperpolarization-activated cyclic nucleotide-gated (HCN) channel function. Eur J Neurosci. 2005 Nov; 22(10):2669-74. Bender RA, Galindo R, Mameli M, Gonzalez-Vega R, Valenzuela CF, Baram TZ. PMID: 16307610; PMCID: PMC2927207.
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Mechanisms of late-onset cognitive decline after early-life stress. J Neurosci. 2005 Oct 12; 25(41):9328-38. Brunson KL, Kramár E, Lin B, Chen Y, Colgin LL, Yanagihara TK, Lynch G, Baram TZ. PMID: 16221841; PMCID: PMC3100717.
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Single channel properties of hyperpolarization-activated cation currents in acutely dissociated rat hippocampal neurones. J Physiol. 2005 Oct 15; 568(Pt 2):371-80. Simeone TA, Rho JM, Baram TZ. PMID: 16123099; PMCID: PMC1474727.
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Enduring, handling-evoked enhancement of hippocampal memory function and glucocorticoid receptor expression involves activation of the corticotropin-releasing factor type 1 receptor. Endocrinology. 2005 Sep; 146(9):4090-6. Fenoglio KA, Brunson KL, Avishai-Eliner S, Stone BA, Kapadia BJ, Baram TZ. PMID: 15932935; PMCID: PMC3100718.
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Formation of heteromeric hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the hippocampus is regulated by developmental seizures. Neurobiol Dis. 2005 Jun-Jul; 19(1-2):200-7. Brewster AL, Bernard JA, Gall CM, Baram TZ. PMID: 15837575; PMCID: PMC2930785.
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When a rat runs cold and hot... Epilepsy Curr. 2005 Mar-Apr; 5(2):81-2. Baram TZ. PMID: 16059444; PMCID: PMC1176316.
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Endogenous neuropeptide Y prevents recurrence of experimental febrile seizures by increasing seizure threshold. J Mol Neurosci. 2005; 25(3):275-84. Dubé C, Brunson KL, Eghbal-Ahmadi M, Gonzalez-Vega R, Baram TZ. PMID: 15800380; PMCID: PMC2930787.
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Interleukin-1beta contributes to the generation of experimental febrile seizures. Ann Neurol. 2005 Jan; 57(1):152-5. Dubé C, Vezzani A, Behrens M, Bartfai T, Baram TZ. PMID: 15622539; PMCID: PMC2909879.
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Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels. Hippocampus. 2005; 15(4):491-501. Brunson KL, Baram TZ, Bender RA. PMID: 15744738; PMCID: PMC2921196.
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Serial MRI after experimental febrile seizures: altered T2 signal without neuronal death. Ann Neurol. 2004 Nov; 56(5):709-14. Dubé C, Yu H, Nalcioglu O, Baram TZ. PMID: 15389889; PMCID: PMC3084032.
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Modulation of dendritic differentiation by corticotropin-releasing factor in the developing hippocampus. Proc Natl Acad Sci U S A. 2004 Nov 02; 101(44):15782-7. Chen Y, Bender RA, Brunson KL, Pomper JK, Grigoriadis DE, Wurst W, Baram TZ. PMID: 15496472; PMCID: PMC524840.
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Practice parameter: medical treatment of infantile spasms: report of the American Academy of Neurology and the Child Neurology Society. Neurology. 2004 May 25; 62(10):1668-81. Mackay MT, Weiss SK, Adams-Webber T, Ashwal S, Stephens D, Ballaban-Gill K, Baram TZ, Duchowny M, Hirtz D, Pellock JM, Shields WD, Shinnar S, Wyllie E, Snead OC, American Academy of Neurology, Child Neurology Society. PMID: 15159460; PMCID: PMC2937178.
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Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology. 2004 Jun; 145(6):2702-6. Fenoglio KA, Brunson KL, Avishai-Eliner S, Chen Y, Baram TZ. PMID: 15044366; PMCID: PMC3088480.
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Febrile seizures and mechanisms of epileptogenesis: insights from an animal model. Adv Exp Med Biol. 2004; 548:213-25. Bender RA, Dubé C, Baram TZ. PMID: 15250596; PMCID: PMC3086822.
