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Chemokine-chemokine receptor networks in conventional type I dendritic cells: an opportunity to prime and boost anticancer immunity. J Pharmacol Exp Ther. 2025 Nov; 392(11):103725. Kuo N, Shinn CK, Schokrpur S, Idoyaga J, Handel T, Gutkind JS. PMID: 41135412; PMCID: PMC12919738.
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Rules of engagement: Determinants of chemokine receptor activation and selectivity by CCL27 and CCL28. J Biol Chem. 2025 11; 301(11):110736. Huang M, Celniker AF, Chitsazi R, Dyer DP, Jansma AL, Kufareva I, Salanga CL, Handel TM. PMID: 40975172; PMCID: PMC12556802.
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Noncanonical roles of chemokine regions in CCR9 activation revealed by structural modeling and mutational mapping. Nat Commun. 2025 Aug 18; 16(1):7695. De Magalhaes Pinheiro I, Dawson JRD, Calo N, Paolini-Bertrand M, Akondi KB, Tan G, Handel TM, Kufareva I, Hartley O. PMID: 40825773; PMCID: PMC12361432.
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Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28. bioRxiv. 2025 Jun 01. Huang M, Celniker AF, Chitsazi R, Dyer DP, Jansma AL, Kufareva I, Salanga CL, Handel TM. PMID: 40502012; PMCID: PMC12154644.
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Effect of phosphorylation barcodes on arrestin binding to a chemokine receptor. Nature. 2025 Jul; 643(8070):280-287. Chen Q, Schafer CT, Mukherjee S, Wang K, Gustavsson M, Fuller JR, Tepper K, Lamme TD, Aydin Y, Agrawal P, Terashi G, Yao XQ, Kihara D, Kossiakoff AA, Handel TM, Tesmer JJG. PMID: 40399676; PMCID: PMC12445016.
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Activating the CXCR3/CXCL10 pathway overrides tumor immune suppression by enhancing immune trafficking and effector cell priming in head and neck squamous cell carcinoma. bioRxiv. 2025 May 06. Shinn CK, Saddawi-Konefka R, Salanga CL, Schokrpur S, Gutkind JS, Handel TM. PMID: 40654682; PMCID: PMC12247914.
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Distinct activation mechanisms of CXCR4 and ACKR3 revealed by single-molecule analysis of their conformational landscapes. Elife. 2025 Apr 15; 13. Schafer CT, Pauszek RF, Gustavsson M, Handel TM, Millar DP. PMID: 40232828; PMCID: PMC11999697.
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Traffic control: Mechanisms of ligand-specific internalization and intracellular distribution of CCR5. Mol Pharmacol. 2025 Apr; 107(4):100020. Gu S, Maurya S, Lona A, Borrega Roman L, Salanga C, Gonzalez DJ, Kufareva I, Handel TM. PMID: 40199068.
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Distinct Activation Mechanisms of CXCR4 and ACKR3 Revealed by Single-Molecule Analysis of their Conformational Landscapes. bioRxiv. 2025 Feb 06. Schafer CT, Pauszek RF, Gustavsson M, Handel TM, Millar DP. PMID: 37961571; PMCID: PMC10635023.
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Essential strategies for the detection of constitutive and ligand-dependent Gi-directed activity of 7TM receptors using bioluminescence resonance energy transfer. bioRxiv. 2024 Dec 09. Endzhievskaya S, Chahal K, Resnick J, Khare E, Roy S, Handel TM, Kufareva I. PMID: 39713355; PMCID: PMC11661105.
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A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS. Nature. 2024 Nov; 635(8039):736-745. Ocón B, Xiang M, Bi Y, Tan S, Brulois K, Ayesha A, Kunte M, Zhou C, LaJevic M, Lazarus N, Mengoni F, Sharma T, Montgomery S, Hooper JE, Huang M, Handel T, Dawson JRD, Kufareva I, Zabel BA, Pan J, Butcher EC. PMID: 39293486; PMCID: PMC11887596.
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Ligand-Dependent Mechanisms of CC Chemokine Receptor 5 (CCR5) Trafficking Revealed by APEX2 Proximity Labeling Proteomics. bioRxiv. 2024 Aug 08. Gu S, Maurya S, Lona A, Borrega-Roman L, Salanga C, Gonzalez DJ, Kufareva I, Handel TM. PMID: 37961097; PMCID: PMC10635066.
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Molecular determinants of antagonist interactions with chemokine receptors CCR2 and CCR5. bioRxiv. 2024 Feb 12. Dawson JRD, Wadman GM, Zhang P, Tebben A, Carter PH, Gu S, Shroka T, Borrega-Roman L, Salanga CL, Handel TM, Kufareva I. PMID: 38014122; PMCID: PMC10680698.
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On-bead purification and nanodisc reconstitution of human chemokine receptor complexes for structural and biophysical studies. STAR Protoc. 2023 09 15; 4(3):102460. Gu S, Huang M, Handel TM. PMID: 37516969; PMCID: PMC10407235.
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Atypical Chemokine Receptor 3 "Senses" CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. Mol Pharmacol. 2023 10; 104(4):174-186. Schafer CT, Chen Q, Tesmer JJG, Handel TM. PMID: 37474305; PMCID: PMC11033958.
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ACKR3-arrestin2/3 complexes reveal molecular consequences of GRK-dependent barcoding. bioRxiv. 2023 Jul 19. Chen Q, Schafer CT, Mukherjee S, Gustavsson M, Agrawal P, Yao XQ, Kossiakoff AA, Handel TM, Tesmer JJG. PMID: 37502840; PMCID: PMC10370059.
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Atypical Chemokine Receptor 3 'Senses' CXC Chemokine Receptor 4 Activation Through GPCR Kinase Phosphorylation. bioRxiv. 2023 Mar 10. Schafer CT, Chen Q, Tesmer JJG, Handel TM. PMID: 36865154; PMCID: PMC9980177.
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The dual-function chemokine receptor CCR2 drives migration and chemokine scavenging through distinct mechanisms. Sci Signal. 2023 01 31; 16(770):eabo4314. Shroka TM, Kufareva I, Salanga CL, Handel TM. PMID: 36719944; PMCID: PMC10091583.
