Introduction Huntington’s disease (HD) is an autosomal-dominant neurodegenerative disorder caused by an expanded CAG repeat in the first exon of the huntingtin gene ( HTT ) encoding a mutant huntingtin (mHtt) protein with an extended stretch of polyglutamines. 1 mHtt aggregates i…
Paul A. Khavari, MD, PhD's Profile | Stanford Profiles Paul A. Khavari, MD, PhD Carl J. Herzog Professor of Dermatology in the School of Medicine Practices at Stanford Health Care Web page: Print Profile Email Profile View Stanford-only Profile Tab Menu Bio Research & Scholarship…
A review on hepatitis D: From virology to new therapies - PMC Official websites use .gov .gov website belongs to an official government organization in the United States. Secure .gov websites use HTTPS lock ) or means you've safely connected to the .gov website. Share sensitive i…
Abstract RNA-binding proteins (RBPs) control varied processes, including RNA splicing, stability, transport and translation 1-3 . Dysfunctional RNA-RBP interactions contribute to the pathogenesis of human disease 1,4,5 ; however, characterizing the nature and dynamics of multipro…
Enhancers serve as critical regulatory elements for transcrip tional programs by directing development, homeostasis and disease states 1 , 2 . Clusters of enhancers located in a relatively small genomic region, known as super enhancers 3 , 4 or stretch enhancers 5 , exhibit more …
Purpose: Retinal non-perfusion (RNP) is fundamental to disease onset and progression in diabetic retinopathy (DR). Whether anti-vascular endothelial growth factor (anti-VEGF) therapy can modify RNP progression is unclear. This investigation quantified the impact of anti-VEGF ther…
INTRODUCTION Chronic obstructive pulmonary disease (COPD) is a major cause of morbidity and mortality and the third leading cause of death worldwide ( 1 ). The disease encompasses both chronic bronchitis and emphysema resulting from injury to the two major lung compartments, the …
Results Modified primary B cells express the HIV VRC01 bnAb as antigen receptor Wild-type (WT) C57BL/6J (or B6) mice are a useful model in which to explore vaccine elicitation of HIV bnAbs from engineered cells because of similarities between the mouse and human humoral immune sy…
Results B cells can be engineered to express bNAbs using CRISPR/Cas9 and AAV We use CRISPR/Cas9 and recombinant adeno associated viral vectors (rAAV) to target the integration of the 3BNC117 11 HIV-bNAb under an enhancer dependent (ED) Ig promoter 12 into the J-C intron of the Ig…
Determinants of the recognition of enteroviral cloverleaf RNA by coxsackievirus B3 proteinase 3C RNA (2002), 8 :188–201+ Cambridge University Press+ Printed in the USA+ Copyright © 2002 RNA Society+ DOI: 10+1017+S135583820101278X Determinants of the recognition of enteroviral clo…
hPSC culture H9 hPSCs (WiCell) 57 were used throughout this entire study, and were validated to be mycoplasma negative and karyotypically normal. Undifferentiated hPSCs were cultured feeder-free in mTeSR1 media (StemCell Technologies) on cell-culture plates that had been pre-coat…
Genome editing across Dictyostelia species enables comparative functional genetics of social amoebas | Scientific Reports Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up…
Abstract Telomerase is a eukaryotic ribonucleoprotein (RNP) whose specialized reverse transcriptase action performs de novo synthesis of one strand of telomeric DNA. The resulting telomerase-mediated elongation of telomeres, which are the protective end-caps for eukaryotic chromo…
74 David KLOTZ BSÉG 30 (2014-15) BSÉG 30 (2014-15) TWO HYMNS TO ISIS FROM PHILAE REVISITED 75 Two Hymns to Isis from Philae Revisited (Žabkar, Hymns 1-2) David KLOTZ University of Basel, eikones Nouvelle traduction de deux hymnes à la déesse Isis de Philae, avec analyse des princ…
SEEDs enable enrichment of cells with transgene integrations To develop a method for cells with transgene integrations to be enriched through negative selection, we designed two reagents: (1) a guide RNA (gRNA) targeting an intron of a surface-expressed protein that generates a D…