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Hippocampal corticotropin releasing hormone: pre- and postsynaptic location and release by stress. Neuroscience. 2004; 126(3):533-40. Chen Y, Brunson KL, Adelmann G, Bender RA, Frotscher M, Baram TZ. PMID: 15183503; PMCID: PMC2923444.
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Long-term neuroplasticity and functional consequences of single versus recurrent early-life seizures. Ann Neurol. 2003 Dec; 54(6):701-5. Baram TZ. PMID: 14681879; PMCID: PMC2981791.
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The multiple personalities of h-channels. Trends Neurosci. 2003 Oct; 26(10):550-4. Santoro B, Baram TZ. PMID: 14522148; PMCID: PMC2924161.
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Treatment of infantile spasms: the ideal and the mundane. Epilepsia. 2003 Aug; 44(8):993-4. Baram TZ. PMID: 12887429; PMCID: PMC3100716.
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Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. J Neurosci. 2003 Jul 30; 23(17):6826-36. Bender RA, Soleymani SV, Brewster AL, Nguyen ST, Beck H, Mathern GW, Baram TZ. PMID: 12890777; PMCID: PMC3100807.
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Mitochondrial uncoupling protein-2 protects the immature brain from excitotoxic neuronal death. Ann Neurol. 2003 Jun; 53(6):711-7. Sullivan PG, Dubé C, Dorenbos K, Steward O, Baram TZ. PMID: 12783416; PMCID: PMC2930774.
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Stress and the developing hippocampus: a double-edged sword? Mol Neurobiol. 2003 Apr; 27(2):121-36. Brunson KL, Chen Y, Avishai-Eliner S, Baram TZ. PMID: 12777683; PMCID: PMC3084035.
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Mossy fiber plasticity and enhanced hippocampal excitability, without hippocampal cell loss or altered neurogenesis, in an animal model of prolonged febrile seizures. Hippocampus. 2003; 13(3):399-412. Bender RA, Dubé C, Gonzalez-Vega R, Mina EW, Baram TZ. PMID: 12722980; PMCID: PMC2927853.
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Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13908-13. Roozendaal B, Brunson KL, Holloway BL, McGaugh JL, Baram TZ. PMID: 12361983; PMCID: PMC129796.
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Stressed-out, or in (utero)? Trends Neurosci. 2002 Oct; 25(10):518-24. Avishai-Eliner S, Brunson KL, Sandman CA, Baram TZ. PMID: 12220880; PMCID: PMC2930786.
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Corticotropin-releasing hormone (CRH) downregulates the function of its receptor (CRF1) and induces CRF1 expression in hippocampal and cortical regions of the immature rat brain. Exp Neurol. 2002 Jul; 176(1):75-86. Brunson KL, Grigoriadis DE, Lorang MT, Baram TZ. PMID: 12093084; PMCID: PMC2930769.
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Developmental febrile seizures modulate hippocampal gene expression of hyperpolarization-activated channels in an isoform- and cell-specific manner. J Neurosci. 2002 Jun 01; 22(11):4591-9. Brewster A, Bender RA, Chen Y, Dube C, Eghbal-Ahmadi M, Baram TZ. PMID: 12040066; PMCID: PMC3372984.
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The mystery of the Doctor's son, or the riddle of West syndrome. Neurology. 2002 Mar 26; 58(6):953-5. Eling P, Renier WO, Pomper J, Baram TZ. PMID: 11914414; PMCID: PMC3093242.
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Is neuronal death required for seizure-induced epileptogenesis in the immature brain? Prog Brain Res. 2002; 135:365-75. Baram TZ, Eghbal-Ahmadi M, Bender RA. PMID: 12143355; PMCID: PMC3084550.
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ACTH treatment of infantile spasms: mechanisms of its effects in modulation of neuronal excitability. Int Rev Neurobiol. 2002; 49:185-97. Brunson KL, Avishai-Eliner S, Baram TZ. PMID: 12040892; PMCID: PMC3092432.
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Rapid phosphorylation of the CRE binding protein precedes stress-induced activation of the corticotropin releasing hormone gene in medial parvocellular hypothalamic neurons of the immature rat. Brain Res Mol Brain Res. 2001 Nov 30; 96(1-2):39-49. Chen Y, Hatalski CG, Brunson KL, Baram TZ. PMID: 11731007; PMCID: PMC3100731.