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Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors. Cell Rep. 2023 01 31; 42(1):111930. Gray AL, Karlsson R, Roberts ARE, Ridley AJL, Pun N, Khan B, Lawless C, Luís R, Szpakowska M, Chevigné A, Hughes CE, Medina-Ruiz L, Birchenough HL, Mulholland IZ, Salanga CL, Yates EA, Turnbull JE, Handel TM, Graham GJ, Jowitt TA, Schiessl I, Richter RP, Miller RL, Dyer DP. PMID: 36640356; PMCID: PMC11064100.
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Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv. 2022 07 15; 8(28):eabn8063. Yen YC, Schafer CT, Gustavsson M, Eberle SA, Dominik PK, Deneka D, Zhang P, Schall TJ, Kossiakoff AA, Tesmer JJG, Handel TM. PMID: 35857509; PMCID: PMC9278869.
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Anticancer opportunities at every stage of chemokine function. Trends Pharmacol Sci. 2021 11; 42(11):912-928. Ortiz Zacarías NV, Bemelmans MP, Handel TM, de Visser KE, Heitman LH. PMID: 34521537.
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Design and Characterization of an Intracellular Covalent Ligand for CC Chemokine Receptor 2. J Med Chem. 2021 03 11; 64(5):2608-2621. Ortiz Zacarías NV, Chahal KK, Šimková T, van der Horst C, Zheng Y, Inoue A, Theunissen E, Mallee L, van der Es D, Louvel J, IJzerman AP, Handel TM, Kufareva I, Heitman LH. PMID: 33600174; PMCID: PMC7958898.
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Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions. J Histochem Cytochem. 2021 02; 69(2):87-91. Handel TM, Dyer DP. PMID: 33285085; PMCID: PMC7838337.
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Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. J Biol Chem. 2021 Jan-Jun; 296:100139. Ward RJ, Pediani JD, Marsango S, Jolly R, Stoneman MR, Biener G, Handel TM, Raicu V, Milligan G. PMID: 33268380; PMCID: PMC7949023.
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Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis. Sci Signal. 2020 07 14; 13(640). Stephens BS, Ngo T, Kufareva I, Handel TM. PMID: 32665413; PMCID: PMC7437921.
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Differential activity and selectivity of N-terminal modified CXCL12 chemokines at the CXCR4 and ACKR3 receptors. J Leukoc Biol. 2020 06; 107(6):1123-1135. Jaracz-Ros A, Bernadat G, Cutolo P, Gallego C, Gustavsson M, Cecon E, Baleux F, Kufareva I, Handel TM, Bachelerie F, Levoye A. PMID: 32374043; PMCID: PMC7540625.
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Crosslinking-guided geometry of a complete CXC receptor-chemokine complex and the basis of chemokine subfamily selectivity. PLoS Biol. 2020 04; 18(4):e3000656. Ngo T, Stephens BS, Gustavsson M, Holden LG, Abagyan R, Handel TM, Kufareva I. PMID: 32271748; PMCID: PMC7173943.
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CCR2-Mediated Uptake of Constitutively Produced CCL2: A Mechanism for Regulating Chemokine Levels in the Blood. J Immunol. 2019 12 15; 203(12):3157-3165. Zhao BN, Campbell JJ, Salanga CL, Ertl LS, Wang Y, Yau S, Dang T, Zeng Y, McMahon JP, Krasinski A, Zhang P, Kufareva I, Handel TM, Charo IF, Singh R, Schall TJ. PMID: 31676674; PMCID: PMC7028331.
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Kinetics of CXCL12 binding to atypical chemokine receptor 3 reveal a role for the receptor N terminus in chemokine binding. Sci Signal. 2019 09 10; 12(598). Gustavsson M, Dyer DP, Zhao C, Handel TM. PMID: 31506383; PMCID: PMC7063449.
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Leukocyte Adhesion: Reconceptualizing Chemokine Presentation by Glycosaminoglycans. Trends Immunol. 2019 06; 40(6):472-481. Graham GJ, Handel TM, Proudfoot AEI. PMID: 31006548.
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Solution NMR spectroscopy of GPCRs: Residue-specific labeling strategies with a focus on 13C-methyl methionine labeling of the atypical chemokine receptor ACKR3. Methods Cell Biol. 2019; 149:259-288. Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF. PMID: 30616824; PMCID: PMC6941889.
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CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry. Biochem Pharmacol. 2018 12; 158:402-412. Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, Van Loy T, Smit MJ, Schols D. PMID: 30342024.
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A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Rep. 2018 09 18; 24(12):3312-3323.e5. Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. PMID: 30232011; PMCID: PMC6226018.
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Editorial: Chemokines - beyond chemotaxis. Cytokine. 2018 09; 109:1. Proudfoot AE, Handel TM, Graham G. PMID: 29861383.
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Intracellular Receptor Modulation: Novel Approach to Target GPCRs. Trends Pharmacol Sci. 2018 06; 39(6):547-559. Ortiz Zacarías NV, Lenselink EB, IJzerman AP, Handel TM, Heitman LH. PMID: 29653834; PMCID: PMC7048003.
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Glycosaminoglycan Interactions with Chemokines Add Complexity to a Complex System. Pharmaceuticals (Basel). 2017 Aug 09; 10(3). Proudfoot AEI, Johnson Z, Bonvin P, Handel TM. PMID: 28792472; PMCID: PMC5620614.
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Heparan Sulfate Microarray Reveals That Heparan Sulfate-Protein Binding Exhibits Different Ligand Requirements. J Am Chem Soc. 2017 07 19; 139(28):9534-9543. Zong C, Venot A, Li X, Lu W, Xiao W, Wilkes JL, Salanga CL, Handel TM, Wang L, Wolfert MA, Boons GJ. PMID: 28651046; PMCID: PMC5588662.
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Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV. Immunity. 2017 06 20; 46(6):1005-1017.e5. Zheng Y, Han GW, Abagyan R, Wu B, Stevens RC, Cherezov V, Kufareva I, Handel TM. PMID: 28636951; PMCID: PMC5572563.
