Abstract It is well known that fibroblast growth factor receptor 2 ( FGFR2 ) interacts with its ligand of fibroblast growth factor ( FGF ) therefore exerting biological functions on cell proliferation and differentiation. In this study, we first reported that the FGFR2 gene could…

Abstract miR-17 family microRNAs (miRNAs) are crucial for embryo development, however, their role in muscle development is still unclear. miR-20a-5p and miR-20b-5p belong to the miR-17 family and are transcribed from the miR-17~92 and miR-106a~363 clusters respectively. In this s…

Decrypting the microRNA signatures in gastric cancer using high-throughput miRNA array coupled with systems biological approaches for precision medicine Fehmida Bibi1, Peter Natesan Pushparaj2, Muhammad I. Naseer2, Muhammad yasir1, Esam I. Azhar1,3 1 Special Infectious Agents Uni…

Abstract Background. Acute rejection (AR) and recurrent HCV (R-HCV) are significant complications in liver allograft recipients. Noninvasive diagnosis of intragraft pathologies may improve their management. Methods. We performed small RNA sequencing and miRNA microarray profiling…

Introduction MicroRNAs (miRNAs) are a category of single‐stranded non‐coding RNAs which contain about 20~25 nucleotides in length. They play an important role in the regulation of gene expression at the post‐transcriptional and translational level by binding to the 3′untranslated…

JCI - MicroRNA-146a is a therapeutic target and biomarker for peripartum cardiomyopathy Go to JCI Insight About Editors Consulting Editors For authors Publication ethics Publication alerts by email Advertising Job board Contact The Journal of Clinical Investigation Current issue …

Abstract Skeletal muscle differentiation can be regulated by various transcription factors and non-coding RNAs. In our previous work, miR-223 is differentially expressed in the skeletal muscle of chicken with different growth rates, but its role, expression and action mechanism i…

Abstract Simple Summary Exosomes are small (40–160 nanometer) extracellular vesicles with significant roles in cancer development and progression. Exosomes are abundantly produced by cancer cells, carry tumor-specific content, such as DNA, RNA, and proteins, and have the potentia…

Introduction Thymic epithelial cells (TECs) are critical mediators of T cell development in the thymus. Cortical thymic epithelial cells (cTECs) facilitate positive selection as thymocytes rearrange and assemble T cell receptors (TCRs) capable of recognizing self-MHC [ 1 ]. Posit…

Abstract Hepatitis C virus (HCV) depends on liver-specific microRNA miR-122 for efficient viral RNA amplification in liver cells. This microRNA interacts with two different conserved sites at the very 5’ end of the viral RNA, enhancing miR-122 stability and promoting replication …

Frontiers | miR-429-3p/LPIN1 Axis Promotes Chicken Abdominal Fat Deposition via PPARγ Pathway ORIGINAL RESEARCH article Front. Cell Dev. Biol. , 21 December 2020 Sec. Cell Growth and Division Volume 8 - 2020 | https://doi.org/10.3389/fcell.2020.595637 miR-429-3p/ LPIN1 Axis Promo…

Background MicroRNAs (miRNAs) are one category of small single-stranded non-coding RNA molecule (containing 20~25 nucleotides), which function in regulation of gene expression at the posttranscriptional level [ 1 , 2 ]. Generally, miRNAs could cause mRNAs degradation by binding t…

Europe PMC Funders Group Author Manuscript Nat Cell Biol. Author manuscript; available in PMC 2013 January 01. Published in final edited form as: Nat Cell Biol. ; 14(7): 659–665. doi:10.1038/ncb2521. Europe PMC Funders Author Manuscripts The H19 lincRNA is a developmental reservo…

INTRODUCTION A steadily growing number of studies have confirmed that miRNAs play pivotal roles in tumorigenesis, either acting as oncogenes or tumor suppressors to modulate growth, angiogenesis, drug or chemo-resistance, invasion and metastasis of malignant cells [ 1 , 2 ]. Dere…

INTRODUCTION Myelination has evolved in vertebrates to electrically insulate axons to promote rapid, energy efficient action potential propagation. In the central nervous system (CNS), the production of multilamellar myelin sheaths is performed by oligodendrocytes (OLs). The loca…