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Neurobiology of the stress response early in life: evolution of a concept and the role of corticotropin releasing hormone. Mol Psychiatry. 2001 Nov; 6(6):647-56. Brunson KL, Avishai-Eliner S, Hatalski CG, Baram TZ. PMID: 11673792; PMCID: PMC3100722.
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How do the many etiologies of West syndrome lead to excitability and seizures? The corticotropin releasing hormone excess hypothesis. Brain Dev. 2001 Nov; 23(7):533-8. Brunson KL, Eghbal-Ahmadi M, Baram TZ. PMID: 11701250; PMCID: PMC3107538.
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What are the reasons for the strikingly different approaches to the use of ACTH in infants with West syndrome? Brain Dev. 2001 Nov; 23(7):647-8. Baram TZ. PMID: 11701270; PMCID: PMC3100719.
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Novel and transient populations of corticotropin-releasing hormone-expressing neurons in developing hippocampus suggest unique functional roles: a quantitative spatiotemporal analysis. J Neurosci. 2001 Sep 15; 21(18):7171-81. Chen Y, Bender RA, Frotscher M, Baram TZ. PMID: 11549728; PMCID: PMC3107537.
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Altered regulation of gene and protein expression of hypothalamic-pituitary-adrenal axis components in an immature rat model of chronic stress. J Neuroendocrinol. 2001 Sep; 13(9):799-807. Avishai-Eliner S, Gilles EE, Eghbal-Ahmadi M, Bar-El Y, Baram TZ. PMID: 11578530; PMCID: PMC3100736.
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Do febrile seizures improve memory? Neurology. 2001 Jul 10; 57(1):7-8. Baram TZ, Shinnar S. PMID: 11445620; PMCID: PMC3100714.
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Long-term, progressive hippocampal cell loss and dysfunction induced by early-life administration of corticotropin-releasing hormone reproduce the effects of early-life stress. Proc Natl Acad Sci U S A. 2001 Jul 17; 98(15):8856-61. Brunson KL, Eghbal-Ahmadi M, Bender R, Chen Y, Baram TZ. PMID: 11447269; PMCID: PMC37525.
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Corticotropin (ACTH) acts directly on amygdala neurons to down-regulate corticotropin-releasing hormone gene expression. Ann Neurol. 2001 Mar; 49(3):304-12. Brunson KL, Khan N, Eghbal-Ahmadi M, Baram TZ. PMID: 11261504; PMCID: PMC2849730.
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Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med. 2001 Mar; 7(3):331-7. Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. PMID: 11231632; PMCID: PMC3382967.
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Enhanced CREB phosphorylation in immature dentate gyrus granule cells precedes neurotrophin expression and indicates a specific role of CREB in granule cell differentiation. Eur J Neurosci. 2001 Feb; 13(4):679-86. Bender RA, Lauterborn JC, Gall CM, Cariaga W, Baram TZ. PMID: 11207803; PMCID: PMC3108563.
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Down-regulation of hypothalamic corticotropin-releasing hormone messenger ribonucleic acid (mRNA) precedes early-life experience-induced changes in hippocampal glucocorticoid receptor mRNA. Endocrinology. 2001 Jan; 142(1):89-97. Avishai-Eliner S, Eghbal-Ahmadi M, Tabachnik E, Brunson KL, Baram TZ. PMID: 11145570; PMCID: PMC3100725.
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Differential and age-dependent expression of hyperpolarization-activated, cyclic nucleotide-gated cation channel isoforms 1-4 suggests evolving roles in the developing rat hippocampus. Neuroscience. 2001; 106(4):689-98. Bender RA, Brewster A, Santoro B, Ludwig A, Hofmann F, Biel M, Baram TZ. PMID: 11682156; PMCID: PMC3084019.
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Activation of specific neuronal circuits by corticotropin releasing hormone as indicated by c-fos expression and glucose metabolism. J Cereb Blood Flow Metab. 2000 Oct; 20(10):1414-24. Dubé T, Brunson T, Nehlig A, Baram TZ. PMID: 11043904; PMCID: PMC3139465.