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What Do Structures Tell Us About Chemokine Receptor Function and Antagonism? Annu Rev Biophys. 2017 05 22; 46:175-198. Kufareva I, Gustavsson M, Zheng Y, Stephens BS, Handel TM. PMID: 28532213; PMCID: PMC5764094.
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Structural basis of ligand interaction with atypical chemokine receptor 3. Nat Commun. 2017 01 18; 8:14135. Gustavsson M, Wang L, van Gils N, Stephens BS, Zhang P, Schall TJ, Yang S, Abagyan R, Chance MR, Kufareva I, Handel TM. PMID: 28098154; PMCID: PMC5253664.
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Differential structural remodelling of heparan sulfate by chemokines: the role of chemokine oligomerization. Open Biol. 2017 01; 7(1). Dyer DP, Migliorini E, Salanga CL, Thakar D, Handel TM, Richter RP. PMID: 28123055; PMCID: PMC5303277.
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Structure of CC chemokine receptor 2 with orthosteric and allosteric antagonists. Nature. 2016 12 15; 540(7633):458-461. Zheng Y, Qin L, Zacarías NV, de Vries H, Han GW, Gustavsson M, Dabros M, Zhao C, Cherney RJ, Carter P, Stamos D, Abagyan R, Cherezov V, Stevens RC, IJzerman AP, Heitman LH, Tebben A, Kufareva I, Handel TM. PMID: 27926736; PMCID: PMC5159191.
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Signal transmission through the CXC chemokine receptor 4 (CXCR4) transmembrane helices. Proc Natl Acad Sci U S A. 2016 08 30; 113(35):9928-33. Wescott MP, Kufareva I, Paes C, Goodman JR, Thaker Y, Puffer BA, Berdougo E, Rucker JB, Handel TM, Doranz BJ. PMID: 27543332; PMCID: PMC5024644.
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The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions. J Biol Chem. 2016 Jun 10; 291(24):12627-12640. Dyer DP, Salanga CL, Johns SC, Valdambrini E, Fuster MM, Milner CM, Day AJ, Handel TM. PMID: 27044744; PMCID: PMC4933465.
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Examination of Glycosaminoglycan Binding Sites on the XCL1 Dimer. Biochemistry. 2016 Mar 01; 55(8):1214-25. Fox JC, Tyler RC, Peterson FC, Dyer DP, Zhang F, Linhardt RJ, Handel TM, Volkman BF. PMID: 26836755; PMCID: PMC4775286.
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Disulfide Trapping for Modeling and Structure Determination of Receptor: Chemokine Complexes. Methods Enzymol. 2016; 570:389-420. Kufareva I, Gustavsson M, Holden LG, Qin L, Zheng Y, Handel TM. PMID: 26921956; PMCID: PMC4782801.
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Preface. Methods Enzymol. 2016; 570:xxi-xxii. Handel TM. PMID: 26921963.
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Production of Chemokine/Chemokine Receptor Complexes for Structural Biophysical Studies. Methods Enzymol. 2016; 570:233-60. Gustavsson M, Zheng Y, Handel TM. PMID: 26921949; PMCID: PMC4770566.
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The dependence of chemokine-glycosaminoglycan interactions on chemokine oligomerization. Glycobiology. 2016 Mar; 26(3):312-26. Dyer DP, Salanga CL, Volkman BF, Kawamura T, Handel TM. PMID: 26582609; PMCID: PMC4736540.
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Examining Roles of Glycans in Chemokine-Mediated Dendritic-Endothelial Cell Interactions. Methods Enzymol. 2016; 570:335-55. Yin X, Johns SC, El Ghazal R, Salanga CL, Handel TM, Fuster MM. PMID: 26921954.
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Cytokines and growth factors cross-link heparan sulfate. Open Biol. 2015 Aug; 5(8). Migliorini E, Thakar D, Kühnle J, Sadir R, Dyer DP, Li Y, Sun C, Volkman BF, Handel TM, Coche-Guerente L, Fernig DG, Lortat-Jacob H, Richter RP. PMID: 26269427; PMCID: PMC4554917.
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Dual targeting of the chemokine receptors CXCR4 and ACKR3 with novel engineered chemokines. J Biol Chem. 2015 Sep 11; 290(37):22385-97. Hanes MS, Salanga CL, Chowdry AB, Comerford I, McColl SR, Kufareva I, Handel TM. PMID: 26216880; PMCID: PMC4566214.
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The Structure of a CXCR4:Chemokine Complex. Front Immunol. 2015; 6:282. Handel TM. PMID: 26097480; PMCID: PMC4457019.
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Interactions of the Chemokine CCL5/RANTES with Medium-Sized Chondroitin Sulfate Ligands. Structure. 2015 Jun 02; 23(6):1066-77. Deshauer C, Morgan AM, Ryan EO, Handel TM, Prestegard JH, Wang X. PMID: 25982530; PMCID: PMC4456249.
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Chemokine and chemokine receptor structure and interactions: implications for therapeutic strategies. Immunol Cell Biol. 2015 Apr; 93(4):372-83. Kufareva I, Salanga CL, Handel TM. PMID: 25708536; PMCID: PMC4406842.
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Structural biology. Crystal structure of the chemokine receptor CXCR4 in complex with a viral chemokine. Science. 2015 Mar 06; 347(6226):1117-22. Qin L, Kufareva I, Holden LG, Wang C, Zheng Y, Zhao C, Fenalti G, Wu H, Han GW, Cherezov V, Abagyan R, Stevens RC, Handel TM. PMID: 25612609; PMCID: PMC4362693.
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Experiment-Guided Molecular Modeling of Protein-Protein Complexes Involving GPCRs. Methods Mol Biol. 2015; 1335:295-311. Kufareva I, Handel TM, Abagyan R. PMID: 26260608; PMCID: PMC4551442.
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Stoichiometry and geometry of the CXC chemokine receptor 4 complex with CXC ligand 12: molecular modeling and experimental validation. Proc Natl Acad Sci U S A. 2014 Dec 16; 111(50):E5363-72. Kufareva I, Stephens BS, Holden LG, Qin L, Zhao C, Kawamura T, Abagyan R, Handel TM. PMID: 25468967; PMCID: PMC4273337.
