Abstract Activated protein C (APC), derived from the plasma protease zymogen, protein C, is antithrombotic and anti-inflammatory. In preclinical injury models, recombinant APC provides neuroprotection for multiple injuries, including ischemic stroke. APC acts directly on brain en…

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Abstract Mucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy subjects. Here, we test the hypothesis that human colon biofilms comprise microbial communities that are carcino…

Abstract Ischemic stroke is the most widespread cause of disability and a leading cause of death in developed countries. To date, the most potent approved treatment for acute stroke is recanalization therapy with thrombolytic drugs such as tissue plasminogen activator (rt-PA or t…

T cells are activated in a cellular interaction with APCs. The central activating receptor is the TCR ( 1 ). It recognizes antigenic peptides presented by MHC on the surface of the APC. It is remarkably sensitive to small changes in the affinity of the TCR for peptide-MHC ( 1 ). …

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Abstract OBJECTIVE Activated protein C (APC) is neuroprotective in stroke models and promotes post-ischemic neovascularization and neurogenesis. We utilized a controlled cortical impact (CCI) in mice to determine APC's effects on neuroprotection and angiogenesis and neurogenesis …

INTRODUCTION Colorectal cancer (CRC) represents a significant health challenge globally, with high morbidity and mortality rates that are rising in young adults 1 – 4 . The current standard of care for CRC relies on 5-Fluorouracil-based chemotherapy that lacks specificity and is …

Federal Register :: Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems; Quality Reporting Programs; Payment for Intensive Outpatient Services in Hospital Outpatient Departments, Community Mental Health Centers, Rural Health Cl…

Federal Register :: Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; New Categories for Hospital Outpatient Department Prior Authorization Process; Clinical Laboratory Fee Schedule: Laboratory…

Federal Register :: Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; Organ Acquisition; Rural Emergency Hospitals: Payment Policies, Conditions of Participation, Provider Enrollment, Physician…

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Federal Register :: Medicare Program: Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems; Quality Reporting Programs; Overall Hospital Quality Star Rating; Hospital Price Transparency; and Notice of Closure of a Teaching Hospital and Opportunit…

Federal Register :: Medicare Program: Changes to Hospital Outpatient Prospective Payment and Ambulatory Surgical Center Payment Systems and Quality Reporting Programs; Revisions of Organ Procurement Organizations Conditions of Coverage; Prior Authorization Process and Requirement…