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Immunocytochemical distribution of corticotropin-releasing hormone receptor type-1 (CRF(1))-like immunoreactivity in the mouse brain: light microscopy analysis using an antibody directed against the C-terminus. J Comp Neurol. 2000 May 08; 420(3):305-23. Chen Y, Brunson KL, Müller MB, Cariaga W, Baram TZ. PMID: 10754504; PMCID: PMC3119344.
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Prolonged febrile seizures in the immature rat model enhance hippocampal excitability long term. Ann Neurol. 2000 Mar; 47(3):336-44. Dube C, Chen K, Eghbal-Ahmadi M, Brunson K, Soltesz I, Baram TZ. PMID: 10716253; PMCID: PMC3139468.
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Neuronal activity and stress differentially regulate hippocampal and hypothalamic corticotropin-releasing hormone expression in the immature rat. Neuroscience. 2000; 101(3):571-80. Hatalski CG, Brunson KL, Tantayanubutr B, Chen Y, Baram TZ. PMID: 11113306; PMCID: PMC3129847.
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Developmental seizures induced by common early-life insults: short- and long-term effects on seizure susceptibility. Ment Retard Dev Disabil Res Rev. 2000; 6(4):253-7. Jensen FE, Baram TZ. PMID: 11107190; PMCID: PMC3186350.
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Infantile spasms: hypothesis-driven therapy and pilot human infant experiments using corticotropin-releasing hormone receptor antagonists. Dev Neurosci. 1999 Nov; 21(3-5):281-9. Baram TZ, Mitchell WG, Brunson K, Haden E. PMID: 10575251; PMCID: PMC3139473.
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Effects of blocking GABA degradation on corticotropin-releasing hormone gene expression in selected brain regions. Epilepsia. 1999 Sep; 40(9):1190-7. Tran V, Hatalski CG, Yan XX, Baram TZ. PMID: 10487181; PMCID: PMC3129846.
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Febrile seizures in the developing brain result in persistent modification of neuronal excitability in limbic circuits. Nat Med. 1999 Aug; 5(8):888-94. Chen K, Baram TZ, Soltesz I. PMID: 10426311; PMCID: PMC3382971.
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Differential regulation of the expression of corticotropin-releasing factor receptor type 2 (CRF2) in hypothalamus and amygdala of the immature rat by sensory input and food intake. J Neurosci. 1999 May 15; 19(10):3982-91. Eghbal-Ahmadi M, Avishai-Eliner S, Hatalski CG, Baram TZ. PMID: 10234028; PMCID: PMC3139461.
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Differential regulation of glucocorticoid receptor messenger RNA (GR-mRNA) by maternal deprivation in immature rat hypothalamus and limbic regions. Brain Res Dev Brain Res. 1999 May 14; 114(2):265-8. Avishai-Eliner S, Hatalski CG, Tabachnik E, Eghbal-Ahmadi M, Baram TZ. PMID: 10320766; PMCID: PMC3139462.
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Co-localization of corticotropin-releasing hormone with glutamate decarboxylase and calcium-binding proteins in infant rat neocortical interneurons. Exp Brain Res. 1998 Dec; 123(3):334-40. Yan XX, Baram TZ, Gerth A, Schultz L, Ribak CE. PMID: 9860272; PMCID: PMC3786772.
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Neuropeptide-mediated excitability: a key triggering mechanism for seizure generation in the developing brain. Trends Neurosci. 1998 Nov; 21(11):471-6. Baram TZ, Hatalski CG. PMID: 9829688; PMCID: PMC3372323.
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The in vivo proconvulsant effects of corticotropin releasing hormone in the developing rat are independent of ionotropic glutamate receptor activation. Brain Res Dev Brain Res. 1998 Nov 01; 111(1):119-28. Brunson KL, Schultz L, Baram TZ. PMID: 9804917; PMCID: PMC3129849.
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Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998 Nov; 2(5):577-83. Voncken JW, Baram TZ, Gonzales-Gomez I, Van Schaick H, Shih JC, Chen K, Groffen J, Heisterkamp N. PMID: 9858655.