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Identification of the pharmacophore of the CC chemokine-binding proteins Evasin-1 and -4 using phage display. J Biol Chem. 2014 Nov 14; 289(46):31846-31855. Bonvin P, Dunn SM, Rousseau F, Dyer DP, Shaw J, Power CA, Handel TM, Proudfoot AEI. PMID: 25266725; PMCID: PMC4231662.
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Multiple glycosaminoglycan-binding epitopes of monocyte chemoattractant protein-3/CCL7 enable it to function as a non-oligomerizing chemokine. J Biol Chem. 2014 May 23; 289(21):14896-912. Salanga CL, Dyer DP, Kiselar JG, Gupta S, Chance MR, Handel TM. PMID: 24727473; PMCID: PMC4031540.
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Chemokine cooperativity is caused by competitive glycosaminoglycan binding. J Immunol. 2014 Apr 15; 192(8):3908-3914. Verkaar F, van Offenbeek J, van der Lee MMC, van Lith LHCJ, Watts AO, Rops ALWMM, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AEI, Vischer HF, Zaman GJR, Smit MJ. PMID: 24639348; PMCID: PMC4198333.
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TSG-6 inhibits neutrophil migration via direct interaction with the chemokine CXCL8. J Immunol. 2014 Mar 01; 192(5):2177-85. Dyer DP, Thomson JM, Hermant A, Jowitt TA, Handel TM, Proudfoot AE, Day AJ, Milner CM. PMID: 24501198; PMCID: PMC3988464.
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Lymphatic specific disruption in the fine structure of heparan sulfate inhibits dendritic cell traffic and functional T cell responses in the lymph node. J Immunol. 2014 Mar 01; 192(5):2133-42. Yin X, Johns SC, Kim D, Mikulski Z, Salanga CL, Handel TM, Macal M, Zúñiga EI, Fuster MM. PMID: 24493818; PMCID: PMC3960083.
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A general method for site specific fluorescent labeling of recombinant chemokines. PLoS One. 2014; 9(1):e81454. Kawamura T, Stephens B, Qin L, Yin X, Dores MR, Smith TH, Grimsey N, Abagyan R, Trejo J, Kufareva I, Fuster MM, Salanga CL, Handel TM. PMID: 24489642; PMCID: PMC3904831.
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The chemokine receptor CCR1 is constitutively active, which leads to G protein-independent, β-arrestin-mediated internalization. J Biol Chem. 2013 Nov 08; 288(45):32194-32210. Gilliland CT, Salanga CL, Kawamura T, Trejo J, Handel TM. PMID: 24056371; PMCID: PMC3820859.
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Sulfopeptide probes of the CXCR4/CXCL12 interface reveal oligomer-specific contacts and chemokine allostery. ACS Chem Biol. 2013 Sep 20; 8(9):1955-63. Ziarek JJ, Getschman AE, Butler SJ, Taleski D, Stephens B, Kufareva I, Handel TM, Payne RJ, Volkman BF. PMID: 23802178; PMCID: PMC3783652.
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Distinct chemokine receptor axes regulate Th9 cell trafficking to allergic and autoimmune inflammatory sites. J Immunol. 2013 Aug 01; 191(3):1110-7. Kara EE, Comerford I, Bastow CR, Fenix KA, Litchfield W, Handel TM, McColl SR. PMID: 23797668; PMCID: PMC3721028.
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MCP-1 binds to oxidized LDL and is carried by lipoprotein(a) in human plasma. J Lipid Res. 2013 Jul; 54(7):1877-83. Wiesner P, Tafelmeier M, Chittka D, Choi SH, Zhang L, Byun YS, Almazan F, Yang X, Iqbal N, Chowdhury P, Maisel A, Witztum JL, Handel TM, Tsimikas S, Miller YI. PMID: 23667177; PMCID: PMC3679389.
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The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nat Rev Cancer. 2013 06; 13(6):412-24. O'Hayre M, Vázquez-Prado J, Kufareva I, Stawiski EW, Handel TM, Seshagiri S, Gutkind JS. PMID: 23640210; PMCID: PMC4068741.
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A novel approach to quantify G-protein-coupled receptor dimerization equilibrium using bioluminescence resonance energy transfer. Methods Mol Biol. 2013; 1013:93-127. Kufareva I, Stephens B, Gilliland CT, Wu B, Fenalti G, Hamel D, Stevens RC, Abagyan R, Handel TM. PMID: 23625495; PMCID: PMC4091634.
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Chemokine oligomerization in cell signaling and migration. Prog Mol Biol Transl Sci. 2013; 117:531-78. Wang X, Sharp JS, Handel TM, Prestegard JH. PMID: 23663982; PMCID: PMC3937849.
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Chemokine receptor oligomerization and allostery. Prog Mol Biol Transl Sci. 2013; 115:375-420. Stephens B, Handel TM. PMID: 23415099; PMCID: PMC4072031.
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Opportunities for functional selectivity in GPCR antibodies. Biochem Pharmacol. 2013 Jan 15; 85(2):147-52. Webb DR, Handel TM, Kretz-Rommel A, Stevens RC. PMID: 22975405; PMCID: PMC3729224.
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Inactivation of heparan sulfate 2-O-sulfotransferase accentuates neutrophil infiltration during acute inflammation in mice. Blood. 2012 Aug 23; 120(8):1742-51. Axelsson J, Xu D, Kang BN, Nussbacher JK, Handel TM, Ley K, Sriramarao P, Esko JD. PMID: 22791291; PMCID: PMC3429312.
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Sorafenib-induced apoptosis of chronic lymphocytic leukemia cells is associated with downregulation of RAF and myeloid cell leukemia sequence 1 (Mcl-1). Mol Med. 2012 Feb 10; 18:19-28. Fecteau JF, Bharati IS, O'Hayre M, Handel TM, Kipps TJ, Messmer D. PMID: 21979753; PMCID: PMC3269641.
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Mechanisms and consequences of the loss of PHLPP1 phosphatase in chronic lymphocytic leukemia (CLL). Leukemia. 2012 Jul; 26(7):1689-92. O'Hayre M, Niederst M, Fecteau JF, Nguyen VM, Kipps TJ, Messmer D, Newton AC, Handel TM. PMID: 22237780; PMCID: PMC3395972.
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Heparin-induced leukocytosis requires 6-O-sulfation and is caused by blockade of selectin- and CXCL12 protein-mediated leukocyte trafficking in mice. J Biol Chem. 2012 Feb 17; 287(8):5542-53. Zhang S, Condac E, Qiu H, Jiang J, Gutierrez-Sanchez G, Bergmann C, Handel T, Wang L. PMID: 22194593; PMCID: PMC3285330.
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Oligomeric structure of the chemokine CCL5/RANTES from NMR, MS, and SAXS data. Structure. 2011 Aug 10; 19(8):1138-48. Wang X, Watson C, Sharp JS, Handel TM, Prestegard JH. PMID: 21827949; PMCID: PMC3159919.
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Regulation of chemerin chemoattractant and antibacterial activity by human cysteine cathepsins. J Immunol. 2011 Aug 01; 187(3):1403-10. Kulig P, Kantyka T, Zabel BA, Banas M, Chyra A, Stefanska A, Tu H, Allen SJ, Handel TM, Kozik A, Potempa J, Butcher EC, Cichy J. PMID: 21715684; PMCID: PMC3140563.
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A rapid and efficient way to obtain modified chemokines for functional and biophysical studies. Cytokine. 2011 Aug; 55(2):168-73. Allen SJ, Hamel DJ, Handel TM. PMID: 21632261; PMCID: PMC3126891.
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Discovery, optimization, and pharmacological characterization of novel heteroaroylphenylureas antagonists of C-C chemokine ligand 2 function. J Med Chem. 2011 Mar 24; 54(6):1667-81. Laborde E, Macsata RW, Meng F, Peterson BT, Robinson L, Schow SR, Simon RJ, Xu H, Baba K, Inagaki H, Ishiwata Y, Jomori T, Matsumoto Y, Miyachi A, Nakamura T, Okamoto M, Handel TM, Bernard CC. PMID: 21341682; PMCID: PMC3229226.
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Specificity and cooperativity at β-lactamase position 104 in TEM-1/BLIP and SHV-1/BLIP interactions. Proteins. 2011 Apr; 79(4):1267-76. Hanes MS, Reynolds KA, McNamara C, Ghosh P, Bonomo RA, Kirsch JF, Handel TM. PMID: 21294157; PMCID: PMC3417816.
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Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in function. Exp Cell Res. 2011 Mar 10; 317(5):590-601. Salanga CL, Handel TM. PMID: 21223963; PMCID: PMC3089961.
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A critical role for lymphatic endothelial heparan sulfate in lymph node metastasis. Mol Cancer. 2010 Dec 20; 9:316. Yin X, Truty J, Lawrence R, Johns SC, Srinivasan RS, Handel TM, Fuster MM. PMID: 21172016; PMCID: PMC3019167.
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Chronic lymphocytic leukemia cells receive RAF-dependent survival signals in response to CXCL12 that are sensitive to inhibition by sorafenib. Blood. 2011 Jan 20; 117(3):882-9. Messmer D, Fecteau JF, O'Hayre M, Bharati IS, Handel TM, Kipps TJ. PMID: 21079155; PMCID: PMC3035080.
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Emerging concepts and approaches for chemokine-receptor drug discovery. Expert Opin Drug Discov. 2010 Nov; 5(11):1109-22. O'Hayre M, Salanga CL, Handel TM, Hamel DJ. PMID: 21132095; PMCID: PMC2995586.
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Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists. Science. 2010 Nov 19; 330(6007):1066-71. Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. PMID: 20929726; PMCID: PMC3074590.
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Protein-protein binding affinities by pulse proteolysis: application to TEM-1/BLIP protein complexes. Protein Sci. 2010 Oct; 19(10):1996-2000. Hanes MS, Ratcliff K, Marqusee S, Handel TM. PMID: 20669180; PMCID: PMC2998734.
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Elucidating the CXCL12/CXCR4 signaling network in chronic lymphocytic leukemia through phosphoproteomics analysis. PLoS One. 2010 Jul 22; 5(7):e11716. O'Hayre M, Salanga CL, Kipps TJ, Messmer D, Dorrestein PC, Handel TM. PMID: 20661426; PMCID: PMC2908618.
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Duffy antigen inhibitors: useful therapeutics for malaria? Trends Parasitol. 2010 Jul; 26(7):329-33. Handel TM, Horuk R. PMID: 20382562.
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Characterization of the chemokine CXCL11-heparin interaction suggests two different affinities for glycosaminoglycans. J Biol Chem. 2010 Jun 04; 285(23):17713-24. Severin IC, Gaudry JP, Johnson Z, Kungl A, Jansma A, Gesslbauer B, Mulloy B, Power C, Proudfoot AE, Handel T. PMID: 20363748; PMCID: PMC2878535.
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Structure of the minimal interface between ApoE and LRP. J Mol Biol. 2010 Apr 30; 398(2):306-19. Guttman M, Prieto JH, Handel TM, Domaille PJ, Komives EA. PMID: 20303980; PMCID: PMC2880916.
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NMR analysis of the structure, dynamics, and unique oligomerization properties of the chemokine CCL27. J Biol Chem. 2010 May 07; 285(19):14424-37. Jansma AL, Kirkpatrick JP, Hsu AR, Handel TM, Nietlispach D. PMID: 20200157; PMCID: PMC2863231.
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Structural and biochemical characterization of the interaction between KPC-2 beta-lactamase and beta-lactamase inhibitor protein. Biochemistry. 2009 Oct 06; 48(39):9185-93. Hanes MS, Jude KM, Berger JM, Bonomo RA, Handel TM. PMID: 19731932; PMCID: PMC2769493.
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Modulation of chemokine receptor activity through dimerization and crosstalk. Cell Mol Life Sci. 2009 Apr; 66(8):1370-86. Salanga CL, O'Hayre M, Handel T. PMID: 19099182; PMCID: PMC2738873.
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Expression, purification and in vitro functional reconstitution of the chemokine receptor CCR1. Protein Expr Purif. 2009 Jul; 66(1):73-81. Allen SJ, Ribeiro S, Horuk R, Handel TM. PMID: 19275940; PMCID: PMC2706832.