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Corticotropin releasing factor mRNA expression in the hypothalamic paraventricular nucleus and the central nucleus of the amygdala is modulated by repeated acute stress in the immature rat. J Neuroendocrinol. 1998 Sep; 10(9):663-9. Hatalski CG, Guirguis C, Baram TZ. PMID: 9744483; PMCID: PMC3382972.
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Corticotropin releasing hormone antagonist does not prevent adrenalectomy-induced apoptosis in the dentate gyrus of the rat hippocampus. Stress. 1998 Jul; 2(3):159-69. Gerth A, Hatalski CG, Avishai-Eliner S, Baram TZ. PMID: 9787264; PMCID: PMC3392172.
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Seizure-induced neuronal injury: vulnerability to febrile seizures in an immature rat model. J Neurosci. 1998 Jun 01; 18(11):4285-94. Toth Z, Yan XX, Haftoglou S, Ribak CE, Baram TZ. PMID: 9592105; PMCID: PMC3387924.
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Spatial and temporal evolution of neuronal activation, stress and injury in lithium-pilocarpine seizures in adult rats. Brain Res. 1998 May 18; 793(1-2):61-72. Motte J, Fernandes MJ, Baram TZ, Nehlig A. PMID: 9630518; PMCID: PMC3396436.
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The pro-convulsant actions of corticotropin-releasing hormone in the hippocampus of infant rats. Neuroscience. 1998 May; 84(1):71-9. Hollrigel GS, Chen K, Baram TZ, Soltesz I. PMID: 9522363; PMCID: PMC3387920.
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The developmental profile of the corticotropin releasing factor receptor (CRF2) in rat brain predicts distinct age-specific functions. Brain Res Dev Brain Res. 1998 Apr 17; 107(1):81-90. Eghbal-Ahmadi M, Hatalski CG, Lovenberg TW, Avishai-Eliner S, Chalmers DT, Baram TZ. PMID: 9602071; PMCID: PMC3387927.
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Corticotropin-releasing hormone (CRH)-containing neurons in the immature rat hippocampal formation: light and electron microscopic features and colocalization with glutamate decarboxylase and parvalbumin. Hippocampus. 1998; 8(3):231-43. Yan XX, Toth Z, Schultz L, Ribak CE, Baram TZ. PMID: 9662138; PMCID: PMC3387930.
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Stress-induced transcriptional regulation in the developing rat brain involves increased cyclic adenosine 3',5'-monophosphate-regulatory element binding activity. Mol Endocrinol. 1997 Dec; 11(13):2016-24. Hatalski CG, Baram TZ. PMID: 9415405; PMCID: PMC3387925.
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Corticotropin releasing factor receptor type II (CRF2) messenger ribonucleic acid levels in the hypothalamic ventromedial nucleus of the infant rat are reduced by maternal deprivation. Endocrinology. 1997 Nov; 138(11):5048-51. Eghbal-Ahmadi M, Hatalski CG, Avishai-Eliner S, Baram TZ. PMID: 9348237; PMCID: PMC3404504.
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The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist. Brain Res. 1997 Oct 03; 770(1-2):89-95. Baram TZ, Chalmers DT, Chen C, Koutsoukos Y, De Souza EB. PMID: 9372207; PMCID: PMC3387933.
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Development neurobiology of the stress response: multilevel regulation of corticotropin-releasing hormone function. Ann N Y Acad Sci. 1997 Apr 24; 814:252-65. Baram TZ, Yi S, Avishai-Eliner S, Schultz L. PMID: 9160975; PMCID: PMC3399696.
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Cerebellar mutism in children: report of six cases and potential mechanisms. Pediatr Neurol. 1997 Apr; 16(3):218-9. Koh S, Turkel SB, Baram TZ. PMID: 9165512; PMCID: PMC3399684.
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Febrile seizures: an appropriate-aged model suitable for long-term studies. Brain Res Dev Brain Res. 1997 Feb 20; 98(2):265-70. Baram TZ, Gerth A, Schultz L. PMID: 9051269; PMCID: PMC3404508.
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Inhibition of pituitary-adrenal secretion by a corticotropin releasing hormone antagonist in humans. Mol Psychiatry. 1996 Sep; 1(4):320-4. Baram TZ, Mitchell WG, Haden E. PMID: 9118358; PMCID: PMC3399691.