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Phosphoproteomic analysis of chemokine signaling networks. Methods Enzymol. 2009; 460:331-46. O'Hayre M, Salanga CL, Dorrestein PC, Handel TM. PMID: 19446733.
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Chapter 2. Homo- and hetero-oligomerization of chemokines. Methods Enzymol. 2009; 461:31-50. Jansma A, Handel TM, Hamel DJ. PMID: 19480913.
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Chapter 4. Interactions of chemokines with glycosaminoglycans. Methods Enzymol. 2009; 461:71-102. Hamel DJ, Sielaff I, Proudfoot AE, Handel TM. PMID: 19480915.
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Methods to probe the physical characteristics, dynamics, modifications, and interactions of chemokines and chemokine receptors. Preface. Methods Enzymol. 2009; 461:xv. Hamel DJ, Handel TM. PMID: 19480911.
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Formation of the pyridazine natural product azamerone by biosynthetic rearrangement of an aryl diazoketone. Angew Chem Int Ed Engl. 2009; 48(4):767-70. Winter JM, Jansma AL, Handel TM, Moore BS. PMID: 19072974; PMCID: PMC3517086.
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Regulation of chemerin bioactivity by plasma carboxypeptidase N, carboxypeptidase B (activated thrombin-activable fibrinolysis inhibitor), and platelets. J Biol Chem. 2009 Jan 09; 284(2):751-8. Du XY, Zabel BA, Myles T, Allen SJ, Handel TM, Lee PP, Butcher EC, Leung LL. PMID: 19010784; PMCID: PMC2613638.
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Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med. 2008 Sep 29; 205(10):2207-20. Zabel BA, Nakae S, Zúñiga L, Kim JY, Ohyama T, Alt C, Pan J, Suto H, Soler D, Allen SJ, Handel TM, Song CH, Galli SJ, Butcher EC. PMID: 18794339; PMCID: PMC2556791.
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An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo. J Leukoc Biol. 2008 Oct; 84(4):1101-8. Handel TM, Johnson Z, Rodrigues DH, Dos Santos AC, Cirillo R, Muzio V, Riva S, Mack M, Déruaz M, Borlat F, Vitte PA, Wells TN, Teixeira MM, Proudfoot AE. PMID: 18662971; PMCID: PMC2538597.
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Computational redesign of the SHV-1 beta-lactamase/beta-lactamase inhibitor protein interface. J Mol Biol. 2008 Oct 24; 382(5):1265-75. Reynolds KA, Hanes MS, Thomson JM, Antczak AJ, Berger JM, Bonomo RA, Kirsch JF, Handel TM. PMID: 18775544; PMCID: PMC4085744.
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Inhibition of monocyte chemoattractant protein-1 ameliorates rat adjuvant-induced arthritis. J Immunol. 2008 Mar 01; 180(5):3447-56. Shahrara S, Proudfoot AE, Park CC, Volin MV, Haines GK, Woods JM, Aikens CH, Handel TM, Pope RM. PMID: 18292571.
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Chemokines and cancer: migration, intracellular signalling and intercellular communication in the microenvironment. Biochem J. 2008 Feb 01; 409(3):635-49. O'Hayre M, Salanga CL, Handel TM, Allen SJ. PMID: 18177271.
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Quantum mechanical design of enzyme active sites. J Org Chem. 2008 Feb 01; 73(3):889-99. Zhang X, DeChancie J, Gunaydin H, Chowdry AB, Clemente FR, Smith AJ, Handel TM, Houk KN. PMID: 18179229.
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An object-oriented library for computational protein design. J Comput Chem. 2007 Nov 15; 28(14):2378-88. Chowdry AB, Reynolds KA, Hanes MS, Voorhies M, Pokala N, Handel TM. PMID: 17471459.
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NMR assignment of human chemerin, a novel chemoattractant. Biomol NMR Assign. 2007 Dec; 1(2):171-3. Allen SJ, Zabel BA, Kirkpatrick J, Butcher EC, Nietlispach D, Handel TM. PMID: 19636857.
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Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. Protein Sci. 2007 Apr; 16(4):695-703. Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. PMID: 17384234; PMCID: PMC2203349.
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Staphylococcus aureus-derived staphopain B, a potent cysteine protease activator of plasma chemerin. J Immunol. 2007 Mar 15; 178(6):3713-20. Kulig P, Zabel BA, Dubin G, Allen SJ, Ohyama T, Potempa J, Handel TM, Butcher EC, Cichy J. PMID: 17339469.
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Chemokine: receptor structure, interactions, and antagonism. Annu Rev Immunol. 2007; 25:787-820. Allen SJ, Crown SE, Handel TM. PMID: 17291188.
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Chemoattractants, extracellular proteases, and the integrated host defense response. Exp Hematol. 2006 Aug; 34(8):1021-32. Zabel BA, Zuniga L, Ohyama T, Allen SJ, Cichy J, Handel TM, Butcher EC. PMID: 16863908.
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Chemokine-like receptor 1 expression by macrophages in vivo: regulation by TGF-beta and TLR ligands. Exp Hematol. 2006 Aug; 34(8):1106-14. Zabel BA, Ohyama T, Zuniga L, Kim JY, Johnston B, Allen SJ, Guido DG, Handel TM, Butcher EC. PMID: 16863918.
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Structural and computational characterization of the SHV-1 beta-lactamase-beta-lactamase inhibitor protein interface. J Biol Chem. 2006 Sep 08; 281(36):26745-53. Reynolds KA, Thomson JM, Corbett KD, Bethel CR, Berger JM, Kirsch JF, Bonomo RA, Handel TM. PMID: 16809340.
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Heterodimerization of CCR2 chemokines and regulation by glycosaminoglycan binding. J Biol Chem. 2006 Sep 01; 281(35):25438-46. Crown SE, Yu Y, Sweeney MD, Leary JA, Handel TM. PMID: 16803905.
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Chemerin activation by serine proteases of the coagulation, fibrinolytic, and inflammatory cascades. J Biol Chem. 2005 Oct 14; 280(41):34661-6. Zabel BA, Allen SJ, Kulig P, Allen JA, Cichy J, Handel TM, Butcher EC. PMID: 16096270.
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Chemokine-glycosaminoglycan binding: specificity for CCR2 ligand binding to highly sulfated oligosaccharides using FTICR mass spectrometry. J Biol Chem. 2005 Sep 16; 280(37):32200-8. Yu Y, Sweeney MD, Saad OM, Crown SE, Hsu AR, Handel TM, Leary JA. PMID: 16033763.
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Interaction of chemokines and glycosaminoglycans: a new twist in the regulation of chemokine function with opportunities for therapeutic intervention. Cytokine Growth Factor Rev. 2005 Dec; 16(6):625-36. Johnson Z, Proudfoot AE, Handel TM. PMID: 15990353.
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Chronic expression of monocyte chemoattractant protein-1 in the central nervous system causes delayed encephalopathy and impaired microglial function in mice. FASEB J. 2005 May; 19(7):761-72. Huang D, Wujek J, Kidd G, He TT, Cardona A, Sasse ME, Stein EJ, Kish J, Tani M, Charo IF, Proudfoot AE, Rollins BJ, Handel T, Ransohoff RM. PMID: 15857890.
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Chemokines bind to sulfatides as revealed by surface plasmon resonance. Biochim Biophys Acta. 2005 Feb 21; 1687(1-3):52-63. Sandhoff R, Grieshaber H, Djafarzadeh R, Sijmonsma TP, Proudfoot AE, Handel TM, Wiegandt H, Nelson PJ, Gröne HJ. PMID: 15708353.
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Energy functions for protein design: adjustment with protein-protein complex affinities, models for the unfolded state, and negative design of solubility and specificity. J Mol Biol. 2005 Mar 18; 347(1):203-27. Pokala N, Handel TM. PMID: 15733929.
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Regulation of protein function by glycosaminoglycans--as exemplified by chemokines. Annu Rev Biochem. 2005; 74:385-410. Handel TM, Johnson Z, Crown SE, Lau EK, Proudfoot AE. PMID: 15952892.
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Identification of the glycosaminoglycan binding site of the CC chemokine, MCP-1: implications for structure and function in vivo. J Biol Chem. 2004 May 21; 279(21):22294-305. Lau EK, Paavola CD, Johnson Z, Gaudry JP, Geretti E, Borlat F, Kungl AJ, Proudfoot AE, Handel TM. PMID: 15033992.
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Energy functions for protein design I: efficient and accurate continuum electrostatics and solvation. Protein Sci. 2004 Apr; 13(4):925-36. Pokala N, Handel TM. PMID: 15010542; PMCID: PMC2280065.
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Chemokine structure and receptor interactions. Ernst Schering Res Found Workshop. 2004; (45):101-24. Handel TM, Lau EK. PMID: 14699797.
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Chemokine-receptor interactions: GPCRs, glycosaminoglycans and viral chemokine binding proteins. Adv Protein Chem. 2004; 68:351-91. Lau EK, Allen S, Hsu AR, Handel TM. PMID: 15500866.
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Examination of MCP-1 (CCL2) partitioning and presentation during transendothelial leukocyte migration. Lab Invest. 2004 Jan; 84(1):81-90. Hardy LA, Booth TA, Lau EK, Handel TM, Ali S, Kirby JA. PMID: 14647401.
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Analysis of an orf virus chemokine-binding protein: Shifting ligand specificities among a family of poxvirus viroceptors. Proc Natl Acad Sci U S A. 2003 Dec 09; 100(25):15137-42. Seet BT, McCaughan CA, Handel TM, Mercer A, Brunetti C, McFadden G, Fleming SB. PMID: 14657392; PMCID: PMC299921.
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Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc Natl Acad Sci U S A. 2003 Feb 18; 100(4):1885-90. Proudfoot AE, Handel TM, Johnson Z, Lau EK, LiWang P, Clark-Lewis I, Borlat F, Wells TN, Kosco-Vilbois MH. PMID: 12571364; PMCID: PMC149928.
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Structural basis of chemokine sequestration by a herpesvirus decoy receptor. Cell. 2002 Nov 01; 111(3):343-56. Alexander JM, Nelson CA, van Berkel V, Lau EK, Studts JM, Brett TJ, Speck SH, Handel TM, Virgin HW, Fremont DH. PMID: 12419245.
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Solution structure and dynamics of melanoma inhibitory activity protein. J Biomol NMR. 2002 Mar; 22(3):211-23. Lougheed JC, Domaille PJ, Handel TM. PMID: 11991352.
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Molecular determinants for CC-chemokine recognition by a poxvirus CC-chemokine inhibitor. Proc Natl Acad Sci U S A. 2001 Jul 31; 98(16):9008-13. Seet BT, Singh R, Paavola C, Lau EK, Handel TM, McFadden G. PMID: 11470923; PMCID: PMC55364.
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Molecular determinants of receptor binding and signaling by the CX3C chemokine fractalkine. J Biol Chem. 2001 Sep 07; 276(36):33906-14. Mizoue LS, Sullivan SK, King DS, Kledal TN, Schwartz TW, Bacon KB, Handel TM. PMID: 11432858.
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Review: protein design--where we were, where we are, where we're going. J Struct Biol. 2001 May-Jun; 134(2-3):269-81. Pokala N, Handel TM. PMID: 11551185.
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Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain. Chemistry. 2001 Mar 02; 7(5):1129-32. Marcaurelle LA, Mizoue LS, Wilken J, Oldham L, Kent SB, Handel TM, Bertozzi CR. PMID: 11303872.
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The crystal structure of the chemokine domain of fractalkine shows a novel quaternary arrangement. J Biol Chem. 2000 Jul 28; 275(30):23187-93. Hoover DM, Mizoue LS, Handel TM, Lubkowski J. PMID: 10770945.
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Identification of surface residues of the monocyte chemotactic protein 1 that affect signaling through the receptor CCR2. Biochemistry. 1999 Dec 07; 38(49):16167-77. Jarnagin K, Grunberger D, Mulkins M, Wong B, Hemmerich S, Paavola C, Bloom A, Bhakta S, Diehl F, Freedman R, McCarley D, Polsky I, Ping-Tsou A, Kosaka A, Handel TM. PMID: 10587439.