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Abnormal corticosterone regulation in an immature rat model of continuous chronic stress. Pediatr Neurol. 1996 Sep; 15(2):114-9. Gilles EE, Schultz L, Baram TZ. PMID: 8888044; PMCID: PMC3415889.
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The effect of 'Astressin', a novel antagonist of corticotropin releasing hormone (CRH), on CRH-induced seizures in the infant rat: comparison with two other antagonists. Mol Psychiatry. 1996 Jul; 1(3):223-6. Baram TZ, Koutsoukos Y, Schultz L, Rivier J. PMID: 9118346; PMCID: PMC3408242.
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Maternally inherited cardiomyopathy and hearing loss associated with a novel mutation in the mitochondrial tRNA(Lys) gene (G8363A). Am J Hum Genet. 1996 May; 58(5):933-9. Santorelli FM, Mak SC, El-Schahawi M, Casali C, Shanske S, Baram TZ, Madrid RE, DiMauro S. PMID: 8651277; PMCID: PMC1914622.
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High-dose corticotropin (ACTH) versus prednisone for infantile spasms: a prospective, randomized, blinded study. Pediatrics. 1996 Mar; 97(3):375-9. Baram TZ, Mitchell WG, Tournay A, Snead OC, Hanson RA, Horton EJ. PMID: 8604274; PMCID: PMC3100715.
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Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats. Brain Res Dev Brain Res. 1996 Feb 26; 91(2):245-51. Ribak CE, Baram TZ. PMID: 8852375; PMCID: PMC3413264.
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Developmental profile of messenger RNA for the corticotropin-releasing hormone receptor in the rat limbic system. Brain Res Dev Brain Res. 1996 Feb 26; 91(2):159-63. Avishai-Eliner S, Yi SJ, Baram TZ. PMID: 8852365; PMCID: PMC3408243.
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Developmental profile of corticotropin releasing hormone messenger RNA in the rat inferior olive. Int J Dev Neurosci. 1996 Feb; 14(1):69-76. Chang D, Yi SJ, Baram TZ. PMID: 8779310; PMCID: PMC3477861.
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Cerebrospinal fluid corticotropin and cortisol are reduced in infantile spasms. Pediatr Neurol. 1995 Sep; 13(2):108-10. Baram TZ, Mitchell WG, Hanson RA, Snead OC, Horton EJ. PMID: 8534274; PMCID: PMC3498461.
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Effects of maternal and sibling deprivation on basal and stress induced hypothalamic-pituitary-adrenal components in the infant rat. Neurosci Lett. 1995 Jun 02; 192(1):49-52. Avishai-Eliner S, Yi SJ, Newth CJ, Baram TZ. PMID: 7675308; PMCID: PMC3498456.
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ACTH does not control neonatal seizures induced by administration of exogenous corticotropin-releasing hormone. Epilepsia. 1995 Feb; 36(2):174-8. Baram TZ, Schultz L. PMID: 7821275; PMCID: PMC3498458.
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Peptide-induced infant status epilepticus causes neuronal death and synaptic reorganization. Neuroreport. 1995 Jan 26; 6(2):277-80. Baram TZ, Ribak CE. PMID: 7756609; PMCID: PMC3477862.
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Regional localization and developmental expression of the BCR gene in rodent brain. Cell Mol Biol Res. 1995; 41(2):97-102. Fioretos T, Voncken JW, Baram TZ, Kamme F, Groffen J, Heisterkamp N. PMID: 8581068; PMCID: PMC3791888.
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Corticotropin-releasing hormone mediates the response to cold stress in the neonatal rat without compensatory enhancement of the peptide's gene expression. Endocrinology. 1994 Dec; 135(6):2364-8. Yi SJ, Baram TZ. PMID: 7988418; PMCID: PMC3783019.
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Glucocorticoid receptor mRNA ontogeny in the fetal and postnatal rat forebrain. Mol Cell Neurosci. 1994 Oct; 5(5):385-93. Yi SJ, Masters JN, Baram TZ. PMID: 7820362; PMCID: PMC3791878.