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Rotamer strain as a determinant of protein structural specificity. Protein Sci. 1999 Dec; 8(12):2598-610. Lazar GA, Johnson EC, Desjarlais JR, Handel TM. PMID: 10631975; PMCID: PMC2144231.
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Folding of an isolated ribonuclease H core fragment. Protein Sci. 1999 Nov; 8(11):2251-7. Chamberlain AK, Fischer KF, Reardon D, Handel TM, Marqusee AS. PMID: 10595528; PMCID: PMC2144208.
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Identification of residues in the monocyte chemotactic protein-1 that contact the MCP-1 receptor, CCR2. Biochemistry. 1999 Oct 05; 38(40):13013-25. Hemmerich S, Paavola C, Bloom A, Bhakta S, Freedman R, Grunberger D, Krstenansky J, Lee S, McCarley D, Mulkins M, Wong B, Pease J, Mizoue L, Mirzadegan T, Polsky I, Thompson K, Handel TM, Jarnagin K. PMID: 10529171.
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Effect of hydrophobic core packing on sidechain dynamics. J Biomol NMR. 1999 Oct; 15(2):135-43. Johnson EC, Handel TM. PMID: 20872109.
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Solution structure and dynamics of a designed hydrophobic core variant of ubiquitin. Structure. 1999 Aug 15; 7(8):967-76. Johnson EC, Lazar GA, Desjarlais JR, Handel TM. PMID: 10467150.
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Side-chain and backbone flexibility in protein core design. J Mol Biol. 1999 Jul 02; 290(1):305-18. Desjarlais JR, Handel TM. PMID: 10388574.
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Solution structure and dynamics of the CX3C chemokine domain of fractalkine and its interaction with an N-terminal fragment of CX3CR1. Biochemistry. 1999 Feb 02; 38(5):1402-14. Mizoue LS, Bazan JF, Johnson EC, Handel TM. PMID: 9931005.
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Monomeric monocyte chemoattractant protein-1 (MCP-1) binds and activates the MCP-1 receptor CCR2B. J Biol Chem. 1998 Dec 11; 273(50):33157-65. Paavola CD, Hemmerich S, Grunberger D, Polsky I, Bloom A, Freedman R, Mulkins M, Bhakta S, McCarley D, Wiesent L, Wong B, Jarnagin K, Handel TM. PMID: 9837883.
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Hydrophobic core packing and protein design. Curr Opin Chem Biol. 1998 Dec; 2(6):675-9. Lazar GA, Handel TM. PMID: 9914192.
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Characterization of a folding intermediate from HIV-1 ribonuclease H. Protein Sci. 1998 Oct; 7(10):2164-74. Kern G, Handel T, Marqusee S. PMID: 9792104; PMCID: PMC2143833.
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From coiled coils to small globular proteins: design of a native-like three-helix bundle. Protein Sci. 1998 Jun; 7(6):1404-14. Bryson JW, Desjarlais JR, Handel TM, DeGrado WF. PMID: 9655345; PMCID: PMC2144029.
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Alterations in chemical shifts and exchange broadening upon peptide boronic acid inhibitor binding to alpha-lytic protease. J Biomol NMR. 1997 Jul; 10(1):21-7. Davis JH, Agard DA, Handel TM, Basus VJ. PMID: 9335113.
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De novo design of the hydrophobic core of ubiquitin. Protein Sci. 1997 Jun; 6(6):1167-78. Lazar GA, Desjarlais JR, Handel TM. PMID: 9194177; PMCID: PMC2143711.
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Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo. J Immunol. 1997 Feb 15; 158(4):1533-40. Hedrick JA, Saylor V, Figueroa D, Mizoue L, Xu Y, Menon S, Abrams J, Handel T, Zlotnik A. PMID: 9029087.
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Heteronuclear (1H, 13C, 15N) NMR assignments and secondary structure of the basic region-helix-loop-helix domain of E47. Protein Sci. 1997 Jan; 6(1):175-84. Fairman R, Beran-Steed RK, Handel TM. PMID: 9007990; PMCID: PMC2143521.
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The structure of MCP-1 in two crystal forms provides a rare example of variable quaternary interactions. Nat Struct Biol. 1997 Jan; 4(1):64-9. Lubkowski J, Bujacz G, Boqué L, Domaille PJ, Handel TM, Wlodawer A. PMID: 8989326.
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Detection of rare partially folded molecules in equilibrium with the native conformation of RNaseH. Nat Struct Biol. 1996 Sep; 3(9):782-7. Chamberlain AK, Handel TM, Marqusee S. PMID: 8784352.
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Heteronuclear (1H, 13C, 15N) NMR assignments and solution structure of the monocyte chemoattractant protein-1 (MCP-1) dimer. Biochemistry. 1996 May 28; 35(21):6569-84. Handel TM, Domaille PJ. PMID: 8639605.
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De novo design of the hydrophobic cores of proteins. Protein Sci. 1995 Oct; 4(10):2006-18. Desjarlais JR, Handel TM. PMID: 8535237; PMCID: PMC2142989.
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New strategies in protein design. Curr Opin Biotechnol. 1995 Aug; 6(4):460-6. Desjarlais JR, Handel TM. PMID: 7579657.
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Metal ion-dependent modulation of the dynamics of a designed protein. Science. 1993 Aug 13; 261(5123):879-85. Handel TM, Williams SA, DeGrado WF. PMID: 8346440.
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Identification of a peptide which binds to the carbohydrate-specific monoclonal antibody B3. Gene. 1993 Jun 15; 128(1):43-9. Hoess R, Brinkmann U, Handel T, Pastan I. PMID: 7685300.
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Effect of cholesterol on the uptake and intracellular degradation of liposomes by liver and spleen; a combined biochemical and gamma-ray perturbed angular correlation study. Biochim Biophys Acta. 1989 Apr 14; 980(2):234-40. Roerdink FH, Regts J, Handel T, Sullivan SM, Baldeschwieler JD, Scherphof GL. PMID: 2930790.
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Modification of lipid phase behavior with membrane-bound cryoprotectants. Biochim Biophys Acta. 1988 Feb 18; 938(2):143-54. Goodrich RP, Handel TM, Baldeschwieler JD. PMID: 3342228.
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