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Subacute sclerosing panencephalitis in an infant: diagnostic role of viral genome analysis. Ann Neurol. 1994 Jul; 36(1):103-8. Baram TZ, Gonzalez-Gomez I, Xie ZD, Yao D, Gilles FH, Nelson MD, Nguyen HT, Peters J. PMID: 8024248; PMCID: PMC3794670.
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Necrosis in pontine gliomas: radiation induced or natural history? Radiology. 1994 Apr; 191(1):279-82. Nelson MD, Soni D, Baram TZ. PMID: 8134588.
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Status epilepticus results in reversible neuronal injury in infant rat hippocampus: novel use of a marker. Brain Res Dev Brain Res. 1994 Jan 14; 77(1):133-6. Chang D, Baram TZ. PMID: 7510587; PMCID: PMC3789625.
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Methods for implanting steroid-containing cannulae into the paraventricular nucleus of neonatal rats. J Pharmacol Toxicol Methods. 1993 Oct; 30(2):97-102. Yi SJ, Baram TZ. PMID: 8298186.
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Effects of a specific glucocorticoid receptor antagonist on corticotropin releasing hormone gene expression in the paraventricular nucleus of the neonatal rat. Brain Res Dev Brain Res. 1993 Jun 08; 73(2):253-9. Yi SJ, Masters JN, Baram TZ. PMID: 8353935.
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Short-interval amygdala kindling in neonatal rats. Brain Res Dev Brain Res. 1993 May 21; 73(1):79-83. Baram TZ, Hirsch E, Schultz L. PMID: 8513558; PMCID: PMC3794669.
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Pathophysiology of massive infantile spasms: perspective on the putative role of the brain adrenal axis. Ann Neurol. 1993 Mar; 33(3):231-6. Baram TZ. PMID: 8388675; PMCID: PMC3786774.
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CRH gene expression in the fetal rat is not increased after pharmacological adrenalectomy. Neurosci Lett. 1992 Aug 17; 142(2):215-8. Baram TZ, Schultz L. PMID: 1333578.
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Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats. Brain Res. 1992 Jun 26; 583(1-2):120-6. Hirsch E, Baram TZ, Snead OC. PMID: 1324090.
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Brain-adrenal axis hormones are altered in the CSF of infants with massive infantile spasms. Neurology. 1992 Jun; 42(6):1171-5. Baram TZ, Mitchell WG, Snead OC, Horton EJ, Saito M. PMID: 1318521; PMCID: PMC3139472.
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Corticotropin-releasing hormone-induced seizures in infant rats originate in the amygdala. Ann Neurol. 1992 May; 31(5):488-94. Baram TZ, Hirsch E, Snead OC, Schultz L. PMID: 1596084; PMCID: PMC3153947.
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Section of the corpus callosum in kainic acid induced seizures in rats: behavioral, electroencephalographic and neuropathological study. Epilepsy Res. 1992 May; 11(3):173-82. Hirsch E, Snead OC, Gomez I, Baram TZ, Vergnes M. PMID: 1396532.
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Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat. Brain Res Dev Brain Res. 1991 Jul 16; 61(1):97-101. Baram TZ, Schultz L. PMID: 1914160; PMCID: PMC3153946.
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Prognostic significance of acute epilepsia partialis continua. Pediatr Neurol. 1991 Mar-Apr; 7(2):144-6. Baram TZ, Mitchell WG, Snead OC. PMID: 1905543.
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Ontogeny of somatostatin gene expression in rat diencephalon. Dev Neurosci. 1991; 13(3):176-80. Baram TZ, Schultz L. PMID: 1684321.
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Ontogeny of corticotropin releasing hormone gene expression in rat hypothalamus--comparison with somatostatin. Int J Dev Neurosci. 1991; 9(5):473-8. Baram TZ, Lerner SP. PMID: 1685845.
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Bicuculline induced seizures in infant rats: ontogeny of behavioral and electrocortical phenomena. Brain Res Dev Brain Res. 1990 Dec 15; 57(2):291-5. Baram TZ, Snead OC. PMID: 2073726; PMCID: PMC3139479.
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Rhythmic coma in children. J Child Neurol. 1990 Jul; 5(3):242-7. Horton EJ, Goldie WD, Baram TZ. PMID: 2398239.
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Fetal and maternal levels of corticosterone and ACTH after pharmacological adrenalectomy. Life Sci. 1990; 47(6):485-9. Baram TZ, Schultz L. PMID: 2169559.
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Transverse sinus thrombosis in newborns: clinical and magnetic resonance imaging findings. Ann Neurol. 1988 Dec; 24(6):792-4. Baram TZ, Butler IJ, Nelson MD, McArdle CB. PMID: 3207363.
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Salvage chemotherapy for recurrent primary brain tumors in children. J Pediatr. 1988 Sep; 113(3):601-6. van Eys J, Baram TZ, Cangir A, Bruner JM, Martinez-Prieto J. PMID: 3411410.
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Brain metastases in osteosarcoma: incidence, clinical and neuroradiological findings and management options. J Neurooncol. 1988; 6(1):47-52. Baram TZ, van Tassel P, Jaffe NA. PMID: 3165112.
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Phase I trial of procarbazine as a 5-day continuous infusion in children with central nervous system tumors. Cancer Treat Rep. 1987 Oct; 71(10):973-4. van Eys J, Cangir A, Pack R, Baram T. PMID: 3308081.
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Brain stem auditory evoked potentials as a tool in the clinical assessment of children with posterior fossa tumors. J Child Neurol. 1987 Oct; 2(4):272-5. Goldie WD, van Eyes J, Baram TZ. PMID: 3655207.
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CSF polyamines in childhood brain tumors. Ann Neurol. 1987 May; 21(5):511. van Eys J, Takaue Y, Nishioka K, Baram TZ. PMID: 3592641.
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Neurodiagnostic studies in Krabbe's disease. J Child Neurol. 1987 Jan; 2(1):71. Baram TZ, Percy AK. PMID: 3624830.
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Megalencephaly due to impaired cerebral venous return in a Sturge-Weber variant syndrome. J Child Neurol. 1986 Apr; 1(2):115-8. Fishman MA, Baram TZ. PMID: 3598114.
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Palatal myoclonus in a child: herald of acute encephalitis. Neurology. 1986 Feb; 36(2):302-3. Baram TZ, Parke JT, Mahoney DH. PMID: 3945405.
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Krabbe disease: specific MRI and CT findings. Neurology. 1986 Jan; 36(1):111-5. Baram TZ, Goldman AM, Percy AK. PMID: 3941765.
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Degradation of gonadotropin-releasing hormone by anterior pituitary enzymes. FEBS Lett. 1981 May 18; 127(2):273-6. Hazum E, Fridkin M, Baram T, Koch Y. PMID: 7016593.
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Synthesis, biological activity and resistance to enzymic degradation of luteinizing hormone--releasing hormone analogues modified at position 7. FEBS Lett. 1981 Jan 26; 123(2):300-2. Hazum E, Fridkin M, Baram T, Koch Y. PMID: 7014245.
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Resistance to enzymic degradation of LH-RH analogues possessing increased biological activity. Biochem Biophys Res Commun. 1977 Jan 24; 74(2):488-91. Koch Y, Baram T, Hazum E, Fridkin M. PMID: 319798.
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Evidence for the dependence of serum luteinizing hormone surge on a transient, enhanced secretion of gonadotropin-releasing hormone from the hypothalamus. Neuroendocrinology. 1977; 23(3):151-6. Baram T, Koch Y. PMID: 331135.
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Convenient procedure for extraction of gonadotropin-releasing hormone and thyrotropin-releasing hormone from hypothalamic tissue. FEBS Lett. 1976 Aug 15; 67(2):186-8. Koch Y, Baram T. PMID: 821782.
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Generation of specific antiserum to thyrotropin releasing-hormone and its use in a radioimmunoassay. FEBS Lett. 1976 Apr 01; 63(2):295-8. Koch Y, Baram T, Fridkin M. PMID: 816673.
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Enzymic degradation of luteinizing hormone-releasing hormone (LH-RH) by hypothalamic tissue. Biochem Biophys Res Commun. 1974 Nov 06; 61(1):95-103. Koch Y, Baram T, Chobsieng P, Fridkin M. PMID: 4613